RanBP2-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCB8_LEIMA

TriTrypDb:

LmjF.21.0865 , LMJLV39_210015600 , LMJSD75_210015700

Length:

676

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCB8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCB8

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	11
GO:0043167	ion binding	2	11
GO:0043169	cation binding	3	11
GO:0046872	metal ion binding	4	11
GO:0051536	iron-sulfur cluster binding	3	2
GO:0051537	2 iron, 2 sulfur cluster binding	4	2
GO:0051540	metal cluster binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	139	143	PF00656	0.553
CLV_C14_Caspase3-7	223	227	PF00656	0.516
CLV_C14_Caspase3-7	563	567	PF00656	0.460
CLV_C14_Caspase3-7	615	619	PF00656	0.567
CLV_C14_Caspase3-7	77	81	PF00656	0.636
CLV_NRD_NRD_1	267	269	PF00675	0.460
CLV_NRD_NRD_1	31	33	PF00675	0.685
CLV_NRD_NRD_1	577	579	PF00675	0.630
CLV_NRD_NRD_1	7	9	PF00675	0.626
CLV_PCSK_FUR_1	575	579	PF00082	0.577
CLV_PCSK_KEX2_1	266	268	PF00082	0.472
CLV_PCSK_KEX2_1	31	33	PF00082	0.683
CLV_PCSK_KEX2_1	574	576	PF00082	0.592
CLV_PCSK_KEX2_1	577	579	PF00082	0.565
CLV_PCSK_KEX2_1	7	9	PF00082	0.588
CLV_PCSK_PC1ET2_1	574	576	PF00082	0.645
CLV_PCSK_PC7_1	3	9	PF00082	0.561
CLV_PCSK_SKI1_1	165	169	PF00082	0.746
CLV_PCSK_SKI1_1	191	195	PF00082	0.551
CLV_PCSK_SKI1_1	497	501	PF00082	0.553
DEG_Nend_Nbox_1	1	3	PF02207	0.543
DEG_SPOP_SBC_1	98	102	PF00917	0.626
DOC_CKS1_1	19	24	PF01111	0.598
DOC_CYCLIN_RxL_1	494	502	PF00134	0.487
DOC_MAPK_gen_1	358	365	PF00069	0.458
DOC_MAPK_MEF2A_6	177	184	PF00069	0.545
DOC_MAPK_MEF2A_6	312	319	PF00069	0.436
DOC_PP1_RVXF_1	129	135	PF00149	0.622
DOC_SPAK_OSR1_1	360	364	PF12202	0.402
DOC_USP7_MATH_1	146	150	PF00917	0.771
DOC_USP7_MATH_1	167	171	PF00917	0.531
DOC_USP7_MATH_1	222	226	PF00917	0.491
DOC_USP7_MATH_1	232	236	PF00917	0.708
DOC_USP7_MATH_1	412	416	PF00917	0.712
DOC_USP7_MATH_1	423	427	PF00917	0.695
DOC_USP7_MATH_1	462	466	PF00917	0.549
DOC_USP7_MATH_1	523	527	PF00917	0.724
DOC_USP7_MATH_1	557	561	PF00917	0.484
DOC_USP7_MATH_1	612	616	PF00917	0.438
DOC_USP7_MATH_1	74	78	PF00917	0.745
DOC_USP7_MATH_1	99	103	PF00917	0.744
DOC_WW_Pin1_4	15	20	PF00397	0.666
DOC_WW_Pin1_4	33	38	PF00397	0.456
DOC_WW_Pin1_4	402	407	PF00397	0.601
DOC_WW_Pin1_4	419	424	PF00397	0.719
DOC_WW_Pin1_4	434	439	PF00397	0.611
DOC_WW_Pin1_4	447	452	PF00397	0.488
DOC_WW_Pin1_4	460	465	PF00397	0.533
DOC_WW_Pin1_4	508	513	PF00397	0.666
DOC_WW_Pin1_4	526	531	PF00397	0.674
DOC_WW_Pin1_4	54	59	PF00397	0.766
DOC_WW_Pin1_4	662	667	PF00397	0.372
DOC_WW_Pin1_4	87	92	PF00397	0.799
LIG_14-3-3_CanoR_1	13	19	PF00244	0.585
LIG_14-3-3_CanoR_1	257	265	PF00244	0.575
LIG_14-3-3_CanoR_1	360	366	PF00244	0.400
LIG_14-3-3_CanoR_1	456	461	PF00244	0.459
LIG_14-3-3_CanoR_1	63	67	PF00244	0.718
