Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCF8_LEIMA

TriTrypDb:

LmjF.21.0570 , LMJLV39_210011200 , LMJSD75_210011300

Length:

441

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCF8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCF8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	187	191	PF00656	0.657
CLV_NRD_NRD_1	162	164	PF00675	0.555
CLV_NRD_NRD_1	202	204	PF00675	0.709
CLV_NRD_NRD_1	213	215	PF00675	0.563
CLV_NRD_NRD_1	266	268	PF00675	0.686
CLV_NRD_NRD_1	338	340	PF00675	0.808
CLV_NRD_NRD_1	428	430	PF00675	0.474
CLV_NRD_NRD_1	432	434	PF00675	0.505
CLV_NRD_NRD_1	52	54	PF00675	0.476
CLV_NRD_NRD_1	66	68	PF00675	0.472
CLV_PCSK_FUR_1	433	437	PF00082	0.475
CLV_PCSK_KEX2_1	202	204	PF00082	0.692
CLV_PCSK_KEX2_1	213	215	PF00082	0.546
CLV_PCSK_KEX2_1	266	268	PF00082	0.675
CLV_PCSK_KEX2_1	302	304	PF00082	0.696
CLV_PCSK_KEX2_1	338	340	PF00082	0.623
CLV_PCSK_KEX2_1	402	404	PF00082	0.721
CLV_PCSK_KEX2_1	432	434	PF00082	0.499
CLV_PCSK_KEX2_1	435	437	PF00082	0.476
CLV_PCSK_KEX2_1	52	54	PF00082	0.476
CLV_PCSK_KEX2_1	66	68	PF00082	0.472
CLV_PCSK_PC1ET2_1	202	204	PF00082	0.632
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.696
CLV_PCSK_PC1ET2_1	402	404	PF00082	0.721
CLV_PCSK_PC1ET2_1	435	437	PF00082	0.502
CLV_PCSK_SKI1_1	236	240	PF00082	0.656
CLV_PCSK_SKI1_1	299	303	PF00082	0.769
CLV_PCSK_SKI1_1	365	369	PF00082	0.476
CLV_PCSK_SKI1_1	403	407	PF00082	0.706
CLV_PCSK_SKI1_1	45	49	PF00082	0.415
CLV_PCSK_SKI1_1	92	96	PF00082	0.603
DEG_APCC_DBOX_1	87	95	PF00400	0.507
DEG_Nend_UBRbox_1	1	4	PF02207	0.616
DOC_CYCLIN_yCln2_LP_2	142	148	PF00134	0.461
DOC_MAPK_DCC_7	141	150	PF00069	0.534
DOC_MAPK_gen_1	406	416	PF00069	0.552
DOC_MAPK_gen_1	432	441	PF00069	0.430
DOC_MAPK_MEF2A_6	141	150	PF00069	0.448
DOC_MAPK_MEF2A_6	409	416	PF00069	0.528
DOC_MAPK_RevD_3	148	164	PF00069	0.518
DOC_PP2B_LxvP_1	142	145	PF13499	0.457
DOC_PP2B_LxvP_1	358	361	PF13499	0.561
DOC_PP4_FxxP_1	387	390	PF00568	0.615
DOC_USP7_MATH_1	240	244	PF00917	0.786
DOC_USP7_MATH_1	27	31	PF00917	0.547
DOC_USP7_MATH_1	270	274	PF00917	0.641
DOC_USP7_MATH_1	280	284	PF00917	0.717
DOC_USP7_MATH_1	372	376	PF00917	0.436
DOC_USP7_MATH_1	401	405	PF00917	0.652
DOC_USP7_UBL2_3	402	406	PF12436	0.713
DOC_WW_Pin1_4	104	109	PF00397	0.490
DOC_WW_Pin1_4	247	252	PF00397	0.658
