Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleoporin NUP41

Species:

Leishmania major

UniProt:

Q4QCG3_LEIMA

TriTrypDb:

LmjF.21.0520 , LMJLV39_210010500 , LMJSD75_210010600

Length:

447

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005643	nuclear pore	3	2
GO:0031080	nuclear pore outer ring	3	2
GO:0032991	protein-containing complex	1	2
GO:0140513	nuclear protein-containing complex	2	2

Expansion

Sequence features

Q4QCG3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCG3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	94	98	PF00656	0.645
CLV_NRD_NRD_1	111	113	PF00675	0.410
CLV_NRD_NRD_1	3	5	PF00675	0.647
CLV_NRD_NRD_1	317	319	PF00675	0.560
CLV_NRD_NRD_1	34	36	PF00675	0.519
CLV_PCSK_KEX2_1	111	113	PF00082	0.410
CLV_PCSK_KEX2_1	3	5	PF00082	0.647
CLV_PCSK_KEX2_1	317	319	PF00082	0.560
CLV_PCSK_SKI1_1	218	222	PF00082	0.449
CLV_PCSK_SKI1_1	298	302	PF00082	0.555
DEG_Nend_Nbox_1	1	3	PF02207	0.667
DEG_SPOP_SBC_1	135	139	PF00917	0.561
DOC_CKS1_1	190	195	PF01111	0.441
DOC_CKS1_1	340	345	PF01111	0.563
DOC_MAPK_gen_1	111	117	PF00069	0.482
DOC_MAPK_gen_1	33	43	PF00069	0.525
DOC_PP2B_LxvP_1	239	242	PF13499	0.550
DOC_PP2B_LxvP_1	347	350	PF13499	0.395
DOC_USP7_MATH_1	158	162	PF00917	0.577
DOC_USP7_MATH_1	172	176	PF00917	0.535
DOC_USP7_MATH_1	263	267	PF00917	0.553
DOC_USP7_MATH_1	269	273	PF00917	0.590
DOC_USP7_MATH_1	406	410	PF00917	0.571
DOC_USP7_MATH_1	433	437	PF00917	0.411
DOC_USP7_MATH_1	70	74	PF00917	0.500
DOC_WW_Pin1_4	189	194	PF00397	0.664
DOC_WW_Pin1_4	339	344	PF00397	0.495
DOC_WW_Pin1_4	36	41	PF00397	0.565
LIG_14-3-3_CanoR_1	157	167	PF00244	0.536
LIG_14-3-3_CanoR_1	271	275	PF00244	0.540
LIG_14-3-3_CanoR_1	33	43	PF00244	0.593
LIG_14-3-3_CanoR_1	4	10	PF00244	0.526
LIG_Actin_WH2_2	252	267	PF00022	0.503
LIG_BIR_III_4	359	363	PF00653	0.520
LIG_BRCT_BRCA1_1	38	42	PF00533	0.614
LIG_EH1_1	232	240	PF00400	0.524
LIG_FHA_1	104	110	PF00498	0.444
LIG_FHA_1	222	228	PF00498	0.409
LIG_FHA_1	242	248	PF00498	0.240
LIG_FHA_1	351	357	PF00498	0.469
LIG_FHA_2	415	421	PF00498	0.659
LIG_FHA_2	42	48	PF00498	0.547
LIG_FHA_2	94	100	PF00498	0.666
LIG_LIR_Apic_2	222	228	PF02991	0.533
LIG_LIR_Gen_1	166	173	PF02991	0.558
LIG_LIR_Gen_1	429	435	PF02991	0.541
LIG_LIR_Gen_1	85	93	PF02991	0.504
LIG_LIR_Nem_3	166	170	PF02991	0.558
LIG_LIR_Nem_3	281	287	PF02991	0.425
LIG_LIR_Nem_3	345	351	PF02991	0.483
LIG_LIR_Nem_3	39	45	PF02991	0.557
LIG_LIR_Nem_3	429	434	PF02991	0.502
LIG_LIR_Nem_3	85	90	PF02991	0.498
LIG_SH2_CRK	152	156	PF00017	0.419
LIG_SH2_CRK	7	11	PF00017	0.650
LIG_SH2_PTP2	87	90	PF00017	0.492
LIG_SH2_SRC	87	90	PF00017	0.486
LIG_SH2_STAT3	110	113	PF00017	0.546
LIG_SH2_STAT5	108	111	PF00017	0.407
LIG_SH2_STAT5	444	447	PF00017	0.502
LIG_SH2_STAT5	7	10	PF00017	0.491
LIG_SH2_STAT5	87	90	PF00017	0.492
LIG_SH3_3	187	193	PF00018	0.502
LIG_SH3_3	410	416	PF00018	0.577
LIG_SH3_3	60	66	PF00018	0.468
