Phosphoglucomutase (alpha-D-glucose-1,6-bisphosphate-dependent)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphoglucomutase, putative

Species:

Leishmania major

UniProt:

Q4QCF1_LEIMA

TriTrypDb:

LmjF.21.0640 , LMJLV39_210012000 , LMJSD75_210012100

Length:

589

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 20

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 7

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCF1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCF1

PDB structure(s): 4qg5_A , 4qg5_B , 4qg5_C , 4qg5_D

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	11
GO:0003824	catalytic activity	1	11
GO:0004614	phosphoglucomutase activity	5	11
GO:0005488	binding	1	11
GO:0016853	isomerase activity	2	11
GO:0016866	intramolecular transferase activity	3	11
GO:0016868	intramolecular transferase activity, phosphotransferases	4	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	185	189	PF00656	0.424
CLV_NRD_NRD_1	101	103	PF00675	0.331
CLV_NRD_NRD_1	106	108	PF00675	0.331
CLV_NRD_NRD_1	18	20	PF00675	0.313
CLV_NRD_NRD_1	581	583	PF00675	0.565
CLV_PCSK_FUR_1	99	103	PF00082	0.309
CLV_PCSK_KEX2_1	425	427	PF00082	0.440
CLV_PCSK_KEX2_1	99	101	PF00082	0.339
CLV_PCSK_PC1ET2_1	425	427	PF00082	0.440
CLV_PCSK_SKI1_1	107	111	PF00082	0.309
CLV_PCSK_SKI1_1	20	24	PF00082	0.349
CLV_PCSK_SKI1_1	511	515	PF00082	0.332
CLV_PCSK_SKI1_1	519	523	PF00082	0.332
DEG_Nend_UBRbox_2	1	3	PF02207	0.579
DEG_SCF_FBW7_1	88	95	PF00400	0.315
DOC_ANK_TNKS_1	100	107	PF00023	0.440
DOC_CDC14_PxL_1	158	166	PF14671	0.323
DOC_CKS1_1	429	434	PF01111	0.477
DOC_CKS1_1	89	94	PF01111	0.313
DOC_MAPK_DCC_7	159	169	PF00069	0.516
DOC_MAPK_DCC_7	44	53	PF00069	0.395
DOC_MAPK_MEF2A_6	44	53	PF00069	0.391
DOC_MAPK_MEF2A_6	507	514	PF00069	0.337
DOC_MAPK_MEF2A_6	564	573	PF00069	0.490
DOC_MAPK_RevD_3	569	583	PF00069	0.519
DOC_PP1_RVXF_1	210	216	PF00149	0.406
DOC_PP1_RVXF_1	509	515	PF00149	0.332
DOC_PP2B_LxvP_1	238	241	PF13499	0.332
DOC_PP4_FxxP_1	25	28	PF00568	0.391
DOC_PP4_FxxP_1	313	316	PF00568	0.334
DOC_PP4_FxxP_1	366	369	PF00568	0.332
DOC_SPAK_OSR1_1	311	315	PF12202	0.364
DOC_USP7_MATH_1	13	17	PF00917	0.332
DOC_USP7_MATH_1	241	245	PF00917	0.391
DOC_USP7_MATH_1	316	320	PF00917	0.326
DOC_USP7_MATH_1	557	561	PF00917	0.524
DOC_USP7_MATH_1	92	96	PF00917	0.317
DOC_WD40_RPTOR_TOS_1	182	188	PF00400	0.471
DOC_WW_Pin1_4	428	433	PF00397	0.462
DOC_WW_Pin1_4	581	586	PF00397	0.566
DOC_WW_Pin1_4	88	93	PF00397	0.313
LIG_14-3-3_CanoR_1	19	25	PF00244	0.391
LIG_14-3-3_CanoR_1	59	69	PF00244	0.357
LIG_APCC_ABBA_1	215	220	PF00400	0.437
LIG_APCC_ABBA_1	534	539	PF00400	0.332
LIG_BIR_III_4	103	107	PF00653	0.440
LIG_deltaCOP1_diTrp_1	411	419	PF00928	0.313
LIG_FHA_1	13	19	PF00498	0.313
LIG_FHA_1	143	149	PF00498	0.319
LIG_FHA_1	150	156	PF00498	0.304
LIG_FHA_1	246	252	PF00498	0.403
LIG_FHA_1	429	435	PF00498	0.475
LIG_FHA_1	495	501	PF00498	0.437
LIG_FHA_1	531	537	PF00498	0.333
LIG_FHA_1	582	588	PF00498	0.610
LIG_FHA_1	89	95	PF00498	0.313
LIG_FHA_2	161	167	PF00498	0.530
