LeishMANIAdb
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Putative la RNA binding protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative la RNA binding protein
Gene product:
Lupus La protein homolog, putative
Species:
Leishmania major
UniProt:
Q4QCG1_LEIMA
TriTrypDb:
LmjF.21.0540 , LMJLV39_210010900 * , LMJSD75_210011000 *
Length:
339

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. yes yes: 4
Pissara et al. yes yes: 20
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 7
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005634 nucleus 5 12
GO:0005654 nucleoplasm 2 2
GO:0032991 protein-containing complex 1 12
GO:0043226 organelle 2 12
GO:0043227 membrane-bounded organelle 3 12
GO:0043229 intracellular organelle 3 12
GO:0043231 intracellular membrane-bounded organelle 4 12
GO:0110165 cellular anatomical entity 1 12
GO:1990904 ribonucleoprotein complex 2 12

Expansion

Sequence features

Q4QCG1
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCG1

Function

Biological processes
Term Name Level Count
GO:0006139 nucleobase-containing compound metabolic process 3 12
GO:0006396 RNA processing 6 12
GO:0006399 tRNA metabolic process 7 2
GO:0006725 cellular aromatic compound metabolic process 3 12
GO:0006807 nitrogen compound metabolic process 2 12
GO:0008033 tRNA processing 8 2
GO:0008152 metabolic process 1 12
GO:0009987 cellular process 1 12
GO:0016070 RNA metabolic process 5 12
GO:0034470 ncRNA processing 7 2
GO:0034641 cellular nitrogen compound metabolic process 3 12
GO:0034660 ncRNA metabolic process 6 2
GO:0043170 macromolecule metabolic process 3 12
GO:0044237 cellular metabolic process 2 12
GO:0044238 primary metabolic process 2 12
GO:0046483 heterocycle metabolic process 3 12
GO:0071704 organic substance metabolic process 2 12
GO:0090304 nucleic acid metabolic process 4 12
GO:1901360 organic cyclic compound metabolic process 3 12
Molecular functions
Term Name Level Count
GO:0003676 nucleic acid binding 3 12
GO:0003723 RNA binding 4 12
GO:0003729 mRNA binding 5 2
GO:0005488 binding 1 12
GO:0097159 organic cyclic compound binding 2 12
GO:1901363 heterocyclic compound binding 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 125 127 PF00675 0.317
CLV_NRD_NRD_1 191 193 PF00675 0.680
CLV_NRD_NRD_1 333 335 PF00675 0.854
CLV_NRD_NRD_1 80 82 PF00675 0.473
CLV_NRD_NRD_1 9 11 PF00675 0.380
CLV_PCSK_KEX2_1 125 127 PF00082 0.317
CLV_PCSK_KEX2_1 193 195 PF00082 0.713
CLV_PCSK_KEX2_1 333 335 PF00082 0.811
CLV_PCSK_KEX2_1 80 82 PF00082 0.471
CLV_PCSK_KEX2_1 9 11 PF00082 0.380
CLV_PCSK_PC1ET2_1 193 195 PF00082 0.713
CLV_PCSK_SKI1_1 23 27 PF00082 0.317
CLV_PCSK_SKI1_1 278 282 PF00082 0.687
CLV_PCSK_SKI1_1 82 86 PF00082 0.580
DOC_CKS1_1 210 215 PF01111 0.726
DOC_MAPK_gen_1 140 149 PF00069 0.528
DOC_MAPK_gen_1 7 14 PF00069 0.414
DOC_MAPK_HePTP_8 137 149 PF00069 0.603
DOC_MAPK_MEF2A_6 140 149 PF00069 0.517
DOC_PP1_RVXF_1 8 15 PF00149 0.517
DOC_USP7_MATH_1 103 107 PF00917 0.544
DOC_USP7_MATH_1 136 140 PF00917 0.578
DOC_USP7_MATH_1 216 220 PF00917 0.515
DOC_USP7_MATH_1 63 67 PF00917 0.570
DOC_WW_Pin1_4 209 214 PF00397 0.665
LIG_14-3-3_CanoR_1 278 283 PF00244 0.547
LIG_14-3-3_CanoR_1 49 54 PF00244 0.528
LIG_APCC_ABBA_1 259 264 PF00400 0.476
