Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 91, putative

Species:

Leishmania major

UniProt:

Q4QCD8_LEIMA

TriTrypDb:

LmjF.21.0750 , LMJLV39_210013400 , LMJSD75_210013400

Length:

721

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCD8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCD8

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	1
GO:0006796	phosphate-containing compound metabolic process	4	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016310	phosphorylation	5	1
GO:0044237	cellular metabolic process	2	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016740	transferase activity	2	1
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	545	549	PF00656	0.572
CLV_NRD_NRD_1	152	154	PF00675	0.606
CLV_NRD_NRD_1	33	35	PF00675	0.386
CLV_NRD_NRD_1	412	414	PF00675	0.656
CLV_NRD_NRD_1	512	514	PF00675	0.387
CLV_NRD_NRD_1	619	621	PF00675	0.637
CLV_PCSK_KEX2_1	412	414	PF00082	0.656
CLV_PCSK_KEX2_1	512	514	PF00082	0.378
CLV_PCSK_KEX2_1	619	621	PF00082	0.591
CLV_PCSK_PC7_1	615	621	PF00082	0.625
CLV_PCSK_SKI1_1	160	164	PF00082	0.410
CLV_PCSK_SKI1_1	206	210	PF00082	0.447
CLV_PCSK_SKI1_1	278	282	PF00082	0.644
CLV_PCSK_SKI1_1	284	288	PF00082	0.410
CLV_PCSK_SKI1_1	475	479	PF00082	0.383
CLV_PCSK_SKI1_1	488	492	PF00082	0.370
CLV_PCSK_SKI1_1	512	516	PF00082	0.379
CLV_PCSK_SKI1_1	529	533	PF00082	0.351
CLV_Separin_Metazoa	592	596	PF03568	0.578
DEG_APCC_KENBOX_2	309	313	PF00400	0.455
DEG_Nend_UBRbox_3	1	3	PF02207	0.466
DEG_SPOP_SBC_1	131	135	PF00917	0.525
DEG_SPOP_SBC_1	148	152	PF00917	0.302
DEG_SPOP_SBC_1	353	357	PF00917	0.391
DOC_ANK_TNKS_1	33	40	PF00023	0.337
DOC_CYCLIN_RxL_1	509	521	PF00134	0.385
DOC_CYCLIN_yCln2_LP_2	333	339	PF00134	0.466
DOC_CYCLIN_yCln2_LP_2	502	508	PF00134	0.423
DOC_MAPK_gen_1	308	315	PF00069	0.528
DOC_MAPK_gen_1	509	517	PF00069	0.420
DOC_MAPK_MEF2A_6	595	604	PF00069	0.607
DOC_PP1_RVXF_1	9	15	PF00149	0.374
DOC_PP2B_LxvP_1	163	166	PF13499	0.399
DOC_PP2B_LxvP_1	333	336	PF13499	0.483
DOC_PP2B_LxvP_1	502	505	PF13499	0.431
DOC_PP4_FxxP_1	146	149	PF00568	0.491
DOC_PP4_FxxP_1	162	165	PF00568	0.474
DOC_SPAK_OSR1_1	145	149	PF12202	0.490
DOC_SPAK_OSR1_1	3	7	PF12202	0.361
DOC_USP7_MATH_1	125	129	PF00917	0.409
DOC_USP7_MATH_1	13	17	PF00917	0.348
DOC_USP7_MATH_1	131	135	PF00917	0.471
DOC_USP7_MATH_1	149	153	PF00917	0.316
DOC_USP7_MATH_1	213	217	PF00917	0.506
DOC_USP7_MATH_1	269	273	PF00917	0.536
DOC_USP7_MATH_1	48	52	PF00917	0.390
