Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCD5_LEIMA

TriTrypDb:

LmjF.21.0780 , LMJLV39_210013700 , LMJSD75_210013700

Length:

782

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCD5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCD5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	122	126	PF00656	0.638
CLV_C14_Caspase3-7	442	446	PF00656	0.558
CLV_C14_Caspase3-7	731	735	PF00656	0.477
CLV_NRD_NRD_1	236	238	PF00675	0.491
CLV_NRD_NRD_1	277	279	PF00675	0.610
CLV_NRD_NRD_1	374	376	PF00675	0.484
CLV_NRD_NRD_1	380	382	PF00675	0.460
CLV_NRD_NRD_1	513	515	PF00675	0.699
CLV_NRD_NRD_1	517	519	PF00675	0.500
CLV_NRD_NRD_1	563	565	PF00675	0.499
CLV_NRD_NRD_1	567	569	PF00675	0.488
CLV_NRD_NRD_1	625	627	PF00675	0.622
CLV_NRD_NRD_1	96	98	PF00675	0.657
CLV_PCSK_FUR_1	501	505	PF00082	0.745
CLV_PCSK_FUR_1	511	515	PF00082	0.588
CLV_PCSK_FUR_1	94	98	PF00082	0.598
CLV_PCSK_KEX2_1	236	238	PF00082	0.491
CLV_PCSK_KEX2_1	277	279	PF00082	0.610
CLV_PCSK_KEX2_1	374	376	PF00082	0.484
CLV_PCSK_KEX2_1	380	382	PF00082	0.460
CLV_PCSK_KEX2_1	503	505	PF00082	0.749
CLV_PCSK_KEX2_1	513	515	PF00082	0.579
CLV_PCSK_KEX2_1	517	519	PF00082	0.585
CLV_PCSK_KEX2_1	563	565	PF00082	0.496
CLV_PCSK_KEX2_1	567	569	PF00082	0.490
CLV_PCSK_KEX2_1	625	627	PF00082	0.622
CLV_PCSK_KEX2_1	94	96	PF00082	0.647
CLV_PCSK_PC1ET2_1	503	505	PF00082	0.749
CLV_PCSK_PC7_1	513	519	PF00082	0.575
CLV_PCSK_PC7_1	563	569	PF00082	0.620
CLV_PCSK_SKI1_1	215	219	PF00082	0.641
CLV_PCSK_SKI1_1	237	241	PF00082	0.474
CLV_PCSK_SKI1_1	278	282	PF00082	0.493
CLV_PCSK_SKI1_1	380	384	PF00082	0.558
CLV_PCSK_SKI1_1	563	567	PF00082	0.550
CLV_PCSK_SKI1_1	582	586	PF00082	0.711
CLV_PCSK_SKI1_1	751	755	PF00082	0.508
CLV_PCSK_SKI1_1	764	768	PF00082	0.664
CLV_PCSK_SKI1_1	77	81	PF00082	0.526
DEG_APCC_DBOX_1	202	210	PF00400	0.530
DEG_APCC_DBOX_1	71	79	PF00400	0.573
DEG_APCC_DBOX_1	719	727	PF00400	0.624
DEG_SPOP_SBC_1	119	123	PF00917	0.648
DEG_SPOP_SBC_1	642	646	PF00917	0.609
DEG_SPOP_SBC_1	713	717	PF00917	0.650
DOC_CKS1_1	242	247	PF01111	0.500
DOC_CKS1_1	765	770	PF01111	0.653
DOC_CYCLIN_RxL_1	374	386	PF00134	0.515
DOC_CYCLIN_RxL_1	560	569	PF00134	0.574
DOC_CYCLIN_yCln2_LP_2	242	248	PF00134	0.630
DOC_CYCLIN_yCln2_LP_2	406	412	PF00134	0.585
DOC_MAPK_gen_1	213	220	PF00069	0.566
DOC_MAPK_gen_1	380	387	PF00069	0.584
DOC_MAPK_gen_1	513	523	PF00069	0.587
DOC_MAPK_MEF2A_6	380	387	PF00069	0.526
DOC_MAPK_NFAT4_5	380	388	PF00069	0.528
DOC_PP1_RVXF_1	141	147	PF00149	0.566
DOC_PP1_RVXF_1	75	81	PF00149	0.521
DOC_PP2B_LxvP_1	360	363	PF13499	0.553
DOC_PP2B_LxvP_1	737	740	PF13499	0.568
DOC_USP7_MATH_1	149	153	PF00917	0.609
DOC_USP7_MATH_1	348	352	PF00917	0.680
DOC_USP7_MATH_1	363	367	PF00917	0.471
DOC_USP7_MATH_1	642	646	PF00917	0.741
DOC_USP7_MATH_1	712	716	PF00917	0.511
DOC_WW_Pin1_4	166	171	PF00397	0.613
DOC_WW_Pin1_4	23	28	PF00397	0.503
DOC_WW_Pin1_4	241	246	PF00397	0.494
DOC_WW_Pin1_4	298	303	PF00397	0.679
DOC_WW_Pin1_4	31	36	PF00397	0.596
DOC_WW_Pin1_4	405	410	PF00397	0.586
DOC_WW_Pin1_4	631	636	PF00397	0.672
DOC_WW_Pin1_4	764	769	PF00397	0.680
LIG_14-3-3_CanoR_1	213	220	PF00244	0.652
LIG_14-3-3_CanoR_1	354	363	PF00244	0.561
LIG_14-3-3_CanoR_1	439	447	PF00244	0.565
LIG_14-3-3_CanoR_1	555	565	PF00244	0.533
LIG_14-3-3_CanoR_1	567	573	PF00244	0.607
LIG_14-3-3_CanoR_1	602	608	PF00244	0.519
LIG_14-3-3_CanoR_1	97	107	PF00244	0.651
LIG_Actin_WH2_2	202	217	PF00022	0.513
LIG_Actin_WH2_2	551	569	PF00022	0.543
LIG_Actin_WH2_2	750	766	PF00022	0.603
LIG_BIR_III_2	247	251	PF00653	0.487
LIG_BIR_III_4	125	129	PF00653	0.586
LIG_BRCT_BRCA1_1	579	583	PF00533	0.712
LIG_Clathr_ClatBox_1	471	475	PF01394	0.609
LIG_CSL_BTD_1	322	325	PF09270	0.513
LIG_CtBP_PxDLS_1	578	582	PF00389	0.539
LIG_CtBP_PxDLS_1	672	676	PF00389	0.614
LIG_EVH1_2	324	328	PF00568	0.496
LIG_FHA_1	113	119	PF00498	0.704
LIG_FHA_1	368	374	PF00498	0.503
LIG_FHA_1	425	431	PF00498	0.660
LIG_FHA_1	650	656	PF00498	0.693
LIG_FHA_1	66	72	PF00498	0.557
LIG_FHA_2	242	248	PF00498	0.505
LIG_FHA_2	306	312	PF00498	0.655
LIG_FHA_2	440	446	PF00498	0.562
LIG_FHA_2	505	511	PF00498	0.517
LIG_FHA_2	555	561	PF00498	0.684
LIG_FHA_2	652	658	PF00498	0.613
LIG_FHA_2	86	92	PF00498	0.569
LIG_LIR_Gen_1	113	120	PF02991	0.641
LIG_LIR_Gen_1	221	231	PF02991	0.522
LIG_LIR_Gen_1	271	280	PF02991	0.502
LIG_LIR_Gen_1	386	394	PF02991	0.638
LIG_LIR_Gen_1	46	54	PF02991	0.563
LIG_LIR_Nem_3	113	119	PF02991	0.640
LIG_LIR_Nem_3	169	175	PF02991	0.503
LIG_LIR_Nem_3	221	227	PF02991	0.522
LIG_LIR_Nem_3	261	267	PF02991	0.518
LIG_LIR_Nem_3	271	275	PF02991	0.496
LIG_LIR_Nem_3	321	326	PF02991	0.624
LIG_LIR_Nem_3	386	390	PF02991	0.636
LIG_LIR_Nem_3	46	51	PF02991	0.490
LIG_LIR_Nem_3	559	565	PF02991	0.557
LIG_LIR_Nem_3	690	696	PF02991	0.607
LIG_NRBOX	580	586	PF00104	0.560
LIG_OCRL_FandH_1	386	398	PF00620	0.499
LIG_PCNA_yPIPBox_3	251	265	PF02747	0.434
LIG_Pex14_1	76	80	PF04695	0.466
LIG_Pex14_2	80	84	PF04695	0.466
LIG_PTB_Apo_2	752	759	PF02174	0.370
LIG_PTB_Apo_2	78	85	PF02174	0.466
LIG_PTB_Phospho_1	752	758	PF10480	0.366
LIG_RPA_C_Fungi	272	284	PF08784	0.492
LIG_RPA_C_Fungi	370	382	PF08784	0.535
LIG_SH2_CRK	264	268	PF00017	0.485
LIG_SH2_CRK	279	283	PF00017	0.480
LIG_SH2_CRK	693	697	PF00017	0.649
LIG_SH2_NCK_1	116	120	PF00017	0.636
LIG_SH2_NCK_1	423	427	PF00017	0.556
LIG_SH2_PTP2	272	275	PF00017	0.499
LIG_SH2_SRC	423	426	PF00017	0.608
LIG_SH2_SRC	460	463	PF00017	0.599
LIG_SH2_STAP1	116	120	PF00017	0.636
LIG_SH2_STAP1	279	283	PF00017	0.565
LIG_SH2_STAP1	605	609	PF00017	0.480
LIG_SH2_STAT3	605	608	PF00017	0.605
LIG_SH2_STAT3	620	623	PF00017	0.620
LIG_SH2_STAT5	224	227	PF00017	0.497
LIG_SH2_STAT5	241	244	PF00017	0.523
LIG_SH2_STAT5	272	275	PF00017	0.499
LIG_SH2_STAT5	48	51	PF00017	0.571
LIG_SH2_STAT5	749	752	PF00017	0.662
LIG_SH2_STAT5	85	88	PF00017	0.487
LIG_SH3_3	158	164	PF00018	0.602
LIG_SH3_3	29	35	PF00018	0.692
LIG_SH3_3	665	671	PF00018	0.697
LIG_SH3_3	705	711	PF00018	0.625
LIG_SH3_4	772	779	PF00018	0.552
LIG_SUMO_SIM_anti_2	399	405	PF11976	0.580
LIG_SUMO_SIM_anti_2	614	619	PF11976	0.608
LIG_SUMO_SIM_par_1	265	271	PF11976	0.491
LIG_SUMO_SIM_par_1	63	68	PF11976	0.578
LIG_SUMO_SIM_par_1	671	677	PF11976	0.612
LIG_TRAF2_1	152	155	PF00917	0.605
LIG_TRAF2_1	249	252	PF00917	0.447
LIG_TRAF2_1	466	469	PF00917	0.629
LIG_TRAF2_1	728	731	PF00917	0.604
LIG_TYR_ITSM	689	696	PF00017	0.423
LIG_UBA3_1	257	265	PF00899	0.560
LIG_UBA3_1	753	760	PF00899	0.454
LIG_WRC_WIRS_1	48	53	PF05994	0.528
MOD_CDK_SPK_2	298	303	PF00069	0.562
MOD_CDK_SPK_2	631	636	PF00069	0.493
MOD_CK1_1	121	127	PF00069	0.591
MOD_CK1_1	295	301	PF00069	0.527
MOD_CK1_1	318	324	PF00069	0.714
MOD_CK1_1	367	373	PF00069	0.525
MOD_CK1_1	463	469	PF00069	0.549
MOD_CK1_1	538	544	PF00069	0.614
MOD_CK1_1	631	637	PF00069	0.544
MOD_CK1_1	688	694	PF00069	0.456
MOD_CK1_1	715	721	PF00069	0.584
MOD_CK2_1	149	155	PF00069	0.558
MOD_CK2_1	246	252	PF00069	0.475
MOD_CK2_1	30	36	PF00069	0.679
MOD_CK2_1	305	311	PF00069	0.716
MOD_CK2_1	324	330	PF00069	0.378
MOD_CK2_1	463	469	PF00069	0.646
MOD_CK2_1	490	496	PF00069	0.663
MOD_CK2_1	523	529	PF00069	0.733
MOD_CK2_1	554	560	PF00069	0.504
MOD_CK2_1	98	104	PF00069	0.608
MOD_Cter_Amidation	501	504	PF01082	0.653
MOD_GlcNHglycan	172	175	PF01048	0.733
MOD_GlcNHglycan	176	179	PF01048	0.554
MOD_GlcNHglycan	295	298	PF01048	0.670
MOD_GlcNHglycan	320	323	PF01048	0.726
MOD_GlcNHglycan	350	353	PF01048	0.701
MOD_GlcNHglycan	354	357	PF01048	0.716
MOD_GlcNHglycan	366	369	PF01048	0.549
MOD_GlcNHglycan	465	468	PF01048	0.610
MOD_GlcNHglycan	525	528	PF01048	0.619
MOD_GlcNHglycan	531	534	PF01048	0.670
MOD_GlcNHglycan	537	540	PF01048	0.548
MOD_GlcNHglycan	59	62	PF01048	0.592
MOD_GlcNHglycan	699	702	PF01048	0.676
MOD_GlcNHglycan	717	720	PF01048	0.422
MOD_GlcNHglycan	779	782	PF01048	0.491
MOD_GSK3_1	166	173	PF00069	0.686
MOD_GSK3_1	185	192	PF00069	0.659
MOD_GSK3_1	23	30	PF00069	0.761
MOD_GSK3_1	348	355	PF00069	0.592
MOD_GSK3_1	363	370	PF00069	0.403
MOD_GSK3_1	53	60	PF00069	0.579
MOD_GSK3_1	534	541	PF00069	0.603
MOD_GSK3_1	554	561	PF00069	0.454
MOD_GSK3_1	651	658	PF00069	0.715
MOD_GSK3_1	688	695	PF00069	0.508
MOD_N-GLC_1	330	335	PF02516	0.636
MOD_N-GLC_1	504	509	PF02516	0.449
MOD_NEK2_1	258	263	PF00069	0.515
MOD_NEK2_1	292	297	PF00069	0.688
MOD_NEK2_1	383	388	PF00069	0.595
