DUF4833 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCC6_LEIMA

TriTrypDb:

LmjF.21.0835 , LMJLV39_210014800 , LMJSD75_210014800

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 15
NetGPI	no	yes: 0, no: 15

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCC6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCC6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.442
CLV_NRD_NRD_1	136	138	PF00675	0.328
CLV_NRD_NRD_1	152	154	PF00675	0.281
CLV_NRD_NRD_1	61	63	PF00675	0.459
CLV_PCSK_KEX2_1	135	137	PF00082	0.336
CLV_PCSK_KEX2_1	60	62	PF00082	0.431
CLV_PCSK_PC7_1	57	63	PF00082	0.481
DOC_CDC14_PxL_1	215	223	PF14671	0.366
DOC_MAPK_gen_1	185	193	PF00069	0.371
DOC_MAPK_gen_1	82	90	PF00069	0.269
DOC_PP2B_LxvP_1	216	219	PF13499	0.345
DOC_USP7_MATH_1	103	107	PF00917	0.290
DOC_USP7_MATH_1	108	112	PF00917	0.278
DOC_USP7_MATH_1	181	185	PF00917	0.421
DOC_USP7_MATH_1	207	211	PF00917	0.427
DOC_USP7_MATH_1	227	231	PF00917	0.706
DOC_USP7_UBL2_3	276	280	PF12436	0.381
DOC_WW_Pin1_4	237	242	PF00397	0.747
DOC_WW_Pin1_4	24	29	PF00397	0.547
LIG_14-3-3_CanoR_1	168	175	PF00244	0.329
LIG_APCC_ABBA_1	231	236	PF00400	0.479
LIG_APCC_ABBA_1	76	81	PF00400	0.309
LIG_BIR_II_1	1	5	PF00653	0.533
LIG_BIR_III_2	35	39	PF00653	0.490
LIG_FHA_1	25	31	PF00498	0.553
LIG_FHA_2	233	239	PF00498	0.708
LIG_LIR_Gen_1	167	178	PF02991	0.476
LIG_LIR_Gen_1	192	202	PF02991	0.380
LIG_LIR_Nem_3	167	173	PF02991	0.465
LIG_LIR_Nem_3	192	198	PF02991	0.396
LIG_LIR_Nem_3	307	313	PF02991	0.373
LIG_NRP_CendR_1	312	315	PF00754	0.423
LIG_Rb_pABgroove_1	189	197	PF01858	0.410
LIG_SH2_CRK	288	292	PF00017	0.317
LIG_SH2_NCK_1	195	199	PF00017	0.277
LIG_SH2_SRC	195	198	PF00017	0.276
LIG_SH2_STAT5	278	281	PF00017	0.301
LIG_SH2_STAT5	79	82	PF00017	0.312
LIG_SUMO_SIM_anti_2	189	197	PF11976	0.344
LIG_TYR_ITIM	193	198	PF00017	0.309
MOD_CK1_1	111	117	PF00069	0.358
MOD_CK1_1	237	243	PF00069	0.760
MOD_CK1_1	302	308	PF00069	0.317
MOD_CK2_1	232	238	PF00069	0.702
MOD_CK2_1	305	311	PF00069	0.443
MOD_CK2_1	80	86	PF00069	0.291
MOD_CMANNOS	211	214	PF00535	0.449
MOD_GlcNHglycan	105	108	PF01048	0.314
MOD_GlcNHglycan	110	113	PF01048	0.309
MOD_GSK3_1	22	29	PF00069	0.629
MOD_GSK3_1	232	239	PF00069	0.696
MOD_GSK3_1	298	305	PF00069	0.342
MOD_N-GLC_1	55	60	PF02516	0.445
MOD_NEK2_1	55	60	PF00069	0.474
MOD_NEK2_1	95	100	PF00069	0.459
MOD_NEK2_2	17	22	PF00069	0.510
MOD_Plk_1	306	312	PF00069	0.389
MOD_Plk_1	55	61	PF00069	0.356
MOD_Plk_4	256	262	PF00069	0.413
MOD_Plk_4	269	275	PF00069	0.251
MOD_ProDKin_1	237	243	PF00069	0.747
MOD_ProDKin_1	24	30	PF00069	0.549
MOD_SUMO_for_1	291	294	PF00179	0.423
MOD_SUMO_rev_2	147	156	PF00179	0.365
MOD_SUMO_rev_2	281	287	PF00179	0.302
TRG_DiLeu_BaEn_1	189	194	PF01217	0.347
TRG_ENDOCYTIC_2	195	198	PF00928	0.305
TRG_ENDOCYTIC_2	310	313	PF00928	0.369
TRG_ER_diArg_1	135	137	PF00400	0.384
TRG_ER_diArg_1	59	62	PF00400	0.428

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3J1	Leptomonas seymouri	57%	98%
A0A0N0P3Y3	Leptomonas seymouri	35%	84%
A0A1X0NXM7	Trypanosomatidae	40%	100%
A0A3Q8IAB9	Leishmania donovani	34%	82%
A0A3Q8IF47	Leishmania donovani	90%	98%
A0A3R7N4N0	Trypanosoma rangeli	37%	100%
A4HBT1	Leishmania braziliensis	77%	100%
A4HZM6	Leishmania infantum	91%	98%
A4HZM7	Leishmania infantum	34%	82%
D0A1E0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9AV54	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	86%
E9AV55	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	98%
Q4QCC7	Leishmania major	34%	82%
V5BDR4	Trypanosoma cruzi	38%	100%