Putative RNA helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

RNA helicase, putative

Species:

Leishmania major

UniProt:

Q4QCF4_LEIMA

TriTrypDb:

LmjF.21.0610 , LMJLV39_210011600 , LMJSD75_210011700 , LMJSD75_210011800

Length:

697

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QCF4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCF4

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003676	nucleic acid binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	260	264	PF00656	0.753
CLV_C14_Caspase3-7	267	271	PF00656	0.744
CLV_C14_Caspase3-7	330	334	PF00656	0.544
CLV_C14_Caspase3-7	7	11	PF00656	0.627
CLV_NRD_NRD_1	16	18	PF00675	0.678
CLV_NRD_NRD_1	243	245	PF00675	0.748
CLV_NRD_NRD_1	315	317	PF00675	0.408
CLV_NRD_NRD_1	324	326	PF00675	0.404
CLV_NRD_NRD_1	52	54	PF00675	0.582
CLV_PCSK_FUR_1	14	18	PF00082	0.654

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P856	Leptomonas seymouri	64%	100%
A0A0S4J214	Bodo saltans	46%	100%
A0A1X0NXJ9	Trypanosomatidae	47%	100%
A0A3R7MLR3	Trypanosoma rangeli	49%	100%
A0A3S7WWF8	Leishmania donovani	94%	100%
A4HBQ8	Leishmania braziliensis	83%	100%
A4HZ60	Leishmania infantum	94%	100%
D0A1I1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AV28	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BDT6	Trypanosoma cruzi	47%	100%

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