Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCF0_LEIMA

TriTrypDb:

LmjF.21.0650 , LMJLV39_210012100 , LMJSD75_210012200

Length:

639

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCF0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCF0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	343	347	PF00656	0.581
CLV_NRD_NRD_1	230	232	PF00675	0.577
CLV_NRD_NRD_1	237	239	PF00675	0.453
CLV_NRD_NRD_1	310	312	PF00675	0.485
CLV_NRD_NRD_1	589	591	PF00675	0.415
CLV_NRD_NRD_1	604	606	PF00675	0.580
CLV_NRD_NRD_1	630	632	PF00675	0.396
CLV_PCSK_FUR_1	235	239	PF00082	0.537
CLV_PCSK_KEX2_1	230	232	PF00082	0.593
CLV_PCSK_KEX2_1	237	239	PF00082	0.422
CLV_PCSK_KEX2_1	247	249	PF00082	0.496
CLV_PCSK_KEX2_1	310	312	PF00082	0.485
CLV_PCSK_KEX2_1	589	591	PF00082	0.415
CLV_PCSK_KEX2_1	604	606	PF00082	0.392
CLV_PCSK_KEX2_1	629	631	PF00082	0.409
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.531
CLV_PCSK_PC7_1	585	591	PF00082	0.379
CLV_PCSK_SKI1_1	194	198	PF00082	0.503
CLV_PCSK_SKI1_1	282	286	PF00082	0.458
CLV_PCSK_SKI1_1	301	305	PF00082	0.595
CLV_PCSK_SKI1_1	310	314	PF00082	0.577
CLV_PCSK_SKI1_1	351	355	PF00082	0.431
CLV_PCSK_SKI1_1	364	368	PF00082	0.449
CLV_PCSK_SKI1_1	488	492	PF00082	0.401
CLV_PCSK_SKI1_1	498	502	PF00082	0.525
CLV_PCSK_SKI1_1	536	540	PF00082	0.344
CLV_PCSK_SKI1_1	614	618	PF00082	0.450
CLV_PCSK_SKI1_1	630	634	PF00082	0.400
DEG_APCC_DBOX_1	193	201	PF00400	0.505
DEG_APCC_DBOX_1	236	244	PF00400	0.531
DEG_APCC_DBOX_1	363	371	PF00400	0.420
DEG_APCC_DBOX_1	497	505	PF00400	0.532
DEG_APCC_DBOX_1	535	543	PF00400	0.284
DOC_CKS1_1	128	133	PF01111	0.636
DOC_CKS1_1	326	331	PF01111	0.468
DOC_MAPK_gen_1	16	24	PF00069	0.374
DOC_MAPK_gen_1	310	318	PF00069	0.453
DOC_MAPK_MEF2A_6	310	318	PF00069	0.494
DOC_MAPK_MEF2A_6	536	543	PF00069	0.285
DOC_MAPK_MEF2A_6	79	87	PF00069	0.525
DOC_MAPK_NFAT4_5	536	544	PF00069	0.288
DOC_PP1_RVXF_1	236	243	PF00149	0.454
DOC_PP2B_LxvP_1	541	544	PF13499	0.483
DOC_PP4_FxxP_1	481	484	PF00568	0.441
DOC_USP7_MATH_1	110	114	PF00917	0.748
DOC_USP7_MATH_1	129	133	PF00917	0.361
DOC_USP7_MATH_1	196	200	PF00917	0.725
DOC_USP7_MATH_1	3	7	PF00917	0.494
DOC_USP7_MATH_1	31	35	PF00917	0.480
DOC_USP7_MATH_1	382	386	PF00917	0.733
DOC_USP7_MATH_1	398	402	PF00917	0.596
DOC_USP7_MATH_1	420	424	PF00917	0.490
DOC_USP7_MATH_1	490	494	PF00917	0.433
DOC_USP7_MATH_1	503	507	PF00917	0.613
DOC_WW_Pin1_4	127	132	PF00397	0.682
DOC_WW_Pin1_4	158	163	PF00397	0.470
DOC_WW_Pin1_4	224	229	PF00397	0.459
DOC_WW_Pin1_4	310	315	PF00397	0.571
DOC_WW_Pin1_4	325	330	PF00397	0.395
DOC_WW_Pin1_4	522	527	PF00397	0.609
DOC_WW_Pin1_4	551	556	PF00397	0.637
LIG_14-3-3_CanoR_1	301	307	PF00244	0.568
LIG_14-3-3_CanoR_1	351	357	PF00244	0.517
