Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCA7_LEIMA

TriTrypDb:

LmjF.21.0905 , LMJLV39_210016700 , LMJSD75_210016800

Length:

448

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QCA7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCA7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	332	336	PF00656	0.571
CLV_C14_Caspase3-7	386	390	PF00656	0.480
CLV_C14_Caspase3-7	404	408	PF00656	0.636
CLV_C14_Caspase3-7	92	96	PF00656	0.626
CLV_NRD_NRD_1	133	135	PF00675	0.733
CLV_NRD_NRD_1	200	202	PF00675	0.709
CLV_NRD_NRD_1	251	253	PF00675	0.576
CLV_NRD_NRD_1	275	277	PF00675	0.699
CLV_NRD_NRD_1	340	342	PF00675	0.625
CLV_NRD_NRD_1	344	346	PF00675	0.588
CLV_NRD_NRD_1	368	370	PF00675	0.513
CLV_PCSK_KEX2_1	133	135	PF00082	0.733
CLV_PCSK_KEX2_1	199	201	PF00082	0.729
CLV_PCSK_KEX2_1	251	253	PF00082	0.576
CLV_PCSK_KEX2_1	275	277	PF00082	0.696
CLV_PCSK_KEX2_1	340	342	PF00082	0.631
CLV_PCSK_SKI1_1	11	15	PF00082	0.569
CLV_PCSK_SKI1_1	194	198	PF00082	0.589
CLV_PCSK_SKI1_1	306	310	PF00082	0.600
DEG_Nend_Nbox_1	1	3	PF02207	0.535
DEG_SCF_FBW7_1	100	105	PF00400	0.647
DEG_SPOP_SBC_1	102	106	PF00917	0.636
DEG_SPOP_SBC_1	189	193	PF00917	0.608
DEG_SPOP_SBC_1	318	322	PF00917	0.692
DOC_MAPK_gen_1	251	257	PF00069	0.484
DOC_MAPK_gen_1	275	282	PF00069	0.625
DOC_MAPK_HePTP_8	197	214	PF00069	0.441
DOC_MAPK_MEF2A_6	110	118	PF00069	0.518
DOC_MAPK_MEF2A_6	275	284	PF00069	0.615
DOC_PP2B_LxvP_1	36	39	PF13499	0.636
DOC_USP7_MATH_1	103	107	PF00917	0.681
DOC_USP7_MATH_1	274	278	PF00917	0.576
DOC_USP7_MATH_1	317	321	PF00917	0.715
DOC_USP7_MATH_1	325	329	PF00917	0.609
DOC_WW_Pin1_4	98	103	PF00397	0.649
LIG_14-3-3_CanoR_1	11	16	PF00244	0.595
LIG_14-3-3_CanoR_1	110	114	PF00244	0.570
LIG_14-3-3_CanoR_1	275	282	PF00244	0.625
LIG_14-3-3_CanoR_1	369	373	PF00244	0.535
LIG_Actin_WH2_2	72	88	PF00022	0.675
LIG_BRCT_BRCA1_1	28	32	PF00533	0.426
LIG_FHA_1	103	109	PF00498	0.686
LIG_FHA_1	110	116	PF00498	0.477
LIG_FHA_1	17	23	PF00498	0.446
LIG_FHA_1	191	197	PF00498	0.664
LIG_FHA_1	217	223	PF00498	0.573
LIG_FHA_1	248	254	PF00498	0.381
LIG_FHA_1	355	361	PF00498	0.465
LIG_FHA_1	80	86	PF00498	0.471
LIG_FHA_2	175	181	PF00498	0.751
LIG_FHA_2	201	207	PF00498	0.472
LIG_FHA_2	231	237	PF00498	0.481
LIG_FHA_2	442	448	PF00498	0.638
LIG_LIR_Gen_1	112	120	PF02991	0.430
LIG_LIR_Gen_1	29	39	PF02991	0.469
LIG_LIR_Gen_1	350	360	PF02991	0.471
LIG_LIR_Gen_1	430	439	PF02991	0.506
LIG_LIR_Gen_1	59	66	PF02991	0.575
LIG_LIR_Nem_3	112	116	PF02991	0.438
LIG_LIR_Nem_3	29	35	PF02991	0.468
LIG_LIR_Nem_3	350	355	PF02991	0.497
LIG_LIR_Nem_3	430	434	PF02991	0.550
LIG_LIR_Nem_3	59	64	PF02991	0.566
LIG_SH2_PTP2	113	116	PF00017	0.506
LIG_SH2_SRC	148	151	PF00017	0.441
LIG_SH2_SRC	387	390	PF00017	0.480
LIG_SH2_STAP1	356	360	PF00017	0.441
LIG_SH2_STAP1	421	425	PF00017	0.680
LIG_SH2_STAT5	113	116	PF00017	0.506
LIG_SH2_STAT5	148	151	PF00017	0.446
LIG_SH2_STAT5	356	359	PF00017	0.444
LIG_SH2_STAT5	387	390	PF00017	0.480
LIG_SH3_3	10	16	PF00018	0.549
LIG_SH3_3	257	263	PF00018	0.690
LIG_SH3_3	411	417	PF00018	0.639
LIG_SUMO_SIM_anti_2	112	119	PF11976	0.501
LIG_SUMO_SIM_anti_2	211	216	PF11976	0.388
LIG_SUMO_SIM_par_1	112	119	PF11976	0.447
LIG_SUMO_SIM_par_1	218	223	PF11976	0.564
