ABC transporter domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ABC transporter, putative

Species:

Leishmania major

UniProt:

Q4QCB4_LEIMA

TriTrypDb:

LmjF.21.0880 , LMJLV39_210016000 , LMJSD75_210016100

Length:

953

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QCB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCB4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	7
GO:0005488	binding	1	7
GO:0005524	ATP binding	5	7
GO:0017076	purine nucleotide binding	4	7
GO:0030554	adenyl nucleotide binding	5	7
GO:0032553	ribonucleotide binding	3	7
GO:0032555	purine ribonucleotide binding	4	7
GO:0032559	adenyl ribonucleotide binding	5	7
GO:0035639	purine ribonucleoside triphosphate binding	4	7
GO:0036094	small molecule binding	2	7
GO:0043167	ion binding	2	7
GO:0043168	anion binding	3	7
GO:0097159	organic cyclic compound binding	2	7
GO:0097367	carbohydrate derivative binding	2	7
GO:1901265	nucleoside phosphate binding	3	7
GO:1901363	heterocyclic compound binding	2	7
GO:0005215	transporter activity	1	4
GO:0015399	primary active transmembrane transporter activity	4	4
GO:0022804	active transmembrane transporter activity	3	4
GO:0022857	transmembrane transporter activity	2	4
GO:0042626	ATPase-coupled transmembrane transporter activity	2	4
GO:0140359	ABC-type transporter activity	3	4
GO:0140657	ATP-dependent activity	1	4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	22	26	PF00656	0.739
CLV_C14_Caspase3-7	297	301	PF00656	0.624
CLV_C14_Caspase3-7	482	486	PF00656	0.733
CLV_C14_Caspase3-7	51	55	PF00656	0.747
CLV_C14_Caspase3-7	541	545	PF00656	0.721
CLV_C14_Caspase3-7	565	569	PF00656	0.703
CLV_NRD_NRD_1	254	256	PF00675	0.303
CLV_NRD_NRD_1	36	38	PF00675	0.492
CLV_NRD_NRD_1	469	471	PF00675	0.548
CLV_NRD_NRD_1	75	77	PF00675	0.531
CLV_NRD_NRD_1	917	919	PF00675	0.561
CLV_NRD_NRD_1	947	949	PF00675	0.444
CLV_PCSK_FUR_1	73	77	PF00082	0.534
CLV_PCSK_FUR_1	944	948	PF00082	0.442
CLV_PCSK_KEX2_1	253	255	PF00082	0.303
CLV_PCSK_KEX2_1	36	38	PF00082	0.492
CLV_PCSK_KEX2_1	469	471	PF00082	0.548
CLV_PCSK_KEX2_1	75	77	PF00082	0.533
CLV_PCSK_KEX2_1	917	919	PF00082	0.561
CLV_PCSK_KEX2_1	946	948	PF00082	0.455
CLV_PCSK_PC7_1	71	77	PF00082	0.534
CLV_PCSK_SKI1_1	255	259	PF00082	0.303
CLV_PCSK_SKI1_1	260	264	PF00082	0.303
CLV_PCSK_SKI1_1	398	402	PF00082	0.374
CLV_PCSK_SKI1_1	415	419	PF00082	0.355
CLV_PCSK_SKI1_1	746	750	PF00082	0.564
CLV_PCSK_SKI1_1	887	891	PF00082	0.707
