PUA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminoacyltransferase ATEL1, putative

Species:

Leishmania major

UniProt:

Q4QCE2_LEIMA

TriTrypDb:

LmjF.21.0725

Length:

377

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	9
GO:0110165	cellular anatomical entity	1	9
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QCE2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCE2

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	12
GO:0008152	metabolic process	1	12
GO:0009056	catabolic process	2	12
GO:0009057	macromolecule catabolic process	4	12
GO:0019538	protein metabolic process	3	12
GO:0030163	protein catabolic process	4	12
GO:0043170	macromolecule metabolic process	3	12
GO:0044238	primary metabolic process	2	12
GO:0071704	organic substance metabolic process	2	12
GO:1901564	organonitrogen compound metabolic process	3	12
GO:1901565	organonitrogen compound catabolic process	4	12
GO:1901575	organic substance catabolic process	3	12

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	12
GO:0008914	leucyltransferase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016746	acyltransferase activity	3	12
GO:0016755	aminoacyltransferase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	85	89	PF00656	0.406
CLV_NRD_NRD_1	153	155	PF00675	0.543
CLV_NRD_NRD_1	174	176	PF00675	0.314
CLV_NRD_NRD_1	187	189	PF00675	0.328
CLV_NRD_NRD_1	224	226	PF00675	0.306
CLV_NRD_NRD_1	318	320	PF00675	0.332
CLV_NRD_NRD_1	371	373	PF00675	0.525
CLV_PCSK_KEX2_1	187	189	PF00082	0.417
CLV_PCSK_KEX2_1	318	320	PF00082	0.382
CLV_PCSK_KEX2_1	344	346	PF00082	0.488
CLV_PCSK_KEX2_1	362	364	PF00082	0.555
CLV_PCSK_PC1ET2_1	344	346	PF00082	0.488
CLV_PCSK_PC1ET2_1	362	364	PF00082	0.555
CLV_PCSK_SKI1_1	154	158	PF00082	0.411
CLV_PCSK_SKI1_1	212	216	PF00082	0.438
CLV_PCSK_SKI1_1	362	366	PF00082	0.603
CLV_PCSK_SKI1_1	93	97	PF00082	0.249
DEG_APCC_DBOX_1	199	207	PF00400	0.294
DOC_CDC14_PxL_1	107	115	PF14671	0.282
DOC_CYCLIN_yCln2_LP_2	195	201	PF00134	0.339
DOC_MAPK_gen_1	175	182	PF00069	0.369
DOC_MAPK_gen_1	209	219	PF00069	0.279
DOC_MAPK_gen_1	298	306	PF00069	0.343
DOC_MAPK_gen_1	69	78	PF00069	0.361
DOC_MAPK_MEF2A_6	93	102	PF00069	0.316
DOC_PP2B_LxvP_1	108	111	PF13499	0.349
DOC_PP2B_LxvP_1	195	198	PF13499	0.403
DOC_PP4_FxxP_1	207	210	PF00568	0.352
DOC_USP7_MATH_1	160	164	PF00917	0.498
DOC_USP7_UBL2_3	212	216	PF12436	0.421
DOC_USP7_UBL2_3	357	361	PF12436	0.597
DOC_USP7_UBL2_3	362	366	PF12436	0.562
DOC_WW_Pin1_4	233	238	PF00397	0.595
DOC_WW_Pin1_4	76	81	PF00397	0.377
LIG_14-3-3_CanoR_1	28	36	PF00244	0.271
LIG_BRCT_BRCA1_1	78	82	PF00533	0.280
LIG_CaM_IQ_9	3	19	PF13499	0.390
LIG_FHA_1	213	219	PF00498	0.262
LIG_FHA_1	97	103	PF00498	0.254
LIG_FHA_2	63	69	PF00498	0.396
