Putative dual specificity protein phosphatase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

dual specificity protein phosphatase, putative

Species:

Leishmania major

UniProt:

Q4QCE5_LEIMA

TriTrypDb:

LmjF.21.0700 , LMJLV39_210012600 , LMJSD75_210012700

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCE5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCE5

Function

Biological processes
Term	Name	Level	Count
GO:0006470	protein dephosphorylation	5	11
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016311	dephosphorylation	5	11
GO:0019538	protein metabolic process	3	11
GO:0036211	protein modification process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043412	macromolecule modification	4	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004721	phosphoprotein phosphatase activity	3	11
GO:0008138	protein tyrosine/serine/threonine phosphatase activity	4	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0016791	phosphatase activity	5	11
GO:0042578	phosphoric ester hydrolase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	230	234	PF00656	0.678
CLV_NRD_NRD_1	272	274	PF00675	0.607
CLV_NRD_NRD_1	287	289	PF00675	0.638
CLV_NRD_NRD_1	518	520	PF00675	0.644
CLV_NRD_NRD_1	533	535	PF00675	0.669
CLV_NRD_NRD_1	608	610	PF00675	0.633
CLV_NRD_NRD_1	618	620	PF00675	0.571
CLV_PCSK_KEX2_1	153	155	PF00082	0.382
CLV_PCSK_KEX2_1	272	274	PF00082	0.593
CLV_PCSK_KEX2_1	287	289	PF00082	0.541
CLV_PCSK_KEX2_1	518	520	PF00082	0.644
CLV_PCSK_KEX2_1	532	534	PF00082	0.678
CLV_PCSK_KEX2_1	544	546	PF00082	0.564
CLV_PCSK_KEX2_1	608	610	PF00082	0.633
CLV_PCSK_KEX2_1	618	620	PF00082	0.571
CLV_PCSK_PC1ET2_1	153	155	PF00082	0.382
CLV_PCSK_PC1ET2_1	544	546	PF00082	0.752
CLV_PCSK_PC7_1	149	155	PF00082	0.276
CLV_PCSK_PC7_1	528	534	PF00082	0.736
CLV_PCSK_SKI1_1	24	28	PF00082	0.408
CLV_PCSK_SKI1_1	347	351	PF00082	0.741
CLV_PCSK_SKI1_1	499	503	PF00082	0.793
DEG_APCC_DBOX_1	299	307	PF00400	0.693
DEG_Nend_UBRbox_2	1	3	PF02207	0.612
DEG_SCF_FBW7_1	458	465	PF00400	0.755
DEG_SPOP_SBC_1	333	337	PF00917	0.761
DEG_SPOP_SBC_1	429	433	PF00917	0.679
DEG_SPOP_SBC_1	462	466	PF00917	0.617
DOC_CKS1_1	404	409	PF01111	0.633
DOC_CKS1_1	506	511	PF01111	0.595
DOC_MAPK_gen_1	215	223	PF00069	0.602
DOC_MAPK_gen_1	298	305	PF00069	0.574
DOC_MAPK_gen_1	532	541	PF00069	0.619
DOC_PP1_RVXF_1	80	87	PF00149	0.294
DOC_PP2B_LxvP_1	379	382	PF13499	0.633
DOC_USP7_MATH_1	333	337	PF00917	0.715
DOC_USP7_MATH_1	462	466	PF00917	0.657
DOC_USP7_MATH_1	467	471	PF00917	0.629
DOC_USP7_MATH_1	491	495	PF00917	0.605
DOC_USP7_MATH_1	509	513	PF00917	0.570
DOC_USP7_MATH_1	514	518	PF00917	0.619
