Xanthine phosphoribosyltransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

xanthine phosphoribosyltransferase

Species:

Leishmania major

UniProt:

Q4QCC2_LEIMA

TriTrypDb:

LmjF.21.0850 , LMJLV39_210015200 , LMJSD75_210015200

Length:

238

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 16
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0005777	peroxisome	6	2
GO:0005829	cytosol	2	2
GO:0020015	glycosome	7	2
GO:0020022	acidocalcisome	5	2
GO:0031974	membrane-enclosed lumen	2	2
GO:0031981	nuclear lumen	5	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0042579	microbody	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043233	organelle lumen	3	2
GO:0070013	intracellular organelle lumen	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QCC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCC2

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006144	purine nucleobase metabolic process	5	2
GO:0006163	purine nucleotide metabolic process	5	7
GO:0006164	purine nucleotide biosynthetic process	6	7
GO:0006177	GMP biosynthetic process	8	2
GO:0006178	guanine salvage	6	2
GO:0006188	IMP biosynthetic process	8	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006753	nucleoside phosphate metabolic process	4	7
GO:0006793	phosphorus metabolic process	3	7
GO:0006796	phosphate-containing compound metabolic process	4	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009058	biosynthetic process	2	7
GO:0009112	nucleobase metabolic process	4	2
GO:0009113	purine nucleobase biosynthetic process	6	2
GO:0009117	nucleotide metabolic process	5	7
GO:0009123	nucleoside monophosphate metabolic process	5	7
GO:0009124	nucleoside monophosphate biosynthetic process	6	7
GO:0009126	purine nucleoside monophosphate metabolic process	6	7
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	7
GO:0009150	purine ribonucleotide metabolic process	6	7
GO:0009152	purine ribonucleotide biosynthetic process	7	7
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	7
GO:0009161	ribonucleoside monophosphate metabolic process	6	7
GO:0009165	nucleotide biosynthetic process	6	7
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	7
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	7
GO:0009259	ribonucleotide metabolic process	5	7
GO:0009260	ribonucleotide biosynthetic process	6	7
GO:0009987	cellular process	1	7
GO:0018130	heterocycle biosynthetic process	4	7
GO:0019438	aromatic compound biosynthetic process	4	7
GO:0019637	organophosphate metabolic process	3	7
GO:0019693	ribose phosphate metabolic process	4	7
GO:0032261	purine nucleotide salvage	5	7
GO:0032263	GMP salvage	7	2
GO:0032264	IMP salvage	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0034654	nucleobase-containing compound biosynthetic process	4	7
GO:0043094	cellular metabolic compound salvage	3	7
GO:0043096	purine nucleobase salvage	5	2
GO:0043101	purine-containing compound salvage	4	7
GO:0043173	nucleotide salvage	4	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0044249	cellular biosynthetic process	3	7
GO:0044271	cellular nitrogen compound biosynthetic process	4	7
GO:0044281	small molecule metabolic process	2	7
GO:0046037	GMP metabolic process	7	2
GO:0046040	IMP metabolic process	7	7
GO:0046098	guanine metabolic process	6	2
GO:0046099	guanine biosynthetic process	7	2
GO:0046100	hypoxanthine metabolic process	6	2
GO:0046112	nucleobase biosynthetic process	5	2
GO:0046390	ribose phosphate biosynthetic process	5	7
GO:0046483	heterocycle metabolic process	3	7
GO:0055086	nucleobase-containing small molecule metabolic process	3	7
GO:0071704	organic substance metabolic process	2	7
GO:0072521	purine-containing compound metabolic process	4	7
GO:0072522	purine-containing compound biosynthetic process	5	7
GO:0090407	organophosphate biosynthetic process	4	7
GO:0106380	purine ribonucleotide salvage	6	7
GO:1901135	carbohydrate derivative metabolic process	3	7
GO:1901137	carbohydrate derivative biosynthetic process	4	7
GO:1901293	nucleoside phosphate biosynthetic process	5	7
GO:1901360	organic cyclic compound metabolic process	3	7
GO:1901362	organic cyclic compound biosynthetic process	4	7
GO:1901564	organonitrogen compound metabolic process	3	7
GO:1901566	organonitrogen compound biosynthetic process	4	7
GO:1901576	organic substance biosynthetic process	3	7
GO:0006166	purine ribonucleoside salvage	5	5
GO:0009116	nucleoside metabolic process	4	5
GO:0009119	ribonucleoside metabolic process	5	5
GO:0009163	nucleoside biosynthetic process	5	5
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	5
GO:0042278	purine nucleoside metabolic process	5	5
GO:0042451	purine nucleoside biosynthetic process	6	5
GO:0042455	ribonucleoside biosynthetic process	6	5
GO:0043174	nucleoside salvage	4	5
GO:0044283	small molecule biosynthetic process	3	5
GO:0046128	purine ribonucleoside metabolic process	6	5
GO:0046129	purine ribonucleoside biosynthetic process	7	5
GO:1901657	glycosyl compound metabolic process	4	5
GO:1901659	glycosyl compound biosynthetic process	5	5

