Hypoxanthine phosphoribosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypoxanthine-guanine phosphoribosyltransferase

Species:

Leishmania major

UniProt:

Q4QCC3_LEIMA

TriTrypDb:

LmjF.21.0845 , LMJLV39_210015100 , LMJSD75_210015100

Length:

211

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 6
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 16

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	6
GO:0005777	peroxisome	6	2
GO:0005829	cytosol	2	2
GO:0020015	glycosome	7	2
GO:0020022	acidocalcisome	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

Q4QCC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCC3

PDB structure(s): 7cmj_A , 7cmj_B

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	6
GO:0006144	purine nucleobase metabolic process	5	2
GO:0006163	purine nucleotide metabolic process	5	6
GO:0006164	purine nucleotide biosynthetic process	6	6
GO:0006166	purine ribonucleoside salvage	5	6
GO:0006177	GMP biosynthetic process	8	2
GO:0006178	guanine salvage	6	2
GO:0006188	IMP biosynthetic process	8	6
GO:0006725	cellular aromatic compound metabolic process	3	6
GO:0006753	nucleoside phosphate metabolic process	4	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009058	biosynthetic process	2	6
GO:0009112	nucleobase metabolic process	4	2
GO:0009113	purine nucleobase biosynthetic process	6	2
GO:0009116	nucleoside metabolic process	4	6
GO:0009117	nucleotide metabolic process	5	6
GO:0009119	ribonucleoside metabolic process	5	6
GO:0009123	nucleoside monophosphate metabolic process	5	6
GO:0009124	nucleoside monophosphate biosynthetic process	6	6
GO:0009126	purine nucleoside monophosphate metabolic process	6	6
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	6
GO:0009150	purine ribonucleotide metabolic process	6	6
GO:0009152	purine ribonucleotide biosynthetic process	7	6
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	6
GO:0009161	ribonucleoside monophosphate metabolic process	6	6
GO:0009163	nucleoside biosynthetic process	5	6
GO:0009165	nucleotide biosynthetic process	6	6
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	6
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	6
GO:0009259	ribonucleotide metabolic process	5	6
GO:0009260	ribonucleotide biosynthetic process	6	6
GO:0009987	cellular process	1	6
GO:0018130	heterocycle biosynthetic process	4	6
GO:0019438	aromatic compound biosynthetic process	4	6
GO:0019637	organophosphate metabolic process	3	6
GO:0019693	ribose phosphate metabolic process	4	6
GO:0032261	purine nucleotide salvage	5	6
GO:0032263	GMP salvage	7	2
GO:0032264	IMP salvage	7	6
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	6
GO:0034641	cellular nitrogen compound metabolic process	3	6