DOC_AGCK_PIF_1	781	786	PF00069	0.317
DOC_CKS1_1	343	348	PF01111	0.704
DOC_CKS1_1	465	470	PF01111	0.734
DOC_CYCLIN_RxL_1	254	267	PF00134	0.503
DOC_CYCLIN_yCln2_LP_2	236	242	PF00134	0.455
DOC_MAPK_gen_1	244	252	PF00069	0.549
DOC_MAPK_gen_1	917	924	PF00069	0.354
DOC_MAPK_MEF2A_6	746	755	PF00069	0.303
DOC_MAPK_MEF2A_6	917	926	PF00069	0.288
DOC_PP1_RVXF_1	778	785	PF00149	0.549
DOC_PP2B_LxvP_1	293	296	PF13499	0.565
DOC_PP4_FxxP_1	377	380	PF00568	0.711
DOC_PP4_FxxP_1	608	611	PF00568	0.633
DOC_PP4_FxxP_1	738	741	PF00568	0.404
DOC_SPAK_OSR1_1	780	784	PF12202	0.497
DOC_USP7_MATH_1	172	176	PF00917	0.503
DOC_USP7_MATH_1	195	199	PF00917	0.455
DOC_USP7_MATH_1	294	298	PF00917	0.588
DOC_USP7_MATH_1	314	318	PF00917	0.557
DOC_USP7_MATH_1	333	337	PF00917	0.797
DOC_USP7_MATH_1	357	361	PF00917	0.743
DOC_USP7_MATH_1	463	467	PF00917	0.811
DOC_USP7_MATH_1	477	481	PF00917	0.660
DOC_USP7_MATH_1	555	559	PF00917	0.745
DOC_USP7_MATH_1	756	760	PF00917	0.402
DOC_USP7_MATH_1	80	84	PF00917	0.777
DOC_USP7_MATH_1	819	823	PF00917	0.314
DOC_USP7_MATH_1	848	852	PF00917	0.507
DOC_USP7_MATH_1	879	883	PF00917	0.504
DOC_WW_Pin1_4	342	347	PF00397	0.768
DOC_WW_Pin1_4	355	360	PF00397	0.728
DOC_WW_Pin1_4	464	469	PF00397	0.740
DOC_WW_Pin1_4	570	575	PF00397	0.707
DOC_WW_Pin1_4	880	885	PF00397	0.438
DOC_WW_Pin1_4	911	916	PF00397	0.379
LIG_14-3-3_CanoR_1	218	224	PF00244	0.503
LIG_14-3-3_CanoR_1	549	554	PF00244	0.766
LIG_14-3-3_CanoR_1	849	853	PF00244	0.538
LIG_14-3-3_CanoR_1	880	884	PF00244	0.531
LIG_14-3-3_CterR_2	948	953	PF00244	0.656
LIG_Actin_WH2_2	204	220	PF00022	0.503
LIG_Actin_WH2_2	935	952	PF00022	0.464
LIG_BIR_II_1	1	5	PF00653	0.712
LIG_BRCT_BRCA1_1	119	123	PF00533	0.584
LIG_CSL_BTD_1	771	774	PF09270	0.562
LIG_deltaCOP1_diTrp_1	740	749	PF00928	0.394
LIG_FHA_1	127	133	PF00498	0.532
LIG_FHA_1	212	218	PF00498	0.562
LIG_FHA_1	451	457	PF00498	0.743
LIG_FHA_1	7	13	PF00498	0.748
LIG_FHA_1	706	712	PF00498	0.535
LIG_FHA_1	714	720	PF00498	0.337
LIG_FHA_1	786	792	PF00498	0.402
LIG_FHA_1	82	88	PF00498	0.760
LIG_FHA_1	824	830	PF00498	0.374
LIG_FHA_1	94	100	PF00498	0.590
LIG_FHA_2	204	210	PF00498	0.503
LIG_FHA_2	42	48	PF00498	0.760
LIG_FHA_2	563	569	PF00498	0.720
LIG_FHA_2	800	806	PF00498	0.487
LIG_FHA_2	901	907	PF00498	0.371
LIG_LIR_Apic_2	374	380	PF02991	0.712
LIG_LIR_Apic_2	606	611	PF02991	0.637
LIG_LIR_Apic_2	736	741	PF02991	0.396
LIG_LIR_Gen_1	139	148	PF02991	0.549
LIG_LIR_Gen_1	2	12	PF02991	0.652
LIG_LIR_Gen_1	283	294	PF02991	0.604
