Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCC0_LEIMA

TriTrypDb:

LmjF.21.0855 , LMJLV39_210015400 , LMJSD75_210015500

Length:

296

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCC0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCC0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	7
GO:0005515	protein binding	2	7
GO:0051087	protein-folding chaperone binding	3	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	216	220	PF00656	0.693
CLV_C14_Caspase3-7	226	230	PF00656	0.647
CLV_NRD_NRD_1	132	134	PF00675	0.525
CLV_NRD_NRD_1	157	159	PF00675	0.318
CLV_NRD_NRD_1	185	187	PF00675	0.413
CLV_NRD_NRD_1	272	274	PF00675	0.360
CLV_NRD_NRD_1	285	287	PF00675	0.381
CLV_NRD_NRD_1	97	99	PF00675	0.505
CLV_PCSK_KEX2_1	132	134	PF00082	0.526
CLV_PCSK_KEX2_1	157	159	PF00082	0.318
CLV_PCSK_KEX2_1	185	187	PF00082	0.408
CLV_PCSK_KEX2_1	272	274	PF00082	0.350
CLV_PCSK_KEX2_1	285	287	PF00082	0.400
CLV_PCSK_KEX2_1	97	99	PF00082	0.523
CLV_PCSK_SKI1_1	157	161	PF00082	0.364
CLV_PCSK_SKI1_1	273	277	PF00082	0.378
DEG_Nend_Nbox_1	1	3	PF02207	0.437
DEG_SPOP_SBC_1	22	26	PF00917	0.474
DOC_MAPK_DCC_7	286	296	PF00069	0.607
DOC_USP7_MATH_1	110	114	PF00917	0.715
DOC_USP7_MATH_1	21	25	PF00917	0.449
DOC_USP7_MATH_1	213	217	PF00917	0.698
DOC_USP7_UBL2_3	270	274	PF12436	0.600
DOC_WW_Pin1_4	23	28	PF00397	0.504
DOC_WW_Pin1_4	285	290	PF00397	0.650
DOC_WW_Pin1_4	36	41	PF00397	0.525
LIG_14-3-3_CanoR_1	97	106	PF00244	0.727
LIG_BRCT_BRCA1_1	149	153	PF00533	0.547
LIG_FHA_1	250	256	PF00498	0.555
LIG_FHA_1	282	288	PF00498	0.601
LIG_FHA_1	75	81	PF00498	0.329
LIG_FHA_2	170	176	PF00498	0.659
LIG_LIR_Gen_1	141	152	PF02991	0.554
LIG_LIR_Nem_3	141	147	PF02991	0.611
LIG_LIR_Nem_3	149	155	PF02991	0.521
LIG_LIR_Nem_3	39	45	PF02991	0.480
LIG_MLH1_MIPbox_1	149	153	PF16413	0.547
LIG_SH2_NCK_1	20	24	PF00017	0.488
LIG_SH2_NCK_1	65	69	PF00017	0.333
LIG_SH2_SRC	173	176	PF00017	0.471
LIG_SH2_SRC	63	66	PF00017	0.383
LIG_SH2_STAP1	65	69	PF00017	0.333
LIG_SH2_STAT3	59	62	PF00017	0.417
LIG_SH2_STAT5	155	158	PF00017	0.575
LIG_SH2_STAT5	173	176	PF00017	0.564
LIG_SH2_STAT5	63	66	PF00017	0.383
LIG_SH3_1	286	292	PF00018	0.608
LIG_SH3_3	286	292	PF00018	0.630
LIG_SH3_3	34	40	PF00018	0.478
LIG_SH3_3	7	13	PF00018	0.490
LIG_SUMO_SIM_par_1	72	79	PF11976	0.308
LIG_UBA3_1	44	51	PF00899	0.467
MOD_CDK_SPxxK_3	36	43	PF00069	0.489
MOD_CK1_1	100	106	PF00069	0.693
MOD_CK1_1	217	223	PF00069	0.666
MOD_CK1_1	25	31	PF00069	0.481
MOD_CK1_1	4	10	PF00069	0.527
MOD_CK1_1	46	52	PF00069	0.482
MOD_CK2_1	169	175	PF00069	0.533
MOD_CK2_1	190	196	PF00069	0.666
MOD_CMANNOS	2	5	PF00535	0.650
MOD_Cter_Amidation	95	98	PF01082	0.505
MOD_GlcNHglycan	112	115	PF01048	0.502
MOD_GlcNHglycan	149	152	PF01048	0.332
MOD_GlcNHglycan	219	222	PF01048	0.488
MOD_GlcNHglycan	229	232	PF01048	0.435
MOD_GlcNHglycan	33	36	PF01048	0.709
MOD_GlcNHglycan	66	69	PF01048	0.394
MOD_GlcNHglycan	99	102	PF01048	0.518
MOD_GSK3_1	1	8	PF00069	0.479
MOD_GSK3_1	147	154	PF00069	0.632
MOD_GSK3_1	21	28	PF00069	0.518
MOD_GSK3_1	213	220	PF00069	0.804
MOD_GSK3_1	281	288	PF00069	0.550
MOD_GSK3_1	46	53	PF00069	0.448
MOD_GSK3_1	72	79	PF00069	0.473
MOD_N-GLC_1	208	213	PF02516	0.508
MOD_NEK2_1	1	6	PF00069	0.496
MOD_NEK2_1	147	152	PF00069	0.477
MOD_NEK2_1	29	34	PF00069	0.584
MOD_NEK2_1	44	49	PF00069	0.400
MOD_NEK2_1	72	77	PF00069	0.367
MOD_PIKK_1	249	255	PF00454	0.524
MOD_PIKK_1	46	52	PF00454	0.493
MOD_PKA_1	97	103	PF00069	0.727
MOD_PKA_2	263	269	PF00069	0.610
MOD_PKA_2	97	103	PF00069	0.731
MOD_Plk_1	214	220	PF00069	0.623
MOD_Plk_4	169	175	PF00069	0.558
MOD_Plk_4	190	196	PF00069	0.655
MOD_Plk_4	76	82	PF00069	0.383
MOD_ProDKin_1	23	29	PF00069	0.504
MOD_ProDKin_1	285	291	PF00069	0.650
MOD_ProDKin_1	36	42	PF00069	0.525
TRG_DiLeu_BaLyEn_6	163	168	PF01217	0.564
TRG_DiLeu_BaLyEn_6	40	45	PF01217	0.450
TRG_ER_diArg_1	156	158	PF00400	0.521
TRG_ER_diArg_1	184	186	PF00400	0.603
TRG_ER_diArg_1	285	287	PF00400	0.637
TRG_ER_diArg_1	97	99	PF00400	0.678
TRG_NES_CRM1_1	253	267	PF08389	0.576
TRG_Pf-PMV_PEXEL_1	83	87	PF00026	0.353

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P829	Leptomonas seymouri	39%	100%
A0A1X0NYB3	Trypanosomatidae	30%	75%
A0A3Q8IB47	Leishmania donovani	89%	100%
A4HBT9	Leishmania braziliensis	69%	100%
A4HZ86	Leishmania infantum	89%	100%
E9AV61	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%