LIG_LIR_Gen_1	168	173	PF02991	0.309
LIG_LIR_Gen_1	309	317	PF02991	0.343
LIG_LIR_Nem_3	168	172	PF02991	0.307
LIG_LIR_Nem_3	181	186	PF02991	0.259
LIG_LIR_Nem_3	75	81	PF02991	0.310
LIG_Pex14_2	78	82	PF04695	0.295
LIG_REV1ctd_RIR_1	205	209	PF16727	0.275
LIG_SH2_CRK	227	231	PF00017	0.374
LIG_SH2_GRB2like	227	230	PF00017	0.377
LIG_SH2_NCK_1	227	231	PF00017	0.374
LIG_SH2_NCK_1	257	261	PF00017	0.282
LIG_SH2_STAP1	213	217	PF00017	0.351
LIG_SH2_STAT5	251	254	PF00017	0.270
LIG_SH2_STAT5	264	267	PF00017	0.265
LIG_SH2_STAT5	329	332	PF00017	0.459
LIG_SH2_STAT5	5	8	PF00017	0.455
LIG_SH3_3	301	307	PF00018	0.308
LIG_SUMO_SIM_par_1	177	184	PF11976	0.296
LIG_SUMO_SIM_par_1	98	104	PF11976	0.334
LIG_UBA3_1	203	209	PF00899	0.287
LIG_UBA3_1	326	335	PF00899	0.545
LIG_WRC_WIRS_1	50	55	PF05994	0.484
MOD_CK1_1	233	239	PF00069	0.545
MOD_CK1_1	31	37	PF00069	0.448
MOD_CK2_1	62	68	PF00069	0.345
MOD_GlcNHglycan	258	261	PF01048	0.276
MOD_GlcNHglycan	266	269	PF01048	0.296
MOD_GlcNHglycan	282	285	PF01048	0.301
MOD_GlcNHglycan	315	318	PF01048	0.435
MOD_GlcNHglycan	72	75	PF01048	0.413
MOD_GSK3_1	150	157	PF00069	0.409
MOD_GSK3_1	161	168	PF00069	0.333
MOD_GSK3_1	208	215	PF00069	0.317
MOD_GSK3_1	225	232	PF00069	0.356
MOD_GSK3_1	264	271	PF00069	0.302
MOD_GSK3_1	293	300	PF00069	0.513
MOD_N-GLC_1	160	165	PF02516	0.441
MOD_NEK2_1	1	6	PF00069	0.435
MOD_NEK2_1	150	155	PF00069	0.362
MOD_NEK2_1	272	277	PF00069	0.323
MOD_NEK2_1	293	298	PF00069	0.558
MOD_PIKK_1	28	34	PF00454	0.299
MOD_PIKK_1	355	361	PF00454	0.483
MOD_PKA_1	154	160	PF00069	0.491
MOD_PKA_1	225	231	PF00069	0.323
MOD_PKA_2	165	171	PF00069	0.294
MOD_PKA_2	7	13	PF00069	0.447
MOD_PKB_1	223	231	PF00069	0.421
MOD_Plk_1	128	134	PF00069	0.292
MOD_Plk_2-3	62	68	PF00069	0.393
MOD_Plk_4	1	7	PF00069	0.511
MOD_Plk_4	325	331	PF00069	0.415
MOD_Plk_4	49	55	PF00069	0.439
MOD_Plk_4	82	88	PF00069	0.384
MOD_Plk_4	96	102	PF00069	0.262
MOD_ProDKin_1	233	239	PF00069	0.583
MOD_ProDKin_1	76	82	PF00069	0.373
MOD_SUMO_for_1	364	367	PF00179	0.545
TRG_DiLeu_BaEn_1	248	253	PF01217	0.301
TRG_ENDOCYTIC_2	227	230	PF00928	0.386
TRG_ER_diArg_1	186	188	PF00400	0.413
TRG_ER_diArg_1	222	225	PF00400	0.279
TRG_NLS_Bipartite_1	344	366	PF00514	0.386
TRG_NLS_MonoExtC_3	360	365	PF00514	0.568
TRG_NLS_MonoExtN_4	361	366	PF00514	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0U9	Leptomonas seymouri	58%	77%
A0A0S4JCB2	Bodo saltans	45%	98%
A0A1X0NY04	Trypanosomatidae	44%	100%
A0A3Q8IAU3	Leishmania donovani	93%	99%
A0A3R7KMU3	Trypanosoma rangeli	48%	100%
A4HBR8	Leishmania braziliensis	83%	99%
A4HZ72	Leishmania infantum	92%	99%
D0A1G6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9AV39	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	99%
V5BIF1	Trypanosoma cruzi	46%	100%