Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCB6_LEIMA

TriTrypDb:

LmjF.21.0873 , LMJLV39_210015800 , LMJSD75_210015900

Length:

855

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCB6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCB6

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	6
GO:0006793	phosphorus metabolic process	3	6
GO:0006796	phosphate-containing compound metabolic process	4	6
GO:0006807	nitrogen compound metabolic process	2	6
GO:0008152	metabolic process	1	6
GO:0009987	cellular process	1	6
GO:0016310	phosphorylation	5	6
GO:0019538	protein metabolic process	3	6
GO:0036211	protein modification process	4	6
GO:0043170	macromolecule metabolic process	3	6
GO:0043412	macromolecule modification	4	6
GO:0044237	cellular metabolic process	2	6
GO:0044238	primary metabolic process	2	6
GO:0071704	organic substance metabolic process	2	6
GO:1901564	organonitrogen compound metabolic process	3	6

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	6
GO:0003824	catalytic activity	1	6
GO:0004672	protein kinase activity	3	6
GO:0005488	binding	1	6
GO:0005524	ATP binding	5	6
GO:0016301	kinase activity	4	6
GO:0016740	transferase activity	2	6
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	6
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	6
GO:0017076	purine nucleotide binding	4	6
GO:0030554	adenyl nucleotide binding	5	6
GO:0032553	ribonucleotide binding	3	6
GO:0032555	purine ribonucleotide binding	4	6
GO:0032559	adenyl ribonucleotide binding	5	6
GO:0035639	purine ribonucleoside triphosphate binding	4	6
GO:0036094	small molecule binding	2	6
GO:0043167	ion binding	2	6
GO:0043168	anion binding	3	6
GO:0097159	organic cyclic compound binding	2	6
GO:0097367	carbohydrate derivative binding	2	6
GO:0140096	catalytic activity, acting on a protein	2	6
GO:1901265	nucleoside phosphate binding	3	6
GO:1901363	heterocyclic compound binding	2	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	127	129	PF00675	0.416
CLV_NRD_NRD_1	207	209	PF00675	0.366
CLV_NRD_NRD_1	84	86	PF00675	0.429
CLV_NRD_NRD_1	844	846	PF00675	0.599
CLV_PCSK_KEX2_1	127	129	PF00082	0.472
CLV_PCSK_KEX2_1	207	209	PF00082	0.366
CLV_PCSK_KEX2_1	84	86	PF00082	0.332
CLV_PCSK_KEX2_1	844	846	PF00082	0.715
CLV_PCSK_PC7_1	80	86	PF00082	0.299
CLV_PCSK_SKI1_1	118	122	PF00082	0.372
CLV_PCSK_SKI1_1	428	432	PF00082	0.317
CLV_PCSK_SKI1_1	84	88	PF00082	0.336
DEG_APCC_DBOX_1	354	362	PF00400	0.425
DEG_SCF_FBW7_1	683	690	PF00400	0.629
