Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QCG9_LEIMA

TriTrypDb:

LmjF.21.0460 , LMJLV39_210009900 , LMJSD75_210010000

Length:

923

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCG9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCG9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	114	118	PF00656	0.628
CLV_C14_Caspase3-7	439	443	PF00656	0.739
CLV_C14_Caspase3-7	529	533	PF00656	0.715
CLV_C14_Caspase3-7	674	678	PF00656	0.617
CLV_NRD_NRD_1	170	172	PF00675	0.607
CLV_NRD_NRD_1	294	296	PF00675	0.713
CLV_NRD_NRD_1	391	393	PF00675	0.800
CLV_NRD_NRD_1	414	416	PF00675	0.588
CLV_NRD_NRD_1	439	441	PF00675	0.748
CLV_NRD_NRD_1	45	47	PF00675	0.700
CLV_NRD_NRD_1	49	51	PF00675	0.697
CLV_NRD_NRD_1	61	63	PF00675	0.599
CLV_NRD_NRD_1	631	633	PF00675	0.714
CLV_NRD_NRD_1	737	739	PF00675	0.708
CLV_PCSK_KEX2_1	170	172	PF00082	0.607
CLV_PCSK_KEX2_1	294	296	PF00082	0.716
CLV_PCSK_KEX2_1	391	393	PF00082	0.792
CLV_PCSK_KEX2_1	414	416	PF00082	0.632
CLV_PCSK_KEX2_1	45	47	PF00082	0.620
CLV_PCSK_KEX2_1	61	63	PF00082	0.602
CLV_PCSK_KEX2_1	631	633	PF00082	0.714
CLV_PCSK_KEX2_1	737	739	PF00082	0.708
CLV_PCSK_PC7_1	627	633	PF00082	0.693
CLV_PCSK_SKI1_1	223	227	PF00082	0.659
CLV_PCSK_SKI1_1	248	252	PF00082	0.638
CLV_PCSK_SKI1_1	363	367	PF00082	0.623
CLV_PCSK_SKI1_1	436	440	PF00082	0.752
CLV_PCSK_SKI1_1	627	631	PF00082	0.750
CLV_PCSK_SKI1_1	819	823	PF00082	0.655
CLV_Separin_Metazoa	285	289	PF03568	0.636
DEG_APCC_DBOX_1	279	287	PF00400	0.629
DEG_SCF_FBW7_2	572	577	PF00400	0.719
DOC_CKS1_1	187	192	PF01111	0.549
DOC_CKS1_1	308	313	PF01111	0.541
DOC_CKS1_1	339	344	PF01111	0.692
DOC_CKS1_1	681	686	PF01111	0.713
DOC_MAPK_gen_1	294	301	PF00069	0.655
DOC_MAPK_gen_1	849	858	PF00069	0.702
DOC_MAPK_gen_1	913	921	PF00069	0.471
DOC_MAPK_MEF2A_6	188	197	PF00069	0.640
DOC_MAPK_MEF2A_6	836	844	PF00069	0.663
DOC_MAPK_RevD_3	30	46	PF00069	0.571
DOC_PP2B_LxvP_1	797	800	PF13499	0.651
DOC_PP2B_LxvP_1	93	96	PF13499	0.660
DOC_PP2B_PxIxI_1	190	196	PF00149	0.635
DOC_PP4_FxxP_1	869	872	PF00568	0.499
DOC_PP4_MxPP_1	231	234	PF00568	0.688
DOC_USP7_MATH_1	2	6	PF00917	0.699
DOC_USP7_MATH_1	227	231	PF00917	0.753
DOC_USP7_MATH_1	328	332	PF00917	0.621
DOC_USP7_MATH_1	351	355	PF00917	0.653
DOC_USP7_MATH_1	377	381	PF00917	0.657
DOC_USP7_MATH_1	395	399	PF00917	0.558
DOC_USP7_MATH_1	49	53	PF00917	0.665
DOC_USP7_MATH_1	533	537	PF00917	0.601
DOC_USP7_MATH_1	543	547	PF00917	0.733
DOC_USP7_MATH_1	671	675	PF00917	0.810
DOC_USP7_MATH_1	820	824	PF00917	0.811
DOC_USP7_MATH_1	832	836	PF00917	0.614
DOC_USP7_MATH_1	857	861	PF00917	0.594
DOC_USP7_MATH_2	212	218	PF00917	0.516
DOC_USP7_MATH_2	64	70	PF00917	0.581
DOC_WW_Pin1_4	182	187	PF00397	0.611
DOC_WW_Pin1_4	307	312	PF00397	0.565
