Hyperconserved component of the mitochondrial FoF1 synthase complex. Likely contains a transit signal as well.. Interestingly, this gene duplicated in parazitic kinetoplastids multiple times.. Localization: Mitochondrial (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 25 |
| NetGPI | no | yes: 0, no: 25 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0000276 | mitochondrial proton-transporting ATP synthase complex, coupling factor F(o) | 4 | 3 |
| GO:0005739 | mitochondrion | 5 | 2 |
| GO:0016020 | membrane | 2 | 26 |
| GO:0032991 | protein-containing complex | 1 | 26 |
| GO:0033177 | proton-transporting two-sector ATPase complex, proton-transporting domain | 3 | 26 |
| GO:0043226 | organelle | 2 | 2 |
| GO:0043227 | membrane-bounded organelle | 3 | 2 |
| GO:0043229 | intracellular organelle | 3 | 2 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 2 |
| GO:0045263 | proton-transporting ATP synthase complex, coupling factor F(o) | 4 | 26 |
| GO:0098796 | membrane protein complex | 2 | 26 |
| GO:0098798 | mitochondrial protein-containing complex | 2 | 3 |
| GO:0098800 | inner mitochondrial membrane protein complex | 3 | 3 |
| GO:0110165 | cellular anatomical entity | 1 | 26 |
Related structures:
AlphaFold database: Q4QCD9
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0006139 | nucleobase-containing compound metabolic process | 3 | 26 |
| GO:0006163 | purine nucleotide metabolic process | 5 | 26 |
| GO:0006164 | purine nucleotide biosynthetic process | 6 | 26 |
| GO:0006725 | cellular aromatic compound metabolic process | 3 | 26 |
| GO:0006753 | nucleoside phosphate metabolic process | 4 | 26 |
| GO:0006754 | ATP biosynthetic process | 8 | 26 |
| GO:0006793 | phosphorus metabolic process | 3 | 26 |
| GO:0006796 | phosphate-containing compound metabolic process | 4 | 26 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 26 |
| GO:0008152 | metabolic process | 1 | 26 |
| GO:0009058 | biosynthetic process | 2 | 26 |
| GO:0009117 | nucleotide metabolic process | 5 | 26 |
| GO:0009141 | nucleoside triphosphate metabolic process | 5 | 26 |
| GO:0009142 | nucleoside triphosphate biosynthetic process | 6 | 26 |
| GO:0009144 | purine nucleoside triphosphate metabolic process | 6 | 26 |
| GO:0009145 | purine nucleoside triphosphate biosynthetic process | 7 | 26 |
| GO:0009150 | purine ribonucleotide metabolic process | 6 | 26 |
| GO:0009152 | purine ribonucleotide biosynthetic process | 7 | 26 |
| GO:0009165 | nucleotide biosynthetic process | 6 | 26 |
| GO:0009199 | ribonucleoside triphosphate metabolic process | 6 | 26 |
| GO:0009201 | ribonucleoside triphosphate biosynthetic process | 7 | 26 |
| GO:0009205 | purine ribonucleoside triphosphate metabolic process | 7 | 26 |
| GO:0009206 | purine ribonucleoside triphosphate biosynthetic process | 8 | 26 |
| GO:0009259 | ribonucleotide metabolic process | 5 | 26 |
| GO:0009260 | ribonucleotide biosynthetic process | 6 | 26 |
| GO:0009987 | cellular process | 1 | 26 |
| GO:0015986 | proton motive force-driven ATP synthesis | 9 | 26 |
| GO:0018130 | heterocycle biosynthetic process | 4 | 26 |
| GO:0019438 | aromatic compound biosynthetic process | 4 | 26 |
| GO:0019637 | organophosphate metabolic process | 3 | 26 |
| GO:0019693 | ribose phosphate metabolic process | 4 | 26 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 26 |
| GO:0034654 | nucleobase-containing compound biosynthetic process | 4 | 26 |
| GO:0044237 | cellular metabolic process | 2 | 26 |
| GO:0044238 | primary metabolic process | 2 | 26 |
| GO:0044249 | cellular biosynthetic process | 3 | 26 |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 4 | 26 |
| GO:0044281 | small molecule metabolic process | 2 | 26 |
| GO:0046034 | ATP metabolic process | 7 | 26 |
| GO:0046390 | ribose phosphate biosynthetic process | 5 | 26 |
| GO:0046483 | heterocycle metabolic process | 3 | 26 |
| GO:0055086 | nucleobase-containing small molecule metabolic process | 3 | 26 |
| GO:0071704 | organic substance metabolic process | 2 | 26 |
| GO:0072521 | purine-containing compound metabolic process | 4 | 26 |
| GO:0072522 | purine-containing compound biosynthetic process | 5 | 26 |
| GO:0090407 | organophosphate biosynthetic process | 4 | 26 |
| GO:1901135 | carbohydrate derivative metabolic process | 3 | 26 |
| GO:1901137 | carbohydrate derivative biosynthetic process | 4 | 26 |
| GO:1901293 | nucleoside phosphate biosynthetic process | 5 | 26 |
| GO:1901360 | organic cyclic compound metabolic process | 3 | 26 |
| GO:1901362 | organic cyclic compound biosynthetic process | 4 | 26 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 26 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 26 |
| GO:1901576 | organic substance biosynthetic process | 3 | 26 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0005215 | transporter activity | 1 | 26 |
| GO:0005488 | binding | 1 | 26 |
| GO:0008289 | lipid binding | 2 | 26 |
| GO:0008324 | monoatomic cation transmembrane transporter activity | 4 | 26 |
| GO:0015075 | monoatomic ion transmembrane transporter activity | 3 | 26 |
| GO:0015078 | proton transmembrane transporter activity | 5 | 26 |
| GO:0015318 | inorganic molecular entity transmembrane transporter activity | 3 | 26 |
| GO:0016787 | hydrolase activity | 2 | 12 |
| GO:0022857 | transmembrane transporter activity | 2 | 26 |
| GO:0022890 | inorganic cation transmembrane transporter activity | 4 | 26 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 12 | 14 | PF00675 | 0.578 |
| CLV_NRD_NRD_1 | 3 | 5 | PF00675 | 0.580 |
| CLV_PCSK_KEX2_1 | 12 | 14 | PF00082 | 0.578 |
| CLV_PCSK_KEX2_1 | 3 | 5 | PF00082 | 0.580 |
| CLV_PCSK_SKI1_1 | 76 | 80 | PF00082 | 0.232 |
| DOC_CYCLIN_yClb5_NLxxxL_5 | 70 | 78 | PF00134 | 0.432 |
| DOC_MAPK_MEF2A_6 | 26 | 35 | PF00069 | 0.351 |
| DOC_USP7_MATH_1 | 15 | 19 | PF00917 | 0.416 |
| LIG_14-3-3_CanoR_1 | 26 | 32 | PF00244 | 0.357 |
| LIG_FHA_1 | 28 | 34 | PF00498 | 0.349 |
| LIG_FHA_1 | 73 | 79 | PF00498 | 0.432 |
| LIG_FHA_1 | 87 | 93 | PF00498 | 0.285 |
| LIG_LIR_LC3C_4 | 18 | 23 | PF02991 | 0.416 |
| LIG_PCNA_yPIPBox_3 | 70 | 78 | PF02747 | 0.432 |
| LIG_Pex14_2 | 101 | 105 | PF04695 | 0.237 |
| LIG_SH2_CRK | 81 | 85 | PF00017 | 0.432 |
| LIG_SH2_STAT5 | 40 | 43 | PF00017 | 0.280 |
| LIG_SH3_3 | 19 | 25 | PF00018 | 0.414 |
| LIG_SUMO_SIM_par_1 | 29 | 34 | PF11976 | 0.348 |
| MOD_CK1_1 | 29 | 35 | PF00069 | 0.424 |
| MOD_GlcNHglycan | 18 | 21 | PF01048 | 0.582 |
| MOD_GSK3_1 | 27 | 34 | PF00069 | 0.350 |
| MOD_N-GLC_1 | 72 | 77 | PF02516 | 0.232 |
| TRG_ENDOCYTIC_2 | 81 | 84 | PF00928 | 0.432 |
| TRG_ER_diArg_1 | 2 | 4 | PF00400 | 0.380 |
| TRG_Pf-PMV_PEXEL_1 | 4 | 8 | PF00026 | 0.627 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0N1PC53 | Leptomonas seymouri | 89% | 100% |
| A0A0N1PD25 | Leptomonas seymouri | 89% | 100% |
| A0A0S4JH41 | Bodo saltans | 73% | 100% |
| A0A0S4JIC3 | Bodo saltans | 78% | 100% |
| A0A1X0NII7 | Trypanosomatidae | 80% | 97% |
| A0A1X0NQ50 | Trypanosomatidae | 81% | 99% |
| A0A1X0NXV8 | Trypanosomatidae | 79% | 100% |
| A0A381MIF8 | Leishmania infantum | 99% | 100% |
| A0A3R7KS23 | Trypanosoma rangeli | 80% | 99% |
| A0A3R7NDI3 | Trypanosoma rangeli | 82% | 99% |
| A0A3S5H621 | Leishmania donovani | 98% | 100% |
| A0A3S7WZM0 | Leishmania donovani | 99% | 100% |
| A0A422NA05 | Trypanosoma rangeli | 79% | 100% |
| A0A422NVI6 | Trypanosoma rangeli | 81% | 97% |
| A1XQS5 | Sus scrofa | 47% | 78% |
| A4HBS1 | Leishmania braziliensis | 87% | 100% |
| A4HEQ2 | Leishmania braziliensis | 87% | 100% |
| A4HZ75 | Leishmania infantum | 97% | 100% |
| A8EX89 | Rickettsia canadensis (strain McKiel) | 41% | 100% |
| B3CLG2 | Wolbachia pipientis subsp. Culex pipiens (strain wPip) | 36% | 100% |
| C0R5U2 | Wolbachia sp. subsp. Drosophila simulans (strain wRi) | 36% | 100% |
| C9ZS37 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 72% | 91% |
| D0A1G3 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 70% | 90% |
| D0A727 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 72% | 70% |
| E9AV42 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 93% | 100% |
| E9AWQ3 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 95% | 100% |
| P00842 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 54% | 72% |
| P05496 | Homo sapiens | 46% | 78% |
| P07926 | Bos taurus | 41% | 74% |
| P15014 | Rhodospirillum rubrum | 39% | 100% |
| P17605 | Ovis aries | 51% | 78% |
| P21537 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 54% | 100% |
| P32876 | Bos taurus | 51% | 78% |
| P48201 | Homo sapiens | 48% | 75% |
| P48880 | Chondrus crispus | 54% | 100% |
| P56383 | Mus musculus | 51% | 73% |
| P56384 | Mus musculus | 51% | 75% |
| Q01554 | Trichophyton rubrum | 58% | 100% |
| Q03672 | Podospora anserina | 54% | 74% |
| Q06056 | Ovis aries | 41% | 74% |
| Q06645 | Rattus norvegicus | 48% | 78% |
| Q06646 | Rattus norvegicus | 51% | 75% |
| Q0BQY6 | Granulibacter bethesdensis (strain ATCC BAA-1260 / CGDNIH1) | 51% | 100% |
| Q12635 | Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) | 58% | 100% |
| Q2GE12 | Neorickettsia sennetsu (strain ATCC VR-367 / Miyayama) | 40% | 100% |
| Q2LCR3 | Dictyostelium citrinum | 45% | 100% |
| Q2RPA5 | Rhodospirillum rubrum (strain ATCC 11170 / ATH 1.1.1 / DSM 467 / LMG 4362 / NCIMB 8255 / S1) | 39% | 100% |
| Q37315 | Dictyostelium discoideum | 45% | 100% |
| Q37377 | Acanthamoeba castellanii | 52% | 100% |
| Q3ZC75 | Bos taurus | 48% | 75% |
| Q4A8W4 | Mesomycoplasma hyopneumoniae (strain 7448) | 31% | 100% |
| Q4AAW2 | Mesomycoplasma hyopneumoniae (strain J / ATCC 25934 / NCTC 10110) | 33% | 100% |
| Q4QAS0 | Leishmania major | 99% | 100% |
| Q5FRW6 | Gluconobacter oxydans (strain 621H) | 49% | 100% |
| Q5RFL2 | Pongo abelii | 48% | 75% |
| Q602A0 | Mesomycoplasma hyopneumoniae (strain 232) | 32% | 100% |
| Q68XQ0 | Rickettsia typhi (strain ATCC VR-144 / Wilmington) | 39% | 100% |
| Q71S46 | Rattus norvegicus | 48% | 75% |
| Q73HW2 | Wolbachia pipientis wMel | 36% | 100% |
| Q9CR84 | Mus musculus | 48% | 78% |
| Q9U505 | Manduca sexta | 52% | 81% |
| Q9ZEC2 | Rickettsia prowazekii (strain Madrid E) | 38% | 100% |
| V5B9K0 | Trypanosoma cruzi | 87% | 97% |