Metallo-beta-lactamase family-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-beta-lactamase family-like protein

Species:

Leishmania major

UniProt:

Q4QCE8_LEIMA

TriTrypDb:

LmjF.21.0670 , LMJLV39_210012300 , LMJSD75_210012400

Length:

336

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCE8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCE8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	119	123	PF00656	0.323
CLV_C14_Caspase3-7	238	242	PF00656	0.436
CLV_C14_Caspase3-7	308	312	PF00656	0.453
CLV_NRD_NRD_1	101	103	PF00675	0.322
CLV_PCSK_KEX2_1	101	103	PF00082	0.323
CLV_PCSK_SKI1_1	101	105	PF00082	0.155
CLV_PCSK_SKI1_1	160	164	PF00082	0.279
CLV_PCSK_SKI1_1	224	228	PF00082	0.361
CLV_PCSK_SKI1_1	244	248	PF00082	0.388
CLV_PCSK_SKI1_1	276	280	PF00082	0.266
CLV_PCSK_SKI1_1	298	302	PF00082	0.473
CLV_PCSK_SKI1_1	319	323	PF00082	0.471
CLV_PCSK_SKI1_1	83	87	PF00082	0.449
DEG_SCF_FBW7_1	141	148	PF00400	0.260
DOC_CKS1_1	142	147	PF01111	0.258
DOC_CYCLIN_RxL_1	273	281	PF00134	0.470
DOC_CYCLIN_RxL_1	80	87	PF00134	0.316
DOC_CYCLIN_yCln2_LP_2	75	81	PF00134	0.317
DOC_MAPK_gen_1	101	109	PF00069	0.317
DOC_MAPK_gen_1	219	229	PF00069	0.405
DOC_MAPK_MEF2A_6	101	109	PF00069	0.317
DOC_USP7_MATH_1	239	243	PF00917	0.536
DOC_USP7_MATH_1	329	333	PF00917	0.549
DOC_USP7_MATH_1	69	73	PF00917	0.192
DOC_WW_Pin1_4	141	146	PF00397	0.258
LIG_14-3-3_CanoR_1	160	169	PF00244	0.358
LIG_14-3-3_CanoR_1	319	326	PF00244	0.457
LIG_Actin_WH2_2	248	266	PF00022	0.466
LIG_EH1_1	272	280	PF00400	0.449
LIG_eIF4E_1	288	294	PF01652	0.458
LIG_FHA_1	136	142	PF00498	0.354
LIG_FHA_1	207	213	PF00498	0.401
LIG_FHA_1	232	238	PF00498	0.474
LIG_FHA_1	37	43	PF00498	0.258
LIG_FHA_2	117	123	PF00498	0.317
LIG_FHA_2	245	251	PF00498	0.276
LIG_FHA_2	42	48	PF00498	0.317
LIG_LIR_Gen_1	173	184	PF02991	0.317
LIG_LIR_Gen_1	253	263	PF02991	0.439
LIG_LIR_Gen_1	269	279	PF02991	0.357
LIG_LIR_Gen_1	301	310	PF02991	0.460
LIG_LIR_Nem_3	173	179	PF02991	0.277
LIG_LIR_Nem_3	253	259	PF02991	0.439
LIG_LIR_Nem_3	269	275	PF02991	0.357
LIG_LIR_Nem_3	301	306	PF02991	0.441
LIG_LIR_Nem_3	58	63	PF02991	0.323
LIG_PTB_Apo_2	25	32	PF02174	0.405
LIG_PTB_Phospho_1	25	31	PF10480	0.400
LIG_SH2_CRK	256	260	PF00017	0.512
LIG_SH2_CRK	31	35	PF00017	0.413
LIG_SH2_NCK_1	256	260	PF00017	0.439
LIG_SH2_NCK_1	288	292	PF00017	0.420
LIG_SH2_SRC	288	291	PF00017	0.415
LIG_SH2_STAT5	256	259	PF00017	0.470
LIG_SH2_STAT5	303	306	PF00017	0.458
LIG_SH2_STAT5	40	43	PF00017	0.288
LIG_SH3_3	139	145	PF00018	0.263
LIG_TRAF2_1	44	47	PF00917	0.323
LIG_TYR_ITSM	252	259	PF00017	0.376
LIG_WRC_WIRS_1	176	181	PF05994	0.360
MOD_CK1_1	174	180	PF00069	0.285
MOD_CK2_1	244	250	PF00069	0.265
MOD_CK2_1	41	47	PF00069	0.317
MOD_GlcNHglycan	237	240	PF01048	0.565
MOD_GlcNHglycan	332	335	PF01048	0.528
MOD_GlcNHglycan	52	55	PF01048	0.281
MOD_GSK3_1	141	148	PF00069	0.258
MOD_GSK3_1	164	171	PF00069	0.317
MOD_GSK3_1	231	238	PF00069	0.451
MOD_GSK3_1	251	258	PF00069	0.435
MOD_GSK3_1	262	269	PF00069	0.431
MOD_GSK3_1	30	37	PF00069	0.377
MOD_NEK2_1	251	256	PF00069	0.407
MOD_NEK2_1	34	39	PF00069	0.274
MOD_NEK2_1	41	46	PF00069	0.273
MOD_NEK2_1	84	89	PF00069	0.317
MOD_NEK2_2	182	187	PF00069	0.313
MOD_NEK2_2	96	101	PF00069	0.317
MOD_PIKK_1	111	117	PF00454	0.317
MOD_PKA_2	218	224	PF00069	0.364
MOD_Plk_1	301	307	PF00069	0.441
MOD_Plk_1	70	76	PF00069	0.317
MOD_Plk_4	164	170	PF00069	0.309
MOD_Plk_4	171	177	PF00069	0.293
MOD_Plk_4	251	257	PF00069	0.453
MOD_Plk_4	301	307	PF00069	0.469
MOD_Plk_4	36	42	PF00069	0.258
MOD_ProDKin_1	141	147	PF00069	0.258
MOD_SUMO_for_1	132	135	PF00179	0.279
MOD_SUMO_for_1	192	195	PF00179	0.192
MOD_SUMO_rev_2	308	317	PF00179	0.444
TRG_DiLeu_BaEn_4	70	76	PF01217	0.279
TRG_DiLeu_BaLyEn_6	45	50	PF01217	0.323
TRG_ENDOCYTIC_2	256	259	PF00928	0.449
TRG_ENDOCYTIC_2	303	306	PF00928	0.437
TRG_ENDOCYTIC_2	31	34	PF00928	0.418
TRG_ENDOCYTIC_2	60	63	PF00928	0.258
TRG_ER_diArg_1	100	102	PF00400	0.323
TRG_ER_diArg_1	216	219	PF00400	0.304
TRG_Pf-PMV_PEXEL_1	101	106	PF00026	0.294
TRG_Pf-PMV_PEXEL_1	249	253	PF00026	0.266
TRG_Pf-PMV_PEXEL_1	277	281	PF00026	0.270
TRG_Pf-PMV_PEXEL_1	319	323	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	48	52	PF00026	0.258

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2E5	Leptomonas seymouri	66%	96%
A0A0S4JM93	Bodo saltans	43%	97%
A0A1L9WLF1	Aspergillus aculeatus (strain ATCC 16872 / CBS 172.66 / WB 5094)	38%	100%
A0A2I1C3U0	Aspergillus novofumigatus (strain IBT 16806)	39%	100%
A0A3S7WWH9	Leishmania donovani	96%	100%
A0A411PQM3	Paecilomyces divaricatus	38%	100%
A0A4P8DJU1	Cryptosporiopsis sp. (strain 8999)	42%	100%
A0A5B8YUX5	Pestalotiopsis microspora	37%	100%
A1D8J2	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	38%	100%
A2QX23	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	36%	100%
A4HZ66	Leishmania infantum	96%	100%
C5FM60	Arthroderma otae (strain ATCC MYA-4605 / CBS 113480)	37%	98%
D4AWH0	Arthroderma benhamiae (strain ATCC MYA-4681 / CBS 112371)	38%	77%
D4CZZ5	Trichophyton verrucosum (strain HKI 0517)	36%	100%
D7PHZ8	Penicillium aethiopicum	36%	100%
E1ACR1	Aspergillus sp. (strain MF297-2)	34%	100%
E4V2N5	Arthroderma gypseum (strain ATCC MYA-4604 / CBS 118893)	37%	100%
E9AIQ1	Leishmania braziliensis	86%	100%
E9AV33	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
F2PWS8	Trichophyton equinum (strain ATCC MYA-4606 / CBS 127.97)	38%	100%
F2S702	Trichophyton tonsurans (strain CBS 112818)	38%	100%
F2T0M3	Trichophyton rubrum (strain ATCC MYA-4607 / CBS 118892)	37%	100%
G3KLH5	Aspergillus niger	36%	100%
M1WCF7	Claviceps purpurea (strain 20.1)	39%	100%
M3ANL0	Pseudocercospora fijiensis (strain CIRAD86)	36%	100%
P0CU68	Passalora fulva	36%	100%
Q0CCY4	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	38%	100%
Q0V9A9	Xenopus tropicalis	42%	100%
Q1LZ83	Bos taurus	42%	100%
Q4W945	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	41%	100%
Q4WA58	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	38%	100%
Q4WQZ6	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	36%	80%
Q53H82	Homo sapiens	41%	100%
Q561R9	Rattus norvegicus	40%	100%
Q5B0C9	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	37%	100%
Q5XGR8	Xenopus laevis	43%	100%
Q6NYF0	Danio rerio	42%	100%
Q95Q18	Caenorhabditis elegans	38%	100%
Q99KR3	Mus musculus	41%	100%
Q9VLS9	Drosophila melanogaster	38%	100%