DOC_USP7_MATH_1	524	528	PF00917	0.689
DOC_USP7_MATH_1	63	67	PF00917	0.355
DOC_USP7_UBL2_3	119	123	PF12436	0.294
DOC_USP7_UBL2_3	411	415	PF12436	0.680
DOC_WW_Pin1_4	105	110	PF00397	0.276
DOC_WW_Pin1_4	280	285	PF00397	0.563
DOC_WW_Pin1_4	357	362	PF00397	0.539
DOC_WW_Pin1_4	384	389	PF00397	0.599
DOC_WW_Pin1_4	399	404	PF00397	0.639
DOC_WW_Pin1_4	458	463	PF00397	0.630
DOC_WW_Pin1_4	505	510	PF00397	0.647
DOC_WW_Pin1_4	512	517	PF00397	0.580
DOC_WW_Pin1_4	534	539	PF00397	0.621
DOC_WW_Pin1_4	543	548	PF00397	0.585
DOC_WW_Pin1_4	563	568	PF00397	0.491
LIG_14-3-3_CanoR_1	181	185	PF00244	0.345
LIG_14-3-3_CanoR_1	243	248	PF00244	0.674
LIG_14-3-3_CanoR_1	280	284	PF00244	0.655
LIG_14-3-3_CanoR_1	300	304	PF00244	0.688
LIG_14-3-3_CanoR_1	329	333	PF00244	0.692
LIG_14-3-3_CanoR_1	420	425	PF00244	0.730
LIG_14-3-3_CanoR_1	428	438	PF00244	0.715
LIG_14-3-3_CanoR_1	463	467	PF00244	0.628
LIG_14-3-3_CanoR_1	493	497	PF00244	0.645
LIG_14-3-3_CanoR_1	499	504	PF00244	0.732
LIG_14-3-3_CanoR_1	507	516	PF00244	0.592
LIG_14-3-3_CanoR_1	532	537	PF00244	0.662
LIG_Actin_WH2_2	253	271	PF00022	0.580
LIG_Actin_WH2_2	315	331	PF00022	0.592
LIG_BIR_III_4	62	66	PF00653	0.408
LIG_CaM_IQ_9	339	354	PF13499	0.507
LIG_FHA_1	23	29	PF00498	0.308
LIG_FHA_1	235	241	PF00498	0.705
LIG_FHA_1	31	37	PF00498	0.244
LIG_FHA_1	313	319	PF00498	0.681
LIG_FHA_1	412	418	PF00498	0.706
LIG_FHA_1	430	436	PF00498	0.710
LIG_FHA_1	472	478	PF00498	0.610
LIG_FHA_1	602	608	PF00498	0.760
LIG_FHA_1	67	73	PF00498	0.322
LIG_FHA_2	220	226	PF00498	0.631
LIG_FHA_2	228	234	PF00498	0.595
LIG_FHA_2	404	410	PF00498	0.656
LIG_FHA_2	411	417	PF00498	0.627
LIG_FHA_2	498	504	PF00498	0.661
LIG_GBD_Chelix_1	83	91	PF00786	0.196
LIG_LIR_Apic_2	503	509	PF02991	0.626
LIG_LIR_Gen_1	373	382	PF02991	0.691
LIG_LIR_Gen_1	50	59	PF02991	0.363
LIG_LIR_Nem_3	258	262	PF02991	0.628
LIG_LIR_Nem_3	340	344	PF02991	0.626
LIG_LIR_Nem_3	373	379	PF02991	0.684
LIG_LIR_Nem_3	387	392	PF02991	0.536
LIG_LIR_Nem_3	485	489	PF02991	0.614
LIG_LIR_Nem_3	50	56	PF02991	0.372
LIG_NRBOX	184	190	PF00104	0.509
LIG_PCNA_yPIPBox_3	181	189	PF02747	0.497
LIG_PTB_Apo_2	193	200	PF02174	0.517
LIG_PTB_Phospho_1	193	199	PF10480	0.515
LIG_SH2_CRK	376	380	PF00017	0.692
LIG_SH2_CRK	486	490	PF00017	0.607
LIG_SH2_CRK	506	510	PF00017	0.486
LIG_SH2_STAP1	376	380	PF00017	0.687
LIG_SH2_STAT3	190	193	PF00017	0.529
LIG_SH2_STAT5	130	133	PF00017	0.371
LIG_SH2_STAT5	540	543	PF00017	0.627
LIG_SH2_STAT5	55	58	PF00017	0.276
LIG_SH3_3	205	211	PF00018	0.536
LIG_SH3_3	355	361	PF00018	0.649
LIG_SH3_3	435	441	PF00018	0.670
LIG_SH3_4	141	148	PF00018	0.408
LIG_SUMO_SIM_anti_2	25	30	PF11976	0.348
LIG_TYR_ITIM	374	379	PF00017	0.689