LIG_BIR_II_1 1 5 PF00653 0.613
LIG_BIR_III_2 83 87 PF00653 0.593
LIG_FHA_1 102 108 PF00498 0.512
LIG_FHA_1 174 180 PF00498 0.472
LIG_FHA_1 93 99 PF00498 0.369
LIG_FHA_2 175 181 PF00498 0.538
LIG_FHA_2 252 258 PF00498 0.604
LIG_LIR_Apic_2 95 100 PF02991 0.370
LIG_LIR_Gen_1 13 22 PF02991 0.517
LIG_LIR_Gen_1 144 150 PF02991 0.517
LIG_LIR_Gen_1 230 240 PF02991 0.496
LIG_LIR_Gen_1 46 53 PF02991 0.534
LIG_LIR_Nem_3 13 19 PF02991 0.517
LIG_LIR_Nem_3 144 149 PF02991 0.517
LIG_LIR_Nem_3 230 235 PF02991 0.487
LIG_LIR_Nem_3 36 41 PF02991 0.507
LIG_LIR_Nem_3 46 50 PF02991 0.507
LIG_Pex14_1 124 128 PF04695 0.517
LIG_SH2_CRK 165 169 PF00017 0.615
LIG_SH2_PTP2 97 100 PF00017 0.517
LIG_SH2_SRC 178 181 PF00017 0.648
LIG_SH2_STAT5 127 130 PF00017 0.517
LIG_SH2_STAT5 15 18 PF00017 0.517
LIG_SH2_STAT5 178 181 PF00017 0.488
LIG_SH2_STAT5 249 252 PF00017 0.466
LIG_SH2_STAT5 97 100 PF00017 0.517
LIG_SH3_3 156 162 PF00018 0.580
LIG_SH3_3 207 213 PF00018 0.684
LIG_SH3_3 247 253 PF00018 0.475
LIG_TRAF2_1 240 243 PF00917 0.505
LIG_TRAF2_1 254 257 PF00917 0.495
LIG_WRC_WIRS_1 44 49 PF05994 0.517
LIG_WW_1 162 165 PF00397 0.524
MOD_CK1_1 274 280 PF00069 0.647
MOD_CK1_1 88 94 PF00069 0.502
MOD_CK2_1 174 180 PF00069 0.527
MOD_CK2_1 251 257 PF00069 0.610
MOD_Cter_Amidation 331 334 PF01082 0.855
MOD_GlcNHglycan 114 117 PF01048 0.381
MOD_GlcNHglycan 170 173 PF01048 0.603
MOD_GlcNHglycan 206 209 PF01048 0.802
MOD_GlcNHglycan 223 226 PF01048 0.533
MOD_GSK3_1 112 119 PF00069 0.548
MOD_GSK3_1 217 224 PF00069 0.495
MOD_GSK3_1 274 281 PF00069 0.615
MOD_GSK3_1 88 95 PF00069 0.474
MOD_N-GLC_1 217 222 PF02516 0.539
MOD_NEK2_1 174 179 PF00069 0.519
MOD_NEK2_1 26 31 PF00069 0.603
MOD_NEK2_1 271 276 PF00069 0.609
MOD_PIKK_1 185 191 PF00454 0.718
MOD_PKA_2 221 227 PF00069 0.504
MOD_Plk_1 217 223 PF00069 0.523
MOD_Plk_1 296 302 PF00069 0.560
MOD_Plk_1 92 98 PF00069 0.522
MOD_Plk_4 116 122 PF00069 0.603
MOD_Plk_4 141 147 PF00069 0.516
MOD_Plk_4 174 180 PF00069 0.505
MOD_Plk_4 296 302 PF00069 0.508
MOD_Plk_4 92 98 PF00069 0.451
MOD_ProDKin_1 209 215 PF00069 0.644
MOD_SUMO_rev_2 230 238 PF00179 0.549
MOD_SUMO_rev_2 293 300 PF00179 0.544
MOD_SUMO_rev_2 52 60 PF00179 0.558
TRG_ENDOCYTIC_2 165 168 PF00928 0.552
TRG_ENDOCYTIC_2 249 252 PF00928 0.480
TRG_ER_diArg_1 124 126 PF00400 0.517
TRG_ER_diArg_1 192 195 PF00400 0.695
TRG_ER_diArg_1 79 81 PF00400 0.443
TRG_ER_diArg_1 8 10 PF00400 0.580
TRG_ER_FFAT_2 108 119 PF00635 0.622
TRG_NLS_MonoExtC_3 191 196 PF00514 0.700
TRG_NLS_MonoExtN_4 190 196 PF00514 0.696
TRG_Pf-PMV_PEXEL_1 58 62 PF00026 0.365

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PDU8 Leptomonas seymouri 83% 99%
A0A0S4JIJ0 Bodo saltans 59% 98%
A0A1X0NXX1 Trypanosomatidae 64% 100%
A0A3Q8IB28 Leishmania donovani 97% 100%
A0A3R7NHU1 Trypanosoma rangeli 63% 99%
A4HBQ1 Leishmania braziliensis 91% 100%
A4HZ53 Leishmania infantum 97% 100%
D0A1Q9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 63% 100%
E9AV21 Leishmania mexicana (strain MHOM/GT/2001/U1103) 95% 100%
P05455 Homo sapiens 28% 83%
P32067 Mus musculus 27% 82%
P38656 Rattus norvegicus 26% 82%
P40796 Drosophila melanogaster 26% 87%
V5DH11 Trypanosoma cruzi 61% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS