DUF4166 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCE6_LEIMA

TriTrypDb:

LmjF.21.0690 , LMJLV39_210012500 , LMJSD75_210012600

Length:

148

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCE6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCE6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	13	17	PF00656	0.616
CLV_NRD_NRD_1	20	22	PF00675	0.435
CLV_NRD_NRD_1	5	7	PF00675	0.553
CLV_PCSK_KEX2_1	20	22	PF00082	0.576
CLV_PCSK_SKI1_1	133	137	PF00082	0.413
CLV_PCSK_SKI1_1	39	43	PF00082	0.525
CLV_PCSK_SKI1_1	6	10	PF00082	0.574
DEG_MDM2_SWIB_1	51	58	PF02201	0.506
DOC_CDC14_PxL_1	105	113	PF14671	0.651
DOC_MAPK_gen_1	102	110	PF00069	0.642
DOC_MAPK_gen_1	36	44	PF00069	0.584
DOC_PP1_RVXF_1	131	137	PF00149	0.387
DOC_PP1_RVXF_1	74	80	PF00149	0.425
DOC_PP2B_LxvP_1	44	47	PF13499	0.548
DOC_PP4_FxxP_1	119	122	PF00568	0.561
DOC_USP7_MATH_1	85	89	PF00917	0.530
LIG_14-3-3_CanoR_1	104	108	PF00244	0.571
LIG_14-3-3_CanoR_1	76	86	PF00244	0.447
LIG_BIR_II_1	1	5	PF00653	0.606
LIG_BRCT_BRCA1_1	115	119	PF00533	0.595
LIG_BRCT_BRCA1_1	87	91	PF00533	0.487
LIG_FHA_1	78	84	PF00498	0.485
LIG_LIR_Apic_2	116	122	PF02991	0.571
LIG_LIR_LC3C_4	125	129	PF02991	0.433
LIG_LIR_Nem_3	106	110	PF02991	0.608
LIG_LIR_Nem_3	53	58	PF02991	0.471
LIG_MLH1_MIPbox_1	115	119	PF16413	0.595
LIG_MYND_1	109	113	PF01753	0.665
LIG_PCNA_yPIPBox_3	120	133	PF02747	0.551
LIG_Pex14_1	114	118	PF04695	0.533
LIG_Pex14_2	51	55	PF04695	0.450
LIG_REV1ctd_RIR_1	116	121	PF16727	0.578
LIG_SH2_PTP2	96	99	PF00017	0.559
LIG_SH2_SRC	96	99	PF00017	0.575
LIG_SH2_STAT5	10	13	PF00017	0.605
LIG_SH2_STAT5	141	144	PF00017	0.610
LIG_SH2_STAT5	96	99	PF00017	0.473
LIG_SH3_3	107	113	PF00018	0.517
LIG_SUMO_SIM_anti_2	125	131	PF11976	0.539
LIG_SUMO_SIM_anti_2	40	46	PF11976	0.555
LIG_SUMO_SIM_par_1	125	131	PF11976	0.539
LIG_SxIP_EBH_1	104	114	PF03271	0.589
LIG_TRAF2_1	122	125	PF00917	0.536
LIG_WRC_WIRS_1	115	120	PF05994	0.592
LIG_WRC_WIRS_1	51	56	PF05994	0.477
MOD_Cter_Amidation	4	7	PF01082	0.638
MOD_GlcNHglycan	3	6	PF01048	0.452
MOD_GlcNHglycan	80	83	PF01048	0.472
MOD_NEK2_1	1	6	PF00069	0.474
MOD_NEK2_1	75	80	PF00069	0.449
MOD_NEK2_2	114	119	PF00069	0.606
MOD_PKA_2	103	109	PF00069	0.583
MOD_PKA_2	35	41	PF00069	0.517
MOD_PKA_2	75	81	PF00069	0.450
MOD_Plk_4	103	109	PF00069	0.501
MOD_Plk_4	114	120	PF00069	0.537
MOD_Plk_4	40	46	PF00069	0.460
MOD_Plk_4	50	56	PF00069	0.388
MOD_SUMO_rev_2	33	41	PF00179	0.592
TRG_DiLeu_BaEn_1	40	45	PF01217	0.442
TRG_DiLeu_BaEn_2	102	108	PF01217	0.570
TRG_ENDOCYTIC_2	96	99	PF00928	0.473
TRG_ER_diArg_1	19	21	PF00400	0.586
TRG_PTS2	1	29	PF00400	0.623

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P861	Leptomonas seymouri	74%	100%
A0A0S4JGA4	Bodo saltans	39%	100%
A0A1X0NXL6	Trypanosomatidae	47%	100%
A0A3S7WWF3	Leishmania donovani	96%	100%
A4HBR5	Leishmania braziliensis	91%	100%
A4HZ68	Leishmania infantum	96%	100%
D0A1G7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9AV35	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%