GO:0034654	nucleobase-containing compound biosynthetic process	4	6
GO:0042278	purine nucleoside metabolic process	5	6
GO:0042451	purine nucleoside biosynthetic process	6	6
GO:0042455	ribonucleoside biosynthetic process	6	6
GO:0043094	cellular metabolic compound salvage	3	6
GO:0043096	purine nucleobase salvage	5	2
GO:0043101	purine-containing compound salvage	4	6
GO:0043173	nucleotide salvage	4	6
GO:0043174	nucleoside salvage	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0044249	cellular biosynthetic process	3	6
GO:0044271	cellular nitrogen compound biosynthetic process	4	6
GO:0044281	small molecule metabolic process	2	6
GO:0044283	small molecule biosynthetic process	3	6
GO:0046037	GMP metabolic process	7	2
GO:0046040	IMP metabolic process	7	6
GO:0046098	guanine metabolic process	6	2
GO:0046099	guanine biosynthetic process	7	2
GO:0046100	hypoxanthine metabolic process	6	2
GO:0046112	nucleobase biosynthetic process	5	2
GO:0046128	purine ribonucleoside metabolic process	6	6
GO:0046129	purine ribonucleoside biosynthetic process	7	6
GO:0046390	ribose phosphate biosynthetic process	5	6
GO:0046483	heterocycle metabolic process	3	6
GO:0055086	nucleobase-containing small molecule metabolic process	3	6
GO:0071704	organic substance metabolic process	2	6
GO:0072521	purine-containing compound metabolic process	4	6
GO:0072522	purine-containing compound biosynthetic process	5	6
GO:0090407	organophosphate biosynthetic process	4	6
GO:0106380	purine ribonucleotide salvage	6	6
GO:1901135	carbohydrate derivative metabolic process	3	6
GO:1901137	carbohydrate derivative biosynthetic process	4	6
GO:1901293	nucleoside phosphate biosynthetic process	5	6
GO:1901360	organic cyclic compound metabolic process	3	6
GO:1901362	organic cyclic compound biosynthetic process	4	6
GO:1901564	organonitrogen compound metabolic process	3	6
GO:1901566	organonitrogen compound biosynthetic process	4	6
GO:1901576	organic substance biosynthetic process	3	6
GO:1901657	glycosyl compound metabolic process	4	6
GO:1901659	glycosyl compound biosynthetic process	5	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0000287	magnesium ion binding	5	2
GO:0003824	catalytic activity	1	6
GO:0004422	hypoxanthine phosphoribosyltransferase activity	6	6
GO:0005488	binding	1	6
GO:0016740	transferase activity	2	6
GO:0016757	glycosyltransferase activity	3	6
GO:0016763	pentosyltransferase activity	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043169	cation binding	3	6
GO:0046872	metal ion binding	4	6
GO:0052657	guanine phosphoribosyltransferase activity	6	6
GO:0097159	organic cyclic compound binding	2	6
GO:0106130	purine phosphoribosyltransferase activity	5	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.548
CLV_C14_Caspase3-7	126	130	PF00656	0.437
