Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCG4_LEIMA

TriTrypDb:

LmjF.21.0510 , LMJLV39_210010400 , LMJSD75_210010500

Length:

565

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCG4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCG4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	15	19	PF00656	0.550
CLV_C14_Caspase3-7	333	337	PF00656	0.707
CLV_C14_Caspase3-7	50	54	PF00656	0.510
CLV_NRD_NRD_1	256	258	PF00675	0.449
CLV_NRD_NRD_1	465	467	PF00675	0.657
CLV_PCSK_KEX2_1	142	144	PF00082	0.418
CLV_PCSK_KEX2_1	4	6	PF00082	0.596
CLV_PCSK_KEX2_1	464	466	PF00082	0.663
CLV_PCSK_KEX2_1	84	86	PF00082	0.748
CLV_PCSK_PC1ET2_1	142	144	PF00082	0.517
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.596
CLV_PCSK_PC1ET2_1	464	466	PF00082	0.774
CLV_PCSK_PC1ET2_1	84	86	PF00082	0.748
CLV_PCSK_SKI1_1	143	147	PF00082	0.416
CLV_PCSK_SKI1_1	29	33	PF00082	0.690
CLV_PCSK_SKI1_1	37	41	PF00082	0.574
CLV_PCSK_SKI1_1	414	418	PF00082	0.785
DEG_APCC_DBOX_1	142	150	PF00400	0.422
DEG_SCF_FBW7_1	148	154	PF00400	0.531
DEG_SPOP_SBC_1	321	325	PF00917	0.726
DOC_CDC14_PxL_1	131	139	PF14671	0.541
DOC_CDC14_PxL_1	192	200	PF14671	0.557
DOC_CKS1_1	148	153	PF01111	0.531
DOC_CKS1_1	531	536	PF01111	0.801
DOC_CYCLIN_yCln2_LP_2	198	204	PF00134	0.564
DOC_CYCLIN_yCln2_LP_2	444	450	PF00134	0.562
DOC_MAPK_gen_1	142	148	PF00069	0.413
DOC_MAPK_gen_1	412	421	PF00069	0.694
DOC_MAPK_gen_1	462	471	PF00069	0.547
DOC_MAPK_MEF2A_6	414	423	PF00069	0.779
DOC_PP2B_LxvP_1	193	196	PF13499	0.501
DOC_USP7_MATH_1	10	14	PF00917	0.718
DOC_USP7_MATH_1	103	107	PF00917	0.610
DOC_USP7_MATH_1	112	116	PF00917	0.552
DOC_USP7_MATH_1	16	20	PF00917	0.694
DOC_USP7_MATH_1	214	218	PF00917	0.703
DOC_USP7_MATH_1	320	324	PF00917	0.734
DOC_USP7_MATH_1	334	338	PF00917	0.639
DOC_USP7_MATH_1	477	481	PF00917	0.722
DOC_USP7_MATH_1	494	498	PF00917	0.595
DOC_WW_Pin1_4	147	152	PF00397	0.442
DOC_WW_Pin1_4	500	505	PF00397	0.726
DOC_WW_Pin1_4	530	535	PF00397	0.809
DOC_WW_Pin1_4	550	555	PF00397	0.751
DOC_WW_Pin1_4	77	82	PF00397	0.718
LIG_14-3-3_CanoR_1	344	348	PF00244	0.551
LIG_14-3-3_CanoR_1	37	45	PF00244	0.623
LIG_14-3-3_CanoR_1	465	469	PF00244	0.658
LIG_14-3-3_CanoR_1	499	504	PF00244	0.637
LIG_14-3-3_CanoR_1	8	13	PF00244	0.755
LIG_Actin_WH2_2	127	144	PF00022	0.570
LIG_APCC_ABBA_1	248	253	PF00400	0.461
LIG_BIR_II_1	1	5	PF00653	0.740
LIG_BRCT_BRCA1_1	304	308	PF00533	0.669
LIG_BRCT_BRCA1_1	323	327	PF00533	0.440
LIG_BRCT_BRCA1_1	79	83	PF00533	0.642
LIG_FHA_1	148	154	PF00498	0.500
LIG_FHA_1	176	182	PF00498	0.528
LIG_FHA_1	219	225	PF00498	0.662
LIG_FHA_1	273	279	PF00498	0.462
LIG_FHA_1	377	383	PF00498	0.581
LIG_FHA_1	425	431	PF00498	0.611
LIG_FHA_1	525	531	PF00498	0.720
LIG_FHA_1	61	67	PF00498	0.454
LIG_FHA_2	227	233	PF00498	0.591
LIG_FHA_2	331	337	PF00498	0.709
LIG_FHA_2	38	44	PF00498	0.534
LIG_FHA_2	396	402	PF00498	0.757
LIG_LIR_Gen_1	109	119	PF02991	0.453
LIG_LIR_Gen_1	157	165	PF02991	0.498
LIG_LIR_Gen_1	467	476	PF02991	0.555
LIG_LIR_Nem_3	157	162	PF02991	0.477
LIG_LIR_Nem_3	467	471	PF02991	0.550
LIG_MYND_1	196	200	PF01753	0.553
LIG_MYND_1	451	455	PF01753	0.628
LIG_MYND_3	134	138	PF01753	0.533
LIG_NRBOX	176	182	PF00104	0.462
LIG_NRBOX	223	229	PF00104	0.655
LIG_SH2_CRK	119	123	PF00017	0.511
LIG_SH2_NCK_1	304	308	PF00017	0.586
LIG_SH2_SRC	203	206	PF00017	0.617
LIG_SH2_STAP1	203	207	PF00017	0.609
