Putative DNA polymerase eta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase eta, putative

Species:

Leishmania major

UniProt:

Q4QCF3_LEIMA

TriTrypDb:

LmjF.21.0620 , LMJLV39_210011700 , LMJSD75_210011900

Length:

786

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005657	replication fork	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0035861	site of double-strand break	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0090734	site of DNA damage	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCF3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCF3

Function

Biological processes
Term	Name	Level	Count
GO:0000731	DNA synthesis involved in DNA repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006301	postreplication repair	6	2
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009314	response to radiation	3	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	8
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019985	translesion synthesis	7	2
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0042276	error-prone translesion synthesis	8	2
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0071897	DNA biosynthetic process	5	2
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003684	damaged DNA binding	5	8
GO:0003824	catalytic activity	1	2
GO:0003887	DNA-directed DNA polymerase activity	5	2
GO:0005488	binding	1	8
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0034061	DNA polymerase activity	4	2
GO:0097159	organic cyclic compound binding	2	8
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	362	366	PF00656	0.624
CLV_C14_Caspase3-7	388	392	PF00656	0.721
CLV_C14_Caspase3-7	558	562	PF00656	0.705
CLV_NRD_NRD_1	168	170	PF00675	0.342
CLV_NRD_NRD_1	200	202	PF00675	0.283
CLV_NRD_NRD_1	354	356	PF00675	0.349
CLV_NRD_NRD_1	490	492	PF00675	0.669
CLV_NRD_NRD_1	538	540	PF00675	0.678
CLV_NRD_NRD_1	645	647	PF00675	0.667
CLV_NRD_NRD_1	83	85	PF00675	0.328
CLV_NRD_NRD_1	93	95	PF00675	0.307
CLV_PCSK_KEX2_1	168	170	PF00082	0.342
CLV_PCSK_KEX2_1	200	202	PF00082	0.283
CLV_PCSK_KEX2_1	490	492	PF00082	0.669
CLV_PCSK_KEX2_1	538	540	PF00082	0.701
CLV_PCSK_KEX2_1	647	649	PF00082	0.673
CLV_PCSK_KEX2_1	697	699	PF00082	0.653
CLV_PCSK_KEX2_1	83	85	PF00082	0.283
CLV_PCSK_KEX2_1	93	95	PF00082	0.283
CLV_PCSK_PC1ET2_1	647	649	PF00082	0.661
CLV_PCSK_PC1ET2_1	697	699	PF00082	0.676
CLV_PCSK_SKI1_1	137	141	PF00082	0.283
CLV_PCSK_SKI1_1	253	257	PF00082	0.283
CLV_PCSK_SKI1_1	429	433	PF00082	0.454
CLV_PCSK_SKI1_1	527	531	PF00082	0.440
CLV_PCSK_SKI1_1	618	622	PF00082	0.507
CLV_PCSK_SKI1_1	750	754	PF00082	0.729
CLV_Separin_Metazoa	221	225	PF03568	0.483
DEG_APCC_DBOX_1	167	175	PF00400	0.597
