Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCE3_LEIMA

TriTrypDb:

LmjF.21.0720 , LMJLV39_210012800 , LMJSD75_210012900

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCE3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCE3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	228	230	PF00675	0.500
CLV_NRD_NRD_1	235	237	PF00675	0.482
CLV_NRD_NRD_1	271	273	PF00675	0.582
CLV_PCSK_FUR_1	226	230	PF00082	0.489
CLV_PCSK_KEX2_1	228	230	PF00082	0.500
CLV_PCSK_SKI1_1	162	166	PF00082	0.412
CLV_PCSK_SKI1_1	189	193	PF00082	0.436
DEG_SCF_FBW7_1	306	312	PF00400	0.549
DEG_SCF_FBW7_2	315	322	PF00400	0.656
DEG_SPOP_SBC_1	344	348	PF00917	0.654
DOC_CKS1_1	306	311	PF01111	0.643
DOC_CKS1_1	316	321	PF01111	0.580
DOC_MAPK_DCC_7	7	17	PF00069	0.456
DOC_MAPK_gen_1	142	151	PF00069	0.523
DOC_MAPK_MEF2A_6	170	179	PF00069	0.466
DOC_MAPK_MEF2A_6	213	221	PF00069	0.498
DOC_MAPK_MEF2A_6	32	39	PF00069	0.513
DOC_MAPK_MEF2A_6	42	50	PF00069	0.475
DOC_MAPK_MEF2A_6	52	59	PF00069	0.437
DOC_MAPK_NFAT4_5	52	60	PF00069	0.465
DOC_PP1_RVXF_1	142	148	PF00149	0.545
DOC_PP1_RVXF_1	160	166	PF00149	0.495
DOC_PP1_RVXF_1	187	194	PF00149	0.379
DOC_PP2B_LxvP_1	175	178	PF13499	0.520
DOC_USP7_MATH_1	122	126	PF00917	0.564
DOC_USP7_MATH_1	344	348	PF00917	0.594
DOC_WW_Pin1_4	305	310	PF00397	0.738
DOC_WW_Pin1_4	315	320	PF00397	0.542
DOC_WW_Pin1_4	345	350	PF00397	0.658
LIG_14-3-3_CanoR_1	47	51	PF00244	0.553
LIG_14-3-3_CanoR_1	52	56	PF00244	0.550
LIG_14-3-3_CanoR_1	62	72	PF00244	0.610
LIG_Actin_WH2_2	32	49	PF00022	0.508
LIG_AP2alpha_1	218	222	PF02296	0.391
LIG_BIR_II_1	1	5	PF00653	0.472
LIG_BRCT_BRCA1_1	346	350	PF00533	0.581
LIG_Clathr_ClatBox_1	21	25	PF01394	0.498
LIG_deltaCOP1_diTrp_1	9	17	PF00928	0.512
LIG_EH_1	215	219	PF12763	0.452
LIG_EH1_1	241	249	PF00400	0.446
LIG_eIF4E_1	242	248	PF01652	0.450
LIG_FHA_1	109	115	PF00498	0.608
LIG_FHA_1	167	173	PF00498	0.513
LIG_FHA_1	179	185	PF00498	0.398
LIG_FHA_1	65	71	PF00498	0.621
LIG_FHA_2	100	106	PF00498	0.549
LIG_FHA_2	78	84	PF00498	0.418
LIG_FXI_DFP_1	23	27	PF00024	0.436
LIG_GBD_Chelix_1	262	270	PF00786	0.517
LIG_LIR_Apic_2	9	14	PF02991	0.507
LIG_LIR_Gen_1	146	151	PF02991	0.401
LIG_LIR_Gen_1	155	165	PF02991	0.404
LIG_LIR_Gen_1	208	217	PF02991	0.434
LIG_LIR_Gen_1	220	230	PF02991	0.344
LIG_LIR_Nem_3	105	109	PF02991	0.615
LIG_LIR_Nem_3	129	134	PF02991	0.568
LIG_LIR_Nem_3	146	150	PF02991	0.397
LIG_LIR_Nem_3	155	161	PF02991	0.403
LIG_LIR_Nem_3	208	212	PF02991	0.423
LIG_LIR_Nem_3	215	221	PF02991	0.395
LIG_NRBOX	18	24	PF00104	0.457
LIG_Pex14_2	13	17	PF04695	0.463
LIG_Pex14_2	161	165	PF04695	0.365
LIG_Pex14_2	193	197	PF04695	0.339
LIG_Pex14_2	218	222	PF04695	0.378
LIG_RPA_C_Fungi	137	149	PF08784	0.412
LIG_SH2_CRK	317	321	PF00017	0.650
LIG_SH2_STAT3	293	296	PF00017	0.507
LIG_SH2_STAT5	158	161	PF00017	0.407
LIG_SH2_STAT5	242	245	PF00017	0.462
LIG_SH2_STAT5	293	296	PF00017	0.660
LIG_SH2_STAT5	317	320	PF00017	0.705
LIG_SH3_3	303	309	PF00018	0.636
LIG_SUMO_SIM_anti_2	146	152	PF11976	0.489
LIG_SUMO_SIM_anti_2	18	25	PF11976	0.512
LIG_SUMO_SIM_par_1	146	152	PF11976	0.399
LIG_SUMO_SIM_par_1	18	25	PF11976	0.483
LIG_TRAF2_1	75	78	PF00917	0.586
LIG_TRAF2_1	80	83	PF00917	0.571
LIG_UBA3_1	333	340	PF00899	0.562
LIG_WRC_WIRS_1	158	163	PF05994	0.403
MOD_CDK_SPxK_1	315	321	PF00069	0.624
MOD_CDK_SPxK_1	345	351	PF00069	0.522
MOD_CK2_1	72	78	PF00069	0.596
MOD_CK2_1	99	105	PF00069	0.610
MOD_Cter_Amidation	234	237	PF01082	0.475
MOD_GlcNHglycan	1	4	PF01048	0.541
MOD_GlcNHglycan	114	117	PF01048	0.621
MOD_GlcNHglycan	124	127	PF01048	0.632
MOD_GlcNHglycan	252	255	PF01048	0.402
MOD_GlcNHglycan	289	292	PF01048	0.556
MOD_GlcNHglycan	303	306	PF01048	0.513
MOD_GlcNHglycan	73	77	PF01048	0.674
MOD_GSK3_1	108	115	PF00069	0.619
MOD_GSK3_1	246	253	PF00069	0.398
MOD_GSK3_1	254	261	PF00069	0.477
MOD_GSK3_1	262	269	PF00069	0.501
MOD_GSK3_1	301	308	PF00069	0.710
MOD_NEK2_1	1	6	PF00069	0.484
MOD_NEK2_1	109	114	PF00069	0.495
MOD_NEK2_1	149	154	PF00069	0.405
MOD_NEK2_1	15	20	PF00069	0.498
MOD_NEK2_1	262	267	PF00069	0.590
MOD_NEK2_1	46	51	PF00069	0.669
MOD_NEK2_1	63	68	PF00069	0.563
MOD_PIKK_1	254	260	PF00454	0.535
MOD_PIKK_1	321	327	PF00454	0.592
MOD_PKA_2	212	218	PF00069	0.481
MOD_PKA_2	46	52	PF00069	0.603
MOD_Plk_4	152	158	PF00069	0.468
MOD_Plk_4	243	249	PF00069	0.389
MOD_ProDKin_1	305	311	PF00069	0.740
MOD_ProDKin_1	315	321	PF00069	0.542
MOD_ProDKin_1	345	351	PF00069	0.662
TRG_DiLeu_BaLyEn_6	59	64	PF01217	0.598
TRG_ENDOCYTIC_2	106	109	PF00928	0.598
TRG_ENDOCYTIC_2	131	134	PF00928	0.658
TRG_ENDOCYTIC_2	158	161	PF00928	0.407
TRG_ENDOCYTIC_2	317	320	PF00928	0.715
TRG_ENDOCYTIC_2	93	96	PF00928	0.519
TRG_ER_diArg_1	142	145	PF00400	0.481
TRG_ER_diArg_1	225	228	PF00400	0.474
TRG_ER_diArg_1	85	88	PF00400	0.647
TRG_Pf-PMV_PEXEL_1	264	268	PF00026	0.522

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDD8	Leptomonas seymouri	61%	100%
A0A1X0NXM4	Trypanosomatidae	41%	100%
A0A3Q8IF37	Leishmania donovani	89%	98%
A0A3R7NME4	Trypanosoma rangeli	36%	100%
A4HZ71	Leishmania infantum	89%	98%
E9AIQ2	Leishmania braziliensis	76%	100%
E9AV38	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%