CLV_NRD_NRD_1	160	162	PF00675	0.445
CLV_NRD_NRD_1	17	19	PF00675	0.484
CLV_PCSK_KEX2_1	17	19	PF00082	0.484
CLV_PCSK_SKI1_1	107	111	PF00082	0.379
CLV_PCSK_SKI1_1	119	123	PF00082	0.359
CLV_PCSK_SKI1_1	139	143	PF00082	0.211
CLV_PCSK_SKI1_1	39	43	PF00082	0.324
CLV_PCSK_SKI1_1	49	53	PF00082	0.285
DOC_CYCLIN_RxL_1	104	114	PF00134	0.543
DOC_MAPK_gen_1	161	167	PF00069	0.561
DOC_PP1_RVXF_1	85	91	PF00149	0.543
DOC_USP7_UBL2_3	206	210	PF12436	0.609
DOC_USP7_UBL2_3	39	43	PF12436	0.496
DOC_WW_Pin1_4	4	9	PF00397	0.654
LIG_Actin_WH2_2	134	152	PF00022	0.543
LIG_BIR_II_1	1	5	PF00653	0.663
LIG_BRCT_BRCA1_1	67	71	PF00533	0.645
LIG_FHA_1	149	155	PF00498	0.552
LIG_FHA_1	70	76	PF00498	0.543
LIG_FHA_2	96	102	PF00498	0.496
LIG_LIR_Apic_2	202	207	PF02991	0.528
LIG_LIR_Nem_3	168	172	PF02991	0.635
LIG_LIR_Nem_3	188	193	PF02991	0.408
LIG_LIR_Nem_3	46	51	PF02991	0.638
LIG_LYPXL_yS_3	169	172	PF13949	0.543
LIG_PDZ_Class_1	206	211	PF00595	0.618
LIG_PTB_Apo_2	54	61	PF02174	0.512
LIG_PTB_Phospho_1	54	60	PF10480	0.512
LIG_SH2_NCK_1	204	208	PF00017	0.511
LIG_SH2_SRC	186	189	PF00017	0.434
LIG_SH2_STAP1	186	190	PF00017	0.406
LIG_SH2_STAT5	136	139	PF00017	0.606
LIG_SH2_STAT5	60	63	PF00017	0.599
LIG_SH3_3	164	170	PF00018	0.543
LIG_SUMO_SIM_anti_2	151	156	PF11976	0.543
LIG_SUMO_SIM_par_1	108	115	PF11976	0.579
LIG_SUMO_SIM_par_1	120	126	PF11976	0.559
LIG_SUMO_SIM_par_1	150	156	PF11976	0.543
LIG_TYR_ITIM	167	172	PF00017	0.543
LIG_UBA3_1	137	145	PF00899	0.550
LIG_UBA3_1	61	66	PF00899	0.614
LIG_WRC_WIRS_1	48	53	PF05994	0.512
MOD_CK1_1	130	136	PF00069	0.645
MOD_CK1_1	148	154	PF00069	0.422
MOD_CK1_1	23	29	PF00069	0.484
MOD_CK1_1	4	10	PF00069	0.647
MOD_CK1_1	95	101	PF00069	0.575
MOD_CK2_1	186	192	PF00069	0.466
MOD_CK2_1	95	101	PF00069	0.523
MOD_Cter_Amidation	15	18	PF01082	0.519
MOD_Cter_Amidation	159	162	PF01082	0.312
MOD_GlcNHglycan	101	105	PF01048	0.395
MOD_GlcNHglycan	129	132	PF01048	0.445
MOD_GlcNHglycan	158	161	PF01048	0.312
MOD_GlcNHglycan	22	25	PF01048	0.464
MOD_GlcNHglycan	3	6	PF01048	0.681
MOD_GlcNHglycan	8	11	PF01048	0.610
MOD_GSK3_1	47	54	PF00069	0.533
MOD_GSK3_1	65	72	PF00069	0.645
MOD_GSK3_1	91	98	PF00069	0.559
MOD_NEK2_1	1	6	PF00069	0.620
MOD_NEK2_1	51	56	PF00069	0.495
MOD_NEK2_1	65	70	PF00069	0.645
MOD_PIKK_1	26	32	PF00454	0.471
MOD_PKA_2	112	118	PF00069	0.553
MOD_Plk_4	148	154	PF00069	0.631
MOD_Plk_4	23	29	PF00069	0.449
MOD_Plk_4	65	71	PF00069	0.639
MOD_ProDKin_1	4	10	PF00069	0.651
MOD_SUMO_for_1	199	202	PF00179	0.478
MOD_SUMO_for_1	86	89	PF00179	0.512
MOD_SUMO_rev_2	202	211	PF00179	0.527
TRG_ENDOCYTIC_2	169	172	PF00928	0.645
TRG_ENDOCYTIC_2	190	193	PF00928	0.581
TRG_ENDOCYTIC_2	48	51	PF00928	0.645
TRG_Pf-PMV_PEXEL_1	107	111	PF00026	0.343
TRG_Pf-PMV_PEXEL_1	191	195	PF00026	0.443
TRG_Pf-PMV_PEXEL_1	77	81	PF00026	0.445

