Ferredoxin NADP+ reductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADPH:adrenodoxin oxidoreductase, mitochondrial, putative

Species:

Leishmania major

UniProt:

Q4QCH3_LEIMA

TriTrypDb:

LmjF.21.0420 , LMJLV39_210009500 , LMJSD75_210009600

Length:

699

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005747	mitochondrial respiratory chain complex I	4	2
GO:0030964	NADH dehydrogenase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0045271	respiratory chain complex I	4	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0098803	respiratory chain complex	3	2
GO:0110165	cellular anatomical entity	1	3
GO:1902494	catalytic complex	2	2
GO:1902495	transmembrane transporter complex	3	2
GO:1990204	oxidoreductase complex	3	2
GO:1990351	transporter complex	2	2
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

Q4QCH3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCH3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004324	ferredoxin-NADP+ reductase activity	6	5
GO:0008937	ferredoxin-NAD(P) reductase activity	5	5
GO:0016491	oxidoreductase activity	2	10
GO:0016730	oxidoreductase activity, acting on iron-sulfur proteins as donors	3	7
GO:0016731	oxidoreductase activity, acting on iron-sulfur proteins as donors, NAD or NADP as acceptor	4	7
GO:0015039	NADPH-adrenodoxin reductase activity	5	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.357
CLV_C14_Caspase3-7	504	508	PF00656	0.327
CLV_NRD_NRD_1	283	285	PF00675	0.345
CLV_NRD_NRD_1	415	417	PF00675	0.432
CLV_NRD_NRD_1	42	44	PF00675	0.445
CLV_NRD_NRD_1	86	88	PF00675	0.440
CLV_PCSK_FUR_1	230	234	PF00082	0.447
CLV_PCSK_KEX2_1	232	234	PF00082	0.443
CLV_PCSK_KEX2_1	283	285	PF00082	0.345
CLV_PCSK_KEX2_1	333	335	PF00082	0.372
CLV_PCSK_KEX2_1	42	44	PF00082	0.446
CLV_PCSK_KEX2_1	426	428	PF00082	0.354
CLV_PCSK_KEX2_1	85	87	PF00082	0.489
CLV_PCSK_PC1ET2_1	232	234	PF00082	0.443
CLV_PCSK_PC1ET2_1	333	335	PF00082	0.348
CLV_PCSK_PC1ET2_1	426	428	PF00082	0.354
CLV_PCSK_PC1ET2_1	85	87	PF00082	0.574
CLV_PCSK_SKI1_1	20	24	PF00082	0.624
CLV_PCSK_SKI1_1	297	301	PF00082	0.327
CLV_PCSK_SKI1_1	341	345	PF00082	0.391
CLV_PCSK_SKI1_1	627	631	PF00082	0.347
CLV_PCSK_SKI1_1	647	651	PF00082	0.366
CLV_PCSK_SKI1_1	661	665	PF00082	0.529
DEG_APCC_DBOX_1	401	409	PF00400	0.318
DEG_Nend_Nbox_1	1	3	PF02207	0.481
DEG_SCF_FBW7_1	649	654	PF00400	0.622
DEG_SPOP_SBC_1	48	52	PF00917	0.503
DEG_SPOP_SBC_1	542	546	PF00917	0.708
DEG_SPOP_SBC_1	574	578	PF00917	0.652
DEG_SPOP_SBC_1	74	78	PF00917	0.641