Molecular functions
Term	Name	Level	Count
GO:0000287	magnesium ion binding	5	2
GO:0000310	xanthine phosphoribosyltransferase activity	6	4
GO:0003824	catalytic activity	1	17
GO:0004422	hypoxanthine phosphoribosyltransferase activity	6	10
GO:0005488	binding	1	7
GO:0016740	transferase activity	2	17
GO:0016757	glycosyltransferase activity	3	17
GO:0016763	pentosyltransferase activity	4	10
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0052657	guanine phosphoribosyltransferase activity	6	10
GO:0106130	purine phosphoribosyltransferase activity	5	10
GO:0000166	nucleotide binding	3	5
GO:0036094	small molecule binding	2	5
GO:0097159	organic cyclic compound binding	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	187	189	PF00675	0.249
CLV_PCSK_SKI1_1	144	148	PF00082	0.246
CLV_PCSK_SKI1_1	173	177	PF00082	0.323
CLV_PCSK_SKI1_1	221	225	PF00082	0.389
DOC_ANK_TNKS_1	15	22	PF00023	0.507
DOC_CYCLIN_RxL_1	183	195	PF00134	0.378
DOC_MAPK_gen_1	142	149	PF00069	0.457
DOC_MAPK_gen_1	173	181	PF00069	0.526
DOC_MAPK_gen_1	216	225	PF00069	0.384
DOC_PP1_RVXF_1	155	162	PF00149	0.506
DOC_PP1_RVXF_1	186	193	PF00149	0.493
DOC_PP2B_PxIxI_1	81	87	PF00149	0.463
DOC_USP7_MATH_1	25	29	PF00917	0.443
DOC_USP7_MATH_1	3	7	PF00917	0.492
DOC_USP7_UBL2_3	169	173	PF12436	0.538
DOC_WW_Pin1_4	60	65	PF00397	0.627
LIG_14-3-3_CanoR_1	116	121	PF00244	0.459
LIG_BIR_III_4	12	16	PF00653	0.519
LIG_BRCT_BRCA1_1	91	95	PF00533	0.448
LIG_FHA_1	125	131	PF00498	0.498
LIG_FHA_1	31	37	PF00498	0.391
LIG_LIR_Apic_2	78	82	PF02991	0.545
LIG_LIR_Gen_1	113	120	PF02991	0.448
LIG_LIR_Nem_3	113	117	PF02991	0.448
LIG_LIR_Nem_3	193	199	PF02991	0.494
LIG_LIR_Nem_3	215	220	PF02991	0.373
LIG_LIR_Nem_3	51	55	PF02991	0.475
LIG_LIR_Nem_3	96	102	PF02991	0.556
LIG_Pex14_2	95	99	PF04695	0.545
LIG_SH2_CRK	52	56	PF00017	0.454
LIG_SH2_CRK	79	83	PF00017	0.545
LIG_SH2_GRB2like	79	82	PF00017	0.545
LIG_SH2_SRC	79	82	PF00017	0.545
LIG_SH2_STAT5	102	105	PF00017	0.463
LIG_SH2_STAT5	165	168	PF00017	0.471
LIG_SH2_STAT5	196	199	PF00017	0.455
LIG_SH2_STAT5	205	208	PF00017	0.440
LIG_SH2_STAT5	93	96	PF00017	0.463
LIG_SUMO_SIM_par_1	145	151	PF11976	0.463
LIG_SUMO_SIM_par_1	80	87	PF11976	0.466
LIG_UBA3_1	83	90	PF00899	0.439
MOD_CK1_1	119	125	PF00069	0.501
MOD_CK1_1	155	161	PF00069	0.449
MOD_CK1_1	174	180	PF00069	0.344
MOD_CK1_1	63	69	PF00069	0.599
MOD_GlcNHglycan	154	157	PF01048	0.255
MOD_GlcNHglycan	27	30	PF01048	0.416
MOD_GSK3_1	119	126	PF00069	0.466
MOD_GSK3_1	89	96	PF00069	0.446
MOD_N-GLC_1	3	8	PF02516	0.563
MOD_NEK2_1	44	49	PF00069	0.463
MOD_NEK2_1	89	94	PF00069	0.448
MOD_NEK2_2	3	8	PF00069	0.490
MOD_Plk_1	229	235	PF00069	0.484
MOD_Plk_4	174	180	PF00069	0.475
MOD_Plk_4	89	95	PF00069	0.448
MOD_ProDKin_1	60	66	PF00069	0.636
TRG_DiLeu_BaLyEn_6	79	84	PF01217	0.455
TRG_ENDOCYTIC_2	196	199	PF00928	0.521
TRG_ENDOCYTIC_2	217	220	PF00928	0.347
TRG_ENDOCYTIC_2	52	55	PF00928	0.439
TRG_Pf-PMV_PEXEL_1	101	105	PF00026	0.235
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.242
TRG_Pf-PMV_PEXEL_1	188	193	PF00026	0.178
TRG_PTS1	235	238	PF00515	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHW3	Leptomonas seymouri	68%	100%