DOC_WW_Pin1_4	276	281	PF00397	0.646
DOC_WW_Pin1_4	283	288	PF00397	0.605
DOC_WW_Pin1_4	382	387	PF00397	0.587
DOC_WW_Pin1_4	404	409	PF00397	0.618
LIG_14-3-3_CanoR_1	2	8	PF00244	0.701
LIG_14-3-3_CanoR_1	254	263	PF00244	0.658
LIG_14-3-3_CanoR_1	267	277	PF00244	0.617
LIG_14-3-3_CanoR_1	325	330	PF00244	0.628
LIG_14-3-3_CanoR_1	45	54	PF00244	0.510
LIG_Clathr_ClatBox_1	68	72	PF01394	0.573
LIG_FHA_1	126	132	PF00498	0.468
LIG_FHA_1	154	160	PF00498	0.511
LIG_FHA_1	195	201	PF00498	0.698
LIG_FHA_1	292	298	PF00498	0.572
LIG_FHA_2	182	188	PF00498	0.521
LIG_FHA_2	93	99	PF00498	0.604
LIG_LIR_Apic_2	385	390	PF02991	0.521
LIG_LIR_Gen_1	154	162	PF02991	0.433
LIG_LIR_Gen_1	166	175	PF02991	0.451
LIG_LIR_Gen_1	366	376	PF02991	0.422
LIG_LIR_Gen_1	41	50	PF02991	0.429
LIG_LIR_Nem_3	112	117	PF02991	0.443
LIG_LIR_Nem_3	125	130	PF02991	0.382
LIG_LIR_Nem_3	154	160	PF02991	0.426
LIG_LIR_Nem_3	166	171	PF02991	0.455
LIG_LIR_Nem_3	366	371	PF02991	0.431
LIG_LIR_Nem_3	41	46	PF02991	0.443
LIG_LIR_Nem_3	418	422	PF02991	0.466
LIG_MYND_1	177	181	PF01753	0.543
LIG_PCNA_yPIPBox_3	406	420	PF02747	0.603
LIG_PTAP_UEV_1	329	334	PF05743	0.571
LIG_SH2_CRK	117	121	PF00017	0.429
LIG_SH2_STAT5	130	133	PF00017	0.474
LIG_SH2_STAT5	43	46	PF00017	0.426
LIG_SH2_STAT5	93	96	PF00017	0.522
LIG_SH3_2	177	182	PF14604	0.554
LIG_SH3_3	103	109	PF00018	0.479
LIG_SH3_3	141	147	PF00018	0.444
LIG_SH3_3	174	180	PF00018	0.522
LIG_SH3_3	222	228	PF00018	0.701
LIG_SH3_3	274	280	PF00018	0.651
LIG_SH3_3	327	333	PF00018	0.652
LIG_SH3_CIN85_PxpxPR_1	228	233	PF14604	0.546
LIG_SUMO_SIM_par_1	146	152	PF11976	0.525
LIG_TRAF2_1	36	39	PF00917	0.524
LIG_TRAF2_1	423	426	PF00917	0.430
LIG_TYR_ITIM	115	120	PF00017	0.528
LIG_WW_3	160	164	PF00397	0.640
LIG_WW_3	179	183	PF00397	0.386
MOD_CDK_SPK_2	404	409	PF00069	0.618
MOD_CDK_SPxxK_3	247	254	PF00069	0.581
MOD_CK1_1	107	113	PF00069	0.474
MOD_CK1_1	125	131	PF00069	0.403
MOD_CK1_1	279	285	PF00069	0.684
MOD_CK1_1	321	327	PF00069	0.678
MOD_CK1_1	328	334	PF00069	0.704
MOD_CK1_1	389	395	PF00069	0.702
MOD_CK1_1	396	402	PF00069	0.807
MOD_CK1_1	404	410	PF00069	0.700
MOD_CK2_1	181	187	PF00069	0.511
MOD_CK2_1	372	378	PF00069	0.419
MOD_GlcNHglycan	124	127	PF01048	0.388
MOD_GlcNHglycan	20	23	PF01048	0.534
MOD_GlcNHglycan	217	220	PF01048	0.726
MOD_GlcNHglycan	242	245	PF01048	0.697