LIG_14-3-3_CanoR_1	658	668	PF00244	0.413
LIG_Actin_WH2_2	178	196	PF00022	0.468
LIG_BIR_III_4	147	151	PF00653	0.609
LIG_BIR_III_4	413	417	PF00653	0.505
LIG_Clathr_ClatBox_1	184	188	PF01394	0.460
LIG_FHA_1	153	159	PF00498	0.738
LIG_FHA_1	166	172	PF00498	0.534
LIG_FHA_1	19	25	PF00498	0.597
LIG_FHA_1	260	266	PF00498	0.595
LIG_FHA_1	312	318	PF00498	0.474
LIG_FHA_1	63	69	PF00498	0.698
LIG_FHA_2	299	305	PF00498	0.601
LIG_FHA_2	91	97	PF00498	0.672
LIG_Integrin_RGDW_4	642	645	PF00362	0.375
LIG_LIR_Apic_2	644	648	PF02991	0.369
LIG_LIR_Gen_1	118	124	PF02991	0.651
LIG_LIR_Gen_1	214	222	PF02991	0.469
LIG_LIR_Gen_1	307	317	PF02991	0.502
LIG_LIR_Gen_1	477	487	PF02991	0.422
LIG_LIR_Gen_1	550	561	PF02991	0.519
LIG_LIR_Nem_3	118	122	PF02991	0.658
LIG_LIR_Nem_3	214	220	PF02991	0.393
LIG_LIR_Nem_3	477	482	PF02991	0.488
LIG_LIR_Nem_3	550	556	PF02991	0.534
LIG_LYPXL_SIV_4	478	486	PF13949	0.285
LIG_NRBOX	495	501	PF00104	0.419
LIG_Pex14_1	134	138	PF04695	0.570
LIG_SH2_CRK	479	483	PF00017	0.439
LIG_SH2_CRK	553	557	PF00017	0.525
LIG_SH3_1	16	22	PF00018	0.473
LIG_SH3_2	666	671	PF14604	0.426
LIG_SH3_3	16	22	PF00018	0.629
LIG_SH3_3	362	368	PF00018	0.367
LIG_SH3_3	426	432	PF00018	0.670
LIG_SH3_3	47	53	PF00018	0.644
LIG_SH3_3	509	515	PF00018	0.664
LIG_SH3_3	663	669	PF00018	0.382
LIG_SUMO_SIM_par_1	183	189	PF11976	0.460
LIG_SUMO_SIM_par_1	313	318	PF11976	0.436
LIG_TYR_ITSM	475	482	PF00017	0.284
LIG_WRC_WIRS_1	561	566	PF05994	0.430
LIG_WW_2	512	515	PF00397	0.457
MOD_CDK_SPK_2	15	20	PF00069	0.477
MOD_CDK_SPK_2	526	531	PF00069	0.540
MOD_CDK_SPK_2	662	667	PF00069	0.372
MOD_CK1_1	140	146	PF00069	0.683
MOD_CK1_1	153	159	PF00069	0.572
MOD_CK1_1	18	24	PF00069	0.604
MOD_CK1_1	183	189	PF00069	0.523
MOD_CK1_1	225	231	PF00069	0.661
MOD_CK1_1	233	239	PF00069	0.722
MOD_CK1_1	298	304	PF00069	0.661
MOD_CK1_1	366	372	PF00069	0.492
MOD_CK1_1	405	411	PF00069	0.715
MOD_CK1_1	437	443	PF00069	0.476
MOD_CK1_1	526	532	PF00069	0.598
MOD_CK1_1	559	565	PF00069	0.508
MOD_CK1_1	62	68	PF00069	0.596
MOD_CK1_1	638	644	PF00069	0.411
MOD_CK1_1	649	655	PF00069	0.349
MOD_CK1_1	662	668	PF00069	0.312
MOD_CK1_1	90	96	PF00069	0.684
MOD_CK2_1	146	152	PF00069	0.694
MOD_CK2_1	90	96	PF00069	0.714
MOD_Cter_Amidation	575	578	PF01082	0.530
MOD_GlcNHglycan	101	104	PF01048	0.684
MOD_GlcNHglycan	142	145	PF01048	0.640
MOD_GlcNHglycan	147	151	PF01048	0.663
MOD_GlcNHglycan	152	155	PF01048	0.656
MOD_GlcNHglycan	229	232	PF01048	0.696
MOD_GlcNHglycan	28	31	PF01048	0.603
MOD_GlcNHglycan	295	298	PF01048	0.348
MOD_GlcNHglycan	407	410	PF01048	0.705
MOD_GlcNHglycan	413	417	PF01048	0.691
MOD_GlcNHglycan	425	428	PF01048	0.761
MOD_GlcNHglycan	460	463	PF01048	0.516
MOD_GlcNHglycan	501	504	PF01048	0.633
MOD_GlcNHglycan	508	511	PF01048	0.570
MOD_GSK3_1	136	143	PF00069	0.643
