Zinc finger (CCCH type) motif-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCD6_LEIMA

TriTrypDb:

LmjF.21.0770 , LMJLV39_210013600 , LMJSD75_210013600

Length:

497

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCD6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCD6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	2
GO:0003723	RNA binding	4	2
GO:0005488	binding	1	2
GO:0097159	organic cyclic compound binding	2	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	187	189	PF00675	0.513
CLV_NRD_NRD_1	495	497	PF00675	0.743
CLV_NRD_NRD_1	81	83	PF00675	0.394
CLV_PCSK_KEX2_1	187	189	PF00082	0.472
CLV_PCSK_KEX2_1	208	210	PF00082	0.679
CLV_PCSK_KEX2_1	302	304	PF00082	0.632
CLV_PCSK_PC1ET2_1	208	210	PF00082	0.705
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.671
CLV_PCSK_SKI1_1	161	165	PF00082	0.544
CLV_PCSK_SKI1_1	354	358	PF00082	0.716
DEG_APCC_DBOX_1	84	92	PF00400	0.455
DEG_COP1_1	97	106	PF00400	0.472
DEG_SCF_FBW7_1	357	363	PF00400	0.715
DEG_SCF_FBW7_1	409	414	PF00400	0.721
DEG_SPOP_SBC_1	266	270	PF00917	0.654
DOC_CKS1_1	357	362	PF01111	0.749
DOC_CYCLIN_yCln2_LP_2	218	224	PF00134	0.431
DOC_CYCLIN_yCln2_LP_2	7	13	PF00134	0.650
DOC_CYCLIN_yCln2_LP_2	84	90	PF00134	0.484
DOC_MAPK_gen_1	82	92	PF00069	0.412
DOC_MAPK_MEF2A_6	82	90	PF00069	0.445
DOC_PP2B_LxvP_1	218	221	PF13499	0.399
DOC_PP2B_LxvP_1	253	256	PF13499	0.504
DOC_PP2B_LxvP_1	84	87	PF13499	0.385
DOC_PP2B_LxvP_1	90	93	PF13499	0.430
DOC_PP4_FxxP_1	13	16	PF00568	0.698
DOC_PP4_FxxP_1	27	30	PF00568	0.681
DOC_USP7_MATH_1	14	18	PF00917	0.780
DOC_USP7_MATH_1	195	199	PF00917	0.645
DOC_USP7_MATH_1	360	364	PF00917	0.716
DOC_USP7_MATH_1	446	450	PF00917	0.702
DOC_USP7_MATH_1	51	55	PF00917	0.741
DOC_USP7_UBL2_3	157	161	PF12436	0.466
DOC_USP7_UBL2_3	68	72	PF12436	0.602
DOC_WW_Pin1_4	137	142	PF00397	0.570
DOC_WW_Pin1_4	280	285	PF00397	0.616
DOC_WW_Pin1_4	308	313	PF00397	0.621
DOC_WW_Pin1_4	333	338	PF00397	0.630
DOC_WW_Pin1_4	356	361	PF00397	0.710
DOC_WW_Pin1_4	363	368	PF00397	0.701
DOC_WW_Pin1_4	369	374	PF00397	0.672
DOC_WW_Pin1_4	377	382	PF00397	0.653
DOC_WW_Pin1_4	407	412	PF00397	0.764
DOC_WW_Pin1_4	413	418	PF00397	0.748
DOC_WW_Pin1_4	440	445	PF00397	0.705
DOC_WW_Pin1_4	474	479	PF00397	0.725
DOC_WW_Pin1_4	96	101	PF00397	0.562
LIG_14-3-3_CanoR_1	179	185	PF00244	0.380
LIG_14-3-3_CanoR_1	307	312	PF00244	0.656