LIG_LIR_Gen_1	479	488	PF02991	0.687
LIG_LIR_Gen_1	636	646	PF02991	0.358
LIG_LIR_Gen_1	691	700	PF02991	0.554
LIG_LIR_Gen_1	708	717	PF02991	0.503
LIG_LIR_Gen_1	726	735	PF02991	0.235
LIG_LIR_Gen_1	811	820	PF02991	0.326
LIG_LIR_Gen_1	905	915	PF02991	0.413
LIG_LIR_Gen_1	916	926	PF02991	0.276
LIG_LIR_Gen_1	936	945	PF02991	0.216
LIG_LIR_Gen_1	95	106	PF02991	0.582
LIG_LIR_Nem_3	139	144	PF02991	0.578
LIG_LIR_Nem_3	2	7	PF02991	0.723
LIG_LIR_Nem_3	283	289	PF02991	0.604
LIG_LIR_Nem_3	479	484	PF02991	0.693
LIG_LIR_Nem_3	530	536	PF02991	0.756
LIG_LIR_Nem_3	636	641	PF02991	0.358
LIG_LIR_Nem_3	691	695	PF02991	0.552
LIG_LIR_Nem_3	708	712	PF02991	0.503
LIG_LIR_Nem_3	726	730	PF02991	0.337
LIG_LIR_Nem_3	740	745	PF02991	0.356
LIG_LIR_Nem_3	785	789	PF02991	0.317
LIG_LIR_Nem_3	811	815	PF02991	0.339
LIG_LIR_Nem_3	844	850	PF02991	0.484
LIG_LIR_Nem_3	905	910	PF02991	0.376
LIG_LIR_Nem_3	916	922	PF02991	0.351
LIG_LIR_Nem_3	95	101	PF02991	0.603
LIG_NRBOX	231	237	PF00104	0.503
LIG_Pex14_2	622	626	PF04695	0.546
LIG_Pex14_2	738	742	PF04695	0.410
LIG_Pex14_2	760	764	PF04695	0.356
LIG_Pex14_2	768	772	PF04695	0.316
LIG_SH2_CRK	745	749	PF00017	0.376
LIG_SH2_NCK_1	481	485	PF00017	0.690
LIG_SH2_STAP1	213	217	PF00017	0.503
LIG_SH2_STAP1	787	791	PF00017	0.337
LIG_SH2_STAP1	820	824	PF00017	0.315
LIG_SH2_STAP1	907	911	PF00017	0.412
LIG_SH2_STAT3	170	173	PF00017	0.503
LIG_SH2_STAT3	654	657	PF00017	0.374
LIG_SH2_STAT5	213	216	PF00017	0.486
LIG_SH2_STAT5	251	254	PF00017	0.503
LIG_SH2_STAT5	286	289	PF00017	0.598
LIG_SH2_STAT5	344	347	PF00017	0.703
LIG_SH2_STAT5	709	712	PF00017	0.532
LIG_SH2_STAT5	787	790	PF00017	0.337
LIG_SH2_STAT5	902	905	PF00017	0.363
LIG_SH2_STAT5	98	101	PF00017	0.566
LIG_SH3_2	465	470	PF14604	0.734
LIG_SH3_3	356	362	PF00018	0.730
LIG_SH3_3	425	431	PF00018	0.620
LIG_SH3_3	462	468	PF00018	0.732
LIG_SH3_3	599	605	PF00018	0.656
LIG_SH3_3	849	855	PF00018	0.496
LIG_SUMO_SIM_anti_2	267	273	PF11976	0.503
LIG_SUMO_SIM_anti_2	407	412	PF11976	0.544
LIG_SUMO_SIM_anti_2	750	755	PF11976	0.402
LIG_SUMO_SIM_par_1	267	273	PF11976	0.503
LIG_SUMO_SIM_par_1	388	393	PF11976	0.537
LIG_SUMO_SIM_par_1	407	412	PF11976	0.544
LIG_SUMO_SIM_par_1	681	687	PF11976	0.337
LIG_SUMO_SIM_par_1	752	759	PF11976	0.341
LIG_SUMO_SIM_par_1	8	13	PF11976	0.723
LIG_SxIP_EBH_1	849	859	PF03271	0.488
LIG_WRC_WIRS_1	724	729	PF05994	0.402
LIG_WRC_WIRS_1	757	762	PF05994	0.402
LIG_WRC_WIRS_1	783	788	PF05994	0.317
MOD_CDC14_SPxK_1	914	917	PF00782	0.460
