Putative DNA polymerase eta

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DNA polymerase eta, putative

Species:

Leishmania major

UniProt:

Q4QCF2_LEIMA

TriTrypDb:

LmjF.21.0630 , LMJLV39_210011800 , LMJSD75_210012000

Length:

760

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005657	replication fork	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0035861	site of double-strand break	3	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0090734	site of DNA damage	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCF2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCF2

Function

Biological processes
Term	Name	Level	Count
GO:0000731	DNA synthesis involved in DNA repair	6	2
GO:0006139	nucleobase-containing compound metabolic process	3	8
GO:0006259	DNA metabolic process	4	8
GO:0006281	DNA repair	5	8
GO:0006301	postreplication repair	6	2
GO:0006725	cellular aromatic compound metabolic process	3	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0006950	response to stress	2	8
GO:0006974	DNA damage response	4	8
GO:0008152	metabolic process	1	8
GO:0009058	biosynthetic process	2	2
GO:0009059	macromolecule biosynthetic process	4	2
GO:0009314	response to radiation	3	2
GO:0009628	response to abiotic stimulus	2	2
GO:0009987	cellular process	1	8
GO:0018130	heterocycle biosynthetic process	4	2
GO:0019438	aromatic compound biosynthetic process	4	2
GO:0019985	translesion synthesis	7	2
GO:0033554	cellular response to stress	3	8
GO:0034641	cellular nitrogen compound metabolic process	3	8
GO:0034654	nucleobase-containing compound biosynthetic process	4	2
GO:0042276	error-prone translesion synthesis	8	2
GO:0043170	macromolecule metabolic process	3	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0044249	cellular biosynthetic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	8
GO:0044271	cellular nitrogen compound biosynthetic process	4	2
GO:0046483	heterocycle metabolic process	3	8
GO:0050896	response to stimulus	1	8
GO:0051716	cellular response to stimulus	2	8
GO:0071704	organic substance metabolic process	2	8
GO:0071897	DNA biosynthetic process	5	2
GO:0090304	nucleic acid metabolic process	4	8
GO:1901360	organic cyclic compound metabolic process	3	8
GO:1901362	organic cyclic compound biosynthetic process	4	2
GO:1901576	organic substance biosynthetic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	8
GO:0003677	DNA binding	4	8
GO:0003684	damaged DNA binding	5	8
GO:0003824	catalytic activity	1	2
GO:0003887	DNA-directed DNA polymerase activity	5	2
GO:0005488	binding	1	8
GO:0016740	transferase activity	2	2
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	2
GO:0016779	nucleotidyltransferase activity	4	2
GO:0034061	DNA polymerase activity	4	2
GO:0097159	organic cyclic compound binding	2	8
GO:0140097	catalytic activity, acting on DNA	3	2
GO:0140640	catalytic activity, acting on a nucleic acid	2	2
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	342	346	PF00656	0.704
CLV_C14_Caspase3-7	563	567	PF00656	0.675