LIG_14-3-3_CanoR_1	433	440	PF00244	0.520
LIG_14-3-3_CanoR_1	492	502	PF00244	0.474
LIG_BIR_II_1	1	5	PF00653	0.366
LIG_BRCT_BRCA1_1	529	533	PF00533	0.507
LIG_deltaCOP1_diTrp_1	464	471	PF00928	0.437
LIG_deltaCOP1_diTrp_1	576	584	PF00928	0.387
LIG_eIF4E_1	489	495	PF01652	0.488
LIG_EVH1_1	501	505	PF00568	0.528
LIG_FHA_1	311	317	PF00498	0.518
LIG_FHA_1	352	358	PF00498	0.529
LIG_FHA_1	387	393	PF00498	0.747
LIG_FHA_1	434	440	PF00498	0.591
LIG_FHA_1	489	495	PF00498	0.533
LIG_FHA_2	253	259	PF00498	0.496
LIG_FHA_2	535	541	PF00498	0.378
LIG_Integrin_isoDGR_2	468	470	PF01839	0.341
LIG_LIR_Gen_1	401	410	PF02991	0.413
LIG_LIR_Gen_1	423	430	PF02991	0.520
LIG_LIR_Nem_3	401	405	PF02991	0.406
LIG_LIR_Nem_3	423	429	PF02991	0.460
LIG_LIR_Nem_3	485	489	PF02991	0.446
LIG_MAD2	417	425	PF02301	0.349
LIG_MYND_1	499	503	PF01753	0.563
LIG_SH2_CRK	479	483	PF00017	0.507
LIG_SH2_NCK_1	550	554	PF00017	0.570
LIG_SH2_STAP1	534	538	PF00017	0.442
LIG_SH2_STAT5	414	417	PF00017	0.465
LIG_SH3_2	523	528	PF14604	0.608
LIG_SH3_3	128	134	PF00018	0.681
LIG_SH3_3	27	33	PF00018	0.377
LIG_SH3_3	290	296	PF00018	0.522
LIG_SH3_3	419	425	PF00018	0.499
LIG_SH3_3	496	502	PF00018	0.577
LIG_SH3_3	504	510	PF00018	0.661
LIG_SH3_3	520	526	PF00018	0.503
LIG_SH3_3	552	558	PF00018	0.631
LIG_Sin3_3	567	574	PF02671	0.462
LIG_SUMO_SIM_anti_2	315	320	PF11976	0.528
LIG_SUMO_SIM_anti_2	537	543	PF11976	0.342
LIG_SUMO_SIM_par_1	302	307	PF11976	0.377
LIG_SUMO_SIM_par_1	83	91	PF11976	0.510
LIG_TRAF2_1	23	26	PF00917	0.552
LIG_TRAF2_1	255	258	PF00917	0.595
LIG_TRAF2_1	609	612	PF00917	0.467
LIG_WRC_WIRS_1	4	9	PF05994	0.342
LIG_WW_3	554	558	PF00397	0.617
MOD_CDC14_SPxK_1	227	230	PF00782	0.521
MOD_CDC14_SPxK_1	525	528	PF00782	0.612
MOD_CDC14_SPxK_1	554	557	PF00782	0.616
MOD_CDK_SPxK_1	224	230	PF00069	0.503
MOD_CDK_SPxK_1	522	528	PF00069	0.609
MOD_CDK_SPxK_1	551	557	PF00069	0.634
MOD_CDK_SPxxK_3	224	231	PF00069	0.507
MOD_CK1_1	111	117	PF00069	0.718
MOD_CK1_1	2	8	PF00069	0.407
MOD_CK1_1	273	279	PF00069	0.479
MOD_CK1_1	289	295	PF00069	0.516
MOD_CK1_1	359	365	PF00069	0.391
MOD_CK1_1	432	438	PF00069	0.523
MOD_CK1_1	493	499	PF00069	0.475
MOD_CK1_1	527	533	PF00069	0.530
MOD_CK2_1	213	219	PF00069	0.627
MOD_CK2_1	252	258	PF00069	0.584
MOD_CK2_1	534	540	PF00069	0.388
MOD_CK2_1	87	93	PF00069	0.430
MOD_CMANNOS	146	149	PF00535	0.435
MOD_GlcNHglycan	1	4	PF01048	0.466
MOD_GlcNHglycan	110	113	PF01048	0.723
MOD_GlcNHglycan	141	144	PF01048	0.438
MOD_GlcNHglycan	202	205	PF01048	0.656
MOD_GlcNHglycan	210	213	PF01048	0.592
MOD_GlcNHglycan	232	235	PF01048	0.604
MOD_GlcNHglycan	272	275	PF01048	0.524
MOD_GlcNHglycan	288	291	PF01048	0.571
MOD_GlcNHglycan	378	381	PF01048	0.574
MOD_GlcNHglycan	384	387	PF01048	0.576