MOD_GlcNHglycan	257	260	PF01048	0.523
MOD_GlcNHglycan	272	275	PF01048	0.586
MOD_GlcNHglycan	29	32	PF01048	0.458
MOD_GlcNHglycan	299	302	PF01048	0.715
MOD_GlcNHglycan	3	6	PF01048	0.649
MOD_GlcNHglycan	395	398	PF01048	0.639
MOD_GlcNHglycan	403	406	PF01048	0.705
MOD_GSK3_1	100	107	PF00069	0.522
MOD_GSK3_1	191	198	PF00069	0.693
MOD_GSK3_1	23	30	PF00069	0.704
MOD_GSK3_1	240	247	PF00069	0.718
MOD_GSK3_1	266	273	PF00069	0.794
MOD_GSK3_1	276	283	PF00069	0.611
MOD_GSK3_1	285	292	PF00069	0.496
MOD_GSK3_1	293	300	PF00069	0.566
MOD_GSK3_1	303	310	PF00069	0.541
MOD_GSK3_1	317	324	PF00069	0.578
MOD_GSK3_1	382	389	PF00069	0.582
MOD_GSK3_1	392	399	PF00069	0.638
MOD_LATS_1	90	96	PF00433	0.601
MOD_N-GLC_1	315	320	PF02516	0.573
MOD_NEK2_1	1	6	PF00069	0.660
MOD_NEK2_1	100	105	PF00069	0.489
MOD_NEK2_1	153	158	PF00069	0.512
MOD_NEK2_1	209	214	PF00069	0.807
MOD_NEK2_1	307	312	PF00069	0.556
MOD_NEK2_2	372	377	PF00069	0.415
MOD_PIKK_1	100	106	PF00454	0.481
MOD_PIKK_1	289	295	PF00454	0.725
MOD_PIKK_1	323	329	PF00454	0.727
MOD_PKA_1	266	272	PF00069	0.633
MOD_PKA_2	1	7	PF00069	0.690
MOD_PKA_2	181	187	PF00069	0.607
MOD_PKA_2	191	197	PF00069	0.639
MOD_PKA_2	266	272	PF00069	0.622
MOD_PKA_2	393	399	PF00069	0.750
MOD_PKA_2	428	434	PF00069	0.472
MOD_Plk_1	303	309	PF00069	0.557
MOD_Plk_1	372	378	PF00069	0.506
MOD_Plk_4	303	309	PF00069	0.583
MOD_Plk_4	318	324	PF00069	0.617
MOD_ProDKin_1	104	110	PF00069	0.484
MOD_ProDKin_1	247	253	PF00069	0.658
MOD_ProDKin_1	276	282	PF00069	0.649
MOD_ProDKin_1	283	289	PF00069	0.606
MOD_ProDKin_1	382	388	PF00069	0.597
MOD_ProDKin_1	404	410	PF00069	0.612
MOD_SUMO_for_1	301	304	PF00179	0.695
TRG_ENDOCYTIC_2	117	120	PF00928	0.518
TRG_ENDOCYTIC_2	168	171	PF00928	0.647
TRG_ENDOCYTIC_2	43	46	PF00928	0.433
TRG_ENDOCYTIC_2	438	441	PF00928	0.419
TRG_ER_diArg_1	265	267	PF00400	0.599
TRG_ER_diArg_1	337	339	PF00400	0.725
TRG_ER_diArg_1	52	54	PF00400	0.474
TRG_ER_diArg_1	65	67	PF00400	0.461
TRG_NLS_MonoExtC_3	428	433	PF00514	0.473
TRG_NLS_MonoExtN_4	201	206	PF00514	0.628

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U2	Leptomonas seymouri	45%	100%
A0A3S7WWD6	Leishmania donovani	92%	100%
A4HBQ4	Leishmania braziliensis	77%	100%
A4HZ56	Leishmania infantum	92%	100%
E9AV24	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%