Putative RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA helicase, putative

Species:

Leishmania major

UniProt:

Q4QCF4_LEIMA

TriTrypDb:

LmjF.21.0610 , LMJLV39_210011600 , LMJSD75_210011700 , LMJSD75_210011800

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCF4

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.753
CLV_C14_Caspase3-7	267	271	PF00656	0.744
CLV_C14_Caspase3-7	330	334	PF00656	0.544
CLV_C14_Caspase3-7	7	11	PF00656	0.627
CLV_NRD_NRD_1	16	18	PF00675	0.678
CLV_NRD_NRD_1	243	245	PF00675	0.748
CLV_NRD_NRD_1	315	317	PF00675	0.408
CLV_NRD_NRD_1	324	326	PF00675	0.404
CLV_NRD_NRD_1	52	54	PF00675	0.582
CLV_PCSK_FUR_1	14	18	PF00082	0.654
CLV_PCSK_KEX2_1	16	18	PF00082	0.694
CLV_PCSK_KEX2_1	238	240	PF00082	0.679
CLV_PCSK_KEX2_1	315	317	PF00082	0.408
CLV_PCSK_PC1ET2_1	238	240	PF00082	0.679
CLV_PCSK_SKI1_1	101	105	PF00082	0.240
CLV_PCSK_SKI1_1	130	134	PF00082	0.346
CLV_PCSK_SKI1_1	17	21	PF00082	0.648
CLV_PCSK_SKI1_1	315	319	PF00082	0.427
CLV_PCSK_SKI1_1	396	400	PF00082	0.480
CLV_PCSK_SKI1_1	419	423	PF00082	0.440
CLV_PCSK_SKI1_1	484	488	PF00082	0.320
CLV_PCSK_SKI1_1	535	539	PF00082	0.362
CLV_PCSK_SKI1_1	558	562	PF00082	0.422
CLV_PCSK_SKI1_1	656	660	PF00082	0.599
CLV_PCSK_SKI1_1	71	75	PF00082	0.540
CLV_PCSK_SKI1_1	90	94	PF00082	0.330
DEG_SPOP_SBC_1	442	446	PF00917	0.765
DEG_SPOP_SBC_1	469	473	PF00917	0.628
DOC_CYCLIN_RxL_1	127	135	PF00134	0.537
DOC_CYCLIN_RxL_1	515	526	PF00134	0.476
DOC_CYCLIN_RxL_1	653	661	PF00134	0.603
DOC_CYCLIN_yClb5_NLxxxL_5	646	655	PF00134	0.496
DOC_CYCLIN_yCln2_LP_2	651	657	PF00134	0.506
DOC_MAPK_gen_1	16	27	PF00069	0.558
DOC_MAPK_gen_1	315	323	PF00069	0.443
DOC_MAPK_gen_1	552	562	PF00069	0.595
DOC_MAPK_gen_1	632	640	PF00069	0.641
DOC_MAPK_MEF2A_6	174	182	PF00069	0.489
DOC_MAPK_MEF2A_6	632	640	PF00069	0.675
DOC_PP1_RVXF_1	409	416	PF00149	0.393
DOC_PP1_RVXF_1	46	52	PF00149	0.606
DOC_PP1_RVXF_1	516	523	PF00149	0.476
DOC_PP2B_LxvP_1	531	534	PF13499	0.476
DOC_PP4_FxxP_1	675	678	PF00568	0.400
DOC_USP7_MATH_1	264	268	PF00917	0.781
DOC_USP7_MATH_1	327	331	PF00917	0.416
DOC_USP7_MATH_1	372	376	PF00917	0.563
DOC_USP7_MATH_1	447	451	PF00917	0.794
DOC_USP7_MATH_1	468	472	PF00917	0.763
DOC_USP7_MATH_1	485	489	PF00917	0.479
DOC_USP7_MATH_1	537	541	PF00917	0.562
DOC_USP7_MATH_1	593	597	PF00917	0.655
DOC_USP7_MATH_1	613	617	PF00917	0.707
DOC_USP7_MATH_1	619	623	PF00917	0.511
DOC_USP7_UBL2_3	170	174	PF12436	0.425
DOC_USP7_UBL2_3	318	322	PF12436	0.451
DOC_USP7_UBL2_3	452	456	PF12436	0.824
DOC_USP7_UBL2_3	635	639	PF12436	0.643
DOC_USP7_UBL2_3	81	85	PF12436	0.437
DOC_WW_Pin1_4	287	292	PF00397	0.572
DOC_WW_Pin1_4	443	448	PF00397	0.792
LIG_14-3-3_CanoR_1	239	246	PF00244	0.776
LIG_14-3-3_CanoR_1	315	321	PF00244	0.529
LIG_14-3-3_CanoR_1	394	402	PF00244	0.454
LIG_14-3-3_CanoR_1	484	493	PF00244	0.550
LIG_14-3-3_CanoR_1	546	556	PF00244	0.483
LIG_14-3-3_CanoR_1	66	71	PF00244	0.518
LIG_14-3-3_CanoR_1	676	685	PF00244	0.589
LIG_Actin_WH2_2	164	181	PF00022	0.539
LIG_Actin_WH2_2	306	324	PF00022	0.470
LIG_APCC_ABBA_1	378	383	PF00400	0.500
LIG_BIR_II_1	1	5	PF00653	0.689
LIG_BRCT_BRCA1_1	539	543	PF00533	0.562
LIG_EH_1	628	632	PF12763	0.495
LIG_FHA_1	162	168	PF00498	0.476
LIG_FHA_1	175	181	PF00498	0.476
LIG_FHA_1	20	26	PF00498	0.552
LIG_FHA_1	397	403	PF00498	0.442
LIG_FHA_1	548	554	PF00498	0.537
LIG_FHA_1	576	582	PF00498	0.569
LIG_FHA_1	77	83	PF00498	0.463
LIG_FHA_2	219	225	PF00498	0.654
LIG_FHA_2	33	39	PF00498	0.564
LIG_FHA_2	420	426	PF00498	0.528
LIG_FHA_2	521	527	PF00498	0.562
LIG_FHA_2	691	697	PF00498	0.618
LIG_Integrin_isoDGR_2	105	107	PF01839	0.362
LIG_Integrin_isoDGR_2	409	411	PF01839	0.564
LIG_LIR_Apic_2	120	126	PF02991	0.476
LIG_LIR_Gen_1	34	45	PF02991	0.443
LIG_LIR_Gen_1	383	392	PF02991	0.445
LIG_LIR_Gen_1	521	530	PF02991	0.500
LIG_LIR_LC3C_4	622	627	PF02991	0.546
LIG_LIR_Nem_3	34	40	PF02991	0.420
LIG_LIR_Nem_3	383	388	PF02991	0.377
LIG_LIR_Nem_3	521	525	PF02991	0.476
LIG_LIR_Nem_3	86	92	PF02991	0.495
LIG_Pex14_2	150	154	PF04695	0.476
LIG_RPA_C_Fungi	48	60	PF08784	0.564
LIG_SH2_CRK	100	104	PF00017	0.328
LIG_SH2_CRK	123	127	PF00017	0.328
LIG_SH2_CRK	368	372	PF00017	0.407
LIG_SH2_CRK	633	637	PF00017	0.598
LIG_SH2_NCK_1	633	637	PF00017	0.598
LIG_SH2_STAT3	172	175	PF00017	0.433
LIG_SH2_STAT3	366	369	PF00017	0.465
LIG_SH2_STAT3	692	695	PF00017	0.569
LIG_SH2_STAT5	344	347	PF00017	0.358
LIG_SH2_STAT5	633	636	PF00017	0.602
LIG_SH2_STAT5	692	695	PF00017	0.594
LIG_SH3_3	550	556	PF00018	0.413
LIG_SH3_3	624	630	PF00018	0.441
LIG_SH3_3	635	641	PF00018	0.550
LIG_SH3_4	635	642	PF00018	0.650
LIG_SUMO_SIM_par_1	369	375	PF11976	0.447
LIG_TRAF2_1	222	225	PF00917	0.706
LIG_TRAF2_1	253	256	PF00917	0.746
LIG_TRAF2_1	693	696	PF00917	0.526
LIG_UBA3_1	320	326	PF00899	0.412
MOD_CDC14_SPxK_1	290	293	PF00782	0.523
MOD_CDK_SPxK_1	287	293	PF00069	0.530
MOD_CDK_SPxxK_3	445	452	PF00069	0.682
MOD_CK1_1	117	123	PF00069	0.325
MOD_CK1_1	471	477	PF00069	0.631
MOD_CK1_1	69	75	PF00069	0.563
MOD_CK2_1	163	169	PF00069	0.351
MOD_CK2_1	203	209	PF00069	0.359
MOD_CK2_1	218	224	PF00069	0.647
MOD_CK2_1	419	425	PF00069	0.529
MOD_CK2_1	49	55	PF00069	0.539
MOD_CK2_1	665	671	PF00069	0.574
MOD_CK2_1	690	696	PF00069	0.582
MOD_Cter_Amidation	235	238	PF01082	0.770
MOD_Cter_Amidation	313	316	PF01082	0.424
MOD_Cter_Amidation	454	457	PF01082	0.766