A0A0N1PCR6	Leptomonas seymouri	32%	100%
A0A0S4JHI0	Bodo saltans	41%	100%
A0A0S4JLD9	Bodo saltans	41%	100%
A0A1X0NZ20	Trypanosomatidae	35%	100%
A0A1X0NZ92	Trypanosomatidae	58%	100%
A0A422N3N7	Trypanosoma rangeli	55%	100%
A0A422N3S1	Trypanosoma rangeli	37%	100%
A4HBT6	Leishmania braziliensis	34%	100%
A4HBT7	Leishmania braziliensis	80%	99%
A4II60	Xenopus tropicalis	34%	100%
A5A6I1	Pan troglodytes	34%	100%
D0A1D6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
D0A1D7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
D0A1E6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AGU6	Leishmania infantum	34%	100%
E9AGU7	Leishmania infantum	94%	99%
E9AV58	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	100%
E9AV59	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
O66821	Aquifex aeolicus (strain VF5)	31%	100%
O69537	Mycobacterium leprae (strain TN)	32%	100%
P00492	Homo sapiens	34%	100%
P00493	Mus musculus	34%	100%
P00494	Cricetulus griseus	34%	100%
P07833	Plasmodium falciparum (isolate K1 / Thailand)	30%	100%
P0A5T1	Mycobacterium bovis (strain ATCC BAA-935 / AF2122/97)	32%	100%
P0DD40	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	29%	100%
P0DD41	Streptococcus pyogenes serotype M3 (strain SSI-1)	29%	100%
P20035	Plasmodium falciparum (isolate FCR-3 / Gambia)	30%	100%
P27605	Rattus norvegicus	34%	100%
P37171	Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003)	32%	100%
P43152	Leishmania donovani	34%	100%
P47696	Mycoplasma genitalium (strain ATCC 33530 / DSM 19775 / NCTC 10195 / G37)	22%	100%
P47959	Meriones unguiculatus	35%	100%
P51900	Tritrichomonas foetus	35%	100%
P65827	Staphylococcus aureus (strain Mu50 / ATCC 700699)	29%	100%
P65828	Staphylococcus aureus (strain MW2)	29%	100%
P96794	Mycobacterium avium	33%	100%
P99085	Staphylococcus aureus (strain N315)	29%	100%
P9WHQ8	Mycobacterium tuberculosis (strain CDC 1551 / Oshkosh)	32%	100%
P9WHQ9	Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)	32%	100%
Q07010	Trypanosoma brucei brucei	38%	100%
Q26997	Toxoplasma gondii	31%	100%
Q27541	Crithidia fasciculata	33%	100%
Q3SZ18	Bos taurus	35%	100%
Q45FY6	Sus scrofa	34%	100%
Q4QCC3	Leishmania major	34%	100%
Q54NJ8	Dictyostelium discoideum	27%	100%
Q5HIG5	Staphylococcus aureus (strain COL)	29%	100%
Q5HRP4	Staphylococcus epidermidis (strain ATCC 35984 / RP62A)	30%	100%
Q5M216	Streptococcus thermophilus (strain CNRZ 1066)	30%	100%
Q5M6K8	Streptococcus thermophilus (strain ATCC BAA-250 / LMG 18311)	30%	100%
Q5XEL6	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	29%	100%
Q6DCP3	Xenopus laevis	34%	100%
Q6GBX8	Staphylococcus aureus (strain MSSA476)	29%	100%
Q6GJG1	Staphylococcus aureus (strain MRSA252)	29%	100%
Q6LDD9	Macaca fascicularis	34%	100%
Q6WIT9	Canis lupus familiaris	35%	100%
Q7CNQ9	Streptococcus pyogenes serotype M18 (strain MGAS8232)	29%	100%
Q7KLF3	Leishmania donovani	34%	100%
Q8CQV4	Staphylococcus epidermidis (strain ATCC 12228 / FDA PCI 1200)	30%	100%
Q9U6Y2	Leishmania donovani	94%	99%
Q9W719	Gallus gallus	35%	100%
V5DEL0	Trypanosoma cruzi	56%	77%