NTF2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCH2_LEIMA

TriTrypDb:

LmjF.21.0430 , LMJLV39_210009600 , LMJSD75_210009700

Length:

397

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	yes	yes: 4
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005829	cytosol	2	2
GO:0032991	protein-containing complex	1	2
GO:0110165	cellular anatomical entity	1	2
GO:1990904	ribonucleoprotein complex	2	2

Expansion

Sequence features

Q4QCH2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCH2

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	3
GO:0003723	RNA binding	4	3
GO:0003729	mRNA binding	5	2
GO:0005488	binding	1	3
GO:0097159	organic cyclic compound binding	2	3
GO:1901363	heterocyclic compound binding	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.429
CLV_NRD_NRD_1	167	169	PF00675	0.514
CLV_NRD_NRD_1	174	176	PF00675	0.519
CLV_NRD_NRD_1	232	234	PF00675	0.755
CLV_NRD_NRD_1	244	246	PF00675	0.636
CLV_NRD_NRD_1	286	288	PF00675	0.742
CLV_NRD_NRD_1	312	314	PF00675	0.749
CLV_NRD_NRD_1	316	318	PF00675	0.723
CLV_NRD_NRD_1	78	80	PF00675	0.447
CLV_PCSK_KEX2_1	110	112	PF00082	0.429
CLV_PCSK_KEX2_1	166	168	PF00082	0.528
CLV_PCSK_KEX2_1	174	176	PF00082	0.518
CLV_PCSK_KEX2_1	316	318	PF00082	0.793
CLV_PCSK_SKI1_1	110	114	PF00082	0.418
CLV_PCSK_SKI1_1	175	179	PF00082	0.568
CLV_PCSK_SKI1_1	332	336	PF00082	0.538
CLV_PCSK_SKI1_1	352	356	PF00082	0.441
CLV_PCSK_SKI1_1	381	385	PF00082	0.559
DOC_ANK_TNKS_1	272	279	PF00023	0.749
DOC_CYCLIN_RxL_1	172	179	PF00134	0.571
DOC_MAPK_gen_1	107	116	PF00069	0.438
DOC_MAPK_gen_1	174	180	PF00069	0.573
DOC_MAPK_gen_1	79	86	PF00069	0.454
DOC_MAPK_MEF2A_6	107	116	PF00069	0.491
DOC_PP1_RVXF_1	350	357	PF00149	0.566
DOC_PP2B_LxvP_1	328	331	PF13499	0.512
DOC_USP7_MATH_1	217	221	PF00917	0.710
DOC_USP7_MATH_1	269	273	PF00917	0.716
DOC_USP7_MATH_1	34	38	PF00917	0.485
DOC_WW_Pin1_4	267	272	PF00397	0.740
DOC_WW_Pin1_4	303	308	PF00397	0.768
DOC_WW_Pin1_4	5	10	PF00397	0.516
LIG_14-3-3_CanoR_1	125	130	PF00244	0.476
LIG_14-3-3_CanoR_1	43	49	PF00244	0.469
LIG_BIR_II_1	1	5	PF00653	0.615
LIG_BRCT_BRCA1_1	344	348	PF00533	0.553
LIG_CaM_IQ_9	177	192	PF13499	0.578
LIG_FHA_1	126	132	PF00498	0.450
LIG_FHA_1	320	326	PF00498	0.624
LIG_FHA_1	86	92	PF00498	0.499
LIG_FHA_2	45	51	PF00498	0.476
LIG_LIR_Gen_1	133	139	PF02991	0.497
LIG_LIR_Gen_1	25	34	PF02991	0.485
LIG_LIR_Gen_1	345	355	PF02991	0.518
LIG_LIR_Gen_1	42	51	PF02991	0.480
LIG_LIR_Nem_3	108	112	PF02991	0.507
LIG_LIR_Nem_3	133	138	PF02991	0.427
LIG_LIR_Nem_3	17	22	PF02991	0.432
LIG_LIR_Nem_3	25	30	PF02991	0.410
LIG_LIR_Nem_3	345	351	PF02991	0.517
LIG_LIR_Nem_3	42	48	PF02991	0.475