CLV_C14_Caspase3-7	593	597	PF00656	0.742
CLV_C14_Caspase3-7	693	697	PF00656	0.597
CLV_NRD_NRD_1	148	150	PF00675	0.328
CLV_NRD_NRD_1	180	182	PF00675	0.332
CLV_NRD_NRD_1	334	336	PF00675	0.341
CLV_NRD_NRD_1	355	357	PF00675	0.784
CLV_NRD_NRD_1	358	360	PF00675	0.778
CLV_NRD_NRD_1	362	364	PF00675	0.729
CLV_NRD_NRD_1	427	429	PF00675	0.274
CLV_NRD_NRD_1	64	66	PF00675	0.284
CLV_PCSK_FUR_1	356	360	PF00082	0.726
CLV_PCSK_KEX2_1	148	150	PF00082	0.328
CLV_PCSK_KEX2_1	180	182	PF00082	0.332
CLV_PCSK_KEX2_1	357	359	PF00082	0.741
CLV_PCSK_KEX2_1	364	366	PF00082	0.681
CLV_PCSK_KEX2_1	427	429	PF00082	0.274
CLV_PCSK_KEX2_1	64	66	PF00082	0.332
CLV_PCSK_PC1ET2_1	357	359	PF00082	0.737
CLV_PCSK_PC1ET2_1	364	366	PF00082	0.692
CLV_PCSK_PC7_1	353	359	PF00082	0.645
CLV_PCSK_SKI1_1	117	121	PF00082	0.289
CLV_PCSK_SKI1_1	233	237	PF00082	0.332
CLV_PCSK_SKI1_1	684	688	PF00082	0.667
CLV_PCSK_SKI1_1	695	699	PF00082	0.559
CLV_PCSK_SKI1_1	720	724	PF00082	0.569
CLV_Separin_Metazoa	201	205	PF03568	0.532
CLV_Separin_Metazoa	424	428	PF03568	0.546
DEG_APCC_DBOX_1	147	155	PF00400	0.582
DEG_SPOP_SBC_1	382	386	PF00917	0.568
DOC_CKS1_1	671	676	PF01111	0.593
DOC_CYCLIN_RxL_1	230	241	PF00134	0.532
DOC_CYCLIN_yCln2_LP_2	676	682	PF00134	0.576
DOC_MAPK_gen_1	427	433	PF00069	0.474
DOC_MAPK_gen_1	451	459	PF00069	0.582
DOC_MAPK_MEF2A_6	720	727	PF00069	0.573
DOC_MAPK_NFAT4_5	720	728	PF00069	0.573
DOC_PP2B_LxvP_1	284	287	PF13499	0.432
DOC_PP2B_LxvP_1	723	726	PF13499	0.752
DOC_PP2B_LxvP_1	728	731	PF13499	0.669
DOC_PP4_FxxP_1	199	202	PF00568	0.532
DOC_PP4_FxxP_1	295	298	PF00568	0.478
DOC_USP7_MATH_1	159	163	PF00917	0.517
DOC_USP7_MATH_1	287	291	PF00917	0.442
DOC_USP7_MATH_1	311	315	PF00917	0.550
DOC_USP7_MATH_1	369	373	PF00917	0.660
DOC_USP7_MATH_1	505	509	PF00917	0.582
DOC_USP7_MATH_1	523	527	PF00917	0.674
DOC_WW_Pin1_4	123	128	PF00397	0.474
DOC_WW_Pin1_4	38	43	PF00397	0.532
DOC_WW_Pin1_4	530	535	PF00397	0.630
DOC_WW_Pin1_4	630	635	PF00397	0.719
DOC_WW_Pin1_4	657	662	PF00397	0.696
DOC_WW_Pin1_4	666	671	PF00397	0.689
DOC_WW_Pin1_4	675	680	PF00397	0.637
DOC_WW_Pin1_4	731	736	PF00397	0.732
DOC_WW_Pin1_4	81	86	PF00397	0.568
LIG_14-3-3_CanoR_1	191	196	PF00244	0.532
LIG_14-3-3_CanoR_1	289	298	PF00244	0.469
LIG_14-3-3_CanoR_1	418	424	PF00244	0.582
LIG_14-3-3_CanoR_1	451	456	PF00244	0.578
LIG_14-3-3_CanoR_1	537	544	PF00244	0.761
LIG_14-3-3_CanoR_1	551	556	PF00244	0.648
LIG_APCC_ABBAyCdc20_2	248	254	PF00400	0.479
LIG_BIR_II_1	1	5	PF00653	0.647
LIG_BIR_III_4	348	352	PF00653	0.639
LIG_BRCT_BRCA1_1	217	221	PF00533	0.532
LIG_BRCT_BRCA1_1	291	295	PF00533	0.452
LIG_BRCT_BRCA1_1	412	416	PF00533	0.474
LIG_eIF4E_1	230	236	PF01652	0.532
LIG_FHA_1	124	130	PF00498	0.474
LIG_FHA_1	172	178	PF00498	0.475
LIG_FHA_1	281	287	PF00498	0.429
LIG_FHA_1	338	344	PF00498	0.601
LIG_FHA_1	382	388	PF00498	0.332
LIG_FHA_1	39	45	PF00498	0.487
LIG_FHA_1	418	424	PF00498	0.582
LIG_FHA_1	432	438	PF00498	0.510
LIG_FHA_1	465	471	PF00498	0.515
LIG_FHA_1	472	478	PF00498	0.482
LIG_FHA_1	508	514	PF00498	0.532
LIG_FHA_1	522	528	PF00498	0.748
