Ubiquitin-conjugating enzyme-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin-conjugating enzyme-like protein

Species:

Leishmania major

UniProt:

Q4QCH1_LEIMA

TriTrypDb:

LmjF.21.0440 , LMJLV39_210009700 , LMJSD75_210009800

Length:

270

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	10
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QCH1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCH1

Function

Biological processes
Term	Name	Level	Count
GO:0006082	organic acid metabolic process	3	10
GO:0006629	lipid metabolic process	3	10
GO:0006631	fatty acid metabolic process	4	10
GO:0008152	metabolic process	1	10
GO:0009987	cellular process	1	10
GO:0019752	carboxylic acid metabolic process	5	10
GO:0032787	monocarboxylic acid metabolic process	6	10
GO:0043436	oxoacid metabolic process	4	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044255	cellular lipid metabolic process	3	10
GO:0044281	small molecule metabolic process	2	10
GO:0071704	organic substance metabolic process	2	10

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	17	19	PF00675	0.400
CLV_NRD_NRD_1	201	203	PF00675	0.307
CLV_NRD_NRD_1	216	218	PF00675	0.192
CLV_NRD_NRD_1	30	32	PF00675	0.351
CLV_PCSK_FUR_1	31	35	PF00082	0.432
CLV_PCSK_KEX2_1	33	35	PF00082	0.297
CLV_PCSK_PC1ET2_1	33	35	PF00082	0.316
CLV_PCSK_SKI1_1	33	37	PF00082	0.347
CLV_Separin_Metazoa	258	262	PF03568	0.565
DOC_CDC14_PxL_1	137	145	PF14671	0.464
DOC_CKS1_1	98	103	PF01111	0.464
DOC_CYCLIN_RxL_1	30	37	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	210	216	PF00134	0.525
DOC_MAPK_gen_1	199	209	PF00069	0.541
DOC_MAPK_MEF2A_6	167	175	PF00069	0.527
DOC_MAPK_MEF2A_6	202	211	PF00069	0.535
DOC_USP7_MATH_1	195	199	PF00917	0.525
DOC_USP7_UBL2_3	19	23	PF12436	0.589
DOC_WW_Pin1_4	209	214	PF00397	0.472
DOC_WW_Pin1_4	97	102	PF00397	0.464
LIG_AP2alpha_2	222	224	PF02296	0.535
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_BRCT_BRCA1_1	240	244	PF00533	0.506
LIG_CSL_BTD_1	71	74	PF09270	0.318
LIG_FHA_1	134	140	PF00498	0.464
LIG_FHA_1	175	181	PF00498	0.444
LIG_FHA_1	183	189	PF00498	0.459
LIG_FHA_1	225	231	PF00498	0.492
LIG_FHA_1	254	260	PF00498	0.464
LIG_FHA_2	129	135	PF00498	0.476
LIG_LIR_Apic_2	231	237	PF02991	0.535
LIG_LIR_Apic_2	96	101	PF02991	0.464
LIG_LIR_Gen_1	177	184	PF02991	0.484
LIG_LIR_Nem_3	103	109	PF02991	0.469
LIG_LIR_Nem_3	177	182	PF02991	0.484
LIG_LIR_Nem_3	242	248	PF02991	0.559
LIG_Pex14_1	72	76	PF04695	0.418
LIG_Pex14_2	109	113	PF04695	0.464
LIG_Pex14_2	174	178	PF04695	0.508
LIG_SH2_CRK	147	151	PF00017	0.565
LIG_SH2_STAT5	160	163	PF00017	0.535
LIG_SH2_STAT5	228	231	PF00017	0.464
LIG_SH2_STAT5	29	32	PF00017	0.550
LIG_SH2_STAT5	40	43	PF00017	0.318
LIG_SH2_STAT5	58	61	PF00017	0.303
LIG_SH3_3	135	141	PF00018	0.464
LIG_SH3_3	68	74	PF00018	0.309
LIG_SH3_3	98	104	PF00018	0.504
LIG_TYR_ITIM	145	150	PF00017	0.535
LIG_UBA3_1	210	218	PF00899	0.525
LIG_WRC_WIRS_1	106	111	PF05994	0.478
LIG_WRC_WIRS_1	175	180	PF05994	0.490
MOD_CK1_1	250	256	PF00069	0.491
MOD_CK1_1	42	48	PF00069	0.343
MOD_CK2_1	1	7	PF00069	0.725
MOD_CK2_1	109	115	PF00069	0.464
MOD_GlcNHglycan	155	158	PF01048	0.335
MOD_GlcNHglycan	3	6	PF01048	0.528
MOD_GlcNHglycan	41	44	PF01048	0.418
MOD_GlcNHglycan	87	90	PF01048	0.392
MOD_GSK3_1	105	112	PF00069	0.565
MOD_GSK3_1	128	135	PF00069	0.459
MOD_GSK3_1	149	156	PF00069	0.488
MOD_GSK3_1	224	231	PF00069	0.467
MOD_GSK3_1	247	254	PF00069	0.565
MOD_GSK3_1	47	54	PF00069	0.373
MOD_N-GLC_1	153	158	PF02516	0.306
MOD_NEK2_1	1	6	PF00069	0.698
MOD_NEK2_1	109	114	PF00069	0.464
MOD_NEK2_1	128	133	PF00069	0.464
MOD_NEK2_1	174	179	PF00069	0.464
MOD_NEK2_1	224	229	PF00069	0.486
MOD_NEK2_1	238	243	PF00069	0.469
MOD_NEK2_1	251	256	PF00069	0.469
MOD_NEK2_1	41	46	PF00069	0.361
MOD_NEK2_1	47	52	PF00069	0.321
MOD_OFUCOSY	49	55	PF10250	0.411
MOD_PKA_2	150	156	PF00069	0.533
MOD_Plk_1	118	124	PF00069	0.501
MOD_Plk_1	133	139	PF00069	0.424
MOD_Plk_1	224	230	PF00069	0.464
MOD_Plk_1	263	269	PF00069	0.633
MOD_Plk_4	105	111	PF00069	0.518
MOD_Plk_4	174	180	PF00069	0.507
MOD_Plk_4	247	253	PF00069	0.482
MOD_Plk_4	263	269	PF00069	0.633
MOD_Plk_4	42	48	PF00069	0.343
MOD_ProDKin_1	209	215	PF00069	0.472
MOD_ProDKin_1	97	103	PF00069	0.464
TRG_DiLeu_BaLyEn_6	135	140	PF01217	0.464
TRG_DiLeu_BaLyEn_6	234	239	PF01217	0.525
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.631
TRG_ENDOCYTIC_2	147	150	PF00928	0.506
TRG_ENDOCYTIC_2	58	61	PF00928	0.363
TRG_LysEnd_GGAAcLL_1	264	270	PF00790	0.604
TRG_NLS_Bipartite_1	18	36	PF00514	0.607
TRG_NLS_MonoCore_2	30	35	PF00514	0.572
TRG_NLS_MonoExtC_3	31	37	PF00514	0.563
TRG_NLS_MonoExtN_4	31	36	PF00514	0.571
TRG_Pf-PMV_PEXEL_1	33	37	PF00026	0.411

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I7L1	Leptomonas seymouri	83%	97%
A0A1X0NXG4	Trypanosomatidae	56%	94%
A0A3Q8IBV2	Leishmania donovani	97%	100%
A4HBP2	Leishmania braziliensis	87%	97%
A4HZ43	Leishmania infantum	97%	100%
A5PLL7	Homo sapiens	43%	100%
A6QLM0	Bos taurus	39%	100%
D0A1P4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	90%
E9AV11	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O04584	Arabidopsis thaliana	26%	92%
O81006	Arabidopsis thaliana	30%	97%
Q5UR78	Acanthamoeba polyphaga mimivirus	30%	100%
Q99LQ7	Mus musculus	42%	100%
Q9AE87	Myxococcus xanthus	34%	96%
Q9SZ42	Arabidopsis thaliana	30%	84%
V5B0L9	Trypanosoma cruzi	59%	100%