MOD_GlcNHglycan	529	532	PF01048	0.638
MOD_GlcNHglycan	551	554	PF01048	0.624
MOD_GSK3_1	100	107	PF00069	0.581
MOD_GSK3_1	196	203	PF00069	0.681
MOD_GSK3_1	208	215	PF00069	0.550
MOD_GSK3_1	282	289	PF00069	0.595
MOD_GSK3_1	302	309	PF00069	0.594
MOD_GSK3_1	328	335	PF00069	0.581
MOD_GSK3_1	352	359	PF00069	0.486
MOD_GSK3_1	382	389	PF00069	0.690
MOD_GSK3_1	428	435	PF00069	0.589
MOD_GSK3_1	505	512	PF00069	0.637
MOD_N-GLC_1	386	391	PF02516	0.621
MOD_NEK2_1	102	107	PF00069	0.515
MOD_NEK2_1	141	146	PF00069	0.443
MOD_NEK2_1	304	309	PF00069	0.497
MOD_NEK2_1	429	434	PF00069	0.633
MOD_NEK2_1	598	603	PF00069	0.427
MOD_NEK2_1	95	100	PF00069	0.413
MOD_PIKK_1	100	106	PF00454	0.511
MOD_PIKK_1	141	147	PF00454	0.436
MOD_PIKK_1	304	310	PF00454	0.389
MOD_PIKK_1	368	374	PF00454	0.509
MOD_PKA_1	230	236	PF00069	0.608
MOD_PKA_1	589	595	PF00069	0.395
MOD_PKA_2	230	236	PF00069	0.608
MOD_PKA_2	359	365	PF00069	0.415
MOD_PKA_2	368	374	PF00069	0.445
MOD_PKA_2	432	438	PF00069	0.496
MOD_PKA_2	58	64	PF00069	0.400
MOD_PKA_2	589	595	PF00069	0.417
MOD_Plk_1	238	244	PF00069	0.564
MOD_Plk_1	332	338	PF00069	0.574
MOD_Plk_1	88	94	PF00069	0.553
MOD_Plk_4	196	202	PF00069	0.666
MOD_Plk_4	238	244	PF00069	0.495
MOD_Plk_4	3	9	PF00069	0.347
MOD_Plk_4	352	358	PF00069	0.555
MOD_Plk_4	410	416	PF00069	0.463
MOD_Plk_4	435	441	PF00069	0.530
MOD_Plk_4	598	604	PF00069	0.492
MOD_ProDKin_1	127	133	PF00069	0.673
MOD_ProDKin_1	158	164	PF00069	0.477
MOD_ProDKin_1	224	230	PF00069	0.459
MOD_ProDKin_1	310	316	PF00069	0.563
MOD_ProDKin_1	325	331	PF00069	0.396
MOD_ProDKin_1	522	528	PF00069	0.609
MOD_ProDKin_1	551	557	PF00069	0.634
TRG_DiLeu_BaEn_4	257	263	PF01217	0.460
TRG_DiLeu_BaLyEn_6	151	156	PF01217	0.557
TRG_DiLeu_BaLyEn_6	247	252	PF01217	0.515
TRG_ENDOCYTIC_2	478	481	PF00928	0.493
TRG_ER_diArg_1	177	180	PF00400	0.464
TRG_ER_diArg_1	230	232	PF00400	0.630
TRG_ER_diArg_1	248	251	PF00400	0.549
TRG_ER_diArg_1	310	312	PF00400	0.581
TRG_ER_diArg_1	588	590	PF00400	0.398
TRG_ER_diArg_1	603	605	PF00400	0.356
TRG_ER_diArg_1	628	631	PF00400	0.400
TRG_NES_CRM1_1	442	455	PF08389	0.504
TRG_NLS_Bipartite_1	230	251	PF00514	0.585
TRG_NLS_MonoExtN_4	244	251	PF00514	0.580
TRG_Pf-PMV_PEXEL_1	180	184	PF00026	0.620
TRG_Pf-PMV_PEXEL_1	310	315	PF00026	0.582

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAU6	Leptomonas seymouri	50%	100%
A0A1X0NYZ1	Trypanosomatidae	24%	100%
A0A3Q8IBW5	Leishmania donovani	94%	100%
A0A422NHB0	Trypanosoma rangeli	25%	100%
A4HBR2	Leishmania braziliensis	77%	100%
A4HZ64	Leishmania infantum	94%	80%
D0A1H9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9AV31	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BIF6	Trypanosoma cruzi	25%	100%