MOD_CDK_SPK_2	342	347	PF00069	0.619
MOD_CDK_SPK_2	464	469	PF00069	0.670
MOD_CDK_SPxK_1	464	470	PF00069	0.727
MOD_CDK_SPxK_1	911	917	PF00069	0.445
MOD_CDK_SPxxK_3	880	887	PF00069	0.529
MOD_CDK_SPxxK_3	911	918	PF00069	0.442
MOD_CK1_1	13	19	PF00069	0.701
MOD_CK1_1	166	172	PF00069	0.337
MOD_CK1_1	325	331	PF00069	0.588
MOD_CK1_1	507	513	PF00069	0.597
MOD_CK1_1	548	554	PF00069	0.773
MOD_CK1_1	556	562	PF00069	0.592
MOD_CK1_1	6	12	PF00069	0.630
MOD_CK1_1	684	690	PF00069	0.316
MOD_CK1_1	759	765	PF00069	0.402
MOD_CK1_1	811	817	PF00069	0.378
MOD_CK2_1	172	178	PF00069	0.402
MOD_CK2_1	203	209	PF00069	0.337
MOD_CK2_1	224	230	PF00069	0.337
MOD_CK2_1	41	47	PF00069	0.721
MOD_CK2_1	799	805	PF00069	0.440
MOD_CK2_1	900	906	PF00069	0.507
MOD_DYRK1A_RPxSP_1	880	884	PF00069	0.526
MOD_GlcNHglycan	110	113	PF01048	0.471
MOD_GlcNHglycan	138	141	PF01048	0.389
MOD_GlcNHglycan	165	168	PF01048	0.325
MOD_GlcNHglycan	17	20	PF01048	0.567
MOD_GlcNHglycan	187	192	PF01048	0.375
MOD_GlcNHglycan	197	200	PF01048	0.478
MOD_GlcNHglycan	214	217	PF01048	0.271
MOD_GlcNHglycan	221	224	PF01048	0.342
MOD_GlcNHglycan	296	299	PF01048	0.481
MOD_GlcNHglycan	316	319	PF01048	0.461
MOD_GlcNHglycan	324	327	PF01048	0.576
MOD_GlcNHglycan	352	355	PF01048	0.731
MOD_GlcNHglycan	441	444	PF01048	0.655
MOD_GlcNHglycan	519	522	PF01048	0.709
MOD_GlcNHglycan	555	558	PF01048	0.684
MOD_GlcNHglycan	66	69	PF01048	0.630
MOD_GlcNHglycan	857	860	PF01048	0.737
MOD_GlcNHglycan	928	931	PF01048	0.337
MOD_GSK3_1	104	111	PF00069	0.360
MOD_GSK3_1	14	21	PF00069	0.746
MOD_GSK3_1	151	158	PF00069	0.358
MOD_GSK3_1	187	194	PF00069	0.334
MOD_GSK3_1	365	372	PF00069	0.686
MOD_GSK3_1	37	44	PF00069	0.799
MOD_GSK3_1	435	442	PF00069	0.559
MOD_GSK3_1	450	457	PF00069	0.632
MOD_GSK3_1	545	552	PF00069	0.758
MOD_GSK3_1	556	563	PF00069	0.670
MOD_GSK3_1	6	13	PF00069	0.668
MOD_GSK3_1	60	67	PF00069	0.615
MOD_GSK3_1	755	762	PF00069	0.402
MOD_GSK3_1	799	806	PF00069	0.442
MOD_GSK3_1	819	826	PF00069	0.276
MOD_GSK3_1	913	920	PF00069	0.451
MOD_GSK3_1	93	100	PF00069	0.516
MOD_LATS_1	35	41	PF00433	0.586
MOD_N-GLC_1	246	251	PF02516	0.317
MOD_N-GLC_2	133	135	PF02516	0.427
MOD_N-GLC_2	414	416	PF02516	0.455
MOD_N-GLC_2	899	901	PF02516	0.505
MOD_NEK2_1	211	216	PF00069	0.315
MOD_NEK2_1	418	423	PF00069	0.453
MOD_NEK2_1	435	440	PF00069	0.596
MOD_NEK2_1	504	509	PF00069	0.548
MOD_NEK2_1	672	677	PF00069	0.402
MOD_NEK2_1	733	738	PF00069	0.442
MOD_NEK2_1	749	754	PF00069	0.337