LIG_SH2_STAP1	304	308	PF00017	0.586
LIG_SH2_STAP1	62	66	PF00017	0.529
LIG_SH2_STAT3	62	65	PF00017	0.567
LIG_SH2_STAT5	272	275	PF00017	0.529
LIG_SH2_STAT5	298	301	PF00017	0.630
LIG_SH2_STAT5	62	65	PF00017	0.547
LIG_SH3_3	145	151	PF00018	0.417
LIG_SH3_3	365	371	PF00018	0.559
LIG_SH3_3	416	422	PF00018	0.730
LIG_SH3_3	445	451	PF00018	0.601
LIG_SH3_3	479	485	PF00018	0.697
LIG_SH3_3	490	496	PF00018	0.693
LIG_SH3_3	509	515	PF00018	0.489
LIG_SH3_3	528	534	PF00018	0.722
LIG_SH3_3	535	541	PF00018	0.697
LIG_SH3_3	542	548	PF00018	0.647
LIG_Sin3_3	456	463	PF02671	0.761
LIG_SUMO_SIM_par_1	189	194	PF11976	0.568
LIG_SUMO_SIM_par_1	226	233	PF11976	0.608
LIG_TRAF2_1	136	139	PF00917	0.475
LIG_TRAF2_1	300	303	PF00917	0.643
LIG_TRAF2_1	40	43	PF00917	0.599
LIG_TYR_ITIM	117	122	PF00017	0.516
LIG_UBA3_1	133	142	PF00899	0.520
MOD_CDK_SPxxK_3	77	84	PF00069	0.722
MOD_CK1_1	240	246	PF00069	0.650
MOD_CK1_1	323	329	PF00069	0.685
MOD_CK1_1	35	41	PF00069	0.690
MOD_CK1_1	92	98	PF00069	0.772
MOD_CK2_1	133	139	PF00069	0.488
MOD_CK2_1	151	157	PF00069	0.424
MOD_CK2_1	226	232	PF00069	0.601
MOD_CK2_1	297	303	PF00069	0.579
MOD_CK2_1	37	43	PF00069	0.540
MOD_GlcNHglycan	114	117	PF01048	0.531
MOD_GlcNHglycan	12	15	PF01048	0.743
MOD_GlcNHglycan	18	21	PF01048	0.746
MOD_GlcNHglycan	212	215	PF01048	0.655
MOD_GlcNHglycan	238	242	PF01048	0.723
MOD_GlcNHglycan	338	341	PF01048	0.497
MOD_GlcNHglycan	479	482	PF01048	0.684
MOD_GlcNHglycan	496	499	PF01048	0.746
MOD_GlcNHglycan	91	94	PF01048	0.538
MOD_GSK3_1	10	17	PF00069	0.737
MOD_GSK3_1	147	154	PF00069	0.462
MOD_GSK3_1	210	217	PF00069	0.655
MOD_GSK3_1	310	317	PF00069	0.651
MOD_GSK3_1	33	40	PF00069	0.606
MOD_GSK3_1	330	337	PF00069	0.658
MOD_GSK3_1	410	417	PF00069	0.772
MOD_GSK3_1	494	501	PF00069	0.691
MOD_N-GLC_1	402	407	PF02516	0.731
MOD_N-GLC_1	8	13	PF02516	0.703
MOD_NEK2_1	164	169	PF00069	0.401
MOD_NEK2_1	180	185	PF00069	0.366
MOD_NEK2_1	32	37	PF00069	0.677
MOD_NEK2_1	343	348	PF00069	0.490
MOD_NEK2_1	362	367	PF00069	0.291
MOD_NEK2_1	374	379	PF00069	0.562
MOD_NEK2_1	395	400	PF00069	0.698
MOD_NEK2_1	97	102	PF00069	0.709
MOD_PIKK_1	396	402	PF00454	0.726
MOD_PIKK_1	60	66	PF00454	0.549
MOD_PK_1	415	421	PF00069	0.748
MOD_PK_1	8	14	PF00069	0.753
MOD_PKA_1	414	420	PF00069	0.737
MOD_PKA_1	464	470	PF00069	0.695
MOD_PKA_2	343	349	PF00069	0.536
MOD_PKA_2	464	470	PF00069	0.676
MOD_PKA_2	498	504	PF00069	0.638
MOD_Plk_1	8	14	PF00069	0.609
MOD_Plk_4	180	186	PF00069	0.490
MOD_Plk_4	323	329	PF00069	0.567
MOD_ProDKin_1	147	153	PF00069	0.440
MOD_ProDKin_1	500	506	PF00069	0.720
MOD_ProDKin_1	530	536	PF00069	0.808
MOD_ProDKin_1	550	556	PF00069	0.750
MOD_ProDKin_1	77	83	PF00069	0.723
TRG_DiLeu_BaEn_1	187	192	PF01217	0.495
TRG_DiLeu_BaLyEn_6	391	396	PF01217	0.716
TRG_DiLeu_BaLyEn_6	419	424	PF01217	0.749
TRG_ENDOCYTIC_2	119	122	PF00928	0.510
TRG_NLS_MonoExtN_4	254	261	PF00514	0.525
TRG_NLS_MonoExtN_4	462	468	PF00514	0.771
TRG_Pf-PMV_PEXEL_1	260	264	PF00026	0.461

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAT9	Leptomonas seymouri	56%	95%
A0A3Q8IAT2	Leishmania donovani	90%	100%
A0A422NBI2	Trypanosoma rangeli	26%	100%
A4HBP8	Leishmania braziliensis	73%	100%
A4HZ50	Leishmania infantum	90%	100%
D0A1Q2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	100%
E9AV18	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
V5BKP0	Trypanosoma cruzi	27%	100%