DOC_ANK_TNKS_1	232	239	PF00023	0.424
DOC_ANK_TNKS_1	428	435	PF00023	0.494
DOC_CYCLIN_RxL_1	105	116	PF00134	0.316
DOC_CYCLIN_RxL_1	658	668	PF00134	0.614
DOC_CYCLIN_yCln2_LP_2	121	127	PF00134	0.275
DOC_MAPK_DCC_7	400	410	PF00069	0.323
DOC_MAPK_gen_1	108	115	PF00069	0.307
DOC_MAPK_gen_1	230	237	PF00069	0.456
DOC_MAPK_gen_1	272	280	PF00069	0.374
DOC_MAPK_gen_1	330	338	PF00069	0.411
DOC_MAPK_gen_1	391	401	PF00069	0.347
DOC_MAPK_gen_1	592	599	PF00069	0.352
DOC_MAPK_gen_1	85	92	PF00069	0.380
DOC_MAPK_MEF2A_6	108	117	PF00069	0.296
DOC_MAPK_MEF2A_6	627	634	PF00069	0.350
DOC_MAPK_MEF2A_6	85	92	PF00069	0.490
DOC_MAPK_NFAT4_5	108	116	PF00069	0.327
DOC_PP1_RVXF_1	152	158	PF00149	0.299
DOC_PP2B_LxvP_1	121	124	PF13499	0.259
DOC_PP2B_LxvP_1	191	194	PF13499	0.339
DOC_USP7_MATH_1	185	189	PF00917	0.367
DOC_USP7_MATH_1	343	347	PF00917	0.370
DOC_USP7_MATH_1	364	368	PF00917	0.623
DOC_USP7_MATH_1	373	377	PF00917	0.725
DOC_USP7_MATH_1	541	545	PF00917	0.704
DOC_USP7_MATH_1	651	655	PF00917	0.617
DOC_USP7_MATH_1	69	73	PF00917	0.676
DOC_USP7_MATH_1	690	694	PF00917	0.514
DOC_USP7_MATH_1	74	78	PF00917	0.671
DOC_USP7_UBL2_3	140	144	PF12436	0.424
DOC_USP7_UBL2_3	268	272	PF12436	0.454
DOC_USP7_UBL2_3	478	482	PF12436	0.469
DOC_USP7_UBL2_3	494	498	PF12436	0.226
DOC_USP7_UBL2_3	618	622	PF12436	0.327
DOC_WW_Pin1_4	130	135	PF00397	0.429
DOC_WW_Pin1_4	217	222	PF00397	0.308
DOC_WW_Pin1_4	255	260	PF00397	0.321
DOC_WW_Pin1_4	368	373	PF00397	0.722
DOC_WW_Pin1_4	403	408	PF00397	0.380
DOC_WW_Pin1_4	563	568	PF00397	0.558
DOC_WW_Pin1_4	647	652	PF00397	0.629
LIG_14-3-3_CanoR_1	154	158	PF00244	0.293
LIG_AP2alpha_1	146	150	PF02296	0.330
LIG_APCC_ABBA_1	111	116	PF00400	0.315
LIG_BIR_III_4	359	363	PF00653	0.446
LIG_BRCT_BRCA1_1	219	223	PF00533	0.323
LIG_BRCT_BRCA1_1	97	101	PF00533	0.404
LIG_CtBP_PxDLS_1	613	618	PF00389	0.370
LIG_eIF4E_1	419	425	PF01652	0.362
LIG_eIF4E_1	580	586	PF01652	0.453
LIG_FHA_1	229	235	PF00498	0.374
LIG_FHA_1	32	38	PF00498	0.638
LIG_FHA_1	469	475	PF00498	0.333
LIG_FHA_1	589	595	PF00498	0.389
LIG_FHA_2	181	187	PF00498	0.333
LIG_FHA_2	343	349	PF00498	0.415
LIG_FHA_2	378	384	PF00498	0.622
LIG_FHA_2	426	432	PF00498	0.483
LIG_FHA_2	623	629	PF00498	0.460
LIG_LIR_Apic_2	253	259	PF02991	0.341
LIG_LIR_Gen_1	116	125	PF02991	0.253
LIG_LIR_Gen_1	143	150	PF02991	0.343
LIG_LIR_Gen_1	209	218	PF02991	0.426
LIG_LIR_Gen_1	440	451	PF02991	0.461
LIG_LIR_Nem_3	116	121	PF02991	0.272
LIG_LIR_Nem_3	143	149	PF02991	0.488
LIG_LIR_Nem_3	206	210	PF02991	0.266
LIG_LIR_Nem_3	220	226	PF02991	0.306
