Hypoxanthine phosphoribosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypoxanthine-guanine phosphoribosyltransferase

Species:

Leishmania major

UniProt:

Q4QCC3_LEIMA

TriTrypDb:

LmjF.21.0845 , LMJLV39_210015100 , LMJSD75_210015100

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005777	peroxisome	6	2
GO:0005829	cytosol	2	2
GO:0020015	glycosome	7	2
GO:0020022	acidocalcisome	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2

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Expansion

Sequence features

Q4QCC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCC3

PDB structure(s): 7cmj_A , 7cmj_B

Function

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Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006144	purine nucleobase metabolic process	5	2
GO:0006163	purine nucleotide metabolic process	5	6
GO:0006164	purine nucleotide biosynthetic process	6	6
GO:0006166	purine ribonucleoside salvage	5	6
GO:0006177	GMP biosynthetic process	8	2
GO:0006178	guanine salvage	6	2
GO:0006188	IMP biosynthetic process	8	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006753	nucleoside phosphate metabolic process	4	6

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0000287	magnesium ion binding	5	2
GO:0003824	catalytic activity	1	6
GO:0004422	hypoxanthine phosphoribosyltransferase activity	6	6
GO:0005488	binding	1	6
GO:0016740	transferase activity	2	6
GO:0016757	glycosyltransferase activity	3	6
GO:0016763	pentosyltransferase activity	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.548
CLV_C14_Caspase3-7	126	130	PF00656	0.437
CLV_NRD_NRD_1	160	162	PF00675	0.445
CLV_NRD_NRD_1	17	19	PF00675	0.484
CLV_PCSK_KEX2_1	17	19	PF00082	0.484
CLV_PCSK_SKI1_1	107	111	PF00082	0.379
CLV_PCSK_SKI1_1	119	123	PF00082	0.359
CLV_PCSK_SKI1_1	139	143	PF00082	0.211
CLV_PCSK_SKI1_1	39	43	PF00082	0.324
CLV_PCSK_SKI1_1	49	53	PF00082	0.285

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHW3	Leptomonas seymouri	34%	88%
A0A0N1PCR6	Leptomonas seymouri	78%	100%
A0A0S4JHI0	Bodo saltans	55%	99%
A0A0S4JLD9	Bodo saltans	53%	100%
A0A1X0NZ20	Trypanosomatidae	60%	100%
A0A1X0NZ92	Trypanosomatidae	37%	91%
A0A422N3N7	Trypanosoma rangeli	36%	92%
A0A422N3S1	Trypanosoma rangeli	59%	97%
A4HBT6	Leishmania braziliensis	82%	100%
A4HBT7	Leishmania braziliensis	35%	88%

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