MOD_GlcNHglycan	116	119	PF01048	0.328
MOD_GlcNHglycan	241	244	PF01048	0.769
MOD_GlcNHglycan	310	313	PF01048	0.613
MOD_GlcNHglycan	374	377	PF01048	0.639
MOD_GlcNHglycan	449	452	PF01048	0.815
MOD_GlcNHglycan	461	464	PF01048	0.677
MOD_GlcNHglycan	595	598	PF01048	0.725
MOD_GlcNHglycan	607	610	PF01048	0.603
MOD_GlcNHglycan	641	644	PF01048	0.445
MOD_GSK3_1	110	117	PF00069	0.327
MOD_GSK3_1	264	271	PF00069	0.748
MOD_GSK3_1	396	403	PF00069	0.430
MOD_GSK3_1	427	434	PF00069	0.559
MOD_GSK3_1	437	444	PF00069	0.721
MOD_GSK3_1	469	476	PF00069	0.673
MOD_GSK3_1	520	527	PF00069	0.403
MOD_GSK3_1	69	76	PF00069	0.552
MOD_LATS_1	112	118	PF00433	0.328
MOD_LATS_1	64	70	PF00433	0.538
MOD_N-GLC_1	327	332	PF02516	0.446
MOD_N-GLC_1	458	463	PF02516	0.745
MOD_NEK2_1	200	205	PF00069	0.363
MOD_NEK2_1	475	480	PF00069	0.597
MOD_NEK2_1	49	54	PF00069	0.617
MOD_NEK2_1	631	636	PF00069	0.596
MOD_NEK2_1	75	80	PF00069	0.487
MOD_NEK2_1	83	88	PF00069	0.452
MOD_NEK2_2	619	624	PF00069	0.569
MOD_PIKK_1	485	491	PF00454	0.351
MOD_PK_1	66	72	PF00069	0.504
MOD_PKA_2	631	637	PF00069	0.619
MOD_PKB_1	394	402	PF00069	0.339
MOD_Plk_1	302	308	PF00069	0.427
MOD_Plk_1	33	39	PF00069	0.423
MOD_Plk_1	403	409	PF00069	0.609
MOD_Plk_4	163	169	PF00069	0.351
MOD_Plk_4	21	27	PF00069	0.540
MOD_Plk_4	316	322	PF00069	0.522
MOD_Plk_4	477	483	PF00069	0.474
MOD_Plk_4	524	530	PF00069	0.392
MOD_Plk_4	539	545	PF00069	0.240
MOD_ProDKin_1	287	293	PF00069	0.571
MOD_ProDKin_1	443	449	PF00069	0.790
TRG_DiLeu_BaEn_1	129	134	PF01217	0.449
TRG_DiLeu_BaLyEn_6	123	128	PF01217	0.474
TRG_DiLeu_BaLyEn_6	397	402	PF01217	0.433
TRG_ENDOCYTIC_2	100	103	PF00928	0.314
TRG_ENDOCYTIC_2	368	371	PF00928	0.431
TRG_ER_diArg_1	15	17	PF00400	0.643
TRG_ER_diArg_1	315	317	PF00400	0.408
TRG_NLS_MonoCore_2	237	242	PF00514	0.746
TRG_NLS_MonoExtC_3	16	21	PF00514	0.660
TRG_NLS_MonoExtC_3	236	241	PF00514	0.748
TRG_NLS_MonoExtN_4	14	21	PF00514	0.713
TRG_NLS_MonoExtN_4	235	242	PF00514	0.710
TRG_Pf-PMV_PEXEL_1	130	135	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	205	209	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	484	489	PF00026	0.449
TRG_Pf-PMV_PEXEL_1	656	660	PF00026	0.448

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P856	Leptomonas seymouri	64%	100%
A0A0S4J214	Bodo saltans	46%	100%
A0A1X0NXJ9	Trypanosomatidae	47%	100%
A0A3R7MLR3	Trypanosoma rangeli	49%	100%
A0A3S7WWF8	Leishmania donovani	94%	100%
A4HBQ8	Leishmania braziliensis	83%	100%
A4HZ60	Leishmania infantum	94%	100%
D0A1I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AV28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BDT6	Trypanosoma cruzi	47%	100%