Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCF5_LEIMA

TriTrypDb:

LmjF.21.0600 , LMJLV39_210011500 , LMJSD75_210011600

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCF5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCF5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	7	9	PF00675	0.521
CLV_PCSK_SKI1_1	298	302	PF00082	0.629
CLV_PCSK_SKI1_1	314	318	PF00082	0.366
CLV_PCSK_SKI1_1	420	424	PF00082	0.499
CLV_Separin_Metazoa	11	15	PF03568	0.591
DEG_Nend_Nbox_1	1	3	PF02207	0.496
DOC_CKS1_1	405	410	PF01111	0.697
DOC_CKS1_1	439	444	PF01111	0.543
DOC_MAPK_gen_1	8	15	PF00069	0.491
DOC_MAPK_gen_1	89	98	PF00069	0.529
DOC_MAPK_MEF2A_6	307	315	PF00069	0.651
DOC_USP7_MATH_1	190	194	PF00917	0.687
DOC_USP7_MATH_1	379	383	PF00917	0.721
DOC_WW_Pin1_4	133	138	PF00397	0.420
DOC_WW_Pin1_4	186	191	PF00397	0.692
DOC_WW_Pin1_4	401	406	PF00397	0.790
DOC_WW_Pin1_4	438	443	PF00397	0.471
LIG_14-3-3_CanoR_1	155	163	PF00244	0.604
LIG_14-3-3_CanoR_1	248	253	PF00244	0.692
LIG_14-3-3_CanoR_1	52	61	PF00244	0.596
LIG_14-3-3_CanoR_1	91	96	PF00244	0.535
LIG_deltaCOP1_diTrp_1	114	121	PF00928	0.378
LIG_FHA_1	167	173	PF00498	0.673
LIG_FHA_1	263	269	PF00498	0.614
LIG_FHA_1	66	72	PF00498	0.545
LIG_FHA_1	74	80	PF00498	0.429
LIG_FHA_2	115	121	PF00498	0.601
LIG_FHA_2	227	233	PF00498	0.683
LIG_FHA_2	249	255	PF00498	0.686
LIG_FHA_2	330	336	PF00498	0.584
LIG_FHA_2	339	345	PF00498	0.537
LIG_FHA_2	348	354	PF00498	0.427
LIG_FHA_2	46	52	PF00498	0.747
LIG_FHA_2	76	82	PF00498	0.550
LIG_Integrin_isoDGR_2	82	84	PF01839	0.647
LIG_LIR_Gen_1	269	277	PF02991	0.631
LIG_LIR_Gen_1	421	431	PF02991	0.554
LIG_LIR_Nem_3	127	132	PF02991	0.570
LIG_LIR_Nem_3	133	138	PF02991	0.405
LIG_LIR_Nem_3	140	146	PF02991	0.526
LIG_LIR_Nem_3	269	274	PF02991	0.644
LIG_LIR_Nem_3	421	426	PF02991	0.621
LIG_NRBOX	296	302	PF00104	0.543
LIG_NRBOX	357	363	PF00104	0.508
LIG_PAM2_1	52	64	PF00658	0.581
LIG_Pex14_1	139	143	PF04695	0.523
LIG_Pex14_1	252	256	PF04695	0.674
LIG_SH2_CRK	143	147	PF00017	0.524
LIG_SH2_PTP2	271	274	PF00017	0.636
LIG_SH2_STAT5	135	138	PF00017	0.500
LIG_SH2_STAT5	271	274	PF00017	0.636
LIG_SH2_STAT5	329	332	PF00017	0.552
LIG_SH2_STAT5	74	77	PF00017	0.456
LIG_SH3_3	399	405	PF00018	0.814
LIG_SH3_3	436	442	PF00018	0.543
LIG_SUMO_SIM_anti_2	76	81	PF11976	0.500
LIG_SUMO_SIM_par_1	158	164	PF11976	0.450
LIG_SUMO_SIM_par_1	75	81	PF11976	0.490
LIG_TRAF2_1	117	120	PF00917	0.540
LIG_TRAF2_1	251	254	PF00917	0.682
LIG_TYR_ITSM	139	146	PF00017	0.615
MOD_CK1_1	159	165	PF00069	0.544
MOD_CK1_1	166	172	PF00069	0.538
MOD_CK1_1	189	195	PF00069	0.682
MOD_CK1_1	206	212	PF00069	0.485
MOD_CK1_1	239	245	PF00069	0.587