DOC_USP7_MATH_1	586	590	PF00917	0.493
DOC_USP7_UBL2_3	31	35	PF12436	0.427
DOC_USP7_UBL2_3	668	672	PF12436	0.540
DOC_WW_Pin1_4	132	137	PF00397	0.463
DOC_WW_Pin1_4	438	443	PF00397	0.518
DOC_WW_Pin1_4	453	458	PF00397	0.461
DOC_WW_Pin1_4	539	544	PF00397	0.562
DOC_WW_Pin1_4	703	708	PF00397	0.701
LIG_14-3-3_CanoR_1	223	229	PF00244	0.361
LIG_14-3-3_CanoR_1	278	283	PF00244	0.441
LIG_14-3-3_CanoR_1	516	523	PF00244	0.412
LIG_14-3-3_CanoR_1	595	604	PF00244	0.502
LIG_14-3-3_CanoR_1	654	660	PF00244	0.529
LIG_Actin_WH2_2	368	383	PF00022	0.383
LIG_APCC_ABBA_1	237	242	PF00400	0.475
LIG_APCC_ABBAyCdc20_2	236	242	PF00400	0.481
LIG_BRCT_BRCA1_1	400	404	PF00533	0.463
LIG_Clathr_ClatBox_1	200	204	PF01394	0.506
LIG_deltaCOP1_diTrp_1	158	162	PF00928	0.585
LIG_deltaCOP1_diTrp_1	91	97	PF00928	0.326
LIG_EH_1	401	405	PF12763	0.493
LIG_FHA_1	100	106	PF00498	0.353
LIG_FHA_1	186	192	PF00498	0.321
LIG_FHA_1	225	231	PF00498	0.354
LIG_FHA_1	266	272	PF00498	0.605
LIG_FHA_1	456	462	PF00498	0.602
LIG_FHA_1	472	478	PF00498	0.388
LIG_FHA_1	482	488	PF00498	0.381
LIG_FHA_1	497	503	PF00498	0.488
LIG_FHA_1	549	555	PF00498	0.463
LIG_FHA_1	90	96	PF00498	0.350
LIG_FHA_2	265	271	PF00498	0.497
LIG_FHA_2	413	419	PF00498	0.725
LIG_FHA_2	550	556	PF00498	0.519
LIG_GBD_Chelix_1	372	380	PF00786	0.405
LIG_HCF-1_HBM_1	245	248	PF13415	0.385
LIG_LIR_Apic_2	144	149	PF02991	0.482
LIG_LIR_Gen_1	245	254	PF02991	0.358
LIG_LIR_Nem_3	158	162	PF02991	0.609
LIG_LIR_Nem_3	216	221	PF02991	0.424
LIG_LIR_Nem_3	245	251	PF02991	0.358
LIG_LIR_Nem_3	334	340	PF02991	0.425
LIG_LIR_Nem_3	348	354	PF02991	0.544
LIG_LIR_Nem_3	401	407	PF02991	0.499
LIG_LIR_Nem_3	635	641	PF02991	0.596
LIG_LIR_Nem_3	698	703	PF02991	0.541
LIG_NRBOX	522	528	PF00104	0.486
LIG_PCNA_yPIPBox_3	513	527	PF02747	0.444
LIG_PCNA_yPIPBox_3	610	624	PF02747	0.621
LIG_Pex14_1	14	18	PF04695	0.364
LIG_Pex14_2	296	300	PF04695	0.476
LIG_PTAP_UEV_1	456	461	PF05743	0.346
LIG_RPA_C_Fungi	582	594	PF08784	0.501
LIG_SH2_CRK	248	252	PF00017	0.362
LIG_SH2_NCK_1	248	252	PF00017	0.398
LIG_SH2_NCK_1	447	451	PF00017	0.356
LIG_SH2_PTP2	337	340	PF00017	0.306
LIG_SH2_SRC	337	340	PF00017	0.488
LIG_SH2_STAP1	248	252	PF00017	0.362
LIG_SH2_STAP1	596	600	PF00017	0.604
LIG_SH2_STAP1	655	659	PF00017	0.669
LIG_SH2_STAT3	219	222	PF00017	0.496
LIG_SH2_STAT3	263	266	PF00017	0.390
LIG_SH2_STAT5	219	222	PF00017	0.409
LIG_SH2_STAT5	263	266	PF00017	0.425
LIG_SH2_STAT5	337	340	PF00017	0.390
LIG_SH2_STAT5	655	658	PF00017	0.536
LIG_SH3_3	326	332	PF00018	0.474
LIG_SH3_3	333	339	PF00018	0.426
LIG_SH3_3	451	457	PF00018	0.382
LIG_SH3_3	502	508	PF00018	0.469
LIG_SH3_3	537	543	PF00018	0.557
LIG_SUMO_SIM_anti_2	188	193	PF11976	0.374
LIG_SUMO_SIM_anti_2	197	202	PF11976	0.400
LIG_SUMO_SIM_par_1	187	193	PF11976	0.457
LIG_SUMO_SIM_par_1	226	232	PF11976	0.398
LIG_TRAF2_1	347	350	PF00917	0.448
LIG_TRAF2_1	356	359	PF00917	0.353
LIG_TRAF2_1	415	418	PF00917	0.646
LIG_TRAF2_1	421	424	PF00917	0.544
LIG_TYR_ITIM	335	340	PF00017	0.375
LIG_UBA3_1	189	195	PF00899	0.385
LIG_WRC_WIRS_1	49	54	PF05994	0.392
LIG_WW_3	164	168	PF00397	0.406
MOD_CDK_SPxxK_3	132	139	PF00069	0.440
MOD_CK1_1	129	135	PF00069	0.572
MOD_CK1_1	232	238	PF00069	0.400
MOD_CK1_1	345	351	PF00069	0.594
MOD_CK1_1	364	370	PF00069	0.281
MOD_CK1_1	388	394	PF00069	0.478
MOD_CK1_1	455	461	PF00069	0.467
MOD_CK1_1	542	548	PF00069	0.545
MOD_CK1_1	64	70	PF00069	0.520
MOD_CK1_1	689	695	PF00069	0.607
MOD_CK2_1	250	256	PF00069	0.505
MOD_CK2_1	264	270	PF00069	0.467
MOD_CK2_1	344	350	PF00069	0.449
MOD_CK2_1	353	359	PF00069	0.443
MOD_CK2_1	412	418	PF00069	0.758
MOD_CK2_1	516	522	PF00069	0.514
MOD_CK2_1	586	592	PF00069	0.613
MOD_CK2_1	595	601	PF00069	0.559
MOD_DYRK1A_RPxSP_1	453	457	PF00069	0.404
MOD_DYRK1A_RPxSP_1	539	543	PF00069	0.516
MOD_GlcNHglycan	129	132	PF01048	0.575
MOD_GlcNHglycan	181	184	PF01048	0.354
MOD_GlcNHglycan	213	216	PF01048	0.462
MOD_GlcNHglycan	252	255	PF01048	0.512
MOD_GlcNHglycan	363	366	PF01048	0.317
MOD_GlcNHglycan	416	421	PF01048	0.717
MOD_GlcNHglycan	435	438	PF01048	0.525
MOD_GlcNHglycan	56	59	PF01048	0.539
MOD_GlcNHglycan	621	624	PF01048	0.638
MOD_GlcNHglycan	66	69	PF01048	0.411
MOD_GlcNHglycan	676	679	PF01048	0.526
MOD_GSK3_1	123	130	PF00069	0.420
MOD_GSK3_1	13	20	PF00069	0.484
MOD_GSK3_1	190	197	PF00069	0.460
MOD_GSK3_1	213	220	PF00069	0.562
MOD_GSK3_1	265	272	PF00069	0.609
MOD_GSK3_1	371	378	PF00069	0.435
MOD_GSK3_1	381	388	PF00069	0.426
MOD_GSK3_1	408	415	PF00069	0.629
MOD_GSK3_1	448	455	PF00069	0.502
MOD_GSK3_1	482	489	PF00069	0.481
MOD_GSK3_1	492	499	PF00069	0.461
MOD_GSK3_1	530	537	PF00069	0.411
MOD_GSK3_1	650	657	PF00069	0.574
MOD_GSK3_1	99	106	PF00069	0.300
MOD_LATS_1	652	658	PF00433	0.613
MOD_N-GLC_1	481	486	PF02516	0.397
MOD_N-GLC_1	686	691	PF02516	0.466
MOD_N-GLC_1	76	81	PF02516	0.405
MOD_NEK2_1	141	146	PF00069	0.535
MOD_NEK2_1	190	195	PF00069	0.377
MOD_NEK2_1	264	269	PF00069	0.474
MOD_NEK2_1	296	301	PF00069	0.409
