19S proteasome regulatory subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit 5, putative

Species:

Leishmania major

UniProt:

Q4QCD7_LEIMA

TriTrypDb:

LmjF.21.0760 , LMJLV39_210013500 , LMJSD75_210013500

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0005838	proteasome regulatory particle	2	12
GO:0008541	proteasome regulatory particle, lid subcomplex	2	2
GO:0031595	nuclear proteasome complex	3	2
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:0140535	intracellular protein-containing complex	2	2
GO:1902494	catalytic complex	2	2
GO:1905368	peptidase complex	3	2
GO:1905369	endopeptidase complex	4	2

Expansion

Sequence features

Q4QCD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCD7

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043632	modification-dependent macromolecule catabolic process	5	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044248	cellular catabolic process	3	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0044265	obsolete cellular macromolecule catabolic process	4	2
GO:0051603	proteolysis involved in protein catabolic process	5	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004175	endopeptidase activity	4	2
GO:0008233	peptidase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	440	444	PF00656	0.582
CLV_MEL_PAP_1	339	345	PF00089	0.634
CLV_NRD_NRD_1	162	164	PF00675	0.596
CLV_NRD_NRD_1	211	213	PF00675	0.505
CLV_NRD_NRD_1	430	432	PF00675	0.657
CLV_NRD_NRD_1	470	472	PF00675	0.767
CLV_PCSK_KEX2_1	164	166	PF00082	0.513
CLV_PCSK_KEX2_1	389	391	PF00082	0.400
CLV_PCSK_KEX2_1	97	99	PF00082	0.559
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.513
CLV_PCSK_PC1ET2_1	389	391	PF00082	0.399
CLV_PCSK_PC1ET2_1	97	99	PF00082	0.559
CLV_PCSK_PC7_1	385	391	PF00082	0.435
CLV_Separin_Metazoa	233	237	PF03568	0.489
CLV_Separin_Metazoa	73	77	PF03568	0.593
DEG_APCC_DBOX_1	316	324	PF00400	0.594
DEG_APCC_DBOX_1	384	392	PF00400	0.549
DOC_CDC14_PxL_1	320	328	PF14671	0.539
DOC_MAPK_gen_1	389	397	PF00069	0.570
DOC_MAPK_gen_1	418	428	PF00069	0.549
DOC_MAPK_gen_1	76	86	PF00069	0.578
DOC_MAPK_MEF2A_6	79	88	PF00069	0.586
DOC_MAPK_RevD_3	84	98	PF00069	0.532
DOC_SPAK_OSR1_1	149	153	PF12202	0.487
DOC_USP7_MATH_1	208	212	PF00917	0.520
DOC_WW_Pin1_4	395	400	PF00397	0.542
LIG_14-3-3_CanoR_1	163	171	PF00244	0.611
LIG_14-3-3_CanoR_1	27	37	PF00244	0.656
LIG_14-3-3_CanoR_1	342	350	PF00244	0.580
LIG_14-3-3_CanoR_1	370	378	PF00244	0.554
LIG_14-3-3_CanoR_1	431	441	PF00244	0.631
LIG_14-3-3_CanoR_1	76	86	PF00244	0.587
LIG_BIR_II_1	1	5	PF00653	0.720
LIG_Clathr_ClatBox_1	425	429	PF01394	0.561
LIG_Clathr_ClatBox_1	51	55	PF01394	0.476
LIG_Clathr_ClatBox_1	69	73	PF01394	0.471
LIG_deltaCOP1_diTrp_1	3	11	PF00928	0.687
LIG_eIF4E_1	204	210	PF01652	0.513
LIG_FAT_LD_1	84	92	PF03623	0.609
LIG_FHA_1	149	155	PF00498	0.586
LIG_FHA_1	171	177	PF00498	0.648
LIG_FHA_1	19	25	PF00498	0.577
LIG_FHA_1	30	36	PF00498	0.565
LIG_FHA_1	432	438	PF00498	0.587
LIG_FHA_1	65	71	PF00498	0.481
LIG_FHA_2	154	160	PF00498	0.600
LIG_FHA_2	281	287	PF00498	0.639
LIG_FHA_2	309	315	PF00498	0.665
LIG_FHA_2	351	357	PF00498	0.608
LIG_FHA_2	360	366	PF00498	0.468
LIG_FHA_2	78	84	PF00498	0.587
LIG_LIR_Gen_1	202	210	PF02991	0.603
LIG_LIR_Gen_1	254	263	PF02991	0.617
LIG_LIR_Gen_1	414	422	PF02991	0.580
LIG_LIR_LC3C_4	423	427	PF02991	0.561
LIG_LIR_Nem_3	202	207	PF02991	0.606
LIG_LIR_Nem_3	243	248	PF02991	0.505
LIG_LIR_Nem_3	254	259	PF02991	0.424
LIG_MYND_1	355	359	PF01753	0.650
LIG_MYND_3	182	186	PF01753	0.591
LIG_NRBOX	325	331	PF00104	0.492
LIG_Pex14_1	252	256	PF04695	0.468
LIG_SH2_CRK	256	260	PF00017	0.610
LIG_SH2_CRK	327	331	PF00017	0.620
LIG_SH2_CRK	383	387	PF00017	0.561
LIG_SH2_NCK_1	204	208	PF00017	0.596
LIG_SH2_NCK_1	383	387	PF00017	0.628
LIG_SH2_SRC	204	207	PF00017	0.601
LIG_SH2_SRC	276	279	PF00017	0.465
LIG_SH2_STAT3	78	81	PF00017	0.532
LIG_SH2_STAT5	135	138	PF00017	0.611
LIG_SH2_STAT5	231	234	PF00017	0.457
LIG_SH2_STAT5	276	279	PF00017	0.449
LIG_SH2_STAT5	383	386	PF00017	0.590
LIG_SUMO_SIM_anti_2	335	341	PF11976	0.518
LIG_SUMO_SIM_anti_2	344	351	PF11976	0.545
LIG_SUMO_SIM_anti_2	375	380	PF11976	0.549
LIG_SUMO_SIM_anti_2	448	453	PF11976	0.543
LIG_SUMO_SIM_anti_2	83	90	PF11976	0.612
LIG_SUMO_SIM_par_1	150	156	PF11976	0.561
LIG_SUMO_SIM_par_1	31	40	PF11976	0.620
LIG_SUMO_SIM_par_1	50	55	PF11976	0.347
LIG_SUMO_SIM_par_1	66	73	PF11976	0.484
LIG_SxIP_EBH_1	27	39	PF03271	0.620
LIG_SxIP_EBH_1	379	390	PF03271	0.635
LIG_TRAF2_1	362	365	PF00917	0.549
LIG_TYR_ITIM	229	234	PF00017	0.497
LIG_UBA3_1	406	413	PF00899	0.574
LIG_UBA3_1	464	472	PF00899	0.684
LIG_UBA3_1	51	56	PF00899	0.484
LIG_UBA3_1	87	96	PF00899	0.582
MOD_CK1_1	18	24	PF00069	0.621
MOD_CK1_1	267	273	PF00069	0.524
MOD_CK1_1	310	316	PF00069	0.573
MOD_CK2_1	153	159	PF00069	0.595
MOD_CK2_1	280	286	PF00069	0.581
MOD_CK2_1	308	314	PF00069	0.642
MOD_CK2_1	315	321	PF00069	0.601
MOD_CK2_1	342	348	PF00069	0.573
MOD_CK2_1	350	356	PF00069	0.557
MOD_CK2_1	359	365	PF00069	0.480
MOD_CK2_1	77	83	PF00069	0.614
MOD_Cter_Amidation	161	164	PF01082	0.597
MOD_GlcNHglycan	105	108	PF01048	0.495
MOD_GlcNHglycan	14	20	PF01048	0.688
MOD_GlcNHglycan	165	168	PF01048	0.561
MOD_GlcNHglycan	266	269	PF01048	0.546
MOD_GSK3_1	255	262	PF00069	0.637
MOD_GSK3_1	365	372	PF00069	0.635
MOD_GSK3_1	395	402	PF00069	0.525
MOD_GSK3_1	437	444	PF00069	0.620
MOD_GSK3_1	453	460	PF00069	0.592
MOD_N-GLC_1	28	33	PF02516	0.583
MOD_N-GLC_1	280	285	PF02516	0.642
MOD_N-GLC_1	411	416	PF02516	0.428
MOD_N-GLC_1	432	437	PF02516	0.554
MOD_N-GLC_1	441	446	PF02516	0.559
MOD_N-GLC_2	369	371	PF02516	0.435
MOD_NEK2_1	170	175	PF00069	0.632
MOD_NEK2_1	350	355	PF00069	0.586
MOD_NEK2_1	36	41	PF00069	0.597
MOD_NEK2_1	405	410	PF00069	0.568
MOD_PIKK_1	77	83	PF00454	0.594
MOD_PK_1	332	338	PF00069	0.524
MOD_PKA_1	163	169	PF00069	0.615
MOD_PKA_1	431	437	PF00069	0.651
MOD_PKA_2	148	154	PF00069	0.585
MOD_PKA_2	341	347	PF00069	0.609
MOD_PKA_2	369	375	PF00069	0.545
MOD_PKA_2	37	43	PF00069	0.590
MOD_Plk_1	117	123	PF00069	0.658
MOD_Plk_1	28	34	PF00069	0.586
MOD_Plk_1	291	297	PF00069	0.543
MOD_Plk_1	411	417	PF00069	0.610
MOD_Plk_1	441	447	PF00069	0.555
MOD_Plk_2-3	153	159	PF00069	0.595
MOD_Plk_4	241	247	PF00069	0.543
MOD_Plk_4	405	411	PF00069	0.573
MOD_ProDKin_1	395	401	PF00069	0.542
MOD_SUMO_rev_2	261	267	PF00179	0.614
MOD_SUMO_rev_2	3	9	PF00179	0.757
TRG_DiLeu_BaEn_1	20	25	PF01217	0.685
TRG_ENDOCYTIC_2	204	207	PF00928	0.601
TRG_ENDOCYTIC_2	231	234	PF00928	0.485
TRG_ENDOCYTIC_2	256	259	PF00928	0.593
TRG_ENDOCYTIC_2	327	330	PF00928	0.611
TRG_ENDOCYTIC_2	383	386	PF00928	0.549
TRG_ENDOCYTIC_2	416	419	PF00928	0.549
TRG_NES_CRM1_1	189	205	PF08389	0.481
TRG_NES_CRM1_1	337	352	PF08389	0.664
TRG_Pf-PMV_PEXEL_1	172	177	PF00026	0.594
TRG_Pf-PMV_PEXEL_1	217	222	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	389	393	PF00026	0.416

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAV3	Leptomonas seymouri	90%	100%
A0A0S4IPZ2	Bodo saltans	51%	96%
A0A1X0NY92	Trypanosomatidae	67%	99%
A0A3S7WWF6	Leishmania donovani	99%	100%
A0A422NHB9	Trypanosoma rangeli	67%	99%
A4HBS3	Leishmania braziliensis	95%	100%
A4HZ77	Leishmania infantum	99%	100%
D0A1G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	98%
E9AV44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O00232	Homo sapiens	31%	100%
P0CU17	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
P0CU18	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	100%
Q12250	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	29%	100%
Q2KJ25	Bos taurus	31%	100%
Q54UJ0	Dictyostelium discoideum	31%	100%
Q5RBI3	Pongo abelii	31%	100%
Q8VWK0	Arabidopsis thaliana	29%	100%
Q9D8W5	Mus musculus	31%	100%
Q9FIB6	Arabidopsis thaliana	29%	100%
V5BDS8	Trypanosoma cruzi	65%	66%