DEG_APCC_DBOX_1	92	100	PF00400	0.556
DEG_Nend_Nbox_1	1	3	PF02207	0.537
DOC_ANK_TNKS_1	635	642	PF00023	0.623
DOC_CKS1_1	483	488	PF01111	0.485
DOC_CYCLIN_RxL_1	250	261	PF00134	0.483
DOC_MAPK_DCC_7	93	101	PF00069	0.556
DOC_MAPK_gen_1	471	480	PF00069	0.545
DOC_MAPK_gen_1	496	504	PF00069	0.523
DOC_MAPK_gen_1	662	670	PF00069	0.654
DOC_MAPK_gen_1	747	757	PF00069	0.650
DOC_MAPK_MEF2A_6	144	151	PF00069	0.471
DOC_MAPK_MEF2A_6	471	480	PF00069	0.526
DOC_MAPK_MEF2A_6	662	670	PF00069	0.602
DOC_MAPK_MEF2A_6	93	101	PF00069	0.471
DOC_PP2B_LxvP_1	304	307	PF13499	0.397
DOC_PP2B_LxvP_1	574	577	PF13499	0.604
DOC_PP4_FxxP_1	219	222	PF00568	0.483
DOC_PP4_FxxP_1	315	318	PF00568	0.397
DOC_USP7_MATH_1	179	183	PF00917	0.493
DOC_USP7_MATH_1	22	26	PF00917	0.474
DOC_USP7_MATH_1	307	311	PF00917	0.377
DOC_USP7_MATH_1	331	335	PF00917	0.561
DOC_USP7_MATH_1	439	443	PF00917	0.564
DOC_USP7_MATH_1	545	549	PF00917	0.620
DOC_USP7_MATH_1	567	571	PF00917	0.624
DOC_USP7_MATH_1	631	635	PF00917	0.708
DOC_USP7_MATH_1	7	11	PF00917	0.601
DOC_USP7_MATH_1	712	716	PF00917	0.698
DOC_USP7_MATH_1	732	736	PF00917	0.533
DOC_USP7_MATH_1	767	771	PF00917	0.596
DOC_WW_Pin1_4	18	23	PF00397	0.527
DOC_WW_Pin1_4	482	487	PF00397	0.432
DOC_WW_Pin1_4	539	544	PF00397	0.750
DOC_WW_Pin1_4	57	62	PF00397	0.483
DOC_WW_Pin1_4	641	646	PF00397	0.682
DOC_WW_Pin1_4	698	703	PF00397	0.637
DOC_WW_Pin1_4	713	718	PF00397	0.682
DOC_WW_Pin1_4	85	90	PF00397	0.473
LIG_14-3-3_CanoR_1	100	107	PF00244	0.431
LIG_14-3-3_CanoR_1	17	22	PF00244	0.590
LIG_14-3-3_CanoR_1	211	216	PF00244	0.483
LIG_14-3-3_CanoR_1	309	318	PF00244	0.383
LIG_14-3-3_CanoR_1	461	469	PF00244	0.588
LIG_14-3-3_CanoR_1	618	627	PF00244	0.560
LIG_14-3-3_CanoR_1	750	756	PF00244	0.682
LIG_APCC_ABBAyCdc20_2	268	274	PF00400	0.483
LIG_BIR_III_4	368	372	PF00653	0.618
LIG_BRCT_BRCA1_1	237	241	PF00533	0.483
LIG_BRCT_BRCA1_1	311	315	PF00533	0.367
LIG_BRCT_BRCA1_1	433	437	PF00533	0.413
LIG_CSL_BTD_1	764	767	PF09270	0.603
LIG_eIF4E_1	250	256	PF01652	0.483
LIG_FHA_1	122	128	PF00498	0.574
LIG_FHA_1	192	198	PF00498	0.483
LIG_FHA_1	301	307	PF00498	0.397
LIG_FHA_1	739	745	PF00498	0.737
LIG_FHA_1	752	758	PF00498	0.567
LIG_FHA_2	10	16	PF00498	0.590
LIG_FHA_2	386	392	PF00498	0.579
LIG_FHA_2	419	425	PF00498	0.588
LIG_FHA_2	720	726	PF00498	0.618
LIG_GBD_Chelix_1	454	462	PF00786	0.400
LIG_Integrin_RGD_1	385	387	PF01839	0.612
LIG_LIR_Apic_2	111	117	PF02991	0.471
LIG_LIR_Apic_2	312	318	PF02991	0.383
LIG_LIR_Apic_2	345	350	PF02991	0.388
LIG_LIR_Gen_1	157	167	PF02991	0.483
LIG_LIR_Gen_1	42	53	PF02991	0.483
LIG_LIR_Gen_1	457	465	PF02991	0.416
LIG_LIR_Gen_1	521	529	PF02991	0.529
LIG_LIR_Gen_1	60	70	PF02991	0.483
LIG_LIR_Gen_1	621	632	PF02991	0.596