LIG_FHA_2	174	180	PF00498	0.453
LIG_FHA_2	473	479	PF00498	0.410
LIG_LIR_Apic_2	23	28	PF02991	0.391
LIG_LIR_Apic_2	495	499	PF02991	0.340
LIG_LIR_Gen_1	202	210	PF02991	0.313
LIG_LIR_Gen_1	362	369	PF02991	0.240
LIG_LIR_Gen_1	37	47	PF02991	0.359
LIG_LIR_Gen_1	411	422	PF02991	0.313
LIG_LIR_Gen_1	456	465	PF02991	0.407
LIG_LIR_LC3C_4	50	54	PF02991	0.391
LIG_LIR_Nem_3	174	180	PF02991	0.460
LIG_LIR_Nem_3	192	196	PF02991	0.214
LIG_LIR_Nem_3	202	206	PF02991	0.289
LIG_LIR_Nem_3	362	366	PF02991	0.328
LIG_LIR_Nem_3	37	42	PF02991	0.314
LIG_LIR_Nem_3	370	375	PF02991	0.302
LIG_LIR_Nem_3	389	393	PF02991	0.313
LIG_LIR_Nem_3	411	417	PF02991	0.327
LIG_LIR_Nem_3	441	447	PF02991	0.323
LIG_LIR_Nem_3	456	460	PF02991	0.374
LIG_PCNA_PIPBox_1	437	446	PF02747	0.391
LIG_Pex14_1	414	418	PF04695	0.332
LIG_Pex14_2	294	298	PF04695	0.332
LIG_PTB_Apo_2	490	497	PF02174	0.347
LIG_PTB_Phospho_1	490	496	PF10480	0.347
LIG_Rb_LxCxE_1	389	409	PF01857	0.314
LIG_SH2_NCK_1	457	461	PF00017	0.432
LIG_SH2_SRC	457	460	PF00017	0.400
LIG_SH2_STAP1	149	153	PF00017	0.332
LIG_SH2_STAP1	193	197	PF00017	0.358
LIG_SH2_STAP1	265	269	PF00017	0.313
LIG_SH2_STAP1	30	34	PF00017	0.440
LIG_SH2_STAP1	61	65	PF00017	0.440
LIG_SH2_STAT3	180	183	PF00017	0.498
LIG_SH2_STAT3	537	540	PF00017	0.357
LIG_SH2_STAT3	8	11	PF00017	0.474
LIG_SH2_STAT5	175	178	PF00017	0.536
LIG_SH2_STAT5	229	232	PF00017	0.391
LIG_SH2_STAT5	30	33	PF00017	0.313
LIG_SH2_STAT5	496	499	PF00017	0.437
LIG_SH2_STAT5	537	540	PF00017	0.369
LIG_SH2_STAT5	61	64	PF00017	0.336
LIG_SH3_1	159	165	PF00018	0.324
LIG_SH3_1	426	432	PF00018	0.440
LIG_SH3_3	118	124	PF00018	0.313
LIG_SH3_3	159	165	PF00018	0.324
LIG_SH3_3	222	228	PF00018	0.373
LIG_SH3_3	426	432	PF00018	0.394
LIG_SUMO_SIM_anti_2	317	324	PF11976	0.332
LIG_SUMO_SIM_anti_2	50	55	PF11976	0.419
LIG_UBA3_1	417	425	PF00899	0.440
LIG_WRC_WIRS_1	291	296	PF05994	0.440
MOD_CK1_1	336	342	PF00069	0.370
MOD_CK1_1	347	353	PF00069	0.268
MOD_CK1_1	399	405	PF00069	0.332
MOD_CK1_1	503	509	PF00069	0.440
MOD_CK1_1	530	536	PF00069	0.336
MOD_CK2_1	160	166	PF00069	0.534
MOD_CK2_1	571	577	PF00069	0.475
MOD_Cter_Amidation	105	108	PF01082	0.340
MOD_Cter_Amidation	580	583	PF01082	0.551
MOD_GlcNHglycan	15	18	PF01048	0.313
MOD_GlcNHglycan	225	228	PF01048	0.362
MOD_GlcNHglycan	338	341	PF01048	0.391
MOD_GlcNHglycan	350	353	PF01048	0.230
MOD_GlcNHglycan	458	463	PF01048	0.452
MOD_GlcNHglycan	524	527	PF01048	0.357
MOD_GlcNHglycan	529	532	PF01048	0.332
MOD_GlcNHglycan	543	546	PF01048	0.332
MOD_GlcNHglycan	72	75	PF01048	0.445
MOD_GSK3_1	149	156	PF00069	0.379
MOD_GSK3_1	241	248	PF00069	0.437
MOD_GSK3_1	286	293	PF00069	0.406
MOD_GSK3_1	331	338	PF00069	0.410
MOD_GSK3_1	344	351	PF00069	0.301
MOD_GSK3_1	468	475	PF00069	0.568
MOD_GSK3_1	522	529	PF00069	0.332
MOD_GSK3_1	571	578	PF00069	0.460
MOD_GSK3_1	88	95	PF00069	0.313
MOD_N-GLC_1	261	266	PF02516	0.313
MOD_N-GLC_1	28	33	PF02516	0.448
MOD_N-GLC_1	492	497	PF02516	0.430
MOD_NEK2_1	1	6	PF00069	0.425
MOD_NEK2_1	113	118	PF00069	0.313
MOD_NEK2_1	245	250	PF00069	0.471
MOD_NEK2_1	333	338	PF00069	0.373
