Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24

Quick info Annotations Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

MICOS complex subunit MIC10-1, putative

Species:

Leishmania major

UniProt:

Q4QCE0_LEIMA

TriTrypDb:

LmjF.21.0735 , LMJLV39_210013200 , LMJSD75_210013200

Length:

142

Annotations

LeishMANIAdb annotations

Likely part of the mitochondrial MICOS complex, based on homology.. It is possible that this protein only has a single TM segment as the first can also be a transit signal.. Localization: Mitochondrial inner membrane (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0032991	protein-containing complex	1	6
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0061617	MICOS complex	4	6
GO:0098796	membrane protein complex	2	6
GO:0098798	mitochondrial protein-containing complex	2	6
GO:0098800	inner mitochondrial membrane protein complex	3	6
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCE0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCE0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	118	122	PF00082	0.436
CLV_PCSK_SKI1_1	57	61	PF00082	0.734
DOC_PP2B_PxIxI_1	1	7	PF00149	0.404
DOC_USP7_MATH_1	138	142	PF00917	0.784
DOC_USP7_MATH_1	33	37	PF00917	0.593
DOC_USP7_UBL2_3	43	47	PF12436	0.572
LIG_14-3-3_CanoR_1	23	31	PF00244	0.427
LIG_BRCT_BRCA1_1	77	81	PF00533	0.529
LIG_eIF4E_1	15	21	PF01652	0.384
LIG_FHA_1	115	121	PF00498	0.436
LIG_FHA_1	23	29	PF00498	0.418
LIG_FHA_2	51	57	PF00498	0.756
LIG_LIR_Gen_1	63	74	PF02991	0.529
LIG_LIR_Nem_3	63	69	PF02991	0.529
LIG_NRBOX	16	22	PF00104	0.375
LIG_NRBOX	8	14	PF00104	0.373
LIG_SH2_STAT5	114	117	PF00017	0.529
LIG_SH2_STAT5	119	122	PF00017	0.629
LIG_SH2_STAT5	68	71	PF00017	0.476
LIG_SH3_3	132	138	PF00018	0.724
LIG_SUMO_SIM_par_1	2	7	PF11976	0.396
MOD_CK1_1	36	42	PF00069	0.578
MOD_CK1_1	67	73	PF00069	0.383
MOD_CK1_1	94	100	PF00069	0.529
MOD_GlcNHglycan	131	134	PF01048	0.792
MOD_GSK3_1	110	117	PF00069	0.348
MOD_GSK3_1	60	67	PF00069	0.428
MOD_GSK3_1	99	106	PF00069	0.529
MOD_N-GLC_2	22	24	PF02516	0.408
MOD_NEK2_1	49	54	PF00069	0.759
MOD_NEK2_1	60	65	PF00069	0.348
MOD_PIKK_1	60	66	PF00454	0.529
MOD_PKA_2	22	28	PF00069	0.413
MOD_Plk_1	33	39	PF00069	0.613
MOD_Plk_1	50	56	PF00069	0.633
MOD_Plk_1	70	76	PF00069	0.199
MOD_Plk_4	110	116	PF00069	0.373
MOD_Plk_4	126	132	PF00069	0.629
MOD_Plk_4	50	56	PF00069	0.756
MOD_Plk_4	85	91	PF00069	0.467
MOD_SUMO_rev_2	113	120	PF00179	0.529
TRG_PTS1	139	142	PF00515	0.561

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IB36	Leishmania donovani	98%	100%
A4HBS0	Leishmania braziliensis	95%	100%
A4HZ74	Leishmania infantum	98%	100%
E9AV41	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%