DOC_WW_Pin1_4	338	343	PF00397	0.693
DOC_WW_Pin1_4	45	50	PF00397	0.689
DOC_WW_Pin1_4	458	463	PF00397	0.682
DOC_WW_Pin1_4	570	575	PF00397	0.782
DOC_WW_Pin1_4	60	65	PF00397	0.599
DOC_WW_Pin1_4	680	685	PF00397	0.768
DOC_WW_Pin1_4	689	694	PF00397	0.727
DOC_WW_Pin1_4	724	729	PF00397	0.696
LIG_14-3-3_CanoR_1	235	243	PF00244	0.737
LIG_14-3-3_CanoR_1	248	257	PF00244	0.487
LIG_14-3-3_CanoR_1	327	337	PF00244	0.736
LIG_14-3-3_CanoR_1	420	424	PF00244	0.618
LIG_14-3-3_CanoR_1	447	456	PF00244	0.621
LIG_14-3-3_CanoR_1	50	57	PF00244	0.659
LIG_14-3-3_CanoR_1	67	75	PF00244	0.609
LIG_14-3-3_CanoR_1	687	693	PF00244	0.777
LIG_Actin_WH2_2	422	438	PF00022	0.574
LIG_BIR_II_1	1	5	PF00653	0.698
LIG_BIR_III_2	532	536	PF00653	0.706
LIG_BRCT_BRCA1_1	814	818	PF00533	0.660
LIG_Clathr_ClatBox_1	669	673	PF01394	0.587
LIG_FHA_1	105	111	PF00498	0.673
LIG_FHA_1	13	19	PF00498	0.676
LIG_FHA_1	250	256	PF00498	0.564
LIG_FHA_1	288	294	PF00498	0.679
LIG_FHA_1	339	345	PF00498	0.562
LIG_FHA_1	420	426	PF00498	0.645
LIG_FHA_1	51	57	PF00498	0.663
LIG_FHA_1	512	518	PF00498	0.743
LIG_FHA_1	567	573	PF00498	0.694
LIG_FHA_1	603	609	PF00498	0.680
LIG_FHA_1	752	758	PF00498	0.692
LIG_FHA_1	820	826	PF00498	0.655
LIG_FHA_1	865	871	PF00498	0.523
LIG_FHA_2	107	113	PF00498	0.578
LIG_FHA_2	277	283	PF00498	0.631
LIG_FHA_2	437	443	PF00498	0.740
LIG_FHA_2	694	700	PF00498	0.760
LIG_FHA_2	746	752	PF00498	0.726
LIG_FHA_2	75	81	PF00498	0.701
LIG_FHA_2	877	883	PF00498	0.617
LIG_Integrin_isoDGR_2	389	391	PF01839	0.629
LIG_LIR_Apic_2	867	872	PF02991	0.577
LIG_LIR_Gen_1	130	139	PF02991	0.668
LIG_LIR_Gen_1	140	149	PF02991	0.530
LIG_LIR_Gen_1	19	27	PF02991	0.627
LIG_LIR_Gen_1	213	222	PF02991	0.638
LIG_LIR_Gen_1	252	261	PF02991	0.617
LIG_LIR_Gen_1	909	919	PF02991	0.456
LIG_LIR_Nem_3	130	135	PF02991	0.677
LIG_LIR_Nem_3	140	144	PF02991	0.517
LIG_LIR_Nem_3	145	149	PF02991	0.487
LIG_LIR_Nem_3	19	24	PF02991	0.630
LIG_LIR_Nem_3	246	250	PF02991	0.672
LIG_LIR_Nem_3	252	257	PF02991	0.556
LIG_LIR_Nem_3	602	607	PF02991	0.679
LIG_PCNA_yPIPBox_3	350	362	PF02747	0.443
LIG_PCNA_yPIPBox_3	428	441	PF02747	0.575
LIG_PDZ_Class_2	918	923	PF00595	0.587
LIG_Pex14_1	173	177	PF04695	0.589
LIG_Pex14_2	247	251	PF04695	0.586
LIG_Pex14_2	594	598	PF04695	0.669
LIG_SH2_CRK	14	18	PF00017	0.678
LIG_SH2_CRK	141	145	PF00017	0.637
LIG_SH2_CRK	146	150	PF00017	0.610
LIG_SH2_CRK	874	878	PF00017	0.398
LIG_SH2_SRC	71	74	PF00017	0.648
LIG_SH2_SRC	874	877	PF00017	0.407
LIG_SH2_STAP1	14	18	PF00017	0.678
LIG_SH2_STAP1	604	608	PF00017	0.744
LIG_SH2_STAP1	665	669	PF00017	0.668
LIG_SH2_STAP1	71	75	PF00017	0.647
LIG_SH2_STAT5	14	17	PF00017	0.682
LIG_SH2_STAT5	254	257	PF00017	0.482
LIG_SH2_STAT5	587	590	PF00017	0.584
LIG_SH2_STAT5	604	607	PF00017	0.762