MOD_NEK2_1	302	307	PF00069	0.354
MOD_NEK2_1	375	380	PF00069	0.493
MOD_NEK2_1	471	476	PF00069	0.396
MOD_NEK2_1	567	572	PF00069	0.606
MOD_NEK2_1	594	599	PF00069	0.517
MOD_NEK2_1	603	608	PF00069	0.539
MOD_NEK2_1	83	88	PF00069	0.378
MOD_NEK2_2	13	18	PF00069	0.363
MOD_NEK2_2	339	344	PF00069	0.344
MOD_NEK2_2	448	453	PF00069	0.378
MOD_PIKK_1	108	114	PF00454	0.535
MOD_PIKK_1	354	360	PF00454	0.500
MOD_PIKK_1	385	391	PF00454	0.439
MOD_PIKK_1	516	522	PF00454	0.406
MOD_PIKK_1	628	634	PF00454	0.540
MOD_PKA_1	412	418	PF00069	0.616
MOD_PKA_1	619	625	PF00069	0.644
MOD_PKA_2	412	418	PF00069	0.616
MOD_PKA_2	452	458	PF00069	0.570
MOD_PKA_2	586	592	PF00069	0.475
MOD_PKA_2	594	600	PF00069	0.516
MOD_PKA_2	619	625	PF00069	0.644
MOD_PKA_2	653	659	PF00069	0.551
MOD_Plk_1	106	112	PF00069	0.372
MOD_Plk_1	521	527	PF00069	0.503
MOD_Plk_1	647	653	PF00069	0.634
MOD_Plk_1	689	695	PF00069	0.653
MOD_Plk_4	185	191	PF00069	0.416
MOD_Plk_4	278	284	PF00069	0.629
MOD_Plk_4	339	345	PF00069	0.329
MOD_Plk_4	371	377	PF00069	0.427
MOD_Plk_4	486	492	PF00069	0.457
MOD_Plk_4	522	528	PF00069	0.420
MOD_Plk_4	78	84	PF00069	0.391
MOD_ProDKin_1	132	138	PF00069	0.448
MOD_ProDKin_1	438	444	PF00069	0.509
MOD_ProDKin_1	453	459	PF00069	0.451
MOD_ProDKin_1	539	545	PF00069	0.558
MOD_ProDKin_1	703	709	PF00069	0.702
MOD_SUMO_for_1	571	574	PF00179	0.479
MOD_SUMO_rev_2	364	373	PF00179	0.375
MOD_SUMO_rev_2	57	65	PF00179	0.553
MOD_SUMO_rev_2	7	13	PF00179	0.384
TRG_DiLeu_BaEn_1	424	429	PF01217	0.589
TRG_DiLeu_BaEn_1	522	527	PF01217	0.428
TRG_DiLeu_BaEn_2	157	163	PF01217	0.454
TRG_DiLeu_BaEn_2	310	316	PF01217	0.422
TRG_DiLeu_BaEn_2	466	472	PF01217	0.346
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.493
TRG_DiLeu_BaLyEn_6	677	682	PF01217	0.634
TRG_ENDOCYTIC_2	248	251	PF00928	0.339
TRG_ENDOCYTIC_2	337	340	PF00928	0.488
TRG_ER_diArg_1	233	236	PF00400	0.594
TRG_ER_diArg_1	511	513	PF00400	0.381
TRG_Pf-PMV_PEXEL_1	206	210	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	475	479	PF00026	0.536

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMD9	Leptomonas seymouri	53%	100%
A0A1X0NXN3	Trypanosomatidae	28%	88%
A0A3S5IR71	Trypanosoma rangeli	28%	87%
A0A3S7WWJ2	Leishmania donovani	93%	100%
A4HBS2	Leishmania braziliensis	83%	100%
A4HZ76	Leishmania infantum	94%	100%
D0A1G1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	87%
E9AV43	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5AYE8	Trypanosoma cruzi	30%	88%