LIG_SUMO_SIM_par_1	280	285	PF11976	0.582
LIG_UBA3_1	299	306	PF00899	0.556
LIG_WRC_WIRS_1	363	368	PF05994	0.605
LIG_WW_3	64	68	PF00397	0.517
MOD_CK1_1	106	112	PF00069	0.585
MOD_CK1_1	128	134	PF00069	0.467
MOD_CK1_1	174	180	PF00069	0.729
MOD_CK1_1	183	189	PF00069	0.594
MOD_CK1_1	190	196	PF00069	0.554
MOD_CK1_1	358	364	PF00069	0.478
MOD_CK1_1	89	95	PF00069	0.572
MOD_CK2_1	230	236	PF00069	0.489
MOD_CK2_1	362	368	PF00069	0.501
MOD_CK2_1	441	447	PF00069	0.626
MOD_GlcNHglycan	105	108	PF01048	0.668
MOD_GlcNHglycan	127	130	PF01048	0.599
MOD_GlcNHglycan	139	142	PF01048	0.449
MOD_GlcNHglycan	169	172	PF01048	0.659
MOD_GlcNHglycan	173	176	PF01048	0.620
MOD_GlcNHglycan	222	225	PF01048	0.691
MOD_GlcNHglycan	241	244	PF01048	0.383
MOD_GlcNHglycan	247	250	PF01048	0.457
MOD_GlcNHglycan	270	273	PF01048	0.685
MOD_GlcNHglycan	313	316	PF01048	0.753
MOD_GlcNHglycan	327	330	PF01048	0.552
MOD_GlcNHglycan	393	396	PF01048	0.734
MOD_GlcNHglycan	400	404	PF01048	0.657
MOD_GlcNHglycan	435	438	PF01048	0.567
MOD_GlcNHglycan	5	8	PF01048	0.590
MOD_GlcNHglycan	89	92	PF01048	0.565
MOD_GSK3_1	167	174	PF00069	0.733
MOD_GSK3_1	183	190	PF00069	0.549
MOD_GSK3_1	216	223	PF00069	0.628
MOD_GSK3_1	313	320	PF00069	0.604
MOD_GSK3_1	325	332	PF00069	0.617
MOD_GSK3_1	354	361	PF00069	0.466
MOD_GSK3_1	364	371	PF00069	0.531
MOD_GSK3_1	373	380	PF00069	0.550
MOD_GSK3_1	387	394	PF00069	0.484
MOD_GSK3_1	47	54	PF00069	0.676
MOD_GSK3_1	86	93	PF00069	0.569
MOD_GSK3_1	98	105	PF00069	0.666
MOD_N-GLC_1	181	186	PF02516	0.706
MOD_N-GLC_1	216	221	PF02516	0.499
MOD_N-GLC_1	225	230	PF02516	0.567
MOD_N-GLC_2	268	270	PF02516	0.629
MOD_NEK2_1	225	230	PF00069	0.567
MOD_NEK2_1	286	291	PF00069	0.463
MOD_NEK2_1	3	8	PF00069	0.591
MOD_NEK2_1	355	360	PF00069	0.443
MOD_NEK2_1	87	92	PF00069	0.475
MOD_NEK2_2	16	21	PF00069	0.469
MOD_NEK2_2	319	324	PF00069	0.657
MOD_NEK2_2	56	61	PF00069	0.621
MOD_PIKK_1	340	346	PF00454	0.605
MOD_PIKK_1	65	71	PF00454	0.474
MOD_PIKK_1	77	83	PF00454	0.571
MOD_PKA_1	200	206	PF00069	0.551
MOD_PKA_1	340	346	PF00069	0.623
MOD_PKA_2	109	115	PF00069	0.574
MOD_PKA_2	200	206	PF00069	0.591
MOD_PKA_2	274	280	PF00069	0.679
MOD_PKA_2	340	346	PF00069	0.650
MOD_PKA_2	368	374	PF00069	0.466
MOD_Plk_1	216	222	PF00069	0.529
MOD_Plk_1	26	32	PF00069	0.422
MOD_Plk_1	329	335	PF00069	0.592
MOD_Plk_1	361	367	PF00069	0.468
MOD_Plk_2-3	362	368	PF00069	0.496
MOD_Plk_4	109	115	PF00069	0.544
MOD_Plk_4	208	214	PF00069	0.386
MOD_Plk_4	319	325	PF00069	0.686
MOD_Plk_4	355	361	PF00069	0.448
MOD_Plk_4	56	62	PF00069	0.627
MOD_Plk_4	79	85	PF00069	0.478
MOD_ProDKin_1	98	104	PF00069	0.649
MOD_SUMO_rev_2	362	372	PF00179	0.491
TRG_DiLeu_BaLyEn_6	31	36	PF01217	0.403
TRG_ENDOCYTIC_2	113	116	PF00928	0.426
TRG_ENDOCYTIC_2	356	359	PF00928	0.444
TRG_ER_diArg_1	199	201	PF00400	0.726
TRG_ER_diArg_1	251	253	PF00400	0.485
TRG_ER_diArg_1	339	341	PF00400	0.628
TRG_Pf-PMV_PEXEL_1	252	256	PF00026	0.517

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILY1	Leptomonas seymouri	48%	100%
A0A3S7WWI8	Leishmania donovani	91%	100%
A4HK96	Leishmania braziliensis	70%	100%
E9AGV8	Leishmania infantum	91%	100%
E9AV74	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%