LIG_SH2_STAT5	876	879	PF00017	0.577
LIG_SH3_2	401	406	PF14604	0.679
LIG_SH3_3	184	190	PF00018	0.613
LIG_SH3_3	266	272	PF00018	0.596
LIG_SH3_3	336	342	PF00018	0.762
LIG_SH3_3	398	404	PF00018	0.713
LIG_SH3_3	467	473	PF00018	0.646
LIG_SH3_3	678	684	PF00018	0.768
LIG_SH3_3	694	700	PF00018	0.596
LIG_SH3_3	7	13	PF00018	0.694
LIG_SH3_3	715	721	PF00018	0.817
LIG_SH3_3	766	772	PF00018	0.577
LIG_SUMO_SIM_anti_2	282	288	PF11976	0.621
LIG_SUMO_SIM_anti_2	754	759	PF11976	0.496
LIG_SUMO_SIM_par_1	374	380	PF11976	0.612
LIG_SUMO_SIM_par_1	421	426	PF11976	0.608
LIG_TRAF2_1	279	282	PF00917	0.687
LIG_TRFH_1	21	25	PF08558	0.514
LIG_TYR_ITIM	139	144	PF00017	0.535
LIG_WW_3	232	236	PF00397	0.755
MOD_CDC14_SPxK_1	185	188	PF00782	0.586
MOD_CDC14_SPxK_1	48	51	PF00782	0.668
MOD_CDC14_SPxK_1	692	695	PF00782	0.722
MOD_CDK_SPK_2	45	50	PF00069	0.644
MOD_CDK_SPxK_1	182	188	PF00069	0.586
MOD_CDK_SPxK_1	45	51	PF00069	0.675
MOD_CDK_SPxK_1	689	695	PF00069	0.719
MOD_CDK_SPxxK_3	338	345	PF00069	0.692
MOD_CDK_SPxxK_3	60	67	PF00069	0.658
MOD_CDK_SPxxK_3	680	687	PF00069	0.715
MOD_CK1_1	217	223	PF00069	0.526
MOD_CK1_1	246	252	PF00069	0.684
MOD_CK1_1	449	455	PF00069	0.687
MOD_CK1_1	458	464	PF00069	0.599
MOD_CK1_1	565	571	PF00069	0.768
MOD_CK1_1	60	66	PF00069	0.670
MOD_CK1_1	691	697	PF00069	0.820
MOD_CK1_1	727	733	PF00069	0.765
MOD_CK1_1	739	745	PF00069	0.630
MOD_CK1_1	74	80	PF00069	0.561
MOD_CK1_1	827	833	PF00069	0.708
MOD_CK2_1	106	112	PF00069	0.535
MOD_CK2_1	124	130	PF00069	0.653
MOD_CK2_1	276	282	PF00069	0.691
MOD_CK2_1	328	334	PF00069	0.653
MOD_CK2_1	560	566	PF00069	0.842
MOD_CK2_1	60	66	PF00069	0.662
MOD_CK2_1	876	882	PF00069	0.612
MOD_CMANNOS	154	157	PF00535	0.637
MOD_Cter_Amidation	389	392	PF01082	0.633
MOD_GlcNHglycan	127	130	PF01048	0.593
MOD_GlcNHglycan	318	321	PF01048	0.742
MOD_GlcNHglycan	323	326	PF01048	0.699
MOD_GlcNHglycan	331	334	PF01048	0.603
MOD_GlcNHglycan	379	382	PF01048	0.645
MOD_GlcNHglycan	397	400	PF01048	0.604
MOD_GlcNHglycan	442	445	PF01048	0.729
MOD_GlcNHglycan	457	460	PF01048	0.571
MOD_GlcNHglycan	519	524	PF01048	0.719
MOD_GlcNHglycan	545	548	PF01048	0.802
MOD_GlcNHglycan	57	60	PF01048	0.687
MOD_GlcNHglycan	608	611	PF01048	0.843
MOD_GlcNHglycan	660	664	PF01048	0.680
MOD_GlcNHglycan	68	71	PF01048	0.585
MOD_GlcNHglycan	702	706	PF01048	0.830
MOD_GlcNHglycan	745	748	PF01048	0.718
MOD_GlcNHglycan	769	772	PF01048	0.618
MOD_GlcNHglycan	814	817	PF01048	0.707
MOD_GSK3_1	120	127	PF00069	0.685
MOD_GSK3_1	182	189	PF00069	0.554
MOD_GSK3_1	235	242	PF00069	0.681
MOD_GSK3_1	41	48	PF00069	0.731
MOD_GSK3_1	419	426	PF00069	0.628
MOD_GSK3_1	436	443	PF00069	0.678
MOD_GSK3_1	534	541	PF00069	0.692
MOD_GSK3_1	562	569	PF00069	0.739
MOD_GSK3_1	602	609	PF00069	0.730
MOD_GSK3_1	62	69	PF00069	0.618
