Histone deacetylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Histone deacetylase

Gene product:

histone deacetylase, putative

Species:

Leishmania major

UniProt:

Q4QCE7_LEIMA

TriTrypDb:

LmjF.21.0680 , LMJLV39_210012400 , LMJSD75_210012500

Length:

428

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043231	intracellular membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10

Expansion

Sequence features

Q4QCE7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCE7

Function

Biological processes
Term	Name	Level	Count
GO:0006325	chromatin organization	4	10
GO:0006355	regulation of DNA-templated transcription	6	2
GO:0006357	regulation of transcription by RNA polymerase II	7	2
GO:0006476	protein deacetylation	6	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009889	regulation of biosynthetic process	4	2
GO:0009987	cellular process	1	10
GO:0010468	regulation of gene expression	5	2
GO:0010556	regulation of macromolecule biosynthetic process	5	2
GO:0016043	cellular component organization	3	10
GO:0016570	histone modification	5	10
GO:0016575	histone deacetylation	6	10
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	2
GO:0019222	regulation of metabolic process	3	2
GO:0019538	protein metabolic process	3	10
GO:0031323	regulation of cellular metabolic process	4	2
GO:0031326	regulation of cellular biosynthetic process	5	2
GO:0035601	protein deacylation	5	10
GO:0036211	protein modification process	4	10
GO:0043170	macromolecule metabolic process	3	10
GO:0043412	macromolecule modification	4	10
GO:0044238	primary metabolic process	2	10
GO:0050789	regulation of biological process	2	2
GO:0050794	regulation of cellular process	3	2
GO:0051171	regulation of nitrogen compound metabolic process	4	2
GO:0051252	regulation of RNA metabolic process	5	2
GO:0060255	regulation of macromolecule metabolic process	4	2
GO:0065007	biological regulation	1	2
GO:0071704	organic substance metabolic process	2	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0080090	regulation of primary metabolic process	4	2
GO:0098732	macromolecule deacylation	5	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1903506	regulation of nucleic acid-templated transcription	7	2
GO:2001141	regulation of RNA biosynthetic process	6	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0004407	histone deacetylase activity	4	10
GO:0005488	binding	1	9
GO:0016787	hydrolase activity	2	10
GO:0016810	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds	3	10
GO:0016811	hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides	4	10
GO:0019213	deacetylase activity	3	10
GO:0033558	protein lysine deacetylase activity	3	10
GO:0043167	ion binding	2	9
GO:0043169	cation binding	3	9
GO:0046872	metal ion binding	4	9
GO:0140096	catalytic activity, acting on a protein	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	265	267	PF00675	0.265
CLV_PCSK_KEX2_1	265	267	PF00082	0.302
CLV_PCSK_SKI1_1	107	111	PF00082	0.265
CLV_PCSK_SKI1_1	206	210	PF00082	0.219
CLV_PCSK_SKI1_1	21	25	PF00082	0.377
CLV_PCSK_SKI1_1	405	409	PF00082	0.399
CLV_PCSK_SKI1_1	58	62	PF00082	0.299
CLV_Separin_Metazoa	55	59	PF03568	0.495
DEG_APCC_DBOX_1	284	292	PF00400	0.502
DOC_CYCLIN_yCln2_LP_2	306	312	PF00134	0.435
DOC_MAPK_DCC_7	304	313	PF00069	0.418
DOC_MAPK_DCC_7	67	76	PF00069	0.418
DOC_MAPK_gen_1	233	241	PF00069	0.502
DOC_MAPK_gen_1	46	56	PF00069	0.418
DOC_MAPK_MEF2A_6	183	191	PF00069	0.418
DOC_MAPK_MEF2A_6	235	243	PF00069	0.418
DOC_MAPK_MEF2A_6	304	313	PF00069	0.418
DOC_MAPK_MEF2A_6	67	76	PF00069	0.418
DOC_PP1_RVXF_1	105	111	PF00149	0.435
DOC_PP2B_LxvP_1	306	309	PF13499	0.418
DOC_USP7_MATH_1	103	107	PF00917	0.465
DOC_USP7_MATH_1	126	130	PF00917	0.464
DOC_USP7_MATH_1	259	263	PF00917	0.435
DOC_WW_Pin1_4	265	270	PF00397	0.465
DOC_WW_Pin1_4	357	362	PF00397	0.386
LIG_14-3-3_CanoR_1	206	211	PF00244	0.419
LIG_14-3-3_CanoR_1	235	240	PF00244	0.435
LIG_APCC_Cbox_2	391	397	PF00515	0.430
LIG_BRCT_BRCA1_1	105	109	PF00533	0.465
LIG_Clathr_ClatBox_1	73	77	PF01394	0.435
LIG_DLG_GKlike_1	235	243	PF00625	0.502
LIG_FHA_1	103	109	PF00498	0.465
LIG_FHA_1	207	213	PF00498	0.418
LIG_FHA_1	329	335	PF00498	0.441
LIG_FHA_1	385	391	PF00498	0.383
LIG_FHA_1	419	425	PF00498	0.548
LIG_FHA_2	406	412	PF00498	0.420
LIG_FHA_2	420	426	PF00498	0.649
LIG_GBD_Chelix_1	170	178	PF00786	0.218
LIG_LIR_Gen_1	162	172	PF02991	0.418
LIG_LIR_Nem_3	162	167	PF02991	0.418
LIG_LIR_Nem_3	248	253	PF02991	0.444
LIG_Pex14_2	215	219	PF04695	0.418
LIG_SH2_CRK	48	52	PF00017	0.418
LIG_SH2_GRB2like	166	169	PF00017	0.418
LIG_SH2_PTP2	186	189	PF00017	0.418
LIG_SH2_SRC	186	189	PF00017	0.502
LIG_SH2_STAP1	237	241	PF00017	0.453
LIG_SH2_STAP1	30	34	PF00017	0.486
LIG_SH2_STAP1	329	333	PF00017	0.418
LIG_SH2_STAT5	166	169	PF00017	0.418
LIG_SH2_STAT5	186	189	PF00017	0.332
LIG_SH2_STAT5	252	255	PF00017	0.479
LIG_SH2_STAT5	318	321	PF00017	0.448
LIG_SH2_STAT5	87	90	PF00017	0.418
LIG_SH3_3	335	341	PF00018	0.442
LIG_SH3_3	66	72	PF00018	0.418
LIG_SUMO_SIM_anti_2	359	366	PF11976	0.392
LIG_TYR_ITIM	184	189	PF00017	0.418
LIG_UBA3_1	174	179	PF00899	0.418
LIG_WRC_WIRS_1	291	296	PF05994	0.502
MOD_CK1_1	124	130	PF00069	0.487
MOD_CK1_1	332	338	PF00069	0.516
MOD_CK1_1	95	101	PF00069	0.438
MOD_CK2_1	11	17	PF00069	0.469
MOD_CK2_1	405	411	PF00069	0.422
MOD_CK2_1	419	425	PF00069	0.652
MOD_GlcNHglycan	110	113	PF01048	0.218
MOD_GlcNHglycan	128	131	PF01048	0.218
MOD_GlcNHglycan	139	142	PF01048	0.228
MOD_GlcNHglycan	160	164	PF01048	0.220
MOD_GlcNHglycan	26	30	PF01048	0.366
MOD_GlcNHglycan	352	355	PF01048	0.323
MOD_GlcNHglycan	36	39	PF01048	0.367
MOD_GSK3_1	11	18	PF00069	0.576
MOD_GSK3_1	124	131	PF00069	0.435
MOD_GSK3_1	25	32	PF00069	0.299
MOD_GSK3_1	328	335	PF00069	0.502
MOD_N-GLC_1	289	294	PF02516	0.218
MOD_N-GLC_1	34	39	PF02516	0.424
MOD_NEK2_1	121	126	PF00069	0.449
MOD_NEK2_1	137	142	PF00069	0.369
MOD_NEK2_1	153	158	PF00069	0.502
MOD_NEK2_1	208	213	PF00069	0.436
MOD_NEK2_1	215	220	PF00069	0.450
MOD_NEK2_1	24	29	PF00069	0.324
MOD_NEK2_1	289	294	PF00069	0.418
MOD_NEK2_1	34	39	PF00069	0.364
MOD_NEK2_2	316	321	PF00069	0.435
MOD_NEK2_2	92	97	PF00069	0.502
MOD_PKB_1	233	241	PF00069	0.465
MOD_Plk_1	121	127	PF00069	0.433
MOD_Plk_1	289	295	PF00069	0.429
MOD_Plk_1	329	335	PF00069	0.418
MOD_Plk_1	34	40	PF00069	0.415
MOD_Plk_4	128	134	PF00069	0.418
MOD_Plk_4	215	221	PF00069	0.427
MOD_Plk_4	259	265	PF00069	0.494
MOD_Plk_4	329	335	PF00069	0.418
MOD_Plk_4	340	346	PF00069	0.352
MOD_Plk_4	83	89	PF00069	0.502
MOD_ProDKin_1	265	271	PF00069	0.465
MOD_ProDKin_1	357	363	PF00069	0.378
MOD_SUMO_for_1	74	77	PF00179	0.502
TRG_DiLeu_BaLyEn_6	358	363	PF01217	0.452
TRG_ENDOCYTIC_2	186	189	PF00928	0.421
TRG_ENDOCYTIC_2	236	239	PF00928	0.461
TRG_ENDOCYTIC_2	252	255	PF00928	0.418
TRG_ENDOCYTIC_2	383	386	PF00928	0.461
TRG_ENDOCYTIC_2	48	51	PF00928	0.418
TRG_ER_diArg_1	19	22	PF00400	0.467
TRG_ER_diArg_1	233	236	PF00400	0.493
TRG_ER_diArg_1	264	266	PF00400	0.465
TRG_NES_CRM1_1	245	257	PF08389	0.476
TRG_Pf-PMV_PEXEL_1	183	188	PF00026	0.218
TRG_Pf-PMV_PEXEL_1	58	63	PF00026	0.235

