ABC transmembrane type-1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QCA2_LEIMA

TriTrypDb:

LmjF.21.0940 , LMJLV39_210017100 , LMJSD75_210017300

Length:

348

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0016020	membrane	2	11
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QCA2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCA2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	313	317	PF00656	0.606
CLV_NRD_NRD_1	136	138	PF00675	0.633
CLV_NRD_NRD_1	162	164	PF00675	0.515
CLV_PCSK_SKI1_1	164	168	PF00082	0.563
CLV_PCSK_SKI1_1	224	228	PF00082	0.617
DEG_APCC_DBOX_1	77	85	PF00400	0.589
DOC_MAPK_gen_1	163	169	PF00069	0.350
DOC_MAPK_RevD_3	150	164	PF00069	0.300
DOC_PP4_FxxP_1	325	328	PF00568	0.383
DOC_USP7_MATH_1	13	17	PF00917	0.647
DOC_USP7_MATH_1	187	191	PF00917	0.399
DOC_WW_Pin1_4	18	23	PF00397	0.647
DOC_WW_Pin1_4	290	295	PF00397	0.646
DOC_WW_Pin1_4	56	61	PF00397	0.659
LIG_Actin_WH2_2	103	121	PF00022	0.513
LIG_Actin_WH2_2	210	226	PF00022	0.575
LIG_BIR_III_2	225	229	PF00653	0.468
LIG_BIR_III_2	316	320	PF00653	0.410
LIG_BIR_III_4	143	147	PF00653	0.434
LIG_BRCT_BRCA1_1	58	62	PF00533	0.564
LIG_BRCT_BRCA1_2	58	64	PF00533	0.565
LIG_EH_1	317	321	PF12763	0.455
LIG_FHA_1	107	113	PF00498	0.347
LIG_FHA_1	99	105	PF00498	0.368
LIG_FHA_2	311	317	PF00498	0.576
LIG_FHA_2	328	334	PF00498	0.232
LIG_GBD_Chelix_1	246	254	PF00786	0.437
LIG_LIR_Gen_1	121	129	PF02991	0.391
LIG_LIR_Gen_1	333	340	PF02991	0.475
LIG_LIR_Gen_1	67	76	PF02991	0.663
LIG_LIR_Gen_1	99	107	PF02991	0.388
LIG_LIR_Nem_3	121	125	PF02991	0.382
LIG_LIR_Nem_3	215	219	PