Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein

Species:

Leishmania major

UniProt:

Q4QCA8_LEIMA

TriTrypDb:

LmjF.21.0901 , LMJLV39_210016600 , LMJSD75_210016700

Length:

423

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	83	87	PF00656	0.663
CLV_NRD_NRD_1	15	17	PF00675	0.646
CLV_NRD_NRD_1	332	334	PF00675	0.635
CLV_NRD_NRD_1	397	399	PF00675	0.743
CLV_NRD_NRD_1	54	56	PF00675	0.788
CLV_PCSK_FUR_1	13	17	PF00082	0.577
CLV_PCSK_KEX2_1	13	15	PF00082	0.653
CLV_PCSK_KEX2_1	216	218	PF00082	0.800
CLV_PCSK_KEX2_1	331	333	PF00082	0.634
CLV_PCSK_KEX2_1	397	399	PF00082	0.743
CLV_PCSK_KEX2_1	54	56	PF00082	0.788
CLV_PCSK_PC1ET2_1	216	218	PF00082	0.800
CLV_PCSK_PC7_1	212	218	PF00082	0.762
CLV_PCSK_SKI1_1	108	112	PF00082	0.615
CLV_PCSK_SKI1_1	262	266	PF00082	0.677
CLV_PCSK_SKI1_1	326	330	PF00082	0.598
CLV_PCSK_SKI1_1	398	402	PF00082	0.725
DEG_APCC_DBOX_1	103	111	PF00400	0.713
DEG_APCC_DBOX_1	242	250	PF00400	0.743
DEG_Nend_Nbox_1	1	3	PF02207	0.758
DEG_SPOP_SBC_1	61	65	PF00917	0.744
DOC_CDC14_PxL_1	350	358	PF14671	0.705
DOC_CKS1_1	200	205	PF01111	0.601
DOC_CYCLIN_RxL_1	163	171	PF00134	0.766
DOC_MAPK_MEF2A_6	360	369	PF00069	0.589
DOC_PP1_RVXF_1	164	171	PF00149	0.673
DOC_PP2B_LxvP_1	115	118	PF13499	0.610
DOC_PP4_FxxP_1	128	131	PF00568	0.575
DOC_USP7_MATH_1	141	145	PF00917	0.778
DOC_USP7_MATH_1	149	153	PF00917	0.653
DOC_USP7_MATH_1	188	192	PF00917	0.738
DOC_USP7_MATH_1	257	261	PF00917	0.717
DOC_USP7_MATH_1	345	349	PF00917	0.688
DOC_USP7_MATH_1	61	65	PF00917	0.743
DOC_USP7_MATH_1	69	73	PF00917	0.625
DOC_WW_Pin1_4	180	185	PF00397	0.757
DOC_WW_Pin1_4	186	191	PF00397	0.714
DOC_WW_Pin1_4	199	204	PF00397	0.619
DOC_WW_Pin1_4	274	279	PF00397	0.710
DOC_WW_Pin1_4	290	295	PF00397	0.655
LIG_14-3-3_CanoR_1	14	24	PF00244	0.688
LIG_14-3-3_CanoR_1	262	272	PF00244	0.728
LIG_14-3-3_CanoR_1	397	406	PF00244	0.759
LIG_BRCT_BRCA1_1	272	276	PF00533	0.727
LIG_FHA_1	119	125	PF00498	0.671
LIG_FHA_1	149	155	PF00498	0.641
LIG_FHA_1	15	21	PF00498	0.598
LIG_FHA_1	75	81	PF00498	0.676
LIG_FHA_2	229	235	PF00498	0.695
LIG_FHA_2	302	308	PF00498	0.630
LIG_LIR_Apic_2	126	131	PF02991	0.573
LIG_LIR_Gen_1	206	215	PF02991	0.764
LIG_LIR_Gen_1	317	325	PF02991	0.654
LIG_LIR_Gen_1	341	351	PF02991	0.519
LIG_LIR_Gen_1	374	384	PF02991	0.608
LIG_LIR_Gen_1	419	423	PF02991	0.658
LIG_LIR_Nem_3	181	185	PF02991	0.696
LIG_LIR_Nem_3	206	211	PF02991	0.811
LIG_LIR_Nem_3	260	264	PF02991	0.723
LIG_LIR_Nem_3	317	321	PF02991	0.655
LIG_LIR_Nem_3	341	346	PF02991	0.513
LIG_LIR_Nem_3	374	380	PF02991	0.544
LIG_LIR_Nem_3	419	423	PF02991	0.658
LIG_MYND_1	294	298	PF01753	0.780
LIG_MYND_1	354	358	PF01753	0.553
LIG_NRBOX	106	112	PF00104	0.618
LIG_PCNA_PIPBox_1	100	109	PF02747	0.713
LIG_PCNA_yPIPBox_3	322	333	PF02747	0.600
LIG_SH2_PTP2	318	321	PF00017	0.678
LIG_SH2_SRC	208	211	PF00017	0.771
LIG_SH2_SRC	314	317	PF00017	0.705
LIG_SH2_STAP1	338	342	PF00017	0.745
LIG_SH2_STAP1	377	381	PF00017	0.589
LIG_SH2_STAT5	167	170	PF00017	0.778
LIG_SH2_STAT5	314	317	PF00017	0.608