LIG_FHA_1	624	630	PF00498	0.724
LIG_FHA_1	631	637	PF00498	0.706
LIG_FHA_1	643	649	PF00498	0.695
LIG_FHA_1	671	677	PF00498	0.569
LIG_FHA_1	738	744	PF00498	0.667
LIG_FHA_2	419	425	PF00498	0.582
LIG_LIR_Apic_2	292	298	PF02991	0.421
LIG_LIR_Apic_2	325	330	PF02991	0.419
LIG_LIR_Gen_1	137	147	PF02991	0.474
LIG_LIR_Gen_1	23	34	PF02991	0.474
LIG_LIR_Gen_1	439	448	PF02991	0.492
LIG_LIR_Nem_3	137	143	PF02991	0.505
LIG_LIR_Nem_3	23	29	PF02991	0.474
LIG_LIR_Nem_3	385	391	PF02991	0.383
LIG_LIR_Nem_3	413	419	PF02991	0.572
LIG_LIR_Nem_3	439	444	PF02991	0.483
LIG_LIR_Nem_3	46	51	PF02991	0.457
LIG_PCNA_PIPBox_1	553	562	PF02747	0.605
LIG_PCNA_yPIPBox_3	547	560	PF02747	0.651
LIG_PTB_Apo_2	458	465	PF02174	0.578
LIG_SH2_NCK_1	26	30	PF00017	0.474
LIG_SH2_PTP2	140	143	PF00017	0.532
LIG_SH2_SRC	140	143	PF00017	0.532
LIG_SH2_STAP1	257	261	PF00017	0.474
LIG_SH2_STAT5	140	143	PF00017	0.532
LIG_SH2_STAT5	388	391	PF00017	0.448
LIG_SH3_2	634	639	PF14604	0.549
LIG_SH3_3	166	172	PF00018	0.474
LIG_SH3_3	472	478	PF00018	0.582
LIG_SH3_3	51	57	PF00018	0.471
LIG_SH3_3	631	637	PF00018	0.555
LIG_SH3_3	668	674	PF00018	0.714
LIG_SH3_3	712	718	PF00018	0.748
LIG_SH3_3	729	735	PF00018	0.466
LIG_SH3_4	278	285	PF00018	0.401
LIG_SUMO_SIM_anti_2	625	631	PF11976	0.781
LIG_SUMO_SIM_anti_2	740	746	PF11976	0.717
LIG_SUMO_SIM_anti_2	753	760	PF11976	0.606
LIG_SUMO_SIM_par_1	282	288	PF11976	0.481
LIG_SUMO_SIM_par_1	41	46	PF11976	0.474
LIG_SUMO_SIM_par_1	429	436	PF11976	0.510
LIG_SUMO_SIM_par_1	471	479	PF11976	0.501
LIG_SUMO_SIM_par_1	608	614	PF11976	0.765
LIG_SUMO_SIM_par_1	625	631	PF11976	0.587
LIG_SUMO_SIM_par_1	739	746	PF11976	0.667
LIG_SUMO_SIM_par_1	79	84	PF11976	0.542
LIG_TRAF2_1	686	689	PF00917	0.765
LIG_WRC_WIRS_1	556	561	PF05994	0.681
LIG_WW_2	634	637	PF00397	0.545
LIG_WW_3	717	721	PF00397	0.666
MOD_CDK_SPxxK_3	530	537	PF00069	0.558
MOD_CDK_SPxxK_3	81	88	PF00069	0.431
MOD_CK1_1	471	477	PF00069	0.427
MOD_CK1_1	518	524	PF00069	0.697
MOD_CK1_1	587	593	PF00069	0.696
MOD_CK1_1	597	603	PF00069	0.783
MOD_CK1_1	611	617	PF00069	0.540
MOD_CK1_1	618	624	PF00069	0.654
MOD_CK1_1	67	73	PF00069	0.431
MOD_CK2_1	132	138	PF00069	0.318
MOD_CK2_1	418	424	PF00069	0.412
MOD_CK2_1	436	442	PF00069	0.381
MOD_CK2_1	657	663	PF00069	0.717
MOD_CK2_1	687	693	PF00069	0.669
MOD_Cter_Amidation	354	357	PF01082	0.675
MOD_GlcNHglycan	188	191	PF01048	0.331
MOD_GlcNHglycan	258	262	PF01048	0.331
MOD_GlcNHglycan	273	276	PF01048	0.411
MOD_GlcNHglycan	288	292	PF01048	0.423
MOD_GlcNHglycan	299	302	PF01048	0.380
MOD_GlcNHglycan	313	316	PF01048	0.448
MOD_GlcNHglycan	369	372	PF01048	0.478
MOD_GlcNHglycan	538	541	PF01048	0.640
MOD_GlcNHglycan	562	565	PF01048	0.665
MOD_GlcNHglycan	576	579	PF01048	0.683
MOD_GlcNHglycan	588	592	PF01048	0.665
MOD_GlcNHglycan	620	623	PF01048	0.697
MOD_GlcNHglycan	720	723	PF01048	0.741
MOD_GSK3_1	101	108	PF00069	0.412
MOD_GSK3_1	186	193	PF00069	0.404
MOD_GSK3_1	406	413	PF00069	0.350
MOD_GSK3_1	43	50	PF00069	0.331
MOD_GSK3_1	432	439	PF00069	0.340
MOD_GSK3_1	464	471	PF00069	0.416