MOD_GSK3_1	687	694	PF00069	0.793
MOD_GSK3_1	727	734	PF00069	0.761
MOD_GSK3_1	736	743	PF00069	0.681
MOD_GSK3_1	820	827	PF00069	0.724
MOD_LATS_1	685	691	PF00433	0.740
MOD_N-GLC_1	125	130	PF02516	0.588
MOD_N-GLC_1	570	575	PF02516	0.750
MOD_N-GLC_1	825	830	PF02516	0.686
MOD_NEK2_1	177	182	PF00069	0.593
MOD_NEK2_1	594	599	PF00069	0.720
MOD_NEK2_1	824	829	PF00069	0.687
MOD_NEK2_2	227	232	PF00069	0.687
MOD_NEK2_2	490	495	PF00069	0.607
MOD_PIKK_1	2	8	PF00454	0.637
MOD_PIKK_1	442	448	PF00454	0.766
MOD_PIKK_1	616	622	PF00454	0.798
MOD_PIKK_1	731	737	PF00454	0.768
MOD_PKA_1	440	446	PF00069	0.767
MOD_PKA_1	50	56	PF00069	0.661
MOD_PKA_1	737	743	PF00069	0.721
MOD_PKA_2	104	110	PF00069	0.667
MOD_PKA_2	287	293	PF00069	0.637
MOD_PKA_2	419	425	PF00069	0.637
MOD_PKA_2	446	452	PF00069	0.595
MOD_PKA_2	49	55	PF00069	0.694
MOD_PKA_2	66	72	PF00069	0.565
MOD_PKA_2	736	742	PF00069	0.744
MOD_PKA_2	848	854	PF00069	0.752
MOD_PKB_1	632	640	PF00069	0.672
MOD_Plk_1	2	8	PF00069	0.646
MOD_Plk_1	418	424	PF00069	0.667
MOD_Plk_1	635	641	PF00069	0.700
MOD_Plk_1	71	77	PF00069	0.677
MOD_Plk_2-3	214	220	PF00069	0.505
MOD_Plk_4	120	126	PF00069	0.659
MOD_Plk_4	419	425	PF00069	0.573
MOD_Plk_4	449	455	PF00069	0.726
MOD_Plk_4	751	757	PF00069	0.763
MOD_Plk_4	762	768	PF00069	0.501
MOD_Plk_4	773	779	PF00069	0.492
MOD_Plk_4	820	826	PF00069	0.697
MOD_ProDKin_1	182	188	PF00069	0.611
MOD_ProDKin_1	307	313	PF00069	0.568
MOD_ProDKin_1	338	344	PF00069	0.694
MOD_ProDKin_1	45	51	PF00069	0.687
MOD_ProDKin_1	458	464	PF00069	0.678
MOD_ProDKin_1	570	576	PF00069	0.782
MOD_ProDKin_1	60	66	PF00069	0.599
MOD_ProDKin_1	680	686	PF00069	0.770
MOD_ProDKin_1	689	695	PF00069	0.729
MOD_ProDKin_1	724	730	PF00069	0.698
MOD_SUMO_rev_2	158	163	PF00179	0.635
MOD_SUMO_rev_2	213	222	PF00179	0.699
MOD_SUMO_rev_2	646	654	PF00179	0.656
TRG_DiLeu_BaEn_1	282	287	PF01217	0.621
TRG_DiLeu_BaEn_4	158	164	PF01217	0.638
TRG_DiLeu_BaLyEn_6	273	278	PF01217	0.663
TRG_ENDOCYTIC_2	14	17	PF00928	0.682
TRG_ENDOCYTIC_2	141	144	PF00928	0.624
TRG_ENDOCYTIC_2	146	149	PF00928	0.617
TRG_ENDOCYTIC_2	21	24	PF00928	0.580
TRG_ENDOCYTIC_2	254	257	PF00928	0.609
TRG_ENDOCYTIC_2	368	371	PF00928	0.442
TRG_ENDOCYTIC_2	874	877	PF00928	0.407
TRG_ENDOCYTIC_2	897	900	PF00928	0.620
TRG_ER_diArg_1	169	171	PF00400	0.605
TRG_ER_diArg_1	293	295	PF00400	0.666
TRG_ER_diArg_1	391	393	PF00400	0.792
TRG_ER_diArg_1	45	47	PF00400	0.604
TRG_ER_diArg_1	630	632	PF00400	0.780
TRG_ER_diArg_1	800	803	PF00400	0.606
TRG_Pf-PMV_PEXEL_1	28	33	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IA94	Leishmania donovani	88%	100%
A4HBP4	Leishmania braziliensis	59%	99%
A4HZ45	Leishmania infantum	86%	100%
E9AV13	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	99%