Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QCD0_LEIMA

TriTrypDb:

LmjF.21.0823 , LMJLV39_210014300 , LMJSD75_210014400

Length:

978

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005773	vacuole	5	2
GO:0005776	autophagosome	6	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCD0

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0006996	organelle organization	4	2
GO:0007033	vacuole organization	5	2
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016043	cellular component organization	3	2
GO:0016310	phosphorylation	5	6
GO:0018105	peptidyl-serine phosphorylation	6	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018209	peptidyl-serine modification	6	2
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0046777	protein autophosphorylation	6	2
GO:0071704	organic substance metabolic process	2	6
GO:0071840	cellular component organization or biogenesis	2	2
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1905037	autophagosome organization	6	2
GO:0006914	autophagy	3	4
GO:0009056	catabolic process	2	4
GO:0044248	cellular catabolic process	3	4
GO:0061919	process utilizing autophagic mechanism	2	4

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0004674	protein serine/threonine kinase activity	4	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	604	608	PF00656	0.535
CLV_C14_Caspase3-7	734	738	PF00656	0.580
CLV_NRD_NRD_1	216	218	PF00675	0.299
CLV_NRD_NRD_1	256	258	PF00675	0.279
CLV_NRD_NRD_1	367	369	PF00675	0.250
CLV_NRD_NRD_1	881	883	PF00675	0.561
CLV_PCSK_KEX2_1	214	216	PF00082	0.305
CLV_PCSK_KEX2_1	367	369	PF00082	0.250
CLV_PCSK_KEX2_1	881	883	PF00082	0.561
CLV_PCSK_PC1ET2_1	214	216	PF00082	0.305
CLV_PCSK_PC7_1	877	883	PF00082	0.556
CLV_PCSK_SKI1_1	200	204	PF00082	0.299
CLV_PCSK_SKI1_1	221	225	PF00082	0.347
CLV_PCSK_SKI1_1	303	307	PF00082	0.362
CLV_PCSK_SKI1_1	367	371	PF00082	0.250
CLV_PCSK_SKI1_1	551	555	PF00082	0.700
CLV_PCSK_SKI1_1	610	614	PF00082	0.477
CLV_PCSK_SKI1_1	877	881	PF00082	0.501
CLV_PCSK_SKI1_1	882	886	PF00082	0.505
CLV_PCSK_SKI1_1	938	942	PF00082	0.613
CLV_Separin_Metazoa	324	328	PF03568	0.299
CLV_Separin_Metazoa	342	346	PF03568	0.299
DEG_APCC_DBOX_1	952	960	PF00400	0.523
DEG_COP1_1	560	569	PF00400	0.544
DEG_Nend_UBRbox_2	1	3	PF02207	0.687
DEG_SCF_FBW7_2	60	67	PF00400	0.624
DEG_SPOP_SBC_1	157	161	PF00917	0.314
DEG_SPOP_SBC_1	489	493	PF00917	0.702
DEG_SPOP_SBC_1	561	565	PF00917	0.629
DEG_SPOP_SBC_1	94	98	PF00917	0.677
DEG_SPOP_SBC_1	973	977	PF00917	0.548
DOC_ANK_TNKS_1	256	263	PF00023	0.250
DOC_CKS1_1	293	298	PF01111	0.347
DOC_CKS1_1	464	469	PF01111	0.594
DOC_CKS1_1	61	66	PF01111	0.629
DOC_CYCLIN_RxL_1	607	616	PF00134	0.478
DOC_CYCLIN_yCln2_LP_2	915	918	PF00134	0.565
DOC_MAPK_DCC_7	392	402	PF00069	0.516
DOC_MAPK_gen_1	166	174	PF00069	0.308
DOC_MAPK_gen_1	221	230	PF00069	0.347
DOC_MAPK_gen_1	881	887	PF00069	0.493
DOC_MAPK_JIP1_4	224	230	PF00069	0.299
DOC_MAPK_MEF2A_6	166	174	PF00069	0.299
DOC_MAPK_MEF2A_6	871	880	PF00069	0.506
DOC_MAPK_MEF2A_6	938	947	PF00069	0.492
DOC_PP1_RVXF_1	936	942	PF00149	0.572
DOC_PP2B_LxvP_1	139	142	PF13499	0.362
DOC_PP2B_LxvP_1	775	778	PF13499	0.655
DOC_PP2B_LxvP_1	915	918	PF13499	0.541
DOC_PP4_FxxP_1	402	405	PF00568	0.473
DOC_PP4_FxxP_1	575	578	PF00568	0.620
DOC_PP4_FxxP_1	99	102	PF00568	0.668
DOC_USP7_MATH_1	157	161	PF00917	0.298
DOC_USP7_MATH_1	162	166	PF00917	0.373
DOC_USP7_MATH_1	405	409	PF00917	0.612
DOC_USP7_MATH_1	485	489	PF00917	0.685
DOC_USP7_MATH_1	509	513	PF00917	0.654
DOC_USP7_MATH_1	521	525	PF00917	0.600
DOC_USP7_MATH_1	589	593	PF00917	0.540
DOC_USP7_MATH_1	645	649	PF00917	0.694
DOC_USP7_MATH_1	863	867	PF00917	0.640
DOC_USP7_MATH_1	88	92	PF00917	0.700
DOC_USP7_MATH_1	908	912	PF00917	0.706
DOC_USP7_MATH_1	927	931	PF00917	0.615
DOC_USP7_MATH_1	94	98	PF00917	0.769
DOC_USP7_MATH_1	973	977	PF00917	0.692
DOC_WW_Pin1_4	158	163	PF00397	0.299
DOC_WW_Pin1_4	283	288	PF00397	0.380
DOC_WW_Pin1_4	292	297	PF00397	0.322
DOC_WW_Pin1_4	423	428	PF00397	0.656
DOC_WW_Pin1_4	463	468	PF00397	0.596
DOC_WW_Pin1_4	557	562	PF00397	0.672
DOC_WW_Pin1_4	60	65	PF00397	0.575
DOC_WW_Pin1_4	817	822	PF00397	0.602
DOC_WW_Pin1_4	846	851	PF00397	0.619
DOC_WW_Pin1_4	899	904	PF00397	0.639
LIG_14-3-3_CanoR_1	130	136	PF00244	0.274
LIG_14-3-3_CanoR_1	200	205	PF00244	0.299
LIG_14-3-3_CanoR_1	367	374	PF00244	0.324
LIG_14-3-3_CanoR_1	377	381	PF00244	0.307
LIG_14-3-3_CanoR_1	385	389	PF00244	0.404
LIG_14-3-3_CanoR_1	610	615	PF00244	0.475
LIG_14-3-3_CanoR_1	703	707	PF00244	0.572
LIG_14-3-3_CanoR_1	788	793	PF00244	0.550
LIG_14-3-3_CanoR_1	845	850	PF00244	0.672
LIG_Actin_WH2_2	944	959	PF00022	0.528
LIG_APCC_ABBAyCdc20_2	216	222	PF00400	0.299
LIG_BRCT_BRCA1_1	167	171	PF00533	0.362
LIG_BRCT_BRCA1_1	285	289	PF00533	0.299
LIG_BRCT_BRCA1_1	95	99	PF00533	0.679
LIG_EVH1_2	398	402	PF00568	0.440
LIG_FHA_1	201	207	PF00498	0.304
LIG_FHA_1	237	243	PF00498	0.347
LIG_FHA_1	399	405	PF00498	0.538
LIG_FHA_1	424	430	PF00498	0.605
LIG_FHA_1	561	567	PF00498	0.760
LIG_FHA_1	585	591	PF00498	0.492
LIG_FHA_1	681	687	PF00498	0.519
