C-CAP/cofactor C-like domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Adenylate cyclase associated (CAP) C terminal, putative

Species:

Leishmania major

UniProt:

Q4QCB0_LEIMA

TriTrypDb:

LmjF.21.0891 , LMJLV39_210016400 , LMJSD75_210016500

Length:

712

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCB0

Function

Biological processes
Term	Name	Level	Count
GO:0007015	actin filament organization	5	5
GO:0007165	signal transduction	2	2
GO:0009987	cellular process	1	5
GO:0016043	cellular component organization	3	5
GO:0019932	second-messenger-mediated signaling	4	2
GO:0019933	cAMP-mediated signaling	6	2
GO:0019935	cyclic-nucleotide-mediated signaling	5	2
GO:0031279	regulation of cyclase activity	4	2
GO:0035556	intracellular signal transduction	3	2
GO:0045761	regulation of adenylate cyclase activity	5	2
GO:0050789	regulation of biological process	2	2
GO:0050790	regulation of catalytic activity	3	2
GO:0050794	regulation of cellular process	3	2
GO:0051339	regulation of lyase activity	4	2
GO:0065007	biological regulation	1	2
GO:0065009	regulation of molecular function	2	2
GO:0071840	cellular component organization or biogenesis	2	5
GO:0097435	supramolecular fiber organization	4	5

Molecular functions
Term	Name	Level	Count
GO:0003779	actin binding	4	5
GO:0005488	binding	1	5
GO:0005515	protein binding	2	5
GO:0008092	cytoskeletal protein binding	3	5
GO:0008179	adenylate cyclase binding	4	2
GO:0019899	enzyme binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	576	580	PF00656	0.495
CLV_NRD_NRD_1	246	248	PF00675	0.617
CLV_NRD_NRD_1	253	255	PF00675	0.667
CLV_NRD_NRD_1	339	341	PF00675	0.539
CLV_NRD_NRD_1	470	472	PF00675	0.750
CLV_NRD_NRD_1	481	483	PF00675	0.731
CLV_PCSK_FUR_1	244	248	PF00082	0.593
CLV_PCSK_FUR_1	251	255	PF00082	0.674
CLV_PCSK_KEX2_1	246	248	PF00082	0.596
CLV_PCSK_KEX2_1	253	255	PF00082	0.667
CLV_PCSK_KEX2_1	338	340	PF00082	0.541
CLV_PCSK_KEX2_1	470	472	PF00082	0.750
CLV_PCSK_KEX2_1	481	483	PF00082	0.731
CLV_PCSK_SKI1_1	26	30	PF00082	0.625
CLV_PCSK_SKI1_1	418	422	PF00082	0.538
CLV_PCSK_SKI1_1	423	427	PF00082	0.458
CLV_PCSK_SKI1_1	56	60	PF00082	0.600
CLV_PCSK_SKI1_1	706	710	PF00082	0.579
CLV_Separin_Metazoa	27	31	PF03568	0.421
DEG_APCC_DBOX_1	311	319	PF00400	0.606
DEG_APCC_DBOX_1	417	425	PF00400	0.447
DEG_SCF_FBW7_1	535	540	PF00400	0.697
DEG_SPOP_SBC_1	128	132	PF00917	0.653
DEG_SPOP_SBC_1	486	490	PF00917	0.808
DOC_CKS1_1	166	171	PF01111	0.546
DOC_CYCLIN_yClb3_PxF_3	236	244	PF00134	0.527
DOC_MAPK_gen_1	460	468	PF00069	0.790
DOC_MAPK_HePTP_8	661	673	PF00069	0.320
DOC_MAPK_MEF2A_6	565	573	PF00069	0.495
DOC_MAPK_MEF2A_6	645	653	PF00069	0.405
DOC_MAPK_MEF2A_6	664	673	PF00069	0.190
DOC_PP1_RVXF_1	153	160	PF00149	0.631
DOC_PP2B_LxvP_1	35	38	PF13499	0.638
DOC_PP2B_LxvP_1	4	7	PF13499	0.618
DOC_PP2B_LxvP_1	687	690	PF13499	0.401
DOC_PP4_MxPP_1	513	516	PF00568	0.764
DOC_USP7_MATH_1	115	119	PF00917	0.594
DOC_USP7_MATH_1	122	126	PF00917	0.654
DOC_USP7_MATH_1	128	132	PF00917	0.635
DOC_USP7_MATH_1	190	194	PF00917	0.598
DOC_USP7_MATH_1	199	203	PF00917	0.627
DOC_USP7_MATH_1	373	377	PF00917	0.460
DOC_USP7_MATH_1	530	534	PF00917	0.757
DOC_WW_Pin1_4	165	170	PF00397	0.474
DOC_WW_Pin1_4	195	200	PF00397	0.648
DOC_WW_Pin1_4	441	446	PF00397	0.526
DOC_WW_Pin1_4	533	538	PF00397	0.681
LIG_14-3-3_CanoR_1	121	127	PF00244	0.704
LIG_14-3-3_CanoR_1	189	195	PF00244	0.763
LIG_14-3-3_CanoR_1	30	36	PF00244	0.447
LIG_14-3-3_CanoR_1	303	309	PF00244	0.519
LIG_14-3-3_CanoR_1	408	414	PF00244	0.493
LIG_14-3-3_CanoR_1	470	479	PF00244	0.787
LIG_14-3-3_CanoR_1	56	61	PF00244	0.593
LIG_Actin_WH2_2	14	32	PF00022	0.563
LIG_Actin_WH2_2	202	220	PF00022	0.599
LIG_Actin_WH2_2	277	292	PF00022	0.566
LIG_Actin_WH2_2	506	523	PF00022	0.623
LIG_BRCT_BRCA1_1	155	159	PF00533	0.674
LIG_FHA_1	133	139	PF00498	0.424
LIG_FHA_1	189	195	PF00498	0.588
LIG_FHA_1	294	300	PF00498	0.469
LIG_FHA_1	53	59	PF00498	0.619
LIG_FHA_1	545	551	PF00498	0.401