LIG_LIR_Gen_1	773	781	PF02991	0.544
LIG_LIR_Nem_3	157	163	PF02991	0.483
LIG_LIR_Nem_3	406	412	PF02991	0.350
LIG_LIR_Nem_3	42	48	PF02991	0.483
LIG_LIR_Nem_3	457	462	PF02991	0.404
LIG_LIR_Nem_3	521	525	PF02991	0.512
LIG_LIR_Nem_3	60	65	PF02991	0.483
LIG_LIR_Nem_3	621	627	PF02991	0.588
LIG_LIR_Nem_3	69	73	PF02991	0.483
LIG_LIR_Nem_3	773	777	PF02991	0.576
LIG_PCNA_PIPBox_1	720	729	PF02747	0.674
LIG_SH2_NCK_1	45	49	PF00017	0.483
LIG_SH2_PTP2	160	163	PF00017	0.483
LIG_SH2_PTP2	483	486	PF00017	0.418
LIG_SH2_SRC	160	163	PF00017	0.483
LIG_SH2_STAP1	277	281	PF00017	0.483
LIG_SH2_STAP1	465	469	PF00017	0.587
LIG_SH2_STAT3	498	501	PF00017	0.595
LIG_SH2_STAT5	114	117	PF00017	0.556
LIG_SH2_STAT5	160	163	PF00017	0.483
LIG_SH2_STAT5	483	486	PF00017	0.467
LIG_SH3_1	114	120	PF00018	0.471
LIG_SH3_3	114	120	PF00018	0.471
LIG_SH3_3	186	192	PF00018	0.483
LIG_SH3_3	419	425	PF00018	0.465
LIG_SH3_3	499	505	PF00018	0.548
LIG_SH3_3	537	543	PF00018	0.656
LIG_SH3_3	549	555	PF00018	0.567
LIG_SH3_3	557	563	PF00018	0.747
LIG_SH3_3	70	76	PF00018	0.483
LIG_SH3_3	761	767	PF00018	0.688
LIG_SH3_4	298	305	PF00018	0.402
LIG_SUMO_SIM_anti_2	475	481	PF11976	0.521
LIG_SUMO_SIM_anti_2	583	588	PF11976	0.551
LIG_SUMO_SIM_par_1	302	308	PF11976	0.401
LIG_SUMO_SIM_par_1	580	585	PF11976	0.474
LIG_SUMO_SIM_par_1	666	677	PF11976	0.646
LIG_TRAF2_1	778	781	PF00917	0.542
LIG_TRFH_1	85	89	PF08558	0.433
MOD_CDC14_SPxK_1	644	647	PF00782	0.685
MOD_CDK_SPK_2	18	23	PF00069	0.568
MOD_CDK_SPK_2	641	646	PF00069	0.682
MOD_CDK_SPxK_1	641	647	PF00069	0.683
MOD_CDK_SPxxK_3	641	648	PF00069	0.685
MOD_CDK_SPxxK_3	698	705	PF00069	0.688
MOD_CK1_1	442	448	PF00069	0.432
MOD_CK1_1	616	622	PF00069	0.632
MOD_CK1_1	625	631	PF00069	0.565
MOD_CK1_1	634	640	PF00069	0.642
MOD_CK1_1	743	749	PF00069	0.684
MOD_CK1_1	770	776	PF00069	0.557
MOD_CK2_1	460	466	PF00069	0.587
MOD_CK2_1	734	740	PF00069	0.736
MOD_CK2_1	770	776	PF00069	0.600
MOD_CK2_1	85	91	PF00069	0.314
MOD_Cter_Amidation	695	698	PF01082	0.674
MOD_DYRK1A_RPxSP_1	539	543	PF00069	0.661
MOD_DYRK1A_RPxSP_1	698	702	PF00069	0.676
MOD_GlcNHglycan	208	211	PF01048	0.336
MOD_GlcNHglycan	278	282	PF01048	0.331
MOD_GlcNHglycan	28	31	PF01048	0.527
MOD_GlcNHglycan	293	296	PF01048	0.408
MOD_GlcNHglycan	308	312	PF01048	0.398
MOD_GlcNHglycan	319	322	PF01048	0.405
MOD_GlcNHglycan	333	336	PF01048	0.299
MOD_GlcNHglycan	378	383	PF01048	0.557
MOD_GlcNHglycan	444	447	PF01048	0.399
MOD_GlcNHglycan	570	573	PF01048	0.757
MOD_GlcNHglycan	624	627	PF01048	0.563
MOD_GlcNHglycan	629	632	PF01048	0.558
MOD_GlcNHglycan	707	710	PF01048	0.640
MOD_GlcNHglycan	734	737	PF01048	0.630
MOD_GSK3_1	121	128	PF00069	0.331
MOD_GSK3_1	18	25	PF00069	0.520
MOD_GSK3_1	206	213	PF00069	0.336