MOD_GSK3_1	505	512	PF00069	0.465
MOD_GSK3_1	551	558	PF00069	0.709
MOD_GSK3_1	583	590	PF00069	0.703
MOD_GSK3_1	611	618	PF00069	0.774
MOD_GSK3_1	666	673	PF00069	0.767
MOD_GSK3_1	687	694	PF00069	0.668
MOD_GSK3_1	726	733	PF00069	0.654
MOD_LATS_1	549	555	PF00433	0.755
MOD_N-GLC_1	535	540	PF02516	0.562
MOD_N-GLC_1	597	602	PF02516	0.791
MOD_N-GLC_1	67	72	PF02516	0.331
MOD_NEK2_1	215	220	PF00069	0.409
MOD_NEK2_1	406	411	PF00069	0.482
MOD_NEK2_1	43	48	PF00069	0.331
MOD_NEK2_1	464	469	PF00069	0.423
MOD_NEK2_1	555	560	PF00069	0.685
MOD_NEK2_1	610	615	PF00069	0.787
MOD_OGLYCOS	657	662	PF02709	0.613
MOD_PIKK_1	43	49	PF00454	0.318
MOD_PIKK_1	687	693	PF00454	0.596
MOD_PIKK_1	91	97	PF00454	0.331
MOD_PKA_1	64	70	PF00069	0.431
MOD_PKA_2	190	196	PF00069	0.412
MOD_PKA_2	417	423	PF00069	0.482
MOD_PKA_2	464	470	PF00069	0.381
MOD_PKA_2	536	542	PF00069	0.668
MOD_PKA_2	64	70	PF00069	0.431
MOD_PKB_1	365	373	PF00069	0.585
MOD_Plk_1	397	403	PF00069	0.512
MOD_Plk_1	442	448	PF00069	0.482
MOD_Plk_1	622	628	PF00069	0.718
MOD_Plk_2-3	132	138	PF00069	0.318
MOD_Plk_2-3	754	760	PF00069	0.777
MOD_Plk_4	280	286	PF00069	0.395
MOD_Plk_4	383	389	PF00069	0.359
MOD_Plk_4	397	403	PF00069	0.486
MOD_Plk_4	406	412	PF00069	0.333
MOD_Plk_4	47	53	PF00069	0.412
MOD_Plk_4	551	557	PF00069	0.686
MOD_Plk_4	623	629	PF00069	0.798
MOD_Plk_4	754	760	PF00069	0.777
MOD_ProDKin_1	123	129	PF00069	0.331
MOD_ProDKin_1	38	44	PF00069	0.412
MOD_ProDKin_1	530	536	PF00069	0.631
MOD_ProDKin_1	630	636	PF00069	0.718
MOD_ProDKin_1	657	663	PF00069	0.701
MOD_ProDKin_1	666	672	PF00069	0.692
MOD_ProDKin_1	675	681	PF00069	0.636
MOD_ProDKin_1	731	737	PF00069	0.734
MOD_ProDKin_1	81	87	PF00069	0.463
TRG_AP2beta_CARGO_1	442	451	PF09066	0.381
TRG_DiLeu_BaEn_1	232	237	PF01217	0.365
TRG_DiLeu_BaEn_4	442	448	PF01217	0.381
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.412
TRG_ENDOCYTIC_2	140	143	PF00928	0.412
TRG_ENDOCYTIC_2	252	255	PF00928	0.412
TRG_ENDOCYTIC_2	26	29	PF00928	0.331
TRG_ENDOCYTIC_2	441	444	PF00928	0.347
TRG_ER_diArg_1	247	250	PF00400	0.368
TRG_ER_diArg_1	356	359	PF00400	0.718
TRG_ER_diArg_1	391	394	PF00400	0.337
TRG_ER_diArg_1	426	428	PF00400	0.331
TRG_ER_diArg_1	450	453	PF00400	0.482
TRG_ER_diArg_1	63	65	PF00400	0.356
TRG_NES_CRM1_1	12	23	PF08389	0.403
TRG_NES_CRM1_1	479	493	PF08389	0.482
TRG_NLS_MonoCore_2	355	360	PF00514	0.713
TRG_NLS_MonoExtC_3	355	360	PF00514	0.780
TRG_NLS_MonoExtC_3	362	367	PF00514	0.660
TRG_NLS_MonoExtN_4	353	360	PF00514	0.739
TRG_NLS_MonoExtN_4	363	368	PF00514	0.673
TRG_Pf-PMV_PEXEL_1	149	153	PF00026	0.406
TRG_Pf-PMV_PEXEL_1	175	179	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	394	398	PF00026	0.438

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PEU7	Leptomonas seymouri	54%	96%
A0A1X0NXK7	Trypanosomatidae	43%	100%
A4HBR0	Leishmania braziliensis	79%	100%
A4HZ62	Leishmania infantum	93%	100%
D0A1I0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E8NHQ4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
Q04049	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	25%	100%