LIG_SH2_STAT5	318	321	PF00017	0.581
LIG_SH2_STAT5	338	341	PF00017	0.429
LIG_SH2_STAT5	94	97	PF00017	0.575
LIG_SH3_1	355	361	PF00018	0.546
LIG_SH3_3	197	203	PF00018	0.605
LIG_SH3_3	279	285	PF00018	0.730
LIG_SH3_3	291	297	PF00018	0.666
LIG_SH3_3	351	357	PF00018	0.677
LIG_SH3_3	364	370	PF00018	0.517
LIG_SH3_3	87	93	PF00018	0.738
LIG_SH3_5	334	338	PF00018	0.742
MOD_CDK_SPxxK_3	274	281	PF00069	0.736
MOD_CK1_1	133	139	PF00069	0.733
MOD_CK1_1	189	195	PF00069	0.791
MOD_CK1_1	277	283	PF00069	0.789
MOD_CK1_1	63	69	PF00069	0.696
MOD_CK1_1	71	77	PF00069	0.690
MOD_CK2_1	228	234	PF00069	0.548
MOD_CK2_1	301	307	PF00069	0.564
MOD_GlcNHglycan	143	146	PF01048	0.758
MOD_GlcNHglycan	151	154	PF01048	0.642
MOD_GlcNHglycan	162	165	PF01048	0.656
MOD_GlcNHglycan	196	199	PF01048	0.797
MOD_GlcNHglycan	26	29	PF01048	0.704
MOD_GlcNHglycan	272	275	PF01048	0.773
MOD_GlcNHglycan	285	288	PF01048	0.747
MOD_GlcNHglycan	343	346	PF01048	0.687
MOD_GlcNHglycan	347	350	PF01048	0.650
MOD_GlcNHglycan	351	354	PF01048	0.630
MOD_GlcNHglycan	65	68	PF01048	0.664
MOD_GlcNHglycan	86	89	PF01048	0.661
MOD_GSK3_1	130	137	PF00069	0.708
MOD_GSK3_1	156	163	PF00069	0.714
MOD_GSK3_1	20	27	PF00069	0.670
MOD_GSK3_1	270	277	PF00069	0.749
MOD_GSK3_1	292	299	PF00069	0.777
MOD_GSK3_1	310	317	PF00069	0.602
MOD_GSK3_1	332	339	PF00069	0.644
MOD_GSK3_1	341	348	PF00069	0.553
MOD_GSK3_1	35	42	PF00069	0.475
MOD_GSK3_1	371	378	PF00069	0.604
MOD_GSK3_1	59	66	PF00069	0.785
MOD_GSK3_1	84	91	PF00069	0.705
MOD_N-GLC_1	2	7	PF02516	0.567
MOD_NEK2_1	120	125	PF00069	0.727
MOD_NEK2_1	168	173	PF00069	0.698
MOD_NEK2_1	2	7	PF00069	0.758
MOD_NEK2_1	20	25	PF00069	0.614
MOD_NEK2_1	39	44	PF00069	0.727
MOD_NEK2_1	410	415	PF00069	0.669
MOD_NEK2_1	60	65	PF00069	0.701
MOD_NEK2_2	257	262	PF00069	0.738
MOD_PIKK_1	156	162	PF00454	0.733
MOD_PKA_1	14	20	PF00069	0.576
MOD_PKA_1	332	338	PF00069	0.641
MOD_PKA_2	14	20	PF00069	0.756
MOD_PKA_2	332	338	PF00069	0.641
MOD_PKB_1	13	21	PF00069	0.577
MOD_Plk_1	2	8	PF00069	0.539
MOD_Plk_4	20	26	PF00069	0.698
MOD_Plk_4	228	234	PF00069	0.748
MOD_Plk_4	301	307	PF00069	0.606
MOD_Plk_4	310	316	PF00069	0.603
MOD_ProDKin_1	180	186	PF00069	0.755
MOD_ProDKin_1	191	197	PF00069	0.680
MOD_ProDKin_1	199	205	PF00069	0.619
MOD_ProDKin_1	274	280	PF00069	0.710
MOD_ProDKin_1	290	296	PF00069	0.653
MOD_SUMO_rev_2	210	218	PF00179	0.763
TRG_DiLeu_BaLyEn_6	111	116	PF01217	0.724
TRG_DiLeu_LyEn_5	248	253	PF01217	0.727
TRG_ENDOCYTIC_2	167	170	PF00928	0.778
TRG_ENDOCYTIC_2	208	211	PF00928	0.821
TRG_ENDOCYTIC_2	318	321	PF00928	0.678
TRG_ENDOCYTIC_2	377	380	PF00928	0.538
TRG_ENDOCYTIC_2	420	423	PF00928	0.760
TRG_ER_diArg_1	13	16	PF00400	0.655
TRG_ER_diArg_1	330	333	PF00400	0.636
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.617

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDR9	Leptomonas seymouri	36%	95%
A0A3Q8IAW3	Leishmania donovani	89%	100%
E9AGV7	Leishmania infantum	88%	100%
E9AV73	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%