MOD_NEK2_1	535	540	PF00069	0.590
MOD_NEK2_1	558	563	PF00069	0.561
MOD_NEK2_1	566	571	PF00069	0.642
MOD_PIKK_1	258	264	PF00454	0.594
MOD_PIKK_1	433	439	PF00454	0.518
MOD_PIKK_1	521	527	PF00454	0.636
MOD_PIKK_1	619	625	PF00454	0.554
MOD_PIKK_1	772	778	PF00454	0.631
MOD_PKA_2	198	204	PF00069	0.652
MOD_PKA_2	554	560	PF00069	0.480
MOD_PKA_2	566	572	PF00069	0.545
MOD_PKA_2	603	609	PF00069	0.543
MOD_Plk_1	112	118	PF00069	0.638
MOD_Plk_1	132	138	PF00069	0.694
MOD_Plk_1	330	336	PF00069	0.559
MOD_Plk_1	460	466	PF00069	0.596
MOD_Plk_1	477	483	PF00069	0.551
MOD_Plk_1	495	501	PF00069	0.611
MOD_Plk_1	65	71	PF00069	0.550
MOD_Plk_1	688	694	PF00069	0.411
MOD_Plk_2-3	651	657	PF00069	0.714
MOD_Plk_4	185	191	PF00069	0.702
MOD_Plk_4	37	43	PF00069	0.588
MOD_Plk_4	399	405	PF00069	0.655
MOD_Plk_4	449	455	PF00069	0.478
MOD_Plk_4	47	53	PF00069	0.488
MOD_Plk_4	477	483	PF00069	0.542
MOD_Plk_4	688	694	PF00069	0.411
MOD_Plk_4	85	91	PF00069	0.621
MOD_ProDKin_1	166	172	PF00069	0.614
MOD_ProDKin_1	23	29	PF00069	0.502
MOD_ProDKin_1	241	247	PF00069	0.496
MOD_ProDKin_1	298	304	PF00069	0.678
MOD_ProDKin_1	31	37	PF00069	0.592
MOD_ProDKin_1	405	411	PF00069	0.583
MOD_ProDKin_1	631	637	PF00069	0.673
MOD_ProDKin_1	764	770	PF00069	0.680
MOD_SUMO_rev_2	124	134	PF00179	0.591
MOD_SUMO_rev_2	651	661	PF00179	0.787
TRG_DiLeu_BaEn_1	399	404	PF01217	0.582
TRG_DiLeu_BaEn_1	66	71	PF01217	0.545
TRG_DiLeu_BaEn_2	578	584	PF01217	0.616
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.630
TRG_DiLeu_BaLyEn_6	378	383	PF01217	0.477
TRG_DiLeu_BaLyEn_6	561	566	PF01217	0.589
TRG_ENDOCYTIC_2	116	119	PF00928	0.636
TRG_ENDOCYTIC_2	224	227	PF00928	0.513
TRG_ENDOCYTIC_2	264	267	PF00928	0.505
TRG_ENDOCYTIC_2	272	275	PF00928	0.495
TRG_ENDOCYTIC_2	279	282	PF00928	0.419
TRG_ENDOCYTIC_2	423	426	PF00928	0.496
TRG_ENDOCYTIC_2	48	51	PF00928	0.583
TRG_ENDOCYTIC_2	693	696	PF00928	0.664
TRG_ER_diArg_1	235	237	PF00400	0.484
TRG_ER_diArg_1	277	279	PF00400	0.610
TRG_ER_diArg_1	373	375	PF00400	0.485
TRG_ER_diArg_1	379	381	PF00400	0.456
TRG_ER_diArg_1	512	514	PF00400	0.646
TRG_ER_diArg_1	516	518	PF00400	0.662
TRG_ER_diArg_1	562	564	PF00400	0.482
TRG_ER_diArg_1	566	568	PF00400	0.484
TRG_ER_diArg_1	601	604	PF00400	0.425
TRG_ER_diArg_1	94	97	PF00400	0.651
TRG_Pf-PMV_PEXEL_1	228	232	PF00026	0.572
TRG_Pf-PMV_PEXEL_1	582	586	PF00026	0.565

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZ90	Leptomonas seymouri	57%	72%
A0A3R7K7W4	Trypanosoma rangeli	33%	83%
A0A3S7WWF2	Leishmania donovani	93%	100%
A4HBS5	Leishmania braziliensis	81%	71%
A4HZ79	Leishmania infantum	93%	100%
D0A1F7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	28%	96%
E9AV46	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5DEN0	Trypanosoma cruzi	29%	83%