Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF4499), putative

Species:

Leishmania major

UniProt:

Q4QCB2_LEIMA

TriTrypDb:

LmjF.21.0883 , LMJLV39_210016200 , LMJSD75_210016300

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005635	nuclear envelope	4	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	12
GO:0031967	organelle envelope	3	2
GO:0031975	envelope	2	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QCB2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCB2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	83	85	PF00675	0.538
CLV_PCSK_KEX2_1	83	85	PF00082	0.633
CLV_PCSK_PC7_1	79	85	PF00082	0.518
CLV_PCSK_SKI1_1	160	164	PF00082	0.344
CLV_PCSK_SKI1_1	6	10	PF00082	0.485
CLV_PCSK_SKI1_1	79	83	PF00082	0.573
DEG_APCC_DBOX_1	37	45	PF00400	0.278
DEG_SPOP_SBC_1	196	200	PF00917	0.283
DOC_CYCLIN_RxL_1	61	70	PF00134	0.314
DOC_CYCLIN_yCln2_LP_2	39	45	PF00134	0.302
DOC_MAPK_MEF2A_6	34	43	PF00069	0.497
DOC_PP1_RVXF_1	144	150	PF00149	0.411
DOC_PP2B_LxvP_1	39	42	PF13499	0.309
DOC_PP2B_LxvP_1	66	69	PF13499	0.370
DOC_USP7_MATH_1	196	200	PF00917	0.377
DOC_USP7_MATH_1	2	6	PF00917	0.753
DOC_USP7_MATH_1	21	25	PF00917	0.706
DOC_WW_Pin1_4	10	15	PF00397	0.735
DOC_WW_Pin1_4	171	176	PF00397	0.339
LIG_14-3-3_CanoR_1	146	156	PF00244	0.501
LIG_Actin_WH2_2	68	85	PF00022	0.331
LIG_APCC_ABBA_1	100	105	PF00400	0.303
LIG_BRCT_BRCA1_1	109	113	PF00533	0.276
LIG_FHA_1	188	194	PF00498	0.417
LIG_FHA_1	91	97	PF00498	0.482
LIG_GBD_Chelix_1	45	53	PF00786	0.388
LIG_Pex14_2	145	149	PF04695	0.491
LIG_PTB_Apo_2	49	56	PF02174	0.302
LIG_SH2_SRC	40	43	PF00017	0.350
LIG_SH2_STAT5	40	43	PF00017	0.329
LIG_SH2_STAT5	71	74	PF00017	0.431
LIG_SH3_3	89	95	PF00018	0.445
MOD_CDK_SPxxK_3	171	178	PF00069	0.373
MOD_CK1_1	107	113	PF00069	0.345
MOD_CK1_1	25	31	PF00069	0.540
MOD_GlcNHglycan	109	112	PF01048	0.437
MOD_GlcNHglycan	123	126	PF01048	0.299
MOD_GSK3_1	147	154	PF00069	0.468
MOD_GSK3_1	187	194	PF00069	0.344
MOD_GSK3_1	2	9	PF00069	0.752
MOD_GSK3_1	21	28	PF00069	0.708
MOD_N-GLC_1	151	156	PF02516	0.291
MOD_NEK2_1	104	109	PF00069	0.320
MOD_NEK2_1	119	124	PF00069	0.260
MOD_NEK2_1	162	167	PF00069	0.432
MOD_NEK2_1	187	192	PF00069	0.402
MOD_NEK2_1	197	202	PF00069	0.449
MOD_OFUCOSY	144	151	PF10250	0.417
MOD_PIKK_1	168	174	PF00454	0.308
MOD_PKA_1	6	12	PF00069	0.729
MOD_PKA_2	187	193	PF00069	0.361
MOD_Plk_1	104	110	PF00069	0.392
MOD_Plk_1	151	157	PF00069	0.491
MOD_Plk_4	104	110	PF00069	0.354
MOD_ProDKin_1	10	16	PF00069	0.730
MOD_ProDKin_1	171	177	PF00069	0.339
MOD_SUMO_rev_2	3	8	PF00179	0.692
TRG_DiLeu_BaLyEn_6	172	177	PF01217	0.280
TRG_ENDOCYTIC_2	40	43	PF00928	0.341
TRG_ER_diArg_1	82	84	PF00400	0.336

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7P5	Leptomonas seymouri	45%	100%
A0A0S4IZY4	Bodo saltans	33%	100%
A0A0S4J009	Bodo saltans	29%	100%
A0A1X0NXR6	Trypanosomatidae	36%	100%
A0A3Q8IAC8	Leishmania donovani	93%	100%
A0A3R7KU69	Trypanosoma rangeli	39%	100%
A4HBU7	Leishmania braziliensis	69%	100%
D0A1C5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9AGV3	Leishmania infantum	92%	100%
E9AV69	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%