Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QCF6_LEIMA

TriTrypDb:

LmjF.21.0590 , LMJLV39_210011400 , LMJSD75_210011500

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCF6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCF6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	350	354	PF00656	0.578
CLV_C14_Caspase3-7	72	76	PF00656	0.614
CLV_NRD_NRD_1	261	263	PF00675	0.592
CLV_NRD_NRD_1	303	305	PF00675	0.636
CLV_NRD_NRD_1	368	370	PF00675	0.613
CLV_NRD_NRD_1	385	387	PF00675	0.583
CLV_PCSK_KEX2_1	201	203	PF00082	0.501
CLV_PCSK_KEX2_1	263	265	PF00082	0.586
CLV_PCSK_KEX2_1	303	305	PF00082	0.636
CLV_PCSK_KEX2_1	347	349	PF00082	0.606
CLV_PCSK_KEX2_1	370	372	PF00082	0.614
CLV_PCSK_KEX2_1	385	387	PF00082	0.627
CLV_PCSK_PC1ET2_1	201	203	PF00082	0.495
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.586
CLV_PCSK_PC1ET2_1	347	349	PF00082	0.606
CLV_PCSK_PC1ET2_1	370	372	PF00082	0.605
CLV_PCSK_SKI1_1	279	283	PF00082	0.666
DEG_Nend_UBRbox_2	1	3	PF02207	0.522
DEG_SCF_TRCP1_1	75	80	PF00400	0.643
DEG_SPOP_SBC_1	47	51	PF00917	0.686
DOC_MAPK_gen_1	262	271	PF00069	0.695
DOC_MAPK_gen_1	303	312	PF00069	0.620
DOC_PP2B_LxvP_1	239	242	PF13499	0.512
DOC_PP2B_LxvP_1	310	313	PF13499	0.676
DOC_USP7_MATH_1	176	180	PF00917	0.708
DOC_USP7_MATH_1	208	212	PF00917	0.658
DOC_USP7_MATH_1	320	324	PF00917	0.656
DOC_USP7_MATH_1	355	359	PF00917	0.639
DOC_USP7_MATH_1	47	51	PF00917	0.644
DOC_WW_Pin1_4	181	186	PF00397	0.604
DOC_WW_Pin1_4	204	209	PF00397	0.543
DOC_WW_Pin1_4	99	104	PF00397	0.714
LIG_14-3-3_CanoR_1	206	214	PF00244	0.688
LIG_14-3-3_CanoR_1	225	230	PF00244	0.412
LIG_14-3-3_CanoR_1	262	271	PF00244	0.695
LIG_14-3-3_CanoR_1	303	313	PF00244	0.764
LIG_14-3-3_CanoR_1	4	12	PF00244	0.655
LIG_FHA_1	181	187	PF00498	0.598
LIG_FHA_1	188	194	PF00498	0.481
LIG_FHA_1	26	32	PF00498	0.728
LIG_FHA_1	305	311	PF00498	0.752
LIG_FHA_2	232	238	PF00498	0.507
LIG_LIR_Apic_2	362	367	PF02991	0.537
LIG_LIR_Apic_2	64	70	PF02991	0.778
LIG_LIR_Gen_1	223	233	PF02991	0.533
LIG_LIR_Nem_3	223	229	PF02991	0.524
LIG_LIR_Nem_3	247	252	PF02991	0.579
LIG_LIR_Nem_3	375	381	PF02991	0.715
LIG_LYPXL_yS_3	249	252	PF13949	0.579
LIG_NRP_CendR_1	385	388	PF00754	0.703
LIG_PCNA_yPIPBox_3	156	167	PF02747	0.653
LIG_PTB_Apo_2	52	59	PF02174	0.650
LIG_PTB_Phospho_1	52	58	PF10480	0.652
LIG_SH2_CRK	364	368	PF00017	0.544
LIG_SH2_GRB2like	364	367	PF00017	0.542
LIG_SH2_NCK_1	15	19	PF00017	0.665
LIG_SH2_SRC	364	367	PF00017	0.542
LIG_SH2_STAP1	218	222	PF00017	0.574
LIG_SH2_STAP1	226	230	PF00017	0.487
LIG_SH2_STAT5	340	343	PF00017	0.642