LIG_FHA_1	593	599	PF00498	0.495
LIG_FHA_1	648	654	PF00498	0.414
LIG_FHA_1	657	663	PF00498	0.425
LIG_FHA_1	703	709	PF00498	0.401
LIG_FHA_1	87	93	PF00498	0.594
LIG_FHA_2	142	148	PF00498	0.437
LIG_FHA_2	330	336	PF00498	0.489
LIG_FHA_2	360	366	PF00498	0.566
LIG_FHA_2	472	478	PF00498	0.785
LIG_FHA_2	57	63	PF00498	0.649
LIG_FHA_2	694	700	PF00498	0.401
LIG_FHA_2	73	79	PF00498	0.533
LIG_LIR_Apic_2	165	169	PF02991	0.435
LIG_LIR_Gen_1	263	273	PF02991	0.493
LIG_LIR_Gen_1	410	421	PF02991	0.466
LIG_LIR_Gen_1	592	600	PF02991	0.495
LIG_LIR_LC3C_4	506	510	PF02991	0.632
LIG_LIR_LC3C_4	567	572	PF02991	0.495
LIG_LIR_Nem_3	22	28	PF02991	0.513
LIG_LIR_Nem_3	263	269	PF02991	0.446
LIG_LIR_Nem_3	538	544	PF02991	0.640
LIG_LIR_Nem_3	588	593	PF02991	0.495
LIG_PCNA_yPIPBox_3	44	56	PF02747	0.518
LIG_Rb_LxCxE_1	135	148	PF01857	0.409
LIG_SH2_CRK	430	434	PF00017	0.483
LIG_SH2_CRK	553	557	PF00017	0.401
LIG_SH2_GRB2like	380	383	PF00017	0.395
LIG_SH2_PTP2	593	596	PF00017	0.401
LIG_SH2_STAP1	88	92	PF00017	0.628
LIG_SH2_STAT5	166	169	PF00017	0.603
LIG_SH2_STAT5	380	383	PF00017	0.465
LIG_SH2_STAT5	449	452	PF00017	0.784
LIG_SH2_STAT5	593	596	PF00017	0.401
LIG_SH2_STAT5	693	696	PF00017	0.495
LIG_SH2_STAT5	88	91	PF00017	0.627
LIG_SH3_1	233	239	PF00018	0.662
LIG_SH3_3	233	239	PF00018	0.682
LIG_SH3_3	450	456	PF00018	0.665
LIG_SH3_3	480	486	PF00018	0.720
LIG_SH3_3	494	500	PF00018	0.761
LIG_SH3_3	5	11	PF00018	0.694
LIG_SH3_3	568	574	PF00018	0.401
LIG_SH3_3	591	597	PF00018	0.401
LIG_SUMO_SIM_anti_2	567	573	PF11976	0.495
LIG_SUMO_SIM_par_1	569	576	PF11976	0.495
LIG_TRAF2_1	564	567	PF00917	0.402
LIG_WRC_WIRS_1	87	92	PF05994	0.532
LIG_WW_3	7	11	PF00397	0.780
MOD_CDK_SPxxK_3	441	448	PF00069	0.536
MOD_CK1_1	129	135	PF00069	0.621
MOD_CK1_1	165	171	PF00069	0.559
MOD_CK1_1	175	181	PF00069	0.500
MOD_CK1_1	193	199	PF00069	0.671
MOD_CK1_1	225	231	PF00069	0.575
MOD_CK1_1	376	382	PF00069	0.466
MOD_CK1_1	441	447	PF00069	0.703
MOD_CK1_1	488	494	PF00069	0.700
MOD_CK1_1	533	539	PF00069	0.651
MOD_CK1_1	660	666	PF00069	0.383
MOD_CK2_1	130	136	PF00069	0.611
MOD_CK2_1	141	147	PF00069	0.481
MOD_CK2_1	180	186	PF00069	0.647
MOD_CK2_1	359	365	PF00069	0.456
MOD_CK2_1	471	477	PF00069	0.782
MOD_CK2_1	56	62	PF00069	0.645
MOD_CK2_1	622	628	PF00069	0.401
MOD_CK2_1	693	699	PF00069	0.495
MOD_GlcNHglycan	174	177	PF01048	0.525
MOD_GlcNHglycan	182	185	PF01048	0.546
MOD_GlcNHglycan	375	378	PF01048	0.439
MOD_GlcNHglycan	521	524	PF01048	0.654
MOD_GlcNHglycan	561	564	PF01048	0.515
MOD_GlcNHglycan	635	639	PF01048	0.401
MOD_GlcNHglycan	72	75	PF01048	0.791
MOD_GSK3_1	122	129	PF00069	0.691
MOD_GSK3_1	141	148	PF00069	0.249
MOD_GSK3_1	153	160	PF00069	0.577
MOD_GSK3_1	172	179	PF00069	0.539
MOD_GSK3_1	188	195	PF00069	0.614