LIG_LIR_Nem_3	253	257	PF02991	0.354
LIG_LIR_Nem_3	293	299	PF02991	0.363
LIG_LIR_Nem_3	440	446	PF02991	0.476
LIG_LIR_Nem_3	577	583	PF02991	0.501
LIG_NRBOX	659	665	PF00104	0.470
LIG_Pex14_2	146	150	PF04695	0.274
LIG_SH2_CRK	176	180	PF00017	0.255
LIG_SH2_CRK	211	215	PF00017	0.373
LIG_SH2_CRK	218	222	PF00017	0.362
LIG_SH2_CRK	443	447	PF00017	0.365
LIG_SH2_GRB2like	210	213	PF00017	0.253
LIG_SH2_SRC	302	305	PF00017	0.466
LIG_SH2_STAP1	176	180	PF00017	0.252
LIG_SH2_STAT5	256	259	PF00017	0.362
LIG_SH2_STAT5	419	422	PF00017	0.447
LIG_SH2_STAT5	443	446	PF00017	0.435
LIG_SH2_STAT5	488	491	PF00017	0.270
LIG_SH2_STAT5	588	591	PF00017	0.370
LIG_SH2_STAT5	659	662	PF00017	0.482
LIG_SH3_3	131	137	PF00018	0.294
LIG_SH3_3	360	366	PF00018	0.513
LIG_SH3_3	369	375	PF00018	0.656
LIG_SH3_3	522	528	PF00018	0.467
LIG_SUMO_SIM_anti_2	276	282	PF11976	0.437
LIG_SUMO_SIM_anti_2	406	413	PF11976	0.447
LIG_SUMO_SIM_anti_2	553	559	PF11976	0.587
LIG_SUMO_SIM_par_1	32	38	PF11976	0.480
LIG_SUMO_SIM_par_1	553	559	PF11976	0.521
LIG_TRAF2_1	345	348	PF00917	0.523
LIG_TRFH_1	403	407	PF08558	0.319
LIG_UBA3_1	657	661	PF00899	0.623
LIG_WRC_WIRS_1	557	562	PF05994	0.597
MOD_CDK_SPxK_1	563	569	PF00069	0.561
MOD_CDK_SPxK_1	647	653	PF00069	0.630
MOD_CK1_1	203	209	PF00069	0.311
MOD_CK1_1	346	352	PF00069	0.530
MOD_CK1_1	376	382	PF00069	0.634
MOD_CK1_1	545	551	PF00069	0.666
MOD_CK1_1	67	73	PF00069	0.588
MOD_CK1_1	95	101	PF00069	0.259
MOD_CK2_1	203	209	PF00069	0.413
MOD_CK2_1	342	348	PF00069	0.452
MOD_CK2_1	368	374	PF00069	0.678
MOD_CK2_1	377	383	PF00069	0.637
MOD_CK2_1	425	431	PF00069	0.488
MOD_CK2_1	49	55	PF00069	0.548
MOD_CK2_1	545	551	PF00069	0.519
MOD_Cter_Amidation	616	619	PF01082	0.374
MOD_Cter_Amidation	638	641	PF01082	0.461
MOD_GlcNHglycan	151	154	PF01048	0.328
MOD_GlcNHglycan	202	205	PF01048	0.342
MOD_GlcNHglycan	287	291	PF01048	0.310
MOD_GlcNHglycan	366	369	PF01048	0.642
MOD_GlcNHglycan	37	40	PF01048	0.547
MOD_GlcNHglycan	374	378	PF01048	0.723
MOD_GlcNHglycan	545	548	PF01048	0.567
MOD_GlcNHglycan	59	62	PF01048	0.672
MOD_GlcNHglycan	67	70	PF01048	0.594
MOD_GlcNHglycan	71	74	PF01048	0.555
MOD_GlcNHglycan	94	97	PF01048	0.283
MOD_GSK3_1	149	156	PF00069	0.311
MOD_GSK3_1	25	32	PF00069	0.655
MOD_GSK3_1	286	293	PF00069	0.425
MOD_GSK3_1	342	349	PF00069	0.502
MOD_GSK3_1	364	371	PF00069	0.686
MOD_GSK3_1	373	380	PF00069	0.616
MOD_GSK3_1	44	51	PF00069	0.459
MOD_GSK3_1	541	548	PF00069	0.663
MOD_GSK3_1	647	654	PF00069	0.619
MOD_GSK3_1	65	72	PF00069	0.614
MOD_GSK3_1	74	81	PF00069	0.553