LIG_UBA3_1	128	132	PF00899	0.348
LIG_UBA3_1	184	191	PF00899	0.407
LIG_UBA3_1	26	31	PF00899	0.348
MOD_CDC14_SPxK_1	515	518	PF00782	0.677
MOD_CDK_SPK_2	403	408	PF00069	0.627
MOD_CDK_SPK_2	458	463	PF00069	0.766
MOD_CDK_SPK_2	563	568	PF00069	0.673
MOD_CDK_SPxK_1	512	518	PF00069	0.676
MOD_CDK_SPxxK_3	280	287	PF00069	0.528
MOD_CDK_SPxxK_3	403	410	PF00069	0.624
MOD_CDK_SPxxK_3	512	519	PF00069	0.776
MOD_CK1_1	234	240	PF00069	0.646
MOD_CK1_1	276	282	PF00069	0.639
MOD_CK1_1	283	289	PF00069	0.642
MOD_CK1_1	308	314	PF00069	0.659
MOD_CK1_1	367	373	PF00069	0.704
MOD_CK1_1	431	437	PF00069	0.684
MOD_CK1_1	439	445	PF00069	0.694
MOD_CK1_1	457	463	PF00069	0.634
MOD_CK1_1	482	488	PF00069	0.651
MOD_CK1_1	505	511	PF00069	0.619
MOD_CK1_1	512	518	PF00069	0.627
MOD_CK1_1	54	60	PF00069	0.395
MOD_CK1_1	576	582	PF00069	0.699
MOD_CK1_1	583	589	PF00069	0.642
MOD_CK1_1	601	607	PF00069	0.550
MOD_CK1_1	66	72	PF00069	0.245
MOD_CK2_1	363	369	PF00069	0.729
MOD_CK2_1	410	416	PF00069	0.677
MOD_CK2_1	497	503	PF00069	0.662
MOD_CK2_1	551	557	PF00069	0.749
MOD_Cter_Amidation	270	273	PF01082	0.678
MOD_DYRK1A_RPxSP_1	280	284	PF00069	0.567
MOD_GlcNHglycan	125	128	PF01048	0.319
MOD_GlcNHglycan	269	272	PF01048	0.582
MOD_GlcNHglycan	325	328	PF01048	0.597
MOD_GlcNHglycan	330	333	PF01048	0.677
MOD_GlcNHglycan	345	350	PF01048	0.495
MOD_GlcNHglycan	366	369	PF01048	0.770
MOD_GlcNHglycan	442	445	PF01048	0.709
MOD_GlcNHglycan	481	484	PF01048	0.686
MOD_GlcNHglycan	528	531	PF01048	0.680
MOD_GlcNHglycan	547	550	PF01048	0.621
MOD_GlcNHglycan	553	556	PF01048	0.641
MOD_GlcNHglycan	576	579	PF01048	0.817
MOD_GlcNHglycan	592	595	PF01048	0.543
MOD_GlcNHglycan	596	599	PF01048	0.679
MOD_GSK3_1	219	226	PF00069	0.580
MOD_GSK3_1	227	234	PF00069	0.521
MOD_GSK3_1	263	270	PF00069	0.566
MOD_GSK3_1	276	283	PF00069	0.538
MOD_GSK3_1	288	295	PF00069	0.588
MOD_GSK3_1	307	314	PF00069	0.643
MOD_GSK3_1	328	335	PF00069	0.617
MOD_GSK3_1	363	370	PF00069	0.702
MOD_GSK3_1	380	387	PF00069	0.655
MOD_GSK3_1	388	395	PF00069	0.609
MOD_GSK3_1	399	406	PF00069	0.663
MOD_GSK3_1	416	423	PF00069	0.624
MOD_GSK3_1	424	431	PF00069	0.628
MOD_GSK3_1	436	443	PF00069	0.631
MOD_GSK3_1	453	460	PF00069	0.624
MOD_GSK3_1	463	470	PF00069	0.537
MOD_GSK3_1	505	512	PF00069	0.665
MOD_GSK3_1	522	529	PF00069	0.661
MOD_GSK3_1	539	546	PF00069	0.519
MOD_GSK3_1	549	556	PF00069	0.628
MOD_GSK3_1	559	566	PF00069	0.646
MOD_GSK3_1	576	583	PF00069	0.510
MOD_GSK3_1	586	593	PF00069	0.625
MOD_GSK3_1	594	601	PF00069	0.487
MOD_GSK3_1	63	70	PF00069	0.409
MOD_LATS_1	418	424	PF00433	0.778
MOD_N-GLC_1	399	404	PF02516	0.699
MOD_N-GLC_1	580	585	PF02516	0.727