MOD_GSK3_1	225	232	PF00069	0.578
MOD_GSK3_1	355	362	PF00069	0.432
MOD_GSK3_1	372	379	PF00069	0.520
MOD_GSK3_1	481	488	PF00069	0.782
MOD_GSK3_1	515	522	PF00069	0.731
MOD_GSK3_1	52	59	PF00069	0.630
MOD_GSK3_1	533	540	PF00069	0.608
MOD_GSK3_1	542	549	PF00069	0.553
MOD_GSK3_1	647	654	PF00069	0.425
MOD_GSK3_1	656	663	PF00069	0.382
MOD_GSK3_1	702	709	PF00069	0.401
MOD_LATS_1	54	60	PF00433	0.581
MOD_N-GLC_1	322	327	PF02516	0.569
MOD_N-GLC_1	657	662	PF02516	0.390
MOD_N-GLC_1	669	674	PF02516	0.408
MOD_N-GLC_2	397	399	PF02516	0.634
MOD_NEK2_1	126	131	PF00069	0.615
MOD_NEK2_1	145	150	PF00069	0.291
MOD_NEK2_1	153	158	PF00069	0.671
MOD_NEK2_1	194	199	PF00069	0.733
MOD_NEK2_1	322	327	PF00069	0.569
MOD_NEK2_1	578	583	PF00069	0.320
MOD_NEK2_1	615	620	PF00069	0.495
MOD_NEK2_1	633	638	PF00069	0.206
MOD_NEK2_2	693	698	PF00069	0.495
MOD_NEK2_2	86	91	PF00069	0.588
MOD_PIKK_1	106	112	PF00454	0.514
MOD_PIKK_1	293	299	PF00454	0.556
MOD_PIKK_1	501	507	PF00454	0.800
MOD_PIKK_1	542	548	PF00454	0.609
MOD_PK_1	454	460	PF00069	0.778
MOD_PKA_1	481	487	PF00069	0.640
MOD_PKA_2	188	194	PF00069	0.747
MOD_PKA_2	302	308	PF00069	0.518
MOD_PKA_2	311	317	PF00069	0.526
MOD_PKA_2	407	413	PF00069	0.394
MOD_PKA_2	481	487	PF00069	0.759
MOD_PKA_2	622	628	PF00069	0.401
MOD_PKB_1	254	262	PF00069	0.607
MOD_Plk_1	11	17	PF00069	0.717
MOD_Plk_1	322	328	PF00069	0.570
MOD_Plk_1	52	58	PF00069	0.497
MOD_Plk_1	537	543	PF00069	0.648
MOD_Plk_1	578	584	PF00069	0.342
MOD_Plk_1	657	663	PF00069	0.390
MOD_Plk_1	669	675	PF00069	0.408
MOD_Plk_1	706	712	PF00069	0.606
MOD_Plk_4	101	107	PF00069	0.550
MOD_Plk_4	141	147	PF00069	0.394
MOD_Plk_4	162	168	PF00069	0.471
MOD_Plk_4	265	271	PF00069	0.565
MOD_Plk_4	376	382	PF00069	0.458
MOD_Plk_4	515	521	PF00069	0.618
MOD_Plk_4	56	62	PF00069	0.645
MOD_Plk_4	589	595	PF00069	0.495
MOD_Plk_4	657	663	PF00069	0.320
MOD_ProDKin_1	165	171	PF00069	0.473
MOD_ProDKin_1	195	201	PF00069	0.645
MOD_ProDKin_1	441	447	PF00069	0.528
MOD_ProDKin_1	533	539	PF00069	0.663
MOD_SUMO_for_1	564	567	PF00179	0.495
TRG_DiLeu_BaEn_1	422	427	PF01217	0.555
TRG_DiLeu_BaEn_1	53	58	PF01217	0.609
TRG_DiLeu_BaEn_1	699	704	PF01217	0.495
TRG_DiLeu_LyEn_5	53	58	PF01217	0.609
TRG_ENDOCYTIC_2	593	596	PF00928	0.401
TRG_ER_diArg_1	244	247	PF00400	0.592
TRG_ER_diArg_1	250	253	PF00400	0.658
TRG_ER_diArg_1	337	340	PF00400	0.620
TRG_ER_diArg_1	469	471	PF00400	0.752
TRG_ER_diArg_1	481	483	PF00400	0.731
TRG_NES_CRM1_1	13	27	PF08389	0.639
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.603
TRG_Pf-PMV_PEXEL_1	49	53	PF00026	0.432

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P826	Leptomonas seymouri	48%	100%
A0A3Q8IF57	Leishmania donovani	91%	100%
E9AGV5	Leishmania infantum	92%	100%