MOD_N-GLC_1	159	164	PF02516	0.346
MOD_N-GLC_1	403	408	PF02516	0.436
MOD_N-GLC_1	64	69	PF02516	0.667
MOD_N-GLC_1	74	79	PF02516	0.644
MOD_NEK2_1	101	106	PF00069	0.406
MOD_NEK2_1	149	154	PF00069	0.295
MOD_NEK2_1	2	7	PF00069	0.525
MOD_NEK2_1	228	233	PF00069	0.529
MOD_NEK2_1	250	255	PF00069	0.290
MOD_NEK2_1	31	36	PF00069	0.599
MOD_NEK2_1	37	42	PF00069	0.547
MOD_NEK2_1	425	430	PF00069	0.439
MOD_NEK2_1	450	455	PF00069	0.367
MOD_NEK2_2	4	9	PF00069	0.502
MOD_NEK2_2	575	580	PF00069	0.460
MOD_PKA_1	42	48	PF00069	0.557
MOD_PKA_2	153	159	PF00069	0.322
MOD_PKA_2	393	399	PF00069	0.353
MOD_PKA_2	42	48	PF00069	0.549
MOD_Plk_1	159	165	PF00069	0.378
MOD_Plk_1	286	292	PF00069	0.335
MOD_Plk_2-3	556	562	PF00069	0.536
MOD_Plk_4	153	159	PF00069	0.321
MOD_Plk_4	501	507	PF00069	0.366
MOD_Plk_4	511	517	PF00069	0.286
MOD_Plk_4	575	581	PF00069	0.582
MOD_ProDKin_1	130	136	PF00069	0.432
MOD_ProDKin_1	217	223	PF00069	0.314
MOD_ProDKin_1	255	261	PF00069	0.316
MOD_ProDKin_1	368	374	PF00069	0.725
MOD_ProDKin_1	403	409	PF00069	0.379
MOD_ProDKin_1	563	569	PF00069	0.561
MOD_ProDKin_1	647	653	PF00069	0.630
MOD_SUMO_for_1	307	310	PF00179	0.449
MOD_SUMO_rev_2	133	142	PF00179	0.308
TRG_ENDOCYTIC_2	176	179	PF00928	0.257
TRG_ENDOCYTIC_2	211	214	PF00928	0.315
TRG_ENDOCYTIC_2	254	257	PF00928	0.355
TRG_ENDOCYTIC_2	443	446	PF00928	0.515
TRG_ENDOCYTIC_2	583	586	PF00928	0.336
TRG_ER_diArg_1	41	43	PF00400	0.442
TRG_ER_diArg_1	86	88	PF00400	0.508
TRG_NLS_Bipartite_1	416	430	PF00514	0.362
TRG_NLS_MonoExtC_3	425	431	PF00514	0.415
TRG_NLS_MonoExtN_4	84	89	PF00514	0.546
TRG_Pf-PMV_PEXEL_1	604	609	PF00026	0.379
TRG_Pf-PMV_PEXEL_1	671	676	PF00026	0.459

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDQ8	Leptomonas seymouri	68%	99%
A0A0S4J2F1	Bodo saltans	44%	100%
A0A1X0NYU3	Trypanosomatidae	52%	100%
A0A3S5H794	Leishmania donovani	95%	100%
A0A422MZJ3	Trypanosoma rangeli	51%	100%
A4HBP0	Leishmania braziliensis	84%	100%
A4HZ41	Leishmania infantum	95%	100%
D0A1P2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AV09	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	99%
P08165	Bos taurus	34%	100%
P22570	Homo sapiens	34%	100%
P56522	Rattus norvegicus	33%	100%
P65529	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	31%	100%
P82861	Salvelinus fontinalis	31%	100%
P9WJI0	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	31%	100%
P9WJI1	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	31%	100%
Q61578	Mus musculus	32%	100%
Q8W3L1	Arabidopsis thaliana	30%	100%
V5BQ55	Trypanosoma cruzi	54%	100%