Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCC4_LEIMA

TriTrypDb:

LmjF.21.0843 , LMJLV39_210015000 , LMJSD75_210015000

Length:

319

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	6
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QCC4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCC4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	157	159	PF00675	0.619
CLV_NRD_NRD_1	223	225	PF00675	0.420
CLV_NRD_NRD_1	229	231	PF00675	0.482
CLV_NRD_NRD_1	281	283	PF00675	0.454
CLV_NRD_NRD_1	32	34	PF00675	0.730
CLV_NRD_NRD_1	8	10	PF00675	0.741
CLV_PCSK_FUR_1	202	206	PF00082	0.622
CLV_PCSK_FUR_1	279	283	PF00082	0.452
CLV_PCSK_FUR_1	39	43	PF00082	0.719
CLV_PCSK_KEX2_1	204	206	PF00082	0.504
CLV_PCSK_KEX2_1	223	225	PF00082	0.381
CLV_PCSK_KEX2_1	228	230	PF00082	0.475
CLV_PCSK_KEX2_1	264	266	PF00082	0.514
CLV_PCSK_KEX2_1	281	283	PF00082	0.454
CLV_PCSK_KEX2_1	32	34	PF00082	0.730
CLV_PCSK_KEX2_1	41	43	PF00082	0.627
CLV_PCSK_KEX2_1	7	9	PF00082	0.720
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.546
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.478
CLV_PCSK_PC1ET2_1	264	266	PF00082	0.514
CLV_PCSK_PC1ET2_1	41	43	PF00082	0.723
CLV_PCSK_PC7_1	224	230	PF00082	0.522
CLV_PCSK_PC7_1	4	10	PF00082	0.737
CLV_PCSK_SKI1_1	121	125	PF00082	0.652
CLV_PCSK_SKI1_1	159	163	PF00082	0.621
CLV_PCSK_SKI1_1	187	191	PF00082	0.645
CLV_PCSK_SKI1_1	205	209	PF00082	0.236
CLV_PCSK_SKI1_1	9	13	PF00082	0.736
DEG_APCC_DBOX_1	186	194	PF00400	0.456
DOC_CYCLIN_RxL_1	224	238	PF00134	0.694
DOC_MAPK_gen_1	228	234	PF00069	0.704
DOC_MAPK_RevD_3	208	224	PF00069	0.411
DOC_PP1_RVXF_1	202	209	PF00149	0.346
DOC_USP7_MATH_1	72	76	PF00917	0.595
DOC_WW_Pin1_4	243	248	PF00397	0.709
DOC_WW_Pin1_4	65	70	PF00397	0.581
DOC_WW_Pin1_4	82	87	PF00397	0.483
LIG_14-3-3_CanoR_1	121	129	PF00244	0.449
LIG_14-3-3_CanoR_1	268	274	PF00244	0.707
LIG_14-3-3_CanoR_1	32	40	PF00244	0.487
LIG_14-3-3_CanoR_1	8	17	PF00244	0.555
LIG_BRCT_BRCA1_1	18	22	PF00533	0.532
LIG_BRCT_BRCA1_1	75	79	PF00533	0.577
LIG_FHA_1	166	172	PF00498	0.404
LIG_FHA_2	122	128	PF00498	0.437
LIG_FHA_2	132	138	PF00498	0.384
LIG_FHA_2	21	27	PF00498	0.505
LIG_FHA_2	270	276	PF00498	0.674
LIG_FHA_2	305	311	PF00498	0.640
LIG_Integrin_RGD_1	316	318	PF01839	0.426
LIG_LIR_Gen_1	212	222	PF02991	0.411
LIG_LIR_Gen_1	241	249	PF02991	0.778
LIG_LIR_Nem_3	212	217	PF02991	0.411
LIG_Pex14_1	214	218	PF04695	0.411
LIG_SH2_STAT5	226	229	PF00017	0.652
LIG_TRAF2_1	124	127	PF00917	0.366
LIG_TRAF2_1	35	38	PF00917	0.469
LIG_WRC_WIRS_1	146	151	PF05994	0.505
MOD_CK1_1	73	79	PF00069	0.717
MOD_CK1_1	96	102	PF00069	0.796
MOD_CK2_1	121	127	PF00069	0.634
MOD_CK2_1	131	137	PF00069	0.478
MOD_CK2_1	251	257	PF00069	0.762
MOD_CK2_1	269	275	PF00069	0.500
MOD_CK2_1	304	310	PF00069	0.546
MOD_CK2_1	32	38	PF00069	0.610
MOD_CK2_1	75	81	PF00069	0.785
MOD_GlcNHglycan	18	21	PF01048	0.619
MOD_GlcNHglycan	70	73	PF01048	0.798
MOD_GlcNHglycan	86	89	PF01048	0.723
MOD_GlcNHglycan	96	99	PF01048	0.782
MOD_GSK3_1	11	18	PF00069	0.678
MOD_GSK3_1	165	172	PF00069	0.525
MOD_GSK3_1	243	250	PF00069	0.638
MOD_GSK3_1	68	75	PF00069	0.803
MOD_GSK3_1	80	87	PF00069	0.586
MOD_GSK3_1	89	96	PF00069	0.647
MOD_N-GLC_1	100	105	PF02516	0.718
MOD_NEK2_1	10	15	PF00069	0.676
MOD_NEK2_1	128	133	PF00069	0.545
MOD_NEK2_1	269	274	PF00069	0.646
MOD_NEK2_1	3	8	PF00069	0.659
MOD_NEK2_1	74	79	PF00069	0.791
MOD_NEK2_1	89	94	PF00069	0.572
MOD_PIKK_1	169	175	PF00454	0.521
MOD_PIKK_1	304	310	PF00454	0.546
MOD_PKA_1	32	38	PF00069	0.610
MOD_PKA_2	113	119	PF00069	0.586
MOD_PKA_2	267	273	PF00069	0.713
MOD_PKA_2	3	9	PF00069	0.699
MOD_PKA_2	32	38	PF00069	0.610
MOD_PKB_1	7	15	PF00069	0.678
MOD_Plk_1	165	171	PF00069	0.522
MOD_Plk_4	209	215	PF00069	0.411
MOD_Plk_4	75	81	PF00069	0.684
MOD_ProDKin_1	243	249	PF00069	0.638
MOD_ProDKin_1	65	71	PF00069	0.738
MOD_ProDKin_1	82	88	PF00069	0.603
TRG_ENDOCYTIC_2	120	123	PF00928	0.560
TRG_ENDOCYTIC_2	146	149	PF00928	0.518
TRG_ER_diArg_1	132	135	PF00400	0.550
TRG_ER_diArg_1	222	224	PF00400	0.504
TRG_ER_diArg_1	7	9	PF00400	0.681
TRG_Pf-PMV_PEXEL_1	143	147	PF00026	0.528
TRG_Pf-PMV_PEXEL_1	230	235	PF00026	0.622
TRG_Pf-PMV_PEXEL_1	276	280	PF00026	0.655

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIJ9	Leptomonas seymouri	62%	100%
A0A3S7WWJ0	Leishmania donovani	96%	100%
A4HBT5	Leishmania braziliensis	80%	75%
A4HZM4	Leishmania infantum	96%	100%
E9AV57	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%