Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCF7_LEIMA

TriTrypDb:

LmjF.21.0580 , LMJLV39_210011300 , LMJSD75_210011400

Length:

466

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCF7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCF7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	120	122	PF00675	0.527
CLV_NRD_NRD_1	125	127	PF00675	0.558
CLV_NRD_NRD_1	274	276	PF00675	0.587
CLV_NRD_NRD_1	384	386	PF00675	0.628
CLV_NRD_NRD_1	458	460	PF00675	0.585
CLV_PCSK_KEX2_1	120	122	PF00082	0.435
CLV_PCSK_KEX2_1	125	127	PF00082	0.519
CLV_PCSK_KEX2_1	274	276	PF00082	0.587
CLV_PCSK_KEX2_1	460	462	PF00082	0.620
CLV_PCSK_PC1ET2_1	460	462	PF00082	0.619
CLV_PCSK_PC7_1	121	127	PF00082	0.510
CLV_PCSK_SKI1_1	242	246	PF00082	0.559
CLV_PCSK_SKI1_1	275	279	PF00082	0.565
CLV_PCSK_SKI1_1	370	374	PF00082	0.684
CLV_PCSK_SKI1_1	452	456	PF00082	0.744
CLV_Separin_Metazoa	248	252	PF03568	0.594
DEG_APCC_DBOX_1	310	318	PF00400	0.651
DEG_Nend_UBRbox_2	1	3	PF02207	0.455
DEG_SCF_FBW7_1	210	217	PF00400	0.620
DEG_SPOP_SBC_1	179	183	PF00917	0.614
DEG_SPOP_SBC_1	280	284	PF00917	0.711
DEG_SPOP_SBC_1	75	79	PF00917	0.656
DOC_CKS1_1	211	216	PF01111	0.630
DOC_MAPK_MEF2A_6	242	249	PF00069	0.460
DOC_MAPK_NFAT4_5	242	250	PF00069	0.484
DOC_PP1_RVXF_1	426	432	PF00149	0.669
DOC_PP4_FxxP_1	255	258	PF00568	0.626
DOC_PP4_FxxP_1	414	417	PF00568	0.608
DOC_USP7_MATH_1	180	184	PF00917	0.598
DOC_USP7_MATH_1	186	190	PF00917	0.771
DOC_USP7_MATH_1	203	207	PF00917	0.636
DOC_USP7_MATH_1	223	227	PF00917	0.345
DOC_USP7_MATH_1	234	238	PF00917	0.486
DOC_USP7_MATH_1	280	284	PF00917	0.704
DOC_USP7_MATH_1	348	352	PF00917	0.663
DOC_USP7_MATH_1	444	448	PF00917	0.586
DOC_USP7_MATH_1	73	77	PF00917	0.664
DOC_USP7_MATH_1	99	103	PF00917	0.517
DOC_USP7_UBL2_3	142	146	PF12436	0.601
DOC_WW_Pin1_4	184	189	PF00397	0.689
DOC_WW_Pin1_4	201	206	PF00397	0.599
DOC_WW_Pin1_4	210	215	PF00397	0.665
DOC_WW_Pin1_4	282	287	PF00397	0.687
DOC_WW_Pin1_4	358	363	PF00397	0.502
DOC_WW_Pin1_4	71	76	PF00397	0.667
LIG_14-3-3_CanoR_1	222	232	PF00244	0.620
LIG_14-3-3_CanoR_1	260	264	PF00244	0.621
LIG_14-3-3_CanoR_1	47	53	PF00244	0.537
LIG_APCC_ABBAyCdc20_2	242	248	PF00400	0.467
LIG_BRCT_BRCA1_1	251	255	PF00533	0.637
LIG_BRCT_BRCA1_1	261	265	PF00533	0.522
LIG_BRCT_BRCA1_1	360	364	PF00533	0.551
LIG_deltaCOP1_diTrp_1	91	100	PF00928	0.403
LIG_EH1_1	56	64	PF00400	0.389
LIG_FHA_1	132	138	PF00498	0.467
LIG_FHA_1	352	358	PF00498	0.601
LIG_FHA_2	136	142	PF00498	0.488
LIG_FHA_2	5	11	PF00498	0.564
LIG_FHA_2	75	81	PF00498	0.640
LIG_LIR_Apic_2	252	258	PF02991	0.652
LIG_LIR_Gen_1	361	372	PF02991	0.560
LIG_LIR_Nem_3	361	367	PF02991	0.536
LIG_LIR_Nem_3	378	383	PF02991	0.643
LIG_LIR_Nem_3	396	402	PF02991	0.693
LIG_LIR_Nem_3	54	60	PF02991	0.394
LIG_LIR_Nem_3	91	95	PF02991	0.400
LIG_NRBOX	313	319	PF00104	0.521
LIG_PDZ_Class_3	461	466	PF00595	0.759
LIG_SH2_PTP2	359	362	PF00017	0.596
LIG_SH2_STAP1	368	372	PF00017	0.649
LIG_SH2_STAP1	399	403	PF00017	0.671
LIG_SH2_STAT3	368	371	PF00017	0.642
LIG_SH2_STAT5	209	212	PF00017	0.518
LIG_SH2_STAT5	246	249	PF00017	0.484
LIG_SH2_STAT5	359	362	PF00017	0.536
LIG_SH2_STAT5	399	402	PF00017	0.677
LIG_SH3_3	125	131	PF00018	0.593
LIG_SH3_3	208	214	PF00018	0.664
LIG_UBA3_1	136	142	PF00899	0.436
LIG_WRC_WIRS_1	1	6	PF05994	0.422
MOD_CK1_1	160	166	PF00069	0.694
