Putative DnaJ protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ protein, putative

Species:

Leishmania major

UniProt:

Q4QCG6_LEIMA

TriTrypDb:

LmjF.21.0490 , LMJLV39_210010200 , LMJSD75_210010300

Length:

448

Annotations

LeishMANIAdb annotations

An extensive family in kinetoplastids, these chaperone proteins are likely also involved in the folding of secreted proteins as well.. This group contains both cytoplasmic and secreted (likely ER) proteins.. Localization: Cytoplasmic (by homology) / ER (by feature)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 4
Forrest at al. (procyclic)	no	yes: 4
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 20

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 18
NetGPI	no	yes: 0, no: 18

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Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	3
GO:0005815	microtubule organizing center	2	2
GO:0005829	cytosol	2	3
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0036064	ciliary basal body	3	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2

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Expansion

Sequence features

Q4QCG6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCG6

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006457	protein folding	2	19
GO:0006950	response to stress	2	19
GO:0009266	response to temperature stimulus	3	19
GO:0009408	response to heat	3	19
GO:0009628	response to abiotic stimulus	2	19
GO:0009987	cellular process	1	19
GO:0042026	protein refolding	3	3
GO:0050896	response to stimulus	1	19

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	19
GO:0005488	binding	1	19
GO:0005515	protein binding	2	19
GO:0005524	ATP binding	5	19
GO:0017076	purine nucleotide binding	4	19
GO:0030544	Hsp70 protein binding	4	19
GO:0030554	adenyl nucleotide binding	5	19
GO:0031072	heat shock protein binding	3	19
GO:0032553	ribonucleotide binding	3	19
GO:0032555	purine ribonucleotide binding	4	19

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	284	288	PF00656	0.410
CLV_NRD_NRD_1	27	29	PF00675	0.306
CLV_NRD_NRD_1	63	65	PF00675	0.310
CLV_PCSK_FUR_1	202	206	PF00082	0.330
CLV_PCSK_KEX2_1	151	153	PF00082	0.363
CLV_PCSK_KEX2_1	204	206	PF00082	0.330
CLV_PCSK_KEX2_1	23	25	PF00082	0.306
CLV_PCSK_KEX2_1	27	29	PF00082	0.306
CLV_PCSK_KEX2_1	383	385	PF00082	0.655
CLV_PCSK_KEX2_1	63	65	PF00082	0.323

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I257	Leptomonas seymouri	31%	97%
A0A0N1I2U4	Leptomonas seymouri	51%	100%
A0A0N1ILA6	Leptomonas seymouri	27%	100%
A0A0N1IMD5	Leptomonas seymouri	72%	100%
A0A0N1IMR7	Leptomonas seymouri	30%	100%
A0A0N1P953	Leptomonas seymouri	33%	95%
A0A0N1PCG8	Leptomonas seymouri	34%	100%
A0A0N1PCJ3	Leptomonas seymouri	32%	93%
A0A0S4IL02	Bodo saltans	56%	100%
A0A0S4IM72	Bodo saltans	29%	98%

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