MOD_NEK2_1	34	39	PF00069	0.334
MOD_NEK2_1	418	423	PF00069	0.332
MOD_NEK2_1	522	527	PF00069	0.335
MOD_NEK2_1	571	576	PF00069	0.421
MOD_NEK2_1	70	75	PF00069	0.445
MOD_NEK2_2	149	154	PF00069	0.334
MOD_NEK2_2	241	246	PF00069	0.437
MOD_PIKK_1	143	149	PF00454	0.468
MOD_PIKK_1	331	337	PF00454	0.421
MOD_PKA_1	107	113	PF00069	0.340
MOD_PKA_1	20	26	PF00069	0.391
MOD_PKA_2	522	528	PF00069	0.340
MOD_Plk_1	149	155	PF00069	0.332
MOD_Plk_1	261	267	PF00069	0.313
MOD_Plk_1	396	402	PF00069	0.313
MOD_Plk_1	472	478	PF00069	0.373
MOD_Plk_1	492	498	PF00069	0.327
MOD_Plk_1	552	558	PF00069	0.608
MOD_Plk_2-3	492	498	PF00069	0.437
MOD_Plk_4	20	26	PF00069	0.391
MOD_Plk_4	241	247	PF00069	0.387
MOD_Plk_4	413	419	PF00069	0.332
MOD_Plk_4	472	478	PF00069	0.340
MOD_Plk_4	583	589	PF00069	0.451
MOD_Plk_4	93	99	PF00069	0.440
MOD_ProDKin_1	428	434	PF00069	0.462
MOD_ProDKin_1	581	587	PF00069	0.560
MOD_ProDKin_1	88	94	PF00069	0.313
TRG_DiLeu_BaLyEn_6	389	394	PF01217	0.332
TRG_ENDOCYTIC_2	457	460	PF00928	0.381
TRG_ER_diArg_1	98	101	PF00400	0.335
TRG_Pf-PMV_PEXEL_1	207	211	PF00026	0.287
TRG_Pf-PMV_PEXEL_1	511	515	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD7	Leptomonas seymouri	78%	99%
A0A0S4IYR2	Bodo saltans	60%	100%
A0A1X0NXZ7	Trypanosomatidae	63%	100%
A0A3Q8IBZ3	Leishmania donovani	96%	100%
A0A3S5IR70	Trypanosoma rangeli	62%	100%
A4HBR1	Leishmania braziliensis	90%	100%
A4HZ63	Leishmania infantum	96%	100%
D3ZVR9	Rattus norvegicus	44%	100%
E9AV30	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
O02606	Paramecium tetraurelia	48%	100%
O15820	Entamoeba histolytica	45%	100%
O18719	Entamoeba dispar	45%	100%
O49299	Arabidopsis thaliana	54%	100%
O74374	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	47%	100%
P00949	Oryctolagus cuniculus	50%	100%
P33401	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	44%	100%
P36871	Homo sapiens	50%	100%
P36938	Escherichia coli (strain K12)	28%	100%
P37012	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	45%	100%
P38569	Komagataeibacter xylinus	26%	100%
P38652	Rattus norvegicus	49%	100%
P39671	Rhizobium radiobacter	49%	100%
P47244	Paramecium tetraurelia	48%	100%
P57749	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	48%	100%
P93262	Mesembryanthemum crystallinum	55%	100%
P93804	Zea mays	55%	100%
P93805	Zea mays	55%	100%
Q08DP0	Bos taurus	50%	100%
Q15124	Homo sapiens	43%	100%
Q23919	Dictyostelium discoideum	48%	100%
Q4R5E4	Macaca fascicularis	50%	100%
Q4WY53	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	47%	100%
Q8BZF8	Mus musculus	44%	100%
Q9D0F9	Mus musculus	49%	100%
Q9M4G4	Solanum tuberosum	55%	100%
Q9M4G5	Solanum tuberosum	50%	93%
Q9P931	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	49%	100%
Q9SCY0	Arabidopsis thaliana	50%	95%
Q9SGC1	Arabidopsis thaliana	56%	100%
Q9SM59	Pisum sativum	50%	94%
Q9SM60	Pisum sativum	54%	100%
Q9SMM0	Brassica napus	50%	94%
Q9SNX2	Bromus inermis	55%	100%
Q9VUY9	Drosophila melanogaster	49%	100%
Q9ZSQ4	Populus tremula	56%	100%
V5BMZ6	Trypanosoma cruzi	63%	98%