MOD_CK1_1	169	175	PF00069	0.634
MOD_CK1_1	187	193	PF00069	0.727
MOD_CK1_1	212	218	PF00069	0.598
MOD_CK1_1	259	265	PF00069	0.602
MOD_CK1_1	281	287	PF00069	0.658
MOD_CK1_1	351	357	PF00069	0.705
MOD_CK1_1	393	399	PF00069	0.736
MOD_CK1_1	74	80	PF00069	0.636
MOD_CK2_1	135	141	PF00069	0.450
MOD_CK2_1	151	157	PF00069	0.575
MOD_CK2_1	230	236	PF00069	0.550
MOD_CK2_1	4	10	PF00069	0.551
MOD_CK2_1	74	80	PF00069	0.654
MOD_Cter_Amidation	457	460	PF01082	0.774
MOD_GlcNHglycan	182	185	PF01048	0.684
MOD_GlcNHglycan	205	208	PF01048	0.687
MOD_GlcNHglycan	232	235	PF01048	0.466
MOD_GlcNHglycan	26	29	PF01048	0.476
MOD_GlcNHglycan	290	293	PF01048	0.709
MOD_GlcNHglycan	332	335	PF01048	0.678
MOD_GlcNHglycan	350	353	PF01048	0.629
MOD_GlcNHglycan	392	395	PF01048	0.736
MOD_GlcNHglycan	438	441	PF01048	0.639
MOD_GlcNHglycan	71	74	PF01048	0.589
MOD_GSK3_1	131	138	PF00069	0.528
MOD_GSK3_1	153	160	PF00069	0.701
MOD_GSK3_1	166	173	PF00069	0.543
MOD_GSK3_1	180	187	PF00069	0.570
MOD_GSK3_1	188	195	PF00069	0.777
MOD_GSK3_1	201	208	PF00069	0.719
MOD_GSK3_1	210	217	PF00069	0.657
MOD_GSK3_1	230	237	PF00069	0.526
MOD_GSK3_1	275	282	PF00069	0.595
MOD_GSK3_1	348	355	PF00069	0.591
MOD_GSK3_1	358	365	PF00069	0.418
MOD_GSK3_1	375	382	PF00069	0.653
MOD_GSK3_1	393	400	PF00069	0.611
MOD_GSK3_1	444	451	PF00069	0.708
MOD_GSK3_1	63	70	PF00069	0.503
MOD_GSK3_1	71	78	PF00069	0.596
MOD_LATS_1	254	260	PF00433	0.616
MOD_N-GLC_1	160	165	PF02516	0.701
MOD_NEK2_1	224	229	PF00069	0.535
MOD_NEK2_1	249	254	PF00069	0.624
MOD_NEK2_1	279	284	PF00069	0.573
MOD_NEK2_1	63	68	PF00069	0.495
MOD_NEK2_2	99	104	PF00069	0.530
MOD_PIKK_1	249	255	PF00454	0.631
MOD_PIKK_1	444	450	PF00454	0.704
MOD_PKA_1	459	465	PF00069	0.707
MOD_PKA_2	12	18	PF00069	0.655
MOD_PKA_2	224	230	PF00069	0.569
MOD_PKA_2	259	265	PF00069	0.576
MOD_PKA_2	310	316	PF00069	0.655
MOD_PKA_2	375	381	PF00069	0.683
MOD_PKA_2	46	52	PF00069	0.545
MOD_PKB_1	457	465	PF00069	0.738
MOD_Plk_1	150	156	PF00069	0.532
MOD_Plk_1	275	281	PF00069	0.615
MOD_Plk_1	444	450	PF00069	0.676
MOD_Plk_1	63	69	PF00069	0.482
MOD_Plk_2-3	151	157	PF00069	0.612
MOD_Plk_4	205	211	PF00069	0.753
MOD_Plk_4	352	358	PF00069	0.665
MOD_Plk_4	398	404	PF00069	0.679
MOD_ProDKin_1	184	190	PF00069	0.691
MOD_ProDKin_1	201	207	PF00069	0.595
MOD_ProDKin_1	210	216	PF00069	0.650
MOD_ProDKin_1	282	288	PF00069	0.693
MOD_ProDKin_1	358	364	PF00069	0.496
MOD_ProDKin_1	71	77	PF00069	0.670
MOD_SUMO_for_1	145	148	PF00179	0.716
MOD_SUMO_for_1	404	407	PF00179	0.692
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.526
TRG_ENDOCYTIC_2	246	249	PF00928	0.465
TRG_ER_diArg_1	119	121	PF00400	0.529
TRG_ER_diArg_1	125	127	PF00400	0.558
TRG_ER_diArg_1	273	275	PF00400	0.573
TRG_NES_CRM1_1	312	327	PF08389	0.597
TRG_NLS_MonoExtC_3	458	463	PF00514	0.699
TRG_NLS_MonoExtN_4	457	463	PF00514	0.699
TRG_Pf-PMV_PEXEL_1	125	130	PF00026	0.516
TRG_Pf-PMV_PEXEL_1	452	456	PF00026	0.744

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P858	Leptomonas seymouri	53%	100%
A0A1X0NY71	Trypanosomatidae	28%	100%
A0A3Q8IL02	Leishmania donovani	94%	100%
A0A422NH97	Trypanosoma rangeli	31%	100%
A4HBQ5	Leishmania braziliensis	81%	100%
A4HZ57	Leishmania infantum	94%	100%
D0A1I3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9AV25	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5DEP6	Trypanosoma cruzi	31%	100%