MOD_N-GLC_1	586	591	PF02516	0.693
MOD_NEK2_1	180	185	PF00069	0.382
MOD_NEK2_1	223	228	PF00069	0.533
MOD_NEK2_1	278	283	PF00069	0.563
MOD_NEK2_1	328	333	PF00069	0.764
MOD_NEK2_1	363	368	PF00069	0.784
MOD_NEK2_1	392	397	PF00069	0.593
MOD_NEK2_1	580	585	PF00069	0.695
MOD_NEK2_1	98	103	PF00069	0.305
MOD_PIKK_1	166	172	PF00454	0.494
MOD_PIKK_1	231	237	PF00454	0.533
MOD_PIKK_1	380	386	PF00454	0.697
MOD_PIKK_1	549	555	PF00454	0.815
MOD_PK_1	273	279	PF00069	0.614
MOD_PKA_1	227	233	PF00069	0.669
MOD_PKA_1	410	416	PF00069	0.691
MOD_PKA_1	532	538	PF00069	0.784
MOD_PKA_2	180	186	PF00069	0.348
MOD_PKA_2	279	285	PF00069	0.668
MOD_PKA_2	299	305	PF00069	0.664
MOD_PKA_2	323	329	PF00069	0.776
MOD_PKA_2	364	370	PF00069	0.710
MOD_PKA_2	462	468	PF00069	0.636
MOD_PKA_2	471	477	PF00069	0.627
MOD_PKA_2	479	485	PF00069	0.517
MOD_PKA_2	492	498	PF00069	0.561
MOD_PKA_2	532	538	PF00069	0.631
MOD_Plk_1	166	172	PF00069	0.457
MOD_Plk_1	22	28	PF00069	0.408
MOD_Plk_1	580	586	PF00069	0.737
MOD_Plk_2-3	250	256	PF00069	0.479
MOD_Plk_4	180	186	PF00069	0.377
MOD_Plk_4	22	28	PF00069	0.408
MOD_Plk_4	255	261	PF00069	0.741
MOD_Plk_4	273	279	PF00069	0.453
MOD_Plk_4	492	498	PF00069	0.632
MOD_Plk_4	67	73	PF00069	0.355
MOD_Plk_4	98	104	PF00069	0.355
MOD_ProDKin_1	105	111	PF00069	0.276
MOD_ProDKin_1	280	286	PF00069	0.566
MOD_ProDKin_1	357	363	PF00069	0.538
MOD_ProDKin_1	384	390	PF00069	0.598
MOD_ProDKin_1	399	405	PF00069	0.640
MOD_ProDKin_1	458	464	PF00069	0.631
MOD_ProDKin_1	505	511	PF00069	0.647
MOD_ProDKin_1	512	518	PF00069	0.582
MOD_ProDKin_1	534	540	PF00069	0.624
MOD_ProDKin_1	543	549	PF00069	0.587
MOD_ProDKin_1	563	569	PF00069	0.492
MOD_SUMO_rev_2	137	142	PF00179	0.408
MOD_SUMO_rev_2	340	349	PF00179	0.631
MOD_SUMO_rev_2	554	560	PF00179	0.664
TRG_DiLeu_BaEn_2	254	260	PF01217	0.658
TRG_ENDOCYTIC_2	115	118	PF00928	0.288
TRG_ENDOCYTIC_2	130	133	PF00928	0.384
TRG_ENDOCYTIC_2	376	379	PF00928	0.698
TRG_ENDOCYTIC_2	486	489	PF00928	0.611
TRG_ENDOCYTIC_2	55	58	PF00928	0.276
TRG_ER_diArg_1	272	274	PF00400	0.599
TRG_ER_diArg_1	287	289	PF00400	0.551
TRG_ER_diArg_1	532	534	PF00400	0.718
TRG_ER_diArg_1	607	609	PF00400	0.635
TRG_Pf-PMV_PEXEL_1	146	150	PF00026	0.408
TRG_Pf-PMV_PEXEL_1	287	292	PF00026	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I8	Leptomonas seymouri	58%	93%
A0A0S4JFG5	Bodo saltans	43%	81%
A0A1X0NXL0	Trypanosomatidae	47%	100%
A0A3Q8IAA7	Leishmania donovani	95%	100%
A0A3R7MFE4	Trypanosoma rangeli	45%	100%
A4HBR6	Leishmania braziliensis	80%	100%
A4HZ69	Leishmania infantum	95%	100%
D0A1G8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AV36	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%