tRNA_edit domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Aminoacyl-tRNA editing domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QCA6_LEIMA

TriTrypDb:

LmjF.21.0910 , LMJLV39_210016800 , LMJSD75_210016900

Length:

275

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QCA6

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCA6

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	12
GO:0003824	catalytic activity	1	12
GO:0016787	hydrolase activity	2	12
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0052689	carboxylic ester hydrolase activity	4	12
GO:0140098	catalytic activity, acting on RNA	3	12
GO:0140101	catalytic activity, acting on a tRNA	4	12
GO:0140640	catalytic activity, acting on a nucleic acid	2	12
GO:0004812	aminoacyl-tRNA ligase activity	4	2
GO:0016874	ligase activity	2	2
GO:0016875	ligase activity, forming carbon-oxygen bonds	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	118	120	PF00675	0.415
CLV_NRD_NRD_1	90	92	PF00675	0.446
CLV_PCSK_FUR_1	88	92	PF00082	0.459
CLV_PCSK_KEX2_1	118	120	PF00082	0.415
CLV_PCSK_KEX2_1	90	92	PF00082	0.510
CLV_PCSK_SKI1_1	119	123	PF00082	0.422
CLV_PCSK_SKI1_1	132	136	PF00082	0.266
DEG_SCF_TRCP1_1	95	101	PF00400	0.458
DOC_ANK_TNKS_1	41	48	PF00023	0.622
DOC_MAPK_DCC_7	255	263	PF00069	0.295
DOC_PP2B_LxvP_1	104	107	PF13499	0.422
DOC_PP2B_LxvP_1	122	125	PF13499	0.417
DOC_PP2B_LxvP_1	227	230	PF13499	0.501
DOC_SPAK_OSR1_1	22	26	PF12202	0.526
DOC_USP7_MATH_1	193	197	PF00917	0.468
DOC_USP7_MATH_1	53	57	PF00917	0.705
DOC_USP7_MATH_1	62	66	PF00917	0.615
DOC_USP7_MATH_1	7	11	PF00917	0.615
LIG_Actin_WH2_2	26	44	PF00022	0.604
LIG_CSL_BTD_1	104	107	PF09270	0.539
LIG_FHA_1	229	235	PF00498	0.557
LIG_FHA_1	99	105	PF00498	0.457
LIG_FHA_2	140	146	PF00498	0.491
LIG_FHA_2	264	270	PF00498	0.512
LIG_LIR_Gen_1	101	111	PF02991	0.511
LIG_LIR_Gen_1	152	162	PF02991	0.476
LIG_LIR_Gen_1	247	258	PF02991	0.524
LIG_LIR_Nem_3	101	106	PF02991	0.381
LIG_LIR_Nem_3	152	158	PF02991	0.469
LIG_LIR_Nem_3	247	253	PF02991	0.489
LIG_MYND_1	74	78	PF01753	0.583
LIG_SH2_SRC	159	162	PF00017	0.510
LIG_SH2_STAT5	155	158	PF00017	0.469
LIG_SH2_STAT5	161	164	PF00017	0.462
LIG_SH2_STAT5	233	236	PF00017	0.539
LIG_SH3_3	64	70	PF00018	0.634
LIG_SH3_3	77	83	PF00018	0.614
LIG_SUMO_SIM_par_1	216	221	PF11976	0.474
LIG_TRAF2_1	173	176	PF00917	0.525
LIG_TRAF2_1	266	269	PF00917	0.442
LIG_TYR_ITIM	157	162	PF00017	0.562
MOD_CK1_1	56	62	PF00069	0.709
MOD_CK2_1	263	269	PF00069	0.444
MOD_Cter_Amidation	181	184	PF01082	0.276
MOD_GlcNHglycan	203	206	PF01048	0.352
MOD_GlcNHglycan	27	30	PF01048	0.609
MOD_GlcNHglycan	64	67	PF01048	0.646
MOD_GlcNHglycan	95	98	PF01048	0.462
MOD_GSK3_1	193	200	PF00069	0.504
MOD_GSK3_1	218	225	PF00069	0.537
MOD_GSK3_1	259	266	PF00069	0.413
MOD_GSK3_1	52	59	PF00069	0.703
MOD_N-GLC_1	149	154	PF02516	0.325
MOD_NEK2_1	130	135	PF00069	0.472
MOD_NEK2_1	136	141	PF00069	0.466
MOD_PIKK_1	222	228	PF00454	0.489
MOD_PKA_2	251	257	PF00069	0.612
MOD_Plk_1	149	155	PF00069	0.470
MOD_Plk_1	56	62	PF00069	0.696
MOD_Plk_4	130	136	PF00069	0.475
MOD_Plk_4	228	234	PF00069	0.581
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.447
TRG_ENDOCYTIC_2	154	157	PF00928	0.477
TRG_ENDOCYTIC_2	159	162	PF00928	0.474
TRG_ER_diArg_1	117	119	PF00400	0.407
TRG_ER_diArg_1	88	91	PF00400	0.516
TRG_NES_CRM1_1	14	27	PF08389	0.525
TRG_Pf-PMV_PEXEL_1	172	176	PF00026	0.345
TRG_Pf-PMV_PEXEL_1	31	35	PF00026	0.391

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I030	Leptomonas seymouri	72%	100%
A0A0S4IHR6	Bodo saltans	46%	100%
A0A1X0NXR2	Trypanosomatidae	47%	100%
A0A3Q8IDY4	Leishmania donovani	90%	100%
A0A422NWD3	Trypanosoma rangeli	47%	100%
A4HK97	Leishmania braziliensis	76%	82%
D0A1C2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9AGV9	Leishmania infantum	91%	72%
E9AV75	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5B6I0	Trypanosoma cruzi	47%	100%