MOD_GSK3_1	14	21	PF00069	0.581
MOD_GSK3_1	146	153	PF00069	0.697
MOD_GSK3_1	167	174	PF00069	0.632
MOD_GSK3_1	222	229	PF00069	0.489
MOD_GSK3_1	232	239	PF00069	0.637
MOD_GSK3_1	257	264	PF00069	0.593
MOD_GSK3_1	327	334	PF00069	0.459
MOD_GSK3_1	400	407	PF00069	0.560
MOD_GSK3_1	408	415	PF00069	0.600
MOD_GSK3_1	419	426	PF00069	0.758
MOD_GSK3_1	434	441	PF00069	0.611
MOD_GSK3_1	456	463	PF00069	0.432
MOD_GSK3_1	504	511	PF00069	0.637
MOD_GSK3_1	556	563	PF00069	0.579
MOD_GSK3_1	85	92	PF00069	0.626
MOD_GSK3_1	99	106	PF00069	0.806
MOD_LATS_1	6	12	PF00433	0.550
MOD_N-GLC_1	150	155	PF02516	0.670
MOD_N-GLC_1	226	231	PF02516	0.713
MOD_N-GLC_1	331	336	PF02516	0.550
MOD_N-GLC_1	438	443	PF02516	0.488
MOD_NEK2_1	171	176	PF00069	0.689
MOD_NEK2_1	361	366	PF00069	0.403
MOD_NEK2_1	499	504	PF00069	0.504
MOD_NEK2_1	541	546	PF00069	0.425
MOD_NEK2_1	59	64	PF00069	0.631
MOD_NEK2_1	600	605	PF00069	0.319
MOD_NEK2_1	620	625	PF00069	0.490
MOD_NEK2_1	636	641	PF00069	0.555
MOD_NEK2_2	248	253	PF00069	0.506
MOD_NEK2_2	261	266	PF00069	0.628
MOD_PIKK_1	438	444	PF00454	0.531
MOD_PK_1	295	301	PF00069	0.435
MOD_PKA_2	2	8	PF00069	0.696
MOD_PKA_2	311	317	PF00069	0.573
MOD_PKA_2	332	338	PF00069	0.434
MOD_PKA_2	392	398	PF00069	0.718
MOD_PKA_2	455	461	PF00069	0.465
MOD_PKA_2	62	68	PF00069	0.573
MOD_PKA_2	659	665	PF00069	0.420
MOD_Plk_1	438	444	PF00069	0.520
MOD_Plk_1	557	563	PF00069	0.488
MOD_Plk_1	85	91	PF00069	0.543
MOD_Plk_4	167	173	PF00069	0.584
MOD_Plk_4	180	186	PF00069	0.626
MOD_Plk_4	462	468	PF00069	0.534
MOD_ProDKin_1	15	21	PF00069	0.666
MOD_ProDKin_1	33	39	PF00069	0.457
MOD_ProDKin_1	402	408	PF00069	0.601
MOD_ProDKin_1	419	425	PF00069	0.715
MOD_ProDKin_1	434	440	PF00069	0.602
MOD_ProDKin_1	447	453	PF00069	0.483
MOD_ProDKin_1	460	466	PF00069	0.521
MOD_ProDKin_1	508	514	PF00069	0.665
MOD_ProDKin_1	526	532	PF00069	0.662
MOD_ProDKin_1	54	60	PF00069	0.767
MOD_ProDKin_1	662	668	PF00069	0.375
MOD_ProDKin_1	87	93	PF00069	0.802
TRG_ENDOCYTIC_2	479	482	PF00928	0.442
TRG_ENDOCYTIC_2	553	556	PF00928	0.575
TRG_ER_diArg_1	265	268	PF00400	0.547
TRG_ER_diArg_1	31	34	PF00400	0.712
TRG_ER_diArg_1	482	485	PF00400	0.377
TRG_ER_diArg_1	575	578	PF00400	0.580
TRG_ER_diArg_1	655	658	PF00400	0.521
TRG_ER_diArg_1	7	9	PF00400	0.594
TRG_NLS_MonoExtC_3	573	578	PF00514	0.584
TRG_Pf-PMV_PEXEL_1	250	255	PF00026	0.477

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDJ9	Leptomonas seymouri	41%	100%
A0A1X0NXN9	Trypanosomatidae	33%	100%
A0A3S5H797	Leishmania donovani	91%	100%
A0A422NWI0	Trypanosoma rangeli	34%	100%
A4HBU1	Leishmania braziliensis	69%	95%
A4HZ88	Leishmania infantum	91%	100%
D0A1D1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9AV63	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	99%
V5BMW0	Trypanosoma cruzi	32%	100%