DEG_SIAH_1	686	694	PF03145	0.587
DEG_SPOP_SBC_1	626	630	PF00917	0.702
DOC_CKS1_1	18	23	PF01111	0.466
DOC_CKS1_1	294	299	PF01111	0.359
DOC_CKS1_1	692	697	PF01111	0.627
DOC_CYCLIN_RxL_1	3	13	PF00134	0.495
DOC_CYCLIN_RxL_1	425	434	PF00134	0.319
DOC_MAPK_gen_1	207	213	PF00069	0.415
DOC_MAPK_gen_1	426	433	PF00069	0.463
DOC_MAPK_gen_1	84	91	PF00069	0.335
DOC_MAPK_MEF2A_6	426	433	PF00069	0.438
DOC_MAPK_MEF2A_6	504	513	PF00069	0.305
DOC_MAPK_NFAT4_5	426	434	PF00069	0.322
DOC_MAPK_RevD_3	113	128	PF00069	0.336
DOC_PP2B_LxvP_1	796	799	PF13499	0.601
DOC_PP2B_LxvP_1	89	92	PF13499	0.344
DOC_PP4_FxxP_1	360	363	PF00568	0.362
DOC_USP7_MATH_1	155	159	PF00917	0.455
DOC_USP7_MATH_1	375	379	PF00917	0.590
DOC_USP7_MATH_1	477	481	PF00917	0.481
DOC_USP7_MATH_1	547	551	PF00917	0.310
DOC_USP7_MATH_1	620	624	PF00917	0.633
DOC_USP7_MATH_1	66	70	PF00917	0.536
DOC_USP7_MATH_1	674	678	PF00917	0.654
DOC_USP7_MATH_1	699	703	PF00917	0.641
DOC_USP7_MATH_1	776	780	PF00917	0.617
DOC_USP7_MATH_1	799	803	PF00917	0.693
DOC_USP7_MATH_1	834	838	PF00917	0.559
DOC_USP7_MATH_2	218	224	PF00917	0.470
DOC_USP7_UBL2_3	842	846	PF12436	0.620
DOC_WW_Pin1_4	17	22	PF00397	0.465
DOC_WW_Pin1_4	293	298	PF00397	0.368
DOC_WW_Pin1_4	30	35	PF00397	0.420
DOC_WW_Pin1_4	315	320	PF00397	0.245
DOC_WW_Pin1_4	408	413	PF00397	0.387
DOC_WW_Pin1_4	516	521	PF00397	0.477
DOC_WW_Pin1_4	569	574	PF00397	0.430
DOC_WW_Pin1_4	628	633	PF00397	0.596
DOC_WW_Pin1_4	678	683	PF00397	0.761
DOC_WW_Pin1_4	691	696	PF00397	0.652
DOC_WW_Pin1_4	765	770	PF00397	0.699
DOC_WW_Pin1_4	786	791	PF00397	0.680
LIG_14-3-3_CanoR_1	262	267	PF00244	0.484
LIG_14-3-3_CanoR_1	268	275	PF00244	0.366
LIG_14-3-3_CanoR_1	28	34	PF00244	0.550
LIG_14-3-3_CanoR_1	280	284	PF00244	0.376
LIG_14-3-3_CanoR_1	300	306	PF00244	0.358
LIG_14-3-3_CanoR_1	35	41	PF00244	0.487
LIG_14-3-3_CanoR_1	609	618	PF00244	0.703
LIG_14-3-3_CanoR_1	644	649	PF00244	0.616
LIG_14-3-3_CanoR_1	80	84	PF00244	0.341
LIG_14-3-3_CanoR_1	85	90	PF00244	0.319
LIG_Actin_WH2_2	263	278	PF00022	0.484
LIG_Actin_WH2_2	379	397	PF00022	0.479
LIG_Actin_WH2_2	522	539	PF00022	0.394
LIG_BIR_II_1	1	5	PF00653	0.447
LIG_BIR_III_4	239	243	PF00653	0.352
LIG_BRCT_BRCA1_1	733	737	PF00533	0.611
LIG_BRCT_BRCA1_2	733	739	PF00533	0.615
LIG_Clathr_ClatBox_1	182	186	PF01394	0.270
LIG_Clathr_ClatBox_1	330	334	PF01394	0.412
LIG_Clathr_ClatBox_1	430	434	PF01394	0.331
LIG_CtBP_PxDLS_1	218	222	PF00389	0.492
LIG_deltaCOP1_diTrp_1	239	248	PF00928	0.304
LIG_eIF4E_1	467	473	PF01652	0.348