LIG_Pex14_2	113	117	PF04695	0.387
LIG_Rb_pABgroove_1	34	42	PF01858	0.480
LIG_SH2_CRK	109	113	PF00017	0.485
LIG_SH2_CRK	45	49	PF00017	0.462
LIG_SH2_STAP1	24	28	PF00017	0.466
LIG_SH2_STAT5	105	108	PF00017	0.506
LIG_SH2_STAT5	135	138	PF00017	0.427
LIG_SH2_STAT5	161	164	PF00017	0.574
LIG_SH3_3	232	238	PF00018	0.604
LIG_SH3_3	244	250	PF00018	0.627
LIG_SH3_3	309	315	PF00018	0.777
LIG_SH3_3	86	92	PF00018	0.499
LIG_SUMO_SIM_par_1	82	88	PF11976	0.517
LIG_TRFH_1	117	121	PF08558	0.407
LIG_UBA3_1	325	333	PF00899	0.503
MOD_CDC14_SPxK_1	270	273	PF00782	0.737
MOD_CDK_SPxK_1	267	273	PF00069	0.741
MOD_CK1_1	212	218	PF00069	0.772
MOD_CK1_1	319	325	PF00069	0.649
MOD_CK1_1	44	50	PF00069	0.403
MOD_CK2_1	138	144	PF00069	0.565
MOD_CK2_1	366	372	PF00069	0.561
MOD_Cter_Amidation	277	280	PF01082	0.753
MOD_GlcNHglycan	219	222	PF01048	0.767
MOD_GlcNHglycan	318	321	PF01048	0.694
MOD_GlcNHglycan	360	363	PF01048	0.536
MOD_GSK3_1	11	18	PF00069	0.489
MOD_GSK3_1	119	126	PF00069	0.465
MOD_GSK3_1	299	306	PF00069	0.773
MOD_GSK3_1	342	349	PF00069	0.631
MOD_NEK2_1	162	167	PF00069	0.580
MOD_NEK2_1	72	77	PF00069	0.490
MOD_PIKK_1	342	348	PF00454	0.546
MOD_PKA_1	316	322	PF00069	0.721
MOD_PKA_2	212	218	PF00069	0.697
MOD_PKA_2	316	322	PF00069	0.660
MOD_PKA_2	34	40	PF00069	0.475
MOD_PKA_2	358	364	PF00069	0.578
MOD_Plk_1	41	47	PF00069	0.421
MOD_Plk_1	72	78	PF00069	0.496
MOD_Plk_2-3	82	88	PF00069	0.517
MOD_Plk_4	15	21	PF00069	0.468
MOD_Plk_4	44	50	PF00069	0.409
MOD_ProDKin_1	267	273	PF00069	0.741
MOD_ProDKin_1	303	309	PF00069	0.769
MOD_ProDKin_1	5	11	PF00069	0.510
MOD_SUMO_for_1	339	342	PF00179	0.550
MOD_SUMO_rev_2	240	247	PF00179	0.757
MOD_SUMO_rev_2	252	259	PF00179	0.780
MOD_SUMO_rev_2	261	267	PF00179	0.712
MOD_SUMO_rev_2	337	341	PF00179	0.504
MOD_SUMO_rev_2	345	354	PF00179	0.511
MOD_SUMO_rev_2	376	383	PF00179	0.563
TRG_ENDOCYTIC_2	109	112	PF00928	0.496
TRG_ENDOCYTIC_2	135	138	PF00928	0.427
TRG_ENDOCYTIC_2	24	27	PF00928	0.400
TRG_ENDOCYTIC_2	45	48	PF00928	0.463
TRG_ER_diArg_1	109	111	PF00400	0.497
TRG_ER_diArg_1	166	168	PF00400	0.511
TRG_ER_diArg_1	183	186	PF00400	0.562
TRG_ER_diArg_1	315	317	PF00400	0.781
TRG_NLS_Bipartite_1	316	336	PF00514	0.732
TRG_NLS_MonoCore_2	312	317	PF00514	0.671
TRG_NLS_MonoExtC_3	312	317	PF00514	0.621
TRG_NLS_MonoExtN_4	329	336	PF00514	0.592
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P850	Leptomonas seymouri	58%	84%
A0A3Q8IBY3	Leishmania donovani	89%	95%
A0A422MZN2	Trypanosoma rangeli	31%	80%
A4HBP1	Leishmania braziliensis	81%	94%
A4HZ42	Leishmania infantum	90%	96%
E9AV10	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	95%