MOD_GSK3_1	460	467	PF00069	0.587
MOD_GSK3_1	550	557	PF00069	0.654
MOD_GSK3_1	568	575	PF00069	0.595
MOD_GSK3_1	609	616	PF00069	0.793
MOD_GSK3_1	618	625	PF00069	0.595
MOD_GSK3_1	627	634	PF00069	0.521
MOD_GSK3_1	696	703	PF00069	0.665
MOD_GSK3_1	728	735	PF00069	0.745
MOD_GSK3_1	772	779	PF00069	0.698
MOD_GSK3_1	99	106	PF00069	0.433
MOD_N-GLC_1	650	655	PF02516	0.626
MOD_N-GLC_1	677	682	PF02516	0.677
MOD_NEK2_1	235	240	PF00069	0.492
MOD_NEK2_1	431	436	PF00069	0.408
MOD_NEK2_1	613	618	PF00069	0.609
MOD_NEK2_1	627	632	PF00069	0.537
MOD_NEK2_2	631	636	PF00069	0.653
MOD_PIKK_1	545	551	PF00454	0.596
MOD_PIKK_1	613	619	PF00454	0.642
MOD_PKA_2	210	216	PF00069	0.331
MOD_PKA_2	22	28	PF00069	0.477
MOD_PKA_2	460	466	PF00069	0.554
MOD_PKA_2	728	734	PF00069	0.668
MOD_PKA_2	99	105	PF00069	0.262
MOD_PKB_1	648	656	PF00069	0.671
MOD_Plk_1	582	588	PF00069	0.496
MOD_Plk_2-3	677	683	PF00069	0.682
MOD_Plk_2-3	776	782	PF00069	0.621
MOD_Plk_4	300	306	PF00069	0.396
MOD_Plk_4	582	588	PF00069	0.421
MOD_Plk_4	66	72	PF00069	0.308
MOD_ProDKin_1	18	24	PF00069	0.521
MOD_ProDKin_1	482	488	PF00069	0.433
MOD_ProDKin_1	539	545	PF00069	0.751
MOD_ProDKin_1	57	63	PF00069	0.331
MOD_ProDKin_1	641	647	PF00069	0.683
MOD_ProDKin_1	698	704	PF00069	0.637
MOD_ProDKin_1	713	719	PF00069	0.680
MOD_ProDKin_1	85	91	PF00069	0.318
MOD_SUMO_rev_2	381	390	PF00179	0.611
MOD_SUMO_rev_2	692	699	PF00179	0.706
TRG_DiLeu_BaEn_1	252	257	PF01217	0.492
TRG_DiLeu_BaEn_1	472	477	PF01217	0.524
TRG_DiLeu_BaEn_1	521	526	PF01217	0.419
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.331
TRG_ENDOCYTIC_2	160	163	PF00928	0.331
TRG_ENDOCYTIC_2	272	275	PF00928	0.492
TRG_ENDOCYTIC_2	45	48	PF00928	0.331
TRG_ER_diArg_1	267	270	PF00400	0.341
TRG_ER_diArg_1	412	415	PF00400	0.373
TRG_ER_diArg_1	538	540	PF00400	0.662
TRG_ER_diArg_1	589	592	PF00400	0.497
TRG_ER_diArg_1	645	648	PF00400	0.671
TRG_ER_diArg_1	82	84	PF00400	0.394
TRG_ER_diArg_1	92	94	PF00400	0.365
TRG_NES_CRM1_1	31	42	PF08389	0.320
TRG_NLS_MonoExtC_3	645	650	PF00514	0.659
TRG_NLS_MonoExtN_4	645	651	PF00514	0.663
TRG_Pf-PMV_PEXEL_1	169	173	PF00026	0.414
TRG_Pf-PMV_PEXEL_1	195	199	PF00026	0.331
TRG_Pf-PMV_PEXEL_1	415	420	PF00026	0.482
TRG_Pf-PMV_PEXEL_1	618	622	PF00026	0.563
TRG_Pf-PMV_PEXEL_1	721	725	PF00026	0.619
TRG_Pf-PMV_PEXEL_1	94	98	PF00026	0.433

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU7	Leptomonas seymouri	53%	99%
A0A3S5H795	Leishmania donovani	86%	100%
A4HBQ9	Leishmania braziliensis	79%	100%
A4HZ61	Leishmania infantum	92%	100%
E8NHQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
E9AV29	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q04049	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	100%