MOD_CK1_1	291	297	PF00069	0.526
MOD_CK1_1	337	343	PF00069	0.480
MOD_CK1_1	391	397	PF00069	0.754
MOD_CK1_1	404	410	PF00069	0.560
MOD_CK2_1	114	120	PF00069	0.620
MOD_CK2_1	248	254	PF00069	0.693
MOD_CK2_1	290	296	PF00069	0.607
MOD_CK2_1	329	335	PF00069	0.573
MOD_CK2_1	338	344	PF00069	0.546
MOD_CK2_1	347	353	PF00069	0.499
MOD_CK2_1	45	51	PF00069	0.753
MOD_CK2_1	75	81	PF00069	0.529
MOD_Cter_Amidation	6	9	PF01082	0.517
MOD_GlcNHglycan	143	146	PF01048	0.582
MOD_GlcNHglycan	165	168	PF01048	0.591
MOD_GlcNHglycan	191	195	PF01048	0.665
MOD_GlcNHglycan	199	202	PF01048	0.640
MOD_GlcNHglycan	207	211	PF01048	0.452
MOD_GlcNHglycan	238	241	PF01048	0.538
MOD_GlcNHglycan	293	296	PF01048	0.542
MOD_GlcNHglycan	335	339	PF01048	0.530
MOD_GlcNHglycan	374	377	PF01048	0.685
MOD_GSK3_1	133	140	PF00069	0.466
MOD_GSK3_1	141	148	PF00069	0.433
MOD_GSK3_1	155	162	PF00069	0.605
MOD_GSK3_1	174	181	PF00069	0.348
MOD_GSK3_1	182	189	PF00069	0.563
MOD_GSK3_1	193	200	PF00069	0.529
MOD_GSK3_1	287	294	PF00069	0.548
MOD_GSK3_1	334	341	PF00069	0.629
MOD_GSK3_1	379	386	PF00069	0.751
MOD_GSK3_1	40	47	PF00069	0.754
MOD_GSK3_1	400	407	PF00069	0.749
MOD_NEK2_1	161	166	PF00069	0.439
MOD_NEK2_1	262	267	PF00069	0.576
MOD_NEK2_1	75	80	PF00069	0.512
MOD_NEK2_2	309	314	PF00069	0.541
MOD_NEK2_2	329	334	PF00069	0.557
MOD_PIKK_1	106	112	PF00454	0.532
MOD_PIKK_1	193	199	PF00454	0.742
MOD_PK_1	91	97	PF00069	0.512
MOD_PKA_2	141	147	PF00069	0.496
MOD_PKA_2	247	253	PF00069	0.690
MOD_PKA_2	262	268	PF00069	0.422
MOD_Plk_1	190	196	PF00069	0.557
MOD_Plk_1	287	293	PF00069	0.472
MOD_Plk_1	380	386	PF00069	0.797
MOD_Plk_2-3	114	120	PF00069	0.620
MOD_Plk_4	156	162	PF00069	0.603
MOD_Plk_4	338	344	PF00069	0.581
MOD_Plk_4	347	353	PF00069	0.582
MOD_Plk_4	75	81	PF00069	0.599
MOD_Plk_4	91	97	PF00069	0.590
MOD_ProDKin_1	133	139	PF00069	0.419
MOD_ProDKin_1	186	192	PF00069	0.693
MOD_ProDKin_1	401	407	PF00069	0.780
MOD_ProDKin_1	438	444	PF00069	0.485
TRG_DiLeu_BaEn_1	11	16	PF01217	0.587
TRG_DiLeu_BaEn_1	296	301	PF01217	0.612
TRG_DiLeu_BaEn_1	353	358	PF01217	0.515
TRG_DiLeu_BaLyEn_6	233	238	PF01217	0.669
TRG_DiLeu_LyEn_5	11	16	PF01217	0.587
TRG_ENDOCYTIC_2	135	138	PF00928	0.595
TRG_ENDOCYTIC_2	143	146	PF00928	0.463
TRG_ENDOCYTIC_2	154	157	PF00928	0.506
TRG_ENDOCYTIC_2	271	274	PF00928	0.636
TRG_ENDOCYTIC_2	74	77	PF00928	0.438
TRG_ER_diArg_1	272	275	PF00400	0.627
TRG_Pf-PMV_PEXEL_1	275	279	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IM65	Leptomonas seymouri	38%	74%
A0A3S7WWF0	Leishmania donovani	93%	84%
A4HBQ7	Leishmania braziliensis	75%	100%
A4HZ59	Leishmania infantum	93%	84%
E9AV27	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%