Ras-related protein Rab-21

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ras-related protein Rab21, putative

Species:

Leishmania major

UniProt:

Q4QCD4_LEIMA

TriTrypDb:

LmjF.21.0790 , LMJLV39_210013800 , LMJSD75_210013800

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005768	endosome	7	3
GO:0005769	early endosome	8	2
GO:0016020	membrane	2	6
GO:0031410	cytoplasmic vesicle	6	3
GO:0031982	vesicle	4	3
GO:0043226	organelle	2	3
GO:0043227	membrane-bounded organelle	3	3
GO:0043229	intracellular organelle	3	3
GO:0043231	intracellular membrane-bounded organelle	4	3
GO:0097708	intracellular vesicle	5	3
GO:0110165	cellular anatomical entity	1	7
GO:0005737	cytoplasm	2	1
GO:0030139	endocytic vesicle	7	1

Expansion

Sequence features

Q4QCD4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCD4

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	7
GO:0006886	intracellular protein transport	4	3
GO:0007165	signal transduction	2	6
GO:0007264	small GTPase mediated signal transduction	4	6
GO:0007265	Ras protein signal transduction	5	6
GO:0008104	protein localization	4	7
GO:0009987	cellular process	1	7
GO:0015031	protein transport	4	7
GO:0032482	Rab protein signal transduction	6	6
GO:0033036	macromolecule localization	2	7
GO:0035556	intracellular signal transduction	3	6
GO:0045184	establishment of protein localization	3	7
GO:0046907	intracellular transport	3	3
GO:0050789	regulation of biological process	2	6
GO:0050794	regulation of cellular process	3	6
GO:0051179	localization	1	7
GO:0051234	establishment of localization	2	7
GO:0051641	cellular localization	2	7
GO:0051649	establishment of localization in cell	3	3
GO:0065007	biological regulation	1	6
GO:0070727	cellular macromolecule localization	3	7
GO:0071702	organic substance transport	4	7
GO:0071705	nitrogen compound transport	4	7

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003924	GTPase activity	7	12
GO:0005488	binding	1	12
GO:0005525	GTP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0019001	guanyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032561	guanyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	99	103	PF00656	0.239
CLV_NRD_NRD_1	106	108	PF00675	0.325
CLV_NRD_NRD_1	222	224	PF00675	0.587
CLV_PCSK_FUR_1	220	224	PF00082	0.575
CLV_PCSK_KEX2_1	222	224	PF00082	0.587
CLV_PCSK_PC7_1	218	224	PF00082	0.571
CLV_PCSK_SKI1_1	11	15	PF00082	0.283
CLV_PCSK_SKI1_1	185	189	PF00082	0.576
DEG_APCC_DBOX_1	221	229	PF00400	0.626
DEG_Nend_UBRbox_2	1	3	PF02207	0.477
DEG_SCF_FBW7_1	235	240	PF00400	0.542
DOC_MAPK_gen_1	218	227	PF00069	0.569
DOC_PP1_RVXF_1	4	11	PF00149	0.390
DOC_USP7_MATH_1	196	200	PF00917	0.752
DOC_USP7_MATH_1	216	220	PF00917	0.547
DOC_USP7_MATH_1	237	241	PF00917	0.666
DOC_USP7_MATH_1	282	286	PF00917	0.612
DOC_WW_Pin1_4	133	138	PF00397	0.339
DOC_WW_Pin1_4	212	217	PF00397	0.650
DOC_WW_Pin1_4	233	238	PF00397	0.675
DOC_WW_Pin1_4	249	254	PF00397	0.767
DOC_WW_Pin1_4	272	277	PF00397	0.525
LIG_14-3-3_CanoR_1	107	113	PF00244	0.325
LIG_14-3-3_CanoR_1	19	29	PF00244	0.237
LIG_Actin_WH2_2	93	109	PF00022	0.325
LIG_BRCT_BRCA1_1	157	161	PF00533	0.240
LIG_FHA_1	21	27	PF00498	0.237
LIG_FHA_2	99	105	PF00498	0.237
LIG_LIR_Gen_1	115	125	PF02991	0.293
LIG_LIR_Gen_1	172	182	PF02991	0.322
LIG_LIR_Gen_1	78	88	PF02991	0.237
LIG_LIR_Nem_3	115	120	PF02991	0.314
LIG_LIR_Nem_3	7	13	PF02991	0.457
LIG_LIR_Nem_3	78	83	PF02991	0.285
LIG_MLH1_MIPbox_1	157	161	PF16413	0.240
LIG_SH2_CRK	117	121	PF00017	0.346
LIG_SH2_CRK	208	212	PF00017	0.583
LIG_SH2_CRK	248	252	PF00017	0.625
LIG_SH2_NCK_1	117	121	PF00017	0.325
LIG_SH2_STAT5	208	211	PF00017	0.496
LIG_SH2_STAT5	29	32	PF00017	0.317
LIG_SUMO_SIM_par_1	11	17	PF11976	0.285
LIG_SUMO_SIM_par_1	266	271	PF11976	0.607
LIG_TRAF2_1	75	78	PF00917	0.285
LIG_WW_3	252	256	PF00397	0.665
MOD_CDK_SPxK_1	212	218	PF00069	0.617
MOD_CDK_SPxK_1	233	239	PF00069	0.572
MOD_CDK_SPxK_1	249	255	PF00069	0.620
MOD_CK1_1	163	169	PF00069	0.320
MOD_CK1_1	199	205	PF00069	0.652
MOD_CK1_1	212	218	PF00069	0.633
MOD_CK1_1	24	30	PF00069	0.266
MOD_CK1_1	261	267	PF00069	0.648
MOD_CK1_1	45	51	PF00069	0.364
MOD_CK2_1	141	147	PF00069	0.262
MOD_CK2_1	238	244	PF00069	0.629
MOD_GlcNHglycan	162	165	PF01048	0.283
MOD_GlcNHglycan	174	177	PF01048	0.285
MOD_GlcNHglycan	199	202	PF01048	0.643
MOD_GlcNHglycan	211	214	PF01048	0.780
MOD_GlcNHglycan	261	264	PF01048	0.633
MOD_GlcNHglycan	270	273	PF01048	0.568
MOD_GlcNHglycan	284	287	PF01048	0.582
MOD_GlcNHglycan	58	61	PF01048	0.305
MOD_GSK3_1	172	179	PF00069	0.280
MOD_GSK3_1	181	188	PF00069	0.399
MOD_GSK3_1	196	203	PF00069	0.514
MOD_GSK3_1	20	27	PF00069	0.266
MOD_GSK3_1	212	219	PF00069	0.602
MOD_GSK3_1	233	240	PF00069	0.632
MOD_GSK3_1	268	275	PF00069	0.567
MOD_GSK3_1	38	45	PF00069	0.294
MOD_GSK3_1	98	105	PF00069	0.237
MOD_N-GLC_1	282	287	PF02516	0.489
MOD_NEK2_1	155	160	PF00069	0.249
MOD_NEK2_1	46	51	PF00069	0.337
MOD_NEK2_1	71	76	PF00069	0.373
MOD_PIKK_1	176	182	PF00454	0.269
MOD_PKB_1	183	191	PF00069	0.466
MOD_Plk_1	37	43	PF00069	0.351
MOD_Plk_1	6	12	PF00069	0.367
MOD_Plk_4	21	27	PF00069	0.285
MOD_ProDKin_1	133	139	PF00069	0.339
MOD_ProDKin_1	212	218	PF00069	0.650
MOD_ProDKin_1	233	239	PF00069	0.677
MOD_ProDKin_1	249	255	PF00069	0.770
MOD_ProDKin_1	272	278	PF00069	0.523
TRG_ENDOCYTIC_2	117	120	PF00928	0.346
TRG_ENDOCYTIC_2	208	211	PF00928	0.583
TRG_ENDOCYTIC_2	248	251	PF00928	0.630
TRG_ER_diArg_1	220	223	PF00400	0.560

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8I1	Leptomonas seymouri	35%	100%
A0A0N1HU31	Leptomonas seymouri	29%	100%
A0A0N1I5E3	Leptomonas seymouri	29%	100%
A0A0N1IL60	Leptomonas seymouri	39%	100%
A0A0N1PBC8	Leptomonas seymouri	72%	100%
A0A0N1PE58	Leptomonas seymouri	25%	100%
A0A0S4IJB7	Bodo saltans	29%	100%
A0A0S4IRD6	Bodo saltans	29%	100%
A0A0S4IWD9	Bodo saltans	34%	85%
A0A0S4IWG2	Bodo saltans	27%	83%
A0A0S4IY79	Bodo saltans	32%	100%
A0A0S4J9T5	Bodo saltans	31%	100%
A0A0S4JBJ9	Bodo saltans	38%	100%
A0A0S4JDW3	Bodo saltans	36%	100%
A0A0S4JJX5	Bodo saltans	27%	100%
A0A0S4JKI9	Bodo saltans	44%	100%
A0A0S4JQT6	Bodo saltans	28%	100%
A0A0S4JR87	Bodo saltans	33%	100%
A0A0S4JUQ8	Bodo saltans	31%	100%
A0A0S4JVK4	Bodo saltans	35%	100%
A0A0S4KHE5	Bodo saltans	38%	100%
A0A1X0NKS6	Trypanosomatidae	26%	100%
A0A1X0NLM1	Trypanosomatidae	35%	100%
A0A1X0NN55	Trypanosomatidae	26%	100%
A0A1X0NN96	Trypanosomatidae	38%	100%
A0A1X0NQ87	Trypanosomatidae	31%	78%
A0A1X0NQG4	Trypanosomatidae	26%	100%
A0A1X0NR18	Trypanosomatidae	30%	100%
A0A1X0NXM2	Trypanosomatidae	50%	85%
A0A1X0P706	Trypanosomatidae	32%	100%
A0A3Q8I8T8	Leishmania donovani	30%	100%
A0A3Q8IC02	Leishmania donovani	95%	100%
A0A3Q8ICX9	Leishmania donovani	32%	100%
A0A3Q8ID64	Leishmania donovani	35%	100%
A0A3Q8IE68	Leishmania donovani	34%	100%
A0A3Q8IK84	Leishmania donovani	34%	100%
A0A3R7LXW6	Trypanosoma rangeli	35%	100%
A0A3R7ME44	Trypanosoma rangeli	32%	100%
A0A3R7N3U0	Trypanosoma rangeli	28%	100%
A0A3R7RHV7	Trypanosoma rangeli	29%	100%
A0A3R7RKC1	Trypanosoma rangeli	33%	100%
A0A3S5H4Z2	Leishmania donovani	37%	100%
A0A3S5H5Y5	Leishmania donovani	35%	100%
A0A3S5H6H3	Leishmania donovani	29%	100%
A0A3S7WRA9	Leishmania donovani	36%	100%
A0A3S7WT13	Leishmania donovani	32%	69%
A0A3S7WUY8	Leishmania donovani	34%	100%
A0A3S7WV84	Leishmania donovani	39%	100%
A0A3S7X3D1	Leishmania donovani	30%	100%
A0A3S7X5J2	Leishmania donovani	32%	100%
A0A422P0L6	Trypanosoma rangeli	38%	100%
A1KXP5	Leishmania donovani	43%	100%
A4H506	Leishmania braziliensis	33%	100%
A4H679	Leishmania braziliensis	36%	100%
A4H6A4	Leishmania braziliensis	29%	100%
A4H6A5	Leishmania braziliensis	29%	100%
A4H9M3	Leishmania braziliensis	39%	100%
A4HBS6	Leishmania braziliensis	85%	100%
A4HEE8	Leishmania braziliensis	30%	100%
A4HFK0	Leishmania braziliensis	34%	100%
A4HHR8	Leishmania braziliensis	41%	100%
A4HIB4	Leishmania braziliensis	29%	100%
A4HK33	Leishmania braziliensis	32%	100%
A4HKH2	Leishmania braziliensis	30%	100%
A4HKJ3	Leishmania braziliensis	34%	100%
A4HLP5	Leishmania braziliensis	33%	100%
A4HRM3	Leishmania infantum	37%	100%
A4HT72	Leishmania infantum	35%	100%
A4HUK3	Leishmania infantum	36%	100%
A4HUM8	Leishmania infantum	30%	100%
A4HUM9	Leishmania infantum	29%	100%
A4HVF7	Leishmania infantum	43%	100%
A4HW20	Leishmania infantum	32%	69%
A4HXY7	Leishmania infantum	39%	100%
A4HZ80	Leishmania infantum	95%	100%
A4I1I6	Leishmania infantum	31%	100%
A4I5J8	Leishmania infantum	30%	100%
A4I7N3	Leishmania infantum	32%	100%
A4I7Z9	Leishmania infantum	33%	100%
A4I825	Leishmania infantum	35%	100%
A4I946	Leishmania infantum	34%	100%
B1A5Z4	Leishmania donovani	31%	100%
B6DT76	Bodo saltans	35%	100%
C9ZQX5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
C9ZUL0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
C9ZVR3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
D0A5C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
D0AA91	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
E2RQ15	Canis lupus familiaris	34%	100%
E9AD53	Leishmania major	34%	100%
E9AGQ4	Leishmania infantum	35%	100%
E9AHE8	Leishmania infantum	34%	100%
E9AL68	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ANA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
E9ANC6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9ANC7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	100%
E9AP56	Leishmania mexicana (strain MHOM/GT/2001/U1103)	41%	100%
E9ARM6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9ARQ0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	40%	100%
E9AV47	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
E9AXM1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	31%	100%
E9AYX8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B0U3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	100%
E9B2H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B2W1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	33%	100%
E9B2Y3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	32%	100%
E9B420	Leishmania mexicana (strain MHOM/GT/2001/U1103)	36%	100%
F1PTE3	Canis lupus familiaris	34%	100%
I1RMF2	Gibberella zeae (strain ATCC MYA-4620 / CBS 123657 / FGSC 9075 / NRRL 31084 / PH-1)	32%	100%
O00194	Homo sapiens	33%	100%
O01803	Caenorhabditis elegans	33%	100%
O23561	Arabidopsis thaliana	30%	100%
P01123	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	32%	100%
P05714	Rattus norvegicus	32%	100%
P10536	Rattus norvegicus	33%	100%
P11620	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	34%	100%
P20338	Homo sapiens	32%	100%
P22125	Diplobatis ommata	32%	100%
P31582	Arabidopsis thaliana	39%	100%
P31583	Nicotiana plumbaginifolia	39%	100%
P33723	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	34%	100%
P34140	Dictyostelium discoideum	33%	100%
P35276	Mus musculus	33%	100%
P35280	Rattus norvegicus	29%	100%
P35281	Rattus norvegicus	30%	100%
P35282	Mus musculus	42%	100%
P35286	Rattus norvegicus	35%	100%
P35288	Mus musculus	29%	100%
P35293	Mus musculus	36%	100%
P35294	Mus musculus	31%	100%
P36018	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	37%	100%
P36862	Volvox carteri	34%	100%
P36863	Volvox carteri	28%	100%
P38555	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P46629	Oryctolagus cuniculus	35%	100%
P51996	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	31%	100%
P55258	Mus musculus	29%	100%
P55745	Canis lupus familiaris	42%	100%
P56371	Mus musculus	32%	100%
P61017	Canis lupus familiaris	32%	100%
P61018	Homo sapiens	32%	100%
P61020	Homo sapiens	43%	100%
P61021	Mus musculus	43%	100%
P61028	Mus musculus	29%	100%
P62820	Homo sapiens	32%	100%
P62821	Mus musculus	32%	100%
P62822	Canis lupus familiaris	32%	100%
P70550	Rattus norvegicus	29%	100%
P92963	Arabidopsis thaliana	33%	100%
P93267	Mesembryanthemum crystallinum	31%	100%
Q01387	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	30%	100%
Q05974	Lymnaea stagnalis	32%	100%
Q06AU7	Sus scrofa	33%	100%
Q14964	Homo sapiens	28%	100%
Q17QU4	Bos taurus	30%	100%
Q17R06	Bos taurus	41%	100%
Q2HJH2	Bos taurus	33%	100%
Q2HJI8	Bos taurus	30%	100%
Q2TBH7	Bos taurus	31%	100%
Q38922	Arabidopsis thaliana	32%	100%
Q39570	Chlamydomonas reinhardtii	28%	100%
Q40191	Lotus japonicus	29%	100%
Q40194	Lotus japonicus	35%	100%
Q4Q404	Leishmania major	35%	100%
Q4Q573	Leishmania major	35%	100%
Q4Q595	Leishmania major	32%	100%
Q4Q5N4	Leishmania major	32%	100%
Q4Q7C3	Leishmania major	30%	100%
Q4Q9V1	Leishmania major	31%	100%
Q4QDS9	Leishmania major	39%	100%
Q4QGD2	Leishmania major	43%	100%
Q4QH97	Leishmania major	29%	100%
Q4QH98	Leishmania major	30%	100%
Q4QHC3	Leishmania major	36%	100%
Q4QIN6	Leishmania major	35%	100%
Q4R8X3	Macaca fascicularis	33%	100%
Q52NJ2	Sus scrofa	32%	100%
Q5EB77	Rattus norvegicus	36%	100%
Q5KTJ6	Mesocricetus auratus	34%	100%
Q5M7U5	Rattus norvegicus	30%	100%
Q5R4W9	Pongo abelii	35%	100%
Q5RBG1	Pongo abelii	43%	100%
Q5RE13	Pongo abelii	33%	100%
Q5REC9	Pongo abelii	29%	100%
Q5ZHW4	Gallus gallus	42%	100%
Q63942	Rattus norvegicus	33%	100%
Q68EK7	Danio rerio	32%	100%
Q6AXT5	Rattus norvegicus	42%	100%
Q6GQP4	Rattus norvegicus	37%	100%
Q6IML7	Rattus norvegicus	29%	100%
Q6NYB7	Rattus norvegicus	32%	100%
Q6PHI9	Danio rerio	32%	100%
Q8BHC1	Mus musculus	30%	100%
Q8BHD0	Mus musculus	28%	100%
Q8CFP6	Mus musculus	29%	100%
Q8MXQ2	Dictyostelium discoideum	27%	100%
Q8WQ53	Geodia cydonium	40%	100%
Q921E2	Mus musculus	37%	100%
Q92928	Homo sapiens	33%	100%
Q92930	Homo sapiens	29%	100%
Q948K6	Arabidopsis thaliana	32%	100%
Q948K8	Arabidopsis thaliana	33%	100%
Q96DA2	Homo sapiens	30%	100%
Q99P58	Mus musculus	33%	100%
Q9C2L8	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	32%	100%
Q9C9U7	Arabidopsis thaliana	33%	100%
Q9D1G1	Mus musculus	33%	100%
Q9DD03	Mus musculus	34%	100%
Q9FGK5	Arabidopsis thaliana	33%	100%
Q9FJH0	Arabidopsis thaliana	35%	100%
Q9H0U4	Homo sapiens	33%	100%
Q9LNK1	Arabidopsis thaliana	34%	100%
Q9LNW1	Arabidopsis thaliana	30%	100%
Q9N2P5	Leishmania major	34%	100%
Q9NP90	Homo sapiens	34%	100%
Q9NZQ0	Homo sapiens	29%	100%
Q9SID8	Arabidopsis thaliana	34%	100%
Q9SMQ6	Arabidopsis thaliana	31%	100%
Q9SN35	Arabidopsis thaliana	34%	100%
Q9UL25	Homo sapiens	41%	100%
Q9ULC3	Homo sapiens	30%	100%
Q9WTL2	Mus musculus	35%	100%
Q9XI98	Arabidopsis thaliana	34%	100%
Q9ZRE2	Arabidopsis thaliana	34%	100%
V5D027	Trypanosoma cruzi	36%	100%
V5D9W7	Trypanosoma cruzi	40%	100%
V5DKQ7	Trypanosoma cruzi	30%	91%