LIG_FHA_1	900	906	PF00498	0.567
LIG_FHA_1	907	913	PF00498	0.551
LIG_FHA_2	229	235	PF00498	0.362
LIG_FHA_2	268	274	PF00498	0.377
LIG_FHA_2	368	374	PF00498	0.299
LIG_FHA_2	417	423	PF00498	0.593
LIG_FHA_2	706	712	PF00498	0.598
LIG_FHA_2	738	744	PF00498	0.755
LIG_FHA_2	859	865	PF00498	0.674
LIG_FHA_2	884	890	PF00498	0.581
LIG_GBD_Chelix_1	614	622	PF00786	0.529
LIG_LIR_Apic_2	295	301	PF02991	0.347
LIG_LIR_Apic_2	401	405	PF02991	0.465
LIG_LIR_Apic_2	543	549	PF02991	0.574
LIG_LIR_Apic_2	573	578	PF02991	0.625
LIG_LIR_Apic_2	911	917	PF02991	0.639
LIG_LIR_Apic_2	96	102	PF02991	0.673
LIG_LIR_Gen_1	133	142	PF02991	0.362
LIG_LIR_Gen_1	168	177	PF02991	0.299
LIG_LIR_Gen_1	524	533	PF02991	0.650
LIG_LIR_Gen_1	592	601	PF02991	0.545
LIG_LIR_Nem_3	133	138	PF02991	0.362
LIG_LIR_Nem_3	168	174	PF02991	0.299
LIG_LIR_Nem_3	283	288	PF02991	0.362
LIG_LIR_Nem_3	346	351	PF02991	0.362
LIG_LIR_Nem_3	524	529	PF02991	0.659
LIG_LIR_Nem_3	592	596	PF02991	0.556
LIG_MAD2	217	225	PF02301	0.299
LIG_MAD2	938	946	PF02301	0.564
LIG_MYND_1	395	399	PF01753	0.510
LIG_MYND_1	919	923	PF01753	0.636
LIG_NRBOX	875	881	PF00104	0.501
LIG_Pex14_2	285	289	PF04695	0.481
LIG_Rb_pABgroove_1	112	120	PF01858	0.362
LIG_SH2_CRK	39	43	PF00017	0.463
LIG_SH2_CRK	546	550	PF00017	0.593
LIG_SH2_PTP2	13	16	PF00017	0.513
LIG_SH2_SRC	598	601	PF00017	0.497
LIG_SH2_STAP1	118	122	PF00017	0.362
LIG_SH2_STAP1	626	630	PF00017	0.527
LIG_SH2_STAP1	682	686	PF00017	0.523
LIG_SH2_STAT3	600	603	PF00017	0.500
LIG_SH2_STAT5	13	16	PF00017	0.518
LIG_SH2_STAT5	177	180	PF00017	0.329
LIG_SH2_STAT5	546	549	PF00017	0.628
LIG_SH2_STAT5	598	601	PF00017	0.497
LIG_SH2_STAT5	617	620	PF00017	0.461
LIG_SH2_STAT5	629	632	PF00017	0.416
LIG_SH2_STAT5	635	638	PF00017	0.413
LIG_SH2_STAT5	682	685	PF00017	0.525
LIG_SH2_STAT5	807	810	PF00017	0.630
LIG_SH2_STAT5	914	917	PF00017	0.541
LIG_SH3_1	392	398	PF00018	0.522
LIG_SH3_1	546	552	PF00018	0.652
LIG_SH3_1	847	853	PF00018	0.570
LIG_SH3_2	464	469	PF14604	0.669
LIG_SH3_2	520	525	PF14604	0.587
LIG_SH3_3	135	141	PF00018	0.376
LIG_SH3_3	390	396	PF00018	0.596
LIG_SH3_3	449	455	PF00018	0.674
LIG_SH3_3	461	467	PF00018	0.591
LIG_SH3_3	481	487	PF00018	0.757
LIG_SH3_3	505	511	PF00018	0.683
LIG_SH3_3	517	523	PF00018	0.641
LIG_SH3_3	546	552	PF00018	0.594
LIG_SH3_3	58	64	PF00018	0.614
LIG_SH3_3	681	687	PF00018	0.469
LIG_SH3_3	724	730	PF00018	0.680
LIG_SH3_3	775	781	PF00018	0.729
LIG_SH3_3	847	853	PF00018	0.617
LIG_SH3_3	913	919	PF00018	0.639
LIG_SH3_3	940	946	PF00018	0.513
LIG_SH3_3	99	105	PF00018	0.618
LIG_SH3_4	104	111	PF00018	0.442
LIG_Sin3_3	226	233	PF02671	0.362
LIG_SUMO_SIM_anti_2	112	119	PF11976	0.299
LIG_SUMO_SIM_anti_2	592	598	PF11976	0.539
LIG_SUMO_SIM_par_1	319	324	PF11976	0.299
LIG_SUMO_SIM_par_1	883	889	PF11976	0.501
LIG_TRFH_1	575	579	PF08558	0.622
LIG_TYR_ITIM	37	42	PF00017	0.436
LIG_TYR_ITIM	596	601	PF00017	0.553
LIG_UBA3_1	210	214	PF00899	0.412
LIG_WRC_WIRS_1	590	595	PF05994	0.535
LIG_WW_2	395	398	PF00397	0.503
LIG_WW_3	140	144	PF00397	0.362
MOD_CDC14_SPxK_1	300	303	PF00782	0.299
MOD_CDK_SPxK_1	297	303	PF00069	0.299
MOD_CDK_SPxK_1	463	469	PF00069	0.595
MOD_CK1_1	144	150	PF00069	0.370
MOD_CK1_1	165	171	PF00069	0.505
MOD_CK1_1	436	442	PF00069	0.686
MOD_CK1_1	459	465	PF00069	0.702
MOD_CK1_1	488	494	PF00069	0.702
MOD_CK1_1	560	566	PF00069	0.619
MOD_CK1_1	568	574	PF00069	0.643
MOD_CK1_1	705	711	PF00069	0.680
MOD_CK1_1	736	742	PF00069	0.649
MOD_CK1_1	753	759	PF00069	0.597
MOD_CK1_1	899	905	PF00069	0.564
MOD_CK1_1	95	101	PF00069	0.679
MOD_CK1_1	972	978	PF00069	0.601
MOD_CK2_1	158	164	PF00069	0.362
MOD_CK2_1	267	273	PF00069	0.377
MOD_CK2_1	407	413	PF00069	0.558
MOD_CK2_1	416	422	PF00069	0.563
MOD_CK2_1	480	486	PF00069	0.686
MOD_CK2_1	705	711	PF00069	0.645
MOD_CK2_1	737	743	PF00069	0.653
MOD_CK2_1	883	889	PF00069	0.517
MOD_CK2_1	904	910	PF00069	0.735
MOD_GlcNHglycan	147	150	PF01048	0.445
MOD_GlcNHglycan	231	234	PF01048	0.362
MOD_GlcNHglycan	262	265	PF01048	0.341
MOD_GlcNHglycan	316	319	PF01048	0.299
MOD_GlcNHglycan	409	412	PF01048	0.612
MOD_GlcNHglycan	433	436	PF01048	0.694
MOD_GlcNHglycan	45	48	PF01048	0.490
MOD_GlcNHglycan	486	490	PF01048	0.629
MOD_GlcNHglycan	542	545	PF01048	0.678
MOD_GlcNHglycan	692	695	PF01048	0.595
MOD_GlcNHglycan	7	10	PF01048	0.653
MOD_GlcNHglycan	704	707	PF01048	0.544
MOD_GlcNHglycan	898	901	PF01048	0.678
MOD_GlcNHglycan	90	93	PF01048	0.677
MOD_GlcNHglycan	906	909	PF01048	0.582
MOD_GlcNHglycan	971	974	PF01048	0.582
MOD_GSK3_1	100	107	PF00069	0.530
MOD_GSK3_1	141	148	PF00069	0.392
MOD_GSK3_1	158	165	PF00069	0.371
MOD_GSK3_1	288	295	PF00069	0.391
MOD_GSK3_1	334	341	PF00069	0.362
MOD_GSK3_1	416	423	PF00069	0.620
MOD_GSK3_1	429	436	PF00069	0.779
MOD_GSK3_1	459	466	PF00069	0.644
MOD_GSK3_1	485	492	PF00069	0.670
MOD_GSK3_1	540	547	PF00069	0.562
MOD_GSK3_1	557	564	PF00069	0.609
MOD_GSK3_1	63	70	PF00069	0.655
MOD_GSK3_1	636	643	PF00069	0.562
MOD_GSK3_1	733	740	PF00069	0.625
MOD_GSK3_1	746	753	PF00069	0.599
MOD_GSK3_1	807	814	PF00069	0.609
MOD_GSK3_1	88	95	PF00069	0.679
MOD_GSK3_1	904	911	PF00069	0.674
MOD_GSK3_1	947	954	PF00069	0.565
MOD_GSK3_1	964	971	PF00069	0.509
MOD_N-GLC_1	459	464	PF02516	0.581
MOD_N-GLC_1	845	850	PF02516	0.672
MOD_N-GLC_2	647	649	PF02516	0.592
MOD_NEK2_1	228	233	PF00069	0.308
MOD_NEK2_1	326	331	PF00069	0.299
MOD_NEK2_1	384	389	PF00069	0.323
MOD_NEK2_1	636	641	PF00069	0.587
MOD_NEK2_1	702	707	PF00069	0.534
MOD_NEK2_1	746	751	PF00069	0.707
MOD_NEK2_1	787	792	PF00069	0.613
MOD_NEK2_1	816	821	PF00069	0.654
MOD_NEK2_2	209	214	PF00069	0.299
MOD_NEK2_2	680	685	PF00069	0.483
MOD_PIKK_1	104	110	PF00454	0.562
MOD_PIKK_1	334	340	PF00454	0.299
MOD_PIKK_1	433	439	PF00454	0.722
MOD_PIKK_1	67	73	PF00454	0.641
MOD_PK_1	480	486	PF00069	0.686
MOD_PK_1	788	794	PF00069	0.599
MOD_PKA_1	367	373	PF00069	0.250
MOD_PKA_1	4	10	PF00069	0.545
MOD_PKA_2	165	171	PF00069	0.299
MOD_PKA_2	326	332	PF00069	0.299
MOD_PKA_2	367	373	PF00069	0.328
MOD_PKA_2	376	382	PF00069	0.374
MOD_PKA_2	384	390	PF00069	0.417
MOD_PKA_2	515	521	PF00069	0.691
MOD_PKA_2	640	646	PF00069	0.579
MOD_PKA_2	702	708	PF00069	0.607
MOD_PKA_2	787	793	PF00069	0.608
MOD_Plk_1	736	742	PF00069	0.548
MOD_Plk_1	863	869	PF00069	0.630
MOD_Plk_2-3	737	743	PF00069	0.553
MOD_Plk_2-3	955	961	PF00069	0.545
MOD_Plk_4	384	390	PF00069	0.362
MOD_Plk_4	45	51	PF00069	0.481
MOD_Plk_4	565	571	PF00069	0.538
MOD_Plk_4	610	616	PF00069	0.626
MOD_Plk_4	811	817	PF00069	0.632
MOD_Plk_4	910	916	PF00069	0.543
MOD_ProDKin_1	158	164	PF00069	0.299
MOD_ProDKin_1	283	289	PF00069	0.380
MOD_ProDKin_1	292	298	PF00069	0.322
MOD_ProDKin_1	423	429	PF00069	0.657
MOD_ProDKin_1	463	469	PF00069	0.598
MOD_ProDKin_1	557	563	PF00069	0.669
MOD_ProDKin_1	60	66	PF00069	0.579
MOD_ProDKin_1	817	823	PF00069	0.602
MOD_ProDKin_1	846	852	PF00069	0.617
MOD_ProDKin_1	899	905	PF00069	0.638
MOD_SUMO_for_1	333	336	PF00179	0.362
MOD_SUMO_rev_2	77	84	PF00179	0.692
TRG_DiLeu_BaLyEn_6	697	702	PF01217	0.485
TRG_DiLeu_BaLyEn_6	770	775	PF01217	0.667
TRG_ENDOCYTIC_2	13	16	PF00928	0.576
TRG_ENDOCYTIC_2	39	42	PF00928	0.464
TRG_ENDOCYTIC_2	598	601	PF00928	0.593
TRG_ER_diArg_1	215	217	PF00400	0.299
TRG_ER_diArg_1	366	368	PF00400	0.250
TRG_ER_diArg_1	697	700	PF00400	0.503
TRG_ER_diArg_1	844	847	PF00400	0.639
TRG_ER_diArg_1	880	882	PF00400	0.667
TRG_NLS_MonoCore_2	213	218	PF00514	0.299
TRG_Pf-PMV_PEXEL_1	349	353	PF00026	0.362

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IGM5	Leptomonas seymouri	43%	92%
A0A3S7WWM5	Leishmania donovani	92%	99%
A4HZ84	Leishmania infantum	93%	100%
E9AV51	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	99%