MOD_NEK2_1	755	760	PF00069	0.346
MOD_NEK2_1	933	938	PF00069	0.402
MOD_NEK2_2	203	208	PF00069	0.317
MOD_PIKK_1	280	286	PF00454	0.498
MOD_PIKK_1	573	579	PF00454	0.475
MOD_PIKK_1	823	829	PF00454	0.442
MOD_PK_1	37	43	PF00069	0.586
MOD_PK_1	549	555	PF00069	0.641
MOD_PKA_1	75	81	PF00069	0.612
MOD_PKA_1	917	923	PF00069	0.473
MOD_PKA_2	126	132	PF00069	0.387
MOD_PKA_2	195	201	PF00069	0.345
MOD_PKA_2	435	441	PF00069	0.576
MOD_PKA_2	507	513	PF00069	0.531
MOD_PKA_2	548	554	PF00069	0.704
MOD_PKA_2	75	81	PF00069	0.643
MOD_PKA_2	848	854	PF00069	0.664
MOD_PKA_2	879	885	PF00069	0.658
MOD_PKA_2	917	923	PF00069	0.473
MOD_PKB_1	73	81	PF00069	0.614
MOD_Plk_1	117	123	PF00069	0.603
MOD_Plk_1	203	209	PF00069	0.337
MOD_Plk_1	246	252	PF00069	0.337
MOD_Plk_1	484	490	PF00069	0.652
MOD_Plk_1	749	755	PF00069	0.402
MOD_Plk_4	155	161	PF00069	0.475
MOD_Plk_4	172	178	PF00069	0.271
MOD_Plk_4	246	252	PF00069	0.337
MOD_Plk_4	264	270	PF00069	0.337
MOD_Plk_4	285	291	PF00069	0.413
MOD_Plk_4	390	396	PF00069	0.411
MOD_Plk_4	6	12	PF00069	0.669
MOD_Plk_4	611	617	PF00069	0.494
MOD_Plk_4	705	711	PF00069	0.470
MOD_Plk_4	723	729	PF00069	0.434
MOD_Plk_4	749	755	PF00069	0.402
MOD_Plk_4	811	817	PF00069	0.378
MOD_Plk_4	848	854	PF00069	0.609
MOD_Plk_4	933	939	PF00069	0.337
MOD_Plk_4	94	100	PF00069	0.513
MOD_ProDKin_1	342	348	PF00069	0.709
MOD_ProDKin_1	355	361	PF00069	0.653
MOD_ProDKin_1	464	470	PF00069	0.671
MOD_ProDKin_1	570	576	PF00069	0.618
MOD_ProDKin_1	880	886	PF00069	0.527
MOD_ProDKin_1	911	917	PF00069	0.445
TRG_DiLeu_BaEn_2	905	911	PF01217	0.497
TRG_DiLeu_BaLyEn_6	531	536	PF01217	0.560
TRG_ENDOCYTIC_2	286	289	PF00928	0.471
TRG_ENDOCYTIC_2	4	7	PF00928	0.605
TRG_ENDOCYTIC_2	481	484	PF00928	0.602
TRG_ENDOCYTIC_2	692	695	PF00928	0.403
TRG_ENDOCYTIC_2	709	712	PF00928	0.337
TRG_ENDOCYTIC_2	745	748	PF00928	0.437
TRG_ENDOCYTIC_2	907	910	PF00928	0.445
TRG_ENDOCYTIC_2	98	101	PF00928	0.426
TRG_ER_diArg_1	252	255	PF00400	0.337
TRG_ER_diArg_1	36	38	PF00400	0.602
TRG_ER_diArg_1	468	470	PF00400	0.679
TRG_ER_diArg_1	70	73	PF00400	0.679
TRG_ER_diArg_1	917	919	PF00400	0.419
TRG_ER_diArg_1	943	946	PF00400	0.512
TRG_ER_diArg_1	947	950	PF00400	0.550
TRG_NES_CRM1_1	808	821	PF08389	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8B6	Leptomonas seymouri	53%	99%
A0A3Q8IBV9	Leishmania donovani	92%	100%
A4HBU5	Leishmania braziliensis	71%	99%
E9AGV1	Leishmania infantum	92%	100%
E9AV67	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%