Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCG5_LEIMA

TriTrypDb:

LmjF.21.0500 , LMJLV39_210010300 , LMJSD75_210010400

Length:

214

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCG5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCG5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	154	156	PF00082	0.453
CLV_PCSK_PC1ET2_1	154	156	PF00082	0.471
CLV_PCSK_SKI1_1	189	193	PF00082	0.453
CLV_PCSK_SKI1_1	7	11	PF00082	0.516
DOC_MAPK_gen_1	135	145	PF00069	0.502
DOC_MAPK_JIP1_4	92	98	PF00069	0.500
DOC_MAPK_MEF2A_6	45	53	PF00069	0.542
DOC_MAPK_MEF2A_6	7	14	PF00069	0.514
DOC_PP1_RVXF_1	92	99	PF00149	0.552
DOC_PP2B_LxvP_1	10	13	PF13499	0.447
DOC_USP7_MATH_1	33	37	PF00917	0.575
DOC_WW_Pin1_4	29	34	PF00397	0.509
LIG_14-3-3_CanoR_1	123	128	PF00244	0.577
LIG_14-3-3_CanoR_1	27	33	PF00244	0.449
LIG_APCC_ABBAyCdc20_2	160	166	PF00400	0.282
LIG_BIR_II_1	1	5	PF00653	0.547
LIG_CSL_BTD_1	10	13	PF09270	0.425
LIG_EH1_1	111	119	PF00400	0.440
LIG_eIF4E_1	158	164	PF01652	0.280
LIG_FHA_1	108	114	PF00498	0.421
LIG_FHA_1	166	172	PF00498	0.504
LIG_FHA_2	182	188	PF00498	0.513
LIG_PTB_Apo_2	15	22	PF02174	0.493
LIG_SH2_STAP1	195	199	PF00017	0.510
LIG_SH2_STAT5	158	161	PF00017	0.476
LIG_SUMO_SIM_anti_2	139	148	PF11976	0.463
LIG_SUMO_SIM_par_1	139	148	PF11976	0.425
MOD_CK1_1	107	113	PF00069	0.418
MOD_CK1_1	181	187	PF00069	0.518
MOD_CK1_1	206	212	PF00069	0.604
MOD_CK1_1	3	9	PF00069	0.467
MOD_CK1_1	32	38	PF00069	0.499
MOD_CK2_1	181	187	PF00069	0.559
MOD_Cter_Amidation	152	155	PF01082	0.441
MOD_GlcNHglycan	199	202	PF01048	0.527
MOD_GlcNHglycan	208	211	PF01048	0.592
MOD_GlcNHglycan	74	77	PF01048	0.502
MOD_GSK3_1	100	107	PF00069	0.377
MOD_GSK3_1	28	35	PF00069	0.513
MOD_NEK2_1	100	105	PF00069	0.376
MOD_NEK2_1	208	213	PF00069	0.681
MOD_NEK2_1	21	26	PF00069	0.477
MOD_NEK2_1	28	33	PF00069	0.455
MOD_NEK2_1	63	68	PF00069	0.502
MOD_PK_1	123	129	PF00069	0.499
MOD_PK_1	178	184	PF00069	0.511
MOD_Plk_1	178	184	PF00069	0.511
MOD_Plk_4	203	209	PF00069	0.449
MOD_Plk_4	63	69	PF00069	0.523
MOD_ProDKin_1	29	35	PF00069	0.501
MOD_SUMO_for_1	44	47	PF00179	0.550
MOD_SUMO_rev_2	139	144	PF00179	0.479
TRG_DiLeu_BaLyEn_6	113	118	PF01217	0.461
TRG_DiLeu_BaLyEn_6	24	29	PF01217	0.532
TRG_NES_CRM1_1	115	130	PF08389	0.444
TRG_NES_CRM1_1	61	73	PF08389	0.535
TRG_Pf-PMV_PEXEL_1	135	139	PF00026	0.533

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P855	Leptomonas seymouri	52%	100%
A0A0N0P8I2	Leptomonas seymouri	28%	91%
A0A1X0NXQ6	Trypanosomatidae	27%	93%
A0A1X0NZ15	Trypanosomatidae	31%	99%
A0A3R7KAU9	Trypanosoma rangeli	29%	100%
A0A3S7WWD9	Leishmania donovani	94%	100%
A0A422NBM7	Trypanosoma rangeli	33%	100%
A4HBP7	Leishmania braziliensis	77%	100%
A4HZ49	Leishmania infantum	93%	100%
D0A1Q1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AV17	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%