LIG_FHA_1	104	110	PF00498	0.324
LIG_FHA_1	248	254	PF00498	0.424
LIG_FHA_1	409	415	PF00498	0.401
LIG_FHA_1	506	512	PF00498	0.301
LIG_FHA_1	55	61	PF00498	0.403
LIG_FHA_1	583	589	PF00498	0.516
LIG_FHA_1	692	698	PF00498	0.561
LIG_FHA_1	778	784	PF00498	0.674
LIG_FHA_1	799	805	PF00498	0.577
LIG_FHA_1	827	833	PF00498	0.728
LIG_FHA_2	252	258	PF00498	0.458
LIG_FHA_2	42	48	PF00498	0.451
LIG_FHA_2	577	583	PF00498	0.504
LIG_Integrin_isoDGR_2	260	262	PF01839	0.454
LIG_IRF3_LxIS_1	392	397	PF10401	0.324
LIG_LIR_Apic_2	29	34	PF02991	0.534
LIG_LIR_Gen_1	643	654	PF02991	0.526
LIG_LIR_Nem_3	177	183	PF02991	0.282
LIG_LIR_Nem_3	318	323	PF02991	0.431
LIG_LIR_Nem_3	643	649	PF02991	0.668
LIG_NRBOX	242	248	PF00104	0.304
LIG_NRBOX	326	332	PF00104	0.398
LIG_Pex14_2	179	183	PF04695	0.350
LIG_PTAP_UEV_1	744	749	PF05743	0.582
LIG_PTB_Apo_2	308	315	PF02174	0.392
LIG_REV1ctd_RIR_1	1	10	PF16727	0.505
LIG_RPA_C_Fungi	592	604	PF08784	0.301
LIG_SH2_CRK	215	219	PF00017	0.357
LIG_SH2_CRK	31	35	PF00017	0.468
LIG_SH2_CRK	427	431	PF00017	0.329
LIG_SH2_CRK	459	463	PF00017	0.459
LIG_SH2_CRK	531	535	PF00017	0.382
LIG_SH2_NCK_1	459	463	PF00017	0.428
LIG_SH2_STAP1	138	142	PF00017	0.433
LIG_SH2_STAP1	467	471	PF00017	0.347
LIG_SH2_STAT5	108	111	PF00017	0.282
LIG_SH2_STAT5	130	133	PF00017	0.531
LIG_SH2_STAT5	31	34	PF00017	0.502
LIG_SH2_STAT5	531	534	PF00017	0.385
LIG_SH3_3	12	18	PF00018	0.441
LIG_SH3_3	567	573	PF00018	0.275
LIG_SH3_3	668	674	PF00018	0.590
LIG_SH3_3	679	685	PF00018	0.498
LIG_SH3_3	742	748	PF00018	0.756
LIG_SH3_3	788	794	PF00018	0.729
LIG_Sin3_3	469	476	PF02671	0.386
LIG_SUMO_SIM_anti_2	328	334	PF11976	0.411
LIG_SUMO_SIM_par_1	233	239	PF11976	0.357
LIG_TRAF2_1	254	257	PF00917	0.479
LIG_TYR_ITIM	425	430	PF00017	0.357
MOD_CDC14_SPxK_1	681	684	PF00782	0.570
MOD_CDK_SPK_2	30	35	PF00069	0.392
MOD_CDK_SPxK_1	678	684	PF00069	0.570
MOD_CDK_SPxxK_3	293	300	PF00069	0.369
MOD_CK1_1	174	180	PF00069	0.396
MOD_CK1_1	292	298	PF00069	0.492
MOD_CK1_1	397	403	PF00069	0.378
MOD_CK1_1	460	466	PF00069	0.342
MOD_CK1_1	54	60	PF00069	0.379
MOD_CK1_1	572	578	PF00069	0.473
MOD_CK1_1	580	586	PF00069	0.397
MOD_CK1_1	627	633	PF00069	0.695
MOD_CK1_1	656	662	PF00069	0.608
MOD_CK1_1	677	683	PF00069	0.630
MOD_CK1_1	708	714	PF00069	0.680
MOD_CK1_1	746	752	PF00069	0.602
MOD_CK1_1	758	764	PF00069	0.661
MOD_CK1_1	779	785	PF00069	0.715
MOD_CK1_1	789	795	PF00069	0.737
MOD_CK1_1	826	832	PF00069	0.659
MOD_CK1_1	835	841	PF00069	0.590
MOD_CK2_1	251	257	PF00069	0.458
