DUF4833 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCC7_LEIMA

TriTrypDb:

LmjF.21.0830 , LMJLV39_210014700 , LMJSD75_210014700

Length:

384

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.458
CLV_C14_Caspase3-7	334	338	PF00656	0.342
CLV_NRD_NRD_1	122	124	PF00675	0.484
CLV_PCSK_KEX2_1	121	123	PF00082	0.464
CLV_PCSK_KEX2_1	354	356	PF00082	0.342
CLV_PCSK_KEX2_1	88	90	PF00082	0.424
CLV_PCSK_PC1ET2_1	354	356	PF00082	0.342
CLV_PCSK_PC1ET2_1	88	90	PF00082	0.424
CLV_PCSK_SKI1_1	10	14	PF00082	0.470
DEG_SPOP_SBC_1	278	282	PF00917	0.612
DOC_CKS1_1	35	40	PF01111	0.432
DOC_MAPK_gen_1	10	20	PF00069	0.436
DOC_PP4_FxxP_1	26	29	PF00568	0.400
DOC_USP7_MATH_1	175	179	PF00917	0.537
DOC_USP7_MATH_1	207	211	PF00917	0.615
DOC_USP7_MATH_1	257	261	PF00917	0.707
DOC_USP7_MATH_1	278	282	PF00917	0.587
DOC_USP7_MATH_1	29	33	PF00917	0.437
DOC_USP7_UBL2_3	345	349	PF12436	0.483
DOC_WW_Pin1_4	144	149	PF00397	0.425
DOC_WW_Pin1_4	159	164	PF00397	0.496
DOC_WW_Pin1_4	267	272	PF00397	0.725
DOC_WW_Pin1_4	34	39	PF00397	0.449
LIG_14-3-3_CanoR_1	24	29	PF00244	0.360
LIG_14-3-3_CanoR_1	262	266	PF00244	0.620
LIG_BIR_II_1	1	5	PF00653	0.600
LIG_BRCT_BRCA1_1	15	19	PF00533	0.408
LIG_FHA_1	149	155	PF00498	0.449
LIG_FHA_1	300	306	PF00498	0.782
LIG_FHA_1	317	323	PF00498	0.490
LIG_FHA_1	76	82	PF00498	0.344
LIG_FHA_2	280	286	PF00498	0.754
LIG_FHA_2	291	297	PF00498	0.558
LIG_FHA_2	332	338	PF00498	0.331
LIG_FHA_2	372	378	PF00498	0.341
LIG_FHA_2	9	15	PF00498	0.472
LIG_LIR_Apic_2	226	230	PF02991	0.407
LIG_LIR_Apic_2	23	29	PF02991	0.413
LIG_LIR_Apic_2	32	38	PF02991	0.458
LIG_LIR_Gen_1	164	172	PF02991	0.466
LIG_LIR_Gen_1	236	245	PF02991	0.443
LIG_LIR_Gen_1	363	372	PF02991	0.296
LIG_LIR_Nem_3	16	22	PF02991	0.399
LIG_LIR_Nem_3	164	169	PF02991	0.463
LIG_LIR_Nem_3	226	231	PF02991	0.410
LIG_LIR_Nem_3	236	241	PF02991	0.394
LIG_LIR_Nem_3	243	247	PF02991	0.392
LIG_LIR_Nem_3	363	367	PF02991	0.317
LIG_Pex14_1	227	231	PF04695	0.399
LIG_SH2_CRK	35	39	PF00017	0.506
LIG_SH2_CRK	357	361	PF00017	0.348
LIG_SH2_PTP2	364	367	PF00017	0.306
LIG_SH2_SRC	250	253	PF00017	0.361
LIG_SH2_SRC	364	367	PF00017	0.297
LIG_SH2_STAP1	77	81	PF00017	0.349
LIG_SH2_STAT5	109	112	PF00017	0.397
LIG_SH2_STAT5	117	120	PF00017	0.458
LIG_SH2_STAT5	234	237	PF00017	0.380
LIG_SH2_STAT5	250	253	PF00017	0.395
LIG_SH2_STAT5	347	350	PF00017	0.348
LIG_SH2_STAT5	364	367	PF00017	0.348
LIG_SH2_STAT5	65	68	PF00017	0.457
LIG_SH2_STAT5	77	80	PF00017	0.368
LIG_SH3_3	227	233	PF00018	0.404
LIG_SH3_3	236	242	PF00018	0.315
LIG_SH3_3	246	252	PF00018	0.229
LIG_SH3_3	265	271	PF00018	0.606
LIG_SUMO_SIM_anti_2	131	137	PF11976	0.434
LIG_SUMO_SIM_anti_2	178	184	PF11976	0.507
LIG_SUMO_SIM_anti_2	324	334	PF11976	0.333
LIG_SUMO_SIM_anti_2	339	344	PF11976	0.241
LIG_SUMO_SIM_par_1	324	334	PF11976	0.342