LIG_14-3-3_CanoR_1	358	368	PF00244	0.762
LIG_APCC_ABBA_1	347	352	PF00400	0.511
LIG_BIR_II_1	1	5	PF00653	0.734
LIG_BRCT_BRCA1_1	313	317	PF00533	0.701
LIG_BRCT_BRCA1_1	371	375	PF00533	0.753
LIG_CtBP_PxDLS_1	15	21	PF00389	0.526
LIG_deltaCOP1_diTrp_1	69	75	PF00928	0.497
LIG_EVH1_1	347	351	PF00568	0.509
LIG_EVH1_2	385	389	PF00568	0.696
LIG_FHA_1	181	187	PF00498	0.406
LIG_FHA_1	268	274	PF00498	0.546
LIG_FHA_1	360	366	PF00498	0.794
LIG_FHA_1	48	54	PF00498	0.765
LIG_FHA_1	79	85	PF00498	0.441
LIG_FHA_2	38	44	PF00498	0.731
LIG_LIR_Apic_2	25	30	PF02991	0.686
LIG_LIR_Gen_1	292	301	PF02991	0.573
LIG_LIR_Gen_1	372	381	PF02991	0.666
LIG_LIR_Gen_1	481	492	PF02991	0.693
LIG_LIR_Gen_1	70	80	PF02991	0.442
LIG_LIR_Nem_3	292	298	PF02991	0.522
LIG_LIR_Nem_3	372	378	PF02991	0.669
LIG_LIR_Nem_3	481	487	PF02991	0.732
LIG_LIR_Nem_3	70	76	PF02991	0.452
LIG_SH2_CRK	484	488	PF00017	0.772
LIG_SH2_NCK_1	484	488	PF00017	0.772
LIG_SH2_PTP2	162	165	PF00017	0.430
LIG_SH2_STAP1	3	7	PF00017	0.691
LIG_SH2_STAP1	324	328	PF00017	0.764
LIG_SH2_STAT5	162	165	PF00017	0.430
LIG_SH2_STAT5	189	192	PF00017	0.511
LIG_SH2_STAT5	236	239	PF00017	0.409
LIG_SH2_STAT5	280	283	PF00017	0.625
LIG_SH2_STAT5	39	42	PF00017	0.691
LIG_SH2_STAT5	438	441	PF00017	0.795
LIG_SH3_3	345	351	PF00018	0.695
LIG_SH3_3	362	368	PF00018	0.800
LIG_SH3_3	375	381	PF00018	0.652
LIG_SH3_3	73	79	PF00018	0.441
LIG_SH3_5	349	353	PF00018	0.515
LIG_SUMO_SIM_par_1	267	278	PF11976	0.530
LIG_SUMO_SIM_par_1	283	289	PF11976	0.562
LIG_SxIP_EBH_1	123	134	PF03271	0.463
LIG_TRAF2_1	41	44	PF00917	0.768
LIG_TYR_ITIM	133	138	PF00017	0.520
LIG_UBA3_1	217	223	PF00899	0.492
LIG_WW_1	435	438	PF00397	0.720
MOD_CK1_1	139	145	PF00069	0.530
MOD_CK1_1	17	23	PF00069	0.673
MOD_CK1_1	2	8	PF00069	0.657
MOD_CK1_1	262	268	PF00069	0.615
MOD_CK1_1	269	275	PF00069	0.549
MOD_CK1_1	363	369	PF00069	0.707
MOD_CK1_1	461	467	PF00069	0.733
MOD_CK1_1	469	475	PF00069	0.742
MOD_CK1_1	485	491	PF00069	0.730
MOD_CK1_1	60	66	PF00069	0.666
MOD_CK2_1	37	43	PF00069	0.783
MOD_CK2_1	459	465	PF00069	0.703
MOD_GlcNHglycan	127	130	PF01048	0.473
MOD_GlcNHglycan	197	200	PF01048	0.590
MOD_GlcNHglycan	313	316	PF01048	0.710
MOD_GlcNHglycan	318	321	PF01048	0.697
MOD_GlcNHglycan	340	343	PF01048	0.644
MOD_GlcNHglycan	362	365	PF01048	0.771
MOD_GlcNHglycan	368	371	PF01048	0.723
MOD_GlcNHglycan	43	48	PF01048	0.779
MOD_GlcNHglycan	454	457	PF01048	0.653
MOD_GlcNHglycan	487	490	PF01048	0.690
MOD_GlcNHglycan	60	63	PF01048	0.641
MOD_GSK3_1	195	202	PF00069	0.550
MOD_GSK3_1	258	265	PF00069	0.555
MOD_GSK3_1	267	274	PF00069	0.492
MOD_GSK3_1	307	314	PF00069	0.617
MOD_GSK3_1	329	336	PF00069	0.722
MOD_GSK3_1	356	363	PF00069	0.716
MOD_GSK3_1	39	46	PF00069	0.697
MOD_GSK3_1	403	410	PF00069	0.741
MOD_GSK3_1	436	443	PF00069	0.709
MOD_GSK3_1	448	455	PF00069	0.735
MOD_GSK3_1	466	473	PF00069	0.745
MOD_GSK3_1	47	54	PF00069	0.564
MOD_GSK3_1	474	481	PF00069	0.705
MOD_GSK3_1	488	495	PF00069	0.557
MOD_GSK3_1	56	63	PF00069	0.615
MOD_GSK3_1	91	98	PF00069	0.489
MOD_N-GLC_1	307	312	PF02516	0.652
MOD_N-GLC_1	333	338	PF02516	0.694
MOD_N-GLC_1	360	365	PF02516	0.695
MOD_N-GLC_1	403	408	PF02516	0.663
MOD_NEK2_1	1	6	PF00069	0.728
MOD_NEK2_1	454	459	PF00069	0.805
MOD_NEK2_2	313	318	PF00069	0.566
MOD_PIKK_1	379	385	PF00454	0.778
MOD_PIKK_1	420	426	PF00454	0.681
MOD_PK_1	271	277	PF00069	0.477
MOD_Plk_1	151	157	PF00069	0.453
MOD_Plk_1	360	366	PF00069	0.716
MOD_Plk_2-3	207	213	PF00069	0.450
MOD_Plk_4	482	488	PF00069	0.695
MOD_ProDKin_1	137	143	PF00069	0.566
MOD_ProDKin_1	280	286	PF00069	0.623
MOD_ProDKin_1	308	314	PF00069	0.624
MOD_ProDKin_1	333	339	PF00069	0.621
MOD_ProDKin_1	356	362	PF00069	0.712
MOD_ProDKin_1	363	369	PF00069	0.701
MOD_ProDKin_1	377	383	PF00069	0.693
MOD_ProDKin_1	407	413	PF00069	0.766
MOD_ProDKin_1	440	446	PF00069	0.707
MOD_ProDKin_1	474	480	PF00069	0.725
MOD_ProDKin_1	96	102	PF00069	0.562
MOD_SUMO_rev_2	294	304	PF00179	0.658
MOD_SUMO_rev_2	52	59	PF00179	0.660
MOD_SUMO_rev_2	64	74	PF00179	0.397
TRG_ENDOCYTIC_2	135	138	PF00928	0.533
TRG_ENDOCYTIC_2	162	165	PF00928	0.430
TRG_ENDOCYTIC_2	484	487	PF00928	0.732
TRG_ER_diArg_1	186	188	PF00400	0.509
TRG_ER_diArg_1	233	236	PF00400	0.446
TRG_NLS_Bipartite_1	67	86	PF00514	0.542
TRG_NLS_MonoExtN_4	79	86	PF00514	0.413
TRG_Pf-PMV_PEXEL_1	235	239	PF00026	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P864	Leptomonas seymouri	66%	100%
A0A3R7KEE9	Trypanosoma rangeli	41%	87%
A0A3S5H796	Leishmania donovani	96%	100%
A4HBS4	Leishmania braziliensis	84%	100%
A4HZ78	Leishmania infantum	96%	100%
D0A1F9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	39%	88%
E9AV45	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BMY3	Trypanosoma cruzi	44%	89%