MOD_CK2_1	268	274	PF00069	0.235
MOD_CK2_1	341	347	PF00069	0.532
MOD_CK2_1	460	466	PF00069	0.333
MOD_CK2_1	576	582	PF00069	0.465
MOD_CK2_1	644	650	PF00069	0.485
MOD_GlcNHglycan	173	176	PF01048	0.361
MOD_GlcNHglycan	188	191	PF01048	0.253
MOD_GlcNHglycan	204	207	PF01048	0.295
MOD_GlcNHglycan	224	227	PF01048	0.351
MOD_GlcNHglycan	230	233	PF01048	0.548
MOD_GlcNHglycan	270	273	PF01048	0.448
MOD_GlcNHglycan	327	330	PF01048	0.466
MOD_GlcNHglycan	378	381	PF01048	0.598
MOD_GlcNHglycan	419	422	PF01048	0.354
MOD_GlcNHglycan	459	462	PF01048	0.368
MOD_GlcNHglycan	466	470	PF01048	0.346
MOD_GlcNHglycan	558	561	PF01048	0.425
MOD_GlcNHglycan	579	582	PF01048	0.535
MOD_GlcNHglycan	60	63	PF01048	0.483
MOD_GlcNHglycan	605	608	PF01048	0.511
MOD_GlcNHglycan	655	658	PF01048	0.587
MOD_GlcNHglycan	671	674	PF01048	0.669
MOD_GlcNHglycan	677	680	PF01048	0.641
MOD_GlcNHglycan	68	71	PF01048	0.527
MOD_GlcNHglycan	707	710	PF01048	0.722
MOD_GlcNHglycan	739	742	PF01048	0.706
MOD_GlcNHglycan	745	748	PF01048	0.586
MOD_GlcNHglycan	757	760	PF01048	0.542
MOD_GlcNHglycan	825	828	PF01048	0.698
MOD_GlcNHglycan	834	837	PF01048	0.581
MOD_GSK3_1	167	174	PF00069	0.426
MOD_GSK3_1	247	254	PF00069	0.375
MOD_GSK3_1	26	33	PF00069	0.442
MOD_GSK3_1	279	286	PF00069	0.374
MOD_GSK3_1	289	296	PF00069	0.423
MOD_GSK3_1	341	348	PF00069	0.439
MOD_GSK3_1	512	519	PF00069	0.452
MOD_GSK3_1	536	543	PF00069	0.375
MOD_GSK3_1	54	61	PF00069	0.376
MOD_GSK3_1	547	554	PF00069	0.324
MOD_GSK3_1	572	579	PF00069	0.513
MOD_GSK3_1	582	589	PF00069	0.486
MOD_GSK3_1	62	69	PF00069	0.476
MOD_GSK3_1	620	627	PF00069	0.646
MOD_GSK3_1	640	647	PF00069	0.568
MOD_GSK3_1	652	659	PF00069	0.560
MOD_GSK3_1	674	681	PF00069	0.602
MOD_GSK3_1	683	690	PF00069	0.680
MOD_GSK3_1	761	768	PF00069	0.734
MOD_GSK3_1	777	784	PF00069	0.728
MOD_GSK3_1	785	792	PF00069	0.684
MOD_GSK3_1	794	801	PF00069	0.642
MOD_GSK3_1	826	833	PF00069	0.746
MOD_LATS_1	601	607	PF00433	0.455
MOD_N-GLC_1	268	273	PF02516	0.416
MOD_N-GLC_1	505	510	PF02516	0.296
MOD_N-GLC_1	620	625	PF02516	0.645
MOD_N-GLC_1	799	804	PF02516	0.492
MOD_N-GLC_2	277	279	PF02516	0.443
MOD_NEK2_1	10	15	PF00069	0.470
MOD_NEK2_1	202	207	PF00069	0.495
MOD_NEK2_1	221	226	PF00069	0.553
MOD_NEK2_1	247	252	PF00069	0.362
MOD_NEK2_1	301	306	PF00069	0.445
MOD_NEK2_1	333	338	PF00069	0.464
MOD_NEK2_1	341	346	PF00069	0.469
MOD_NEK2_1	36	41	PF00069	0.382
MOD_NEK2_1	368	373	PF00069	0.387
MOD_NEK2_1	440	445	PF00069	0.401
MOD_NEK2_1	457	462	PF00069	0.264
MOD_NEK2_1	479	484	PF00069	0.418