LIG_TYR_ITIM	362	367	PF00017	0.306
LIG_UBA3_1	247	256	PF00899	0.400
MOD_CK1_1	159	165	PF00069	0.452
MOD_CK1_1	260	266	PF00069	0.651
MOD_CK1_1	270	276	PF00069	0.722
MOD_CK1_1	281	287	PF00069	0.636
MOD_CK1_1	371	377	PF00069	0.348
MOD_CK1_1	8	14	PF00069	0.498
MOD_CK2_1	113	119	PF00069	0.461
MOD_CK2_1	131	137	PF00069	0.445
MOD_CK2_1	290	296	PF00069	0.655
MOD_CK2_1	338	344	PF00069	0.342
MOD_CK2_1	371	377	PF00069	0.394
MOD_CK2_1	8	14	PF00069	0.437
MOD_GlcNHglycan	144	147	PF01048	0.373
MOD_GlcNHglycan	198	202	PF01048	0.664
MOD_GlcNHglycan	210	213	PF01048	0.659
MOD_GlcNHglycan	272	275	PF01048	0.628
MOD_GlcNHglycan	319	322	PF01048	0.559
MOD_GlcNHglycan	7	10	PF01048	0.543
MOD_GlcNHglycan	91	94	PF01048	0.450
MOD_GSK3_1	109	116	PF00069	0.528
MOD_GSK3_1	144	151	PF00069	0.410
MOD_GSK3_1	171	178	PF00069	0.472
MOD_GSK3_1	20	27	PF00069	0.508
MOD_GSK3_1	203	210	PF00069	0.672
MOD_GSK3_1	256	263	PF00069	0.623
MOD_GSK3_1	277	284	PF00069	0.659
MOD_GSK3_1	299	306	PF00069	0.664
MOD_GSK3_1	30	37	PF00069	0.328
MOD_GSK3_1	317	324	PF00069	0.482
MOD_GSK3_1	371	378	PF00069	0.348
MOD_N-GLC_1	303	308	PF02516	0.594
MOD_NEK2_1	136	141	PF00069	0.415
MOD_NEK2_1	20	25	PF00069	0.280
MOD_NEK2_1	299	304	PF00069	0.635
MOD_NEK2_1	368	373	PF00069	0.331
MOD_NEK2_1	44	49	PF00069	0.410
MOD_NEK2_1	5	10	PF00069	0.553
MOD_PIKK_1	30	36	PF00454	0.483
MOD_PIKK_1	83	89	PF00454	0.422
MOD_PK_1	24	30	PF00069	0.420
MOD_PKA_2	261	267	PF00069	0.621
MOD_Plk_1	102	108	PF00069	0.447
MOD_Plk_1	131	137	PF00069	0.470
MOD_Plk_1	257	263	PF00069	0.569
MOD_Plk_1	303	309	PF00069	0.640
MOD_Plk_1	325	331	PF00069	0.316
MOD_Plk_1	338	344	PF00069	0.244
MOD_Plk_2-3	131	137	PF00069	0.456
MOD_Plk_4	113	119	PF00069	0.461
MOD_Plk_4	131	137	PF00069	0.483
MOD_Plk_4	150	156	PF00069	0.318
MOD_Plk_4	177	183	PF00069	0.495
MOD_Plk_4	223	229	PF00069	0.444
MOD_Plk_4	325	331	PF00069	0.348
MOD_Plk_4	338	344	PF00069	0.348
MOD_ProDKin_1	144	150	PF00069	0.427
MOD_ProDKin_1	159	165	PF00069	0.495
MOD_ProDKin_1	267	273	PF00069	0.727
MOD_ProDKin_1	34	40	PF00069	0.445
MOD_SUMO_rev_2	218	226	PF00179	0.352
MOD_SUMO_rev_2	350	356	PF00179	0.350
MOD_SUMO_rev_2	377	383	PF00179	0.308
TRG_ENDOCYTIC_2	364	367	PF00928	0.318
TRG_ER_diArg_1	121	123	PF00400	0.464
TRG_ER_diArg_1	45	48	PF00400	0.441
TRG_ER_diArg_1	49	52	PF00400	0.499
TRG_ER_diLys_1	381	384	PF00400	0.453
TRG_NES_CRM1_1	339	352	PF08389	0.296

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J1	Leptomonas seymouri	36%	100%
A0A0N0P3Y3	Leptomonas seymouri	60%	100%
A0A3Q8IAB9	Leishmania donovani	94%	100%
A0A3Q8IF47	Leishmania donovani	34%	100%
A4HZM6	Leishmania infantum	34%	100%
A4HZM7	Leishmania infantum	94%	100%
E9AV54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
E9AV55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
Q4QCC6	Leishmania major	34%	91%