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHW3	Leptomonas seymouri	34%	88%
A0A0N1PCR6	Leptomonas seymouri	78%	100%
A0A0S4JHI0	Bodo saltans	55%	99%
A0A0S4JLD9	Bodo saltans	53%	100%
A0A1X0NZ20	Trypanosomatidae	60%	100%
A0A1X0NZ92	Trypanosomatidae	37%	91%
A0A422N3N7	Trypanosoma rangeli	36%	92%
A0A422N3S1	Trypanosoma rangeli	59%	97%
A4HBT6	Leishmania braziliensis	82%	100%
A4HBT7	Leishmania braziliensis	35%	88%
A4II60	Xenopus tropicalis	31%	94%
A5A6I1	Pan troglodytes	34%	97%
D0A1D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	90%
D0A1D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
D0A1E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9AGU6	Leishmania infantum	99%	100%
E9AGU7	Leishmania infantum	33%	88%
E9AV58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
E9AV59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	89%
O33799	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	39%	100%
O66821	Aquifex aeolicus (strain VF5)	34%	100%
O69537	Mycobacterium leprae (strain TN)	41%	100%
P00492	Homo sapiens	33%	97%
P00493	Mus musculus	33%	97%
P00494	Cricetulus griseus	29%	97%
P07833	Plasmodium falciparum (isolate K1 / Thailand)	27%	91%
P09383	Schistosoma mansoni	28%	74%
P0A5T1	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	40%	100%
P0A9M2	Escherichia coli (strain K12)	38%	100%
P0A9M3	Escherichia coli O6:H1 (strain CFT073 / ATCC 700928 / UPEC)	38%	100%
P0A9M4	Shigella flexneri	38%	100%
P0DD40	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	39%	100%
P0DD41	Streptococcus pyogenes serotype M3 (strain SSI-1)	39%	100%
P18134	Vibrio harveyi	39%	100%
P20035	Plasmodium falciparum (isolate FCR-3 / Gambia)	27%	91%
P27605	Rattus norvegicus	33%	97%
P37171	Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)	40%	100%
P37472	Bacillus subtilis (strain 168)	41%	100%
P43152	Leishmania donovani	99%	100%
P45078	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	40%	100%
P47696	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	22%	100%
P47959	Meriones unguiculatus	29%	97%
P51900	Tritrichomonas foetus	34%	100%
P57291	Buchnera aphidicola subsp. Acyrthosiphon pisum (strain APS)	37%	100%
P65827	Staphylococcus aureus (strain Mu50 / ATCC 700699)	36%	100%
P65828	Staphylococcus aureus (strain MW2)	36%	100%
P75119	Mycoplasma pneumoniae (strain ATCC 29342 / M129 / Subtype 1)	26%	100%
P96794	Mycobacterium avium	42%	100%
P99085	Staphylococcus aureus (strain N315)	36%	100%
P9WHQ8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	40%	100%
P9WHQ9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	40%	100%
Q02522	Lactococcus lactis subsp. lactis (strain IL1403)	46%	100%
Q07010	Trypanosoma brucei brucei	43%	100%
Q26997	Toxoplasma gondii	29%	92%
Q27541	Crithidia fasciculata	81%	100%
Q3SZ18	Bos taurus	30%	97%
Q45FY6	Sus scrofa	33%	97%
Q4QCC2	Leishmania major	34%	100%
Q54NJ8	Dictyostelium discoideum	42%	100%
Q5HIG5	Staphylococcus aureus (strain COL)	36%	100%
Q5HRP4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	36%	100%
Q5M216	Streptococcus thermophilus (strain CNRZ 1066)	38%	100%
Q5M6K8	Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)	38%	100%
Q5XEL6	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	39%	100%
Q64531	Mus spretus	33%	99%
Q6DCP3	Xenopus laevis	29%	94%
Q6GBX8	Staphylococcus aureus (strain MSSA476)	36%	100%
Q6GJG1	Staphylococcus aureus (strain MRSA252)	36%	100%
Q6LDD9	Macaca fascicularis	33%	97%
Q6WIT9	Canis lupus familiaris	33%	97%
Q7CNQ9	Streptococcus pyogenes serotype M18 (strain MGAS8232)	39%	100%
Q7KLF3	Leishmania donovani	99%	100%
Q839B2	Enterococcus faecalis (strain ATCC 700802 / V583)	44%	100%
Q8CQV4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	36%	100%
Q8DRP8	Streptococcus pneumoniae (strain ATCC BAA-255 / R6)	39%	100%
Q8DWM8	Streptococcus mutans serotype c (strain ATCC 700610 / UA159)	36%	100%
Q8E2H3	Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R)	38%	100%
Q8E7Y1	Streptococcus agalactiae serotype III (strain NEM316)	38%	100%
Q8K9U8	Buchnera aphidicola subsp. Schizaphis graminum (strain Sg)	34%	100%
Q97TC4	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	39%	100%
Q9NRG1	Homo sapiens	35%	94%
Q9U6Y2	Leishmania donovani	33%	88%
Q9W719	Gallus gallus	32%	97%
V5DEL0	Trypanosoma cruzi	36%	69%