LIG_SH3_3	8	14	PF00018	0.474
LIG_Sin3_3	74	81	PF02671	0.456
LIG_SUMO_SIM_anti_2	246	251	PF11976	0.501
LIG_SUMO_SIM_anti_2	73	80	PF11976	0.394
LIG_SUMO_SIM_par_1	113	122	PF11976	0.555
LIG_TRAF2_1	234	237	PF00917	0.433
LIG_TRFH_1	7	11	PF08558	0.650
LIG_TYR_ITIM	150	155	PF00017	0.407
LIG_TYR_ITIM	5	10	PF00017	0.639
MOD_CK1_1	104	110	PF00069	0.434
MOD_CK1_1	139	145	PF00069	0.628
MOD_CK1_1	163	169	PF00069	0.523
MOD_CK1_1	272	278	PF00069	0.574
MOD_CK2_1	252	258	PF00069	0.495
MOD_CK2_1	41	47	PF00069	0.551
MOD_CK2_1	414	420	PF00069	0.669
MOD_CK2_1	93	99	PF00069	0.572
MOD_GlcNHglycan	138	141	PF01048	0.659
MOD_GlcNHglycan	160	163	PF01048	0.608
MOD_GlcNHglycan	200	203	PF01048	0.568
MOD_GlcNHglycan	23	26	PF01048	0.525
MOD_GlcNHglycan	261	264	PF01048	0.541
MOD_GlcNHglycan	265	268	PF01048	0.488
MOD_GlcNHglycan	336	339	PF01048	0.567
MOD_GlcNHglycan	359	363	PF01048	0.520
MOD_GlcNHglycan	396	399	PF01048	0.734
MOD_GlcNHglycan	72	75	PF01048	0.503
MOD_GlcNHglycan	79	82	PF01048	0.505
MOD_GSK3_1	135	142	PF00069	0.668
MOD_GSK3_1	178	185	PF00069	0.728
MOD_GSK3_1	237	244	PF00069	0.511
MOD_GSK3_1	259	266	PF00069	0.538
MOD_GSK3_1	318	325	PF00069	0.598
MOD_GSK3_1	350	357	PF00069	0.438
MOD_N-GLC_1	173	178	PF02516	0.598
MOD_N-GLC_1	259	264	PF02516	0.529
MOD_NEK2_1	20	25	PF00069	0.560
MOD_NEK2_1	214	219	PF00069	0.427
MOD_NEK2_1	221	226	PF00069	0.399
MOD_NEK2_1	334	339	PF00069	0.369
MOD_NEK2_1	394	399	PF00069	0.706
MOD_NEK2_1	41	46	PF00069	0.496
MOD_PIKK_1	241	247	PF00454	0.542
MOD_PIKK_1	400	406	PF00454	0.678
MOD_PKA_1	317	323	PF00069	0.586
MOD_PKA_1	35	41	PF00069	0.558
MOD_PKA_2	270	276	PF00069	0.533
MOD_PKA_2	317	323	PF00069	0.548
MOD_PKA_2	34	40	PF00069	0.512
MOD_PKB_1	33	41	PF00069	0.538
MOD_Plk_1	221	227	PF00069	0.473
MOD_Plk_1	259	265	PF00069	0.516
MOD_Plk_4	104	110	PF00069	0.419
MOD_Plk_4	252	258	PF00069	0.432
MOD_Plk_4	5	11	PF00069	0.549
MOD_ProDKin_1	189	195	PF00069	0.649
MOD_ProDKin_1	339	345	PF00069	0.491
MOD_ProDKin_1	36	42	PF00069	0.553
TRG_DiLeu_BaEn_4	236	242	PF01217	0.350
TRG_DiLeu_BaLyEn_6	15	20	PF01217	0.564
TRG_DiLeu_BaLyEn_6	330	335	PF01217	0.644
TRG_ENDOCYTIC_2	152	155	PF00928	0.406
TRG_ENDOCYTIC_2	7	10	PF00928	0.534
TRG_ENDOCYTIC_2	87	90	PF00928	0.492
TRG_ER_diArg_1	110	112	PF00400	0.396
TRG_ER_diArg_1	149	152	PF00400	0.540
TRG_ER_diArg_1	2	4	PF00400	0.664
TRG_ER_diArg_1	316	318	PF00400	0.543
TRG_ER_diArg_1	407	410	PF00400	0.591
TRG_Pf-PMV_PEXEL_1	285	290	PF00026	0.451

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P853	Leptomonas seymouri	54%	88%
A0A1X0NY38	Trypanosomatidae	29%	100%
A0A3Q8IDW0	Leishmania donovani	96%	100%
A0A422NBK7	Trypanosoma rangeli	31%	100%
A4HBP9	Leishmania braziliensis	85%	100%
A4HZ51	Leishmania infantum	96%	100%
D0A1Q3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AV19	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BQ65	Trypanosoma cruzi	28%	100%