LeishMANIAdb
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DUF4220 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
DUF4220 domain-containing protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QCB3_LEIMA
TriTrypDb:
LmjF.21.0882 , LMJLV39_210016100 , LMJSD75_210016200
Length:
108

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 6
NetGPI no yes: 0, no: 6
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCB3
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCB3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 45 47 PF00675 0.572
CLV_PCSK_KEX2_1 47 49 PF00082 0.525
CLV_PCSK_PC1ET2_1 47 49 PF00082 0.525
LIG_14-3-3_CanoR_1 18 27 PF00244 0.717
LIG_BIR_II_1 1 5 PF00653 0.767
LIG_BIR_III_4 71 75 PF00653 0.692
LIG_FHA_1 20 26 PF00498 0.678
LIG_SH2_NCK_1 37 41 PF00017 0.777
MOD_CK1_1 19 25 PF00069 0.551
MOD_CK1_1 2 8 PF00069 0.761
MOD_CK2_1 39 45 PF00069 0.699
MOD_GlcNHglycan 1 4 PF01048 0.534
MOD_GlcNHglycan 94 97 PF01048 0.784
MOD_NEK2_1 50 55 PF00069 0.546
MOD_PKA_2 19 25 PF00069 0.605
MOD_Plk_1 50 56 PF00069 0.546
MOD_Plk_4 50 56 PF00069 0.546
MOD_Plk_4 61 67 PF00069 0.416

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1IA12 Leptomonas seymouri 58% 100%
A0A3S7WWH6 Leishmania donovani 94% 100%
A4HBU6 Leishmania braziliensis 83% 100%
E9AGV2 Leishmania infantum 94% 100%
E9AV68 Leishmania mexicana (strain MHOM/GT/2001/U1103) 93% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS