19S proteasome regulatory subunit

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

proteasome regulatory non-ATP-ase subunit 5, putative

Species:

Leishmania major

UniProt:

Q4QCD7_LEIMA

TriTrypDb:

LmjF.21.0760 , LMJLV39_210013500 , LMJSD75_210013500

Length:

474

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	yes	yes: 2
Pissara et al.	yes	yes: 8

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 4

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 4

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000502	proteasome complex	3	2
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0005838	proteasome regulatory particle	2	12
GO:0008541	proteasome regulatory particle, lid subcomplex	2	2
GO:0031595	nuclear proteasome complex	3	2
GO:0032991	protein-containing complex	1	12
GO:0110165	cellular anatomical entity	1	2
GO:0140513	nuclear protein-containing complex	2	2
GO:0140535	intracellular protein-containing complex	2	2

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Expansion

Sequence features

Q4QCD7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCD7

Function

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Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	2
GO:0006511	ubiquitin-dependent protein catabolic process	7	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009056	catabolic process	2	2
GO:0009057	macromolecule catabolic process	4	2
GO:0009987	cellular process	1	2
GO:0019538	protein metabolic process	3	2
GO:0019941	modification-dependent protein catabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2

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Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	2
GO:0004175	endopeptidase activity	4	2
GO:0008233	peptidase activity	3	2
GO:0016787	hydrolase activity	2	2
GO:0140096	catalytic activity, acting on a protein	2	2

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	440	444	PF00656	0.582
CLV_MEL_PAP_1	339	345	PF00089	0.634
CLV_NRD_NRD_1	162	164	PF00675	0.596
CLV_NRD_NRD_1	211	213	PF00675	0.505
CLV_NRD_NRD_1	430	432	PF00675	0.657
CLV_NRD_NRD_1	470	472	PF00675	0.767
CLV_PCSK_KEX2_1	164	166	PF00082	0.513
CLV_PCSK_KEX2_1	389	391	PF00082	0.400
CLV_PCSK_KEX2_1	97	99	PF00082	0.559
CLV_PCSK_PC1ET2_1	164	166	PF00082	0.513

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IAV3	Leptomonas seymouri	90%	100%
A0A0S4IPZ2	Bodo saltans	51%	96%
A0A1X0NY92	Trypanosomatidae	67%	99%
A0A3S7WWF6	Leishmania donovani	99%	100%
A0A422NHB9	Trypanosoma rangeli	67%	99%
A4HBS3	Leishmania braziliensis	95%	100%
A4HZ77	Leishmania infantum	99%	100%
D0A1G0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	62%	98%
E9AV44	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
O00232	Homo sapiens	31%	100%

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