MOD_NEK2_1	56	61	PF00069	0.204
MOD_NEK2_1	591	596	PF00069	0.427
MOD_NEK2_1	652	657	PF00069	0.640
MOD_NEK2_1	731	736	PF00069	0.654
MOD_NEK2_1	737	742	PF00069	0.641
MOD_NEK2_1	753	758	PF00069	0.627
MOD_NEK2_2	26	31	PF00069	0.408
MOD_NEK2_2	547	552	PF00069	0.359
MOD_NEK2_2	79	84	PF00069	0.444
MOD_PIKK_1	333	339	PF00454	0.399
MOD_PIKK_1	41	47	PF00454	0.498
MOD_PIKK_1	519	525	PF00454	0.467
MOD_PIKK_1	732	738	PF00454	0.589
MOD_PIKK_1	789	795	PF00454	0.605
MOD_PK_1	262	268	PF00069	0.477
MOD_PKA_2	279	285	PF00069	0.460
MOD_PKA_2	301	307	PF00069	0.432
MOD_PKA_2	51	57	PF00069	0.399
MOD_PKA_2	536	542	PF00069	0.536
MOD_PKA_2	608	614	PF00069	0.666
MOD_PKA_2	621	627	PF00069	0.636
MOD_PKA_2	731	737	PF00069	0.676
MOD_PKA_2	79	85	PF00069	0.462
MOD_Plk_1	505	511	PF00069	0.305
MOD_Plk_1	732	738	PF00069	0.650
MOD_Plk_1	799	805	PF00069	0.510
MOD_Plk_4	103	109	PF00069	0.315
MOD_Plk_4	167	173	PF00069	0.272
MOD_Plk_4	479	485	PF00069	0.459
MOD_Plk_4	51	57	PF00069	0.323
MOD_Plk_4	563	569	PF00069	0.360
MOD_Plk_4	586	592	PF00069	0.463
MOD_Plk_4	687	693	PF00069	0.707
MOD_Plk_4	809	815	PF00069	0.715
MOD_Plk_4	85	91	PF00069	0.333
MOD_ProDKin_1	17	23	PF00069	0.477
MOD_ProDKin_1	293	299	PF00069	0.364
MOD_ProDKin_1	30	36	PF00069	0.415
MOD_ProDKin_1	315	321	PF00069	0.239
MOD_ProDKin_1	408	414	PF00069	0.382
MOD_ProDKin_1	516	522	PF00069	0.479
MOD_ProDKin_1	569	575	PF00069	0.432
MOD_ProDKin_1	628	634	PF00069	0.593
MOD_ProDKin_1	678	684	PF00069	0.762
MOD_ProDKin_1	691	697	PF00069	0.649
MOD_ProDKin_1	765	771	PF00069	0.701
MOD_ProDKin_1	786	792	PF00069	0.680
TRG_DiLeu_BaEn_2	309	315	PF01217	0.401
TRG_ENDOCYTIC_2	427	430	PF00928	0.319
TRG_ER_diArg_1	126	128	PF00400	0.406
TRG_ER_diArg_1	299	302	PF00400	0.497
TRG_ER_diArg_1	83	85	PF00400	0.431
TRG_ER_diArg_1	843	845	PF00400	0.605
TRG_NES_CRM1_1	322	334	PF08389	0.399
TRG_Pf-PMV_PEXEL_1	72	77	PF00026	0.403

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PER2	Leptomonas seymouri	53%	96%
A0A0S4KHN7	Bodo saltans	35%	100%
A0A1X0NY37	Trypanosomatidae	38%	100%
A0A3S5IS35	Trypanosoma rangeli	37%	100%
A0A3S7WWH4	Leishmania donovani	93%	100%
A4HBU3	Leishmania braziliensis	76%	100%
D0A1C9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E9AGU9	Leishmania infantum	93%	100%
E9AV65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
O13733	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	23%	100%
Q55GS2	Dictyostelium discoideum	25%	100%
Q561M0	Xenopus laevis	27%	100%
Q96KG9	Homo sapiens	27%	100%