LIG_SH2_STAT5	380	383	PF00017	0.706
LIG_SH3_1	202	208	PF00018	0.607
LIG_SH3_3	122	128	PF00018	0.744
LIG_SH3_3	179	185	PF00018	0.670
LIG_SH3_3	202	208	PF00018	0.530
LIG_SH3_3	235	241	PF00018	0.502
LIG_SH3_3	247	253	PF00018	0.577
LIG_SH3_3	26	32	PF00018	0.615
LIG_SH3_3	314	320	PF00018	0.746
LIG_SH3_3	97	103	PF00018	0.550
LIG_SUMO_SIM_par_1	242	247	PF11976	0.564
LIG_TRAF2_1	283	286	PF00917	0.595
LIG_TYR_ITSM	245	252	PF00017	0.578
LIG_WRC_WIRS_1	226	231	PF05994	0.531
MOD_CK1_1	102	108	PF00069	0.734
MOD_CK1_1	120	126	PF00069	0.531
MOD_CK1_1	207	213	PF00069	0.515
MOD_CK1_1	228	234	PF00069	0.542
MOD_CK1_1	321	327	PF00069	0.650
MOD_CK1_1	8	14	PF00069	0.699
MOD_CK1_1	90	96	PF00069	0.571
MOD_CK2_1	113	119	PF00069	0.769
MOD_Cter_Amidation	383	386	PF01082	0.585
MOD_GlcNHglycan	110	113	PF01048	0.651
MOD_GlcNHglycan	320	323	PF01048	0.648
MOD_GlcNHglycan	350	353	PF01048	0.646
MOD_GlcNHglycan	357	360	PF01048	0.720
MOD_GlcNHglycan	59	62	PF01048	0.748
MOD_GlcNHglycan	7	10	PF01048	0.712
MOD_GlcNHglycan	75	78	PF01048	0.778
MOD_GlcNHglycan	83	86	PF01048	0.544
MOD_GSK3_1	113	120	PF00069	0.762
MOD_GSK3_1	176	183	PF00069	0.581
MOD_GSK3_1	204	211	PF00069	0.653
MOD_GSK3_1	21	28	PF00069	0.730
MOD_GSK3_1	224	231	PF00069	0.530
MOD_GSK3_1	244	251	PF00069	0.697
MOD_GSK3_1	265	272	PF00069	0.563
MOD_GSK3_1	318	325	PF00069	0.691
MOD_GSK3_1	32	39	PF00069	0.608
MOD_GSK3_1	57	64	PF00069	0.648
MOD_GSK3_1	69	76	PF00069	0.633
MOD_GSK3_1	77	84	PF00069	0.730
MOD_NEK2_1	180	185	PF00069	0.578
MOD_NEK2_1	244	249	PF00069	0.594
MOD_NEK2_1	269	274	PF00069	0.607
MOD_NEK2_1	293	298	PF00069	0.743
MOD_PIKK_1	228	234	PF00454	0.542
MOD_PKA_1	262	268	PF00069	0.701
MOD_PKA_2	117	123	PF00069	0.775
MOD_PKA_2	224	230	PF00069	0.467
MOD_Plk_1	21	27	PF00069	0.627
MOD_Plk_1	277	283	PF00069	0.718
MOD_Plk_4	21	27	PF00069	0.712
MOD_Plk_4	225	231	PF00069	0.493
MOD_Plk_4	244	250	PF00069	0.430
MOD_Plk_4	277	283	PF00069	0.664
MOD_Plk_4	87	93	PF00069	0.569
MOD_ProDKin_1	181	187	PF00069	0.591
MOD_ProDKin_1	204	210	PF00069	0.534
MOD_ProDKin_1	99	105	PF00069	0.716
TRG_ENDOCYTIC_2	226	229	PF00928	0.524
TRG_ENDOCYTIC_2	249	252	PF00928	0.579
TRG_ENDOCYTIC_2	378	381	PF00928	0.600
TRG_ER_diArg_1	302	304	PF00400	0.635
TRG_ER_diArg_1	385	388	PF00400	0.714

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I5	Leptomonas seymouri	40%	81%
A0A3S7WWD4	Leishmania donovani	88%	100%
A4HBQ6	Leishmania braziliensis	65%	100%
A4HZ58	Leishmania infantum	88%	100%
E9AV26	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%