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCD3	Leptomonas seymouri	38%	80%
A0A0N1PFX6	Leptomonas seymouri	84%	100%
A0A1X0NVQ2	Trypanosomatidae	40%	94%
A0A1X0NXU7	Trypanosomatidae	69%	100%
A0A3Q8IC47	Leishmania donovani	39%	80%
A0A3R7L005	Trypanosoma rangeli	72%	100%
A0A3S7WWE6	Leishmania donovani	98%	100%
A0A422N1V5	Trypanosoma rangeli	39%	95%
A4HBR4	Leishmania braziliensis	92%	99%
A4HDK5	Leishmania braziliensis	40%	99%
A4HZ67	Leishmania infantum	98%	100%
A4I0X6	Leishmania infantum	39%	80%
B1H369	Xenopus tropicalis	42%	100%
B1WC68	Rattus norvegicus	42%	100%
D0A1H7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	71%	100%
E9AV34	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	94%
E9AWY0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	39%	79%
O09106	Mus musculus	46%	89%
O13298	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	44%	99%
O15379	Homo sapiens	42%	100%
O17695	Caenorhabditis elegans	41%	93%
O22446	Arabidopsis thaliana	49%	85%
O27262	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	23%	100%
O30107	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	27%	100%
O42227	Xenopus laevis	45%	89%
O59702	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	39%	100%
O88895	Mus musculus	42%	100%
P32561	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	40%	99%
P39067	Bacillus subtilis (strain 168)	32%	100%
P53096	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	43%	95%
P56517	Gallus gallus	41%	89%
P56518	Strongylocentrotus purpuratus	45%	74%
P56519	Gallus gallus	40%	88%
P56520	Gallus gallus	42%	100%
P56521	Zea mays	45%	83%
P64375	Staphylococcus aureus (strain Mu50 / ATCC 700699)	28%	100%
P64376	Staphylococcus aureus (strain N315)	28%	100%
P70288	Mus musculus	41%	88%
Q09440	Caenorhabditis elegans	45%	84%
Q0VCB2	Bos taurus	41%	100%
Q13547	Homo sapiens	46%	89%
Q28DV3	Xenopus tropicalis	42%	100%
Q32PJ8	Bos taurus	46%	89%
Q4QAJ4	Leishmania major	39%	80%
Q4QQW4	Rattus norvegicus	46%	89%
Q4SFA0	Tetraodon nigroviridis	41%	100%
Q55BW2	Dictyostelium discoideum	43%	100%
Q55FN5	Dictyostelium discoideum	44%	86%
Q56195	Staphylococcus xylosus	29%	100%
Q57955	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	26%	100%
Q5HF39	Staphylococcus aureus (strain COL)	28%	100%
Q5RAG0	Pongo abelii	46%	89%
Q5RB76	Pongo abelii	44%	100%
Q6G8J2	Staphylococcus aureus (strain MSSA476)	28%	100%
Q6GFX3	Staphylococcus aureus (strain MRSA252)	28%	100%
Q6IRL9	Xenopus laevis	44%	100%
Q6P6W3	Rattus norvegicus	42%	100%
Q6YV04	Oryza sativa subsp. japonica	48%	84%
Q7SXM0	Danio rerio	40%	100%
Q7Y0Y6	Oryza sativa subsp. japonica	42%	84%
Q7Y0Y8	Oryza sativa subsp. japonica	49%	83%
Q803C3	Danio rerio	43%	100%
Q8H0W2	Arabidopsis thaliana	40%	100%
Q8NW34	Staphylococcus aureus (strain MW2)	28%	100%
Q8VH37	Mus musculus	42%	100%
Q91695	Xenopus laevis	45%	89%
Q92769	Homo sapiens	42%	88%
Q944K3	Arabidopsis thaliana	27%	100%
Q94517	Drosophila melanogaster	46%	82%
Q94EJ2	Arabidopsis thaliana	29%	100%
Q9BY41	Homo sapiens	41%	100%
Q9FH09	Arabidopsis thaliana	38%	100%
Q9FML2	Arabidopsis thaliana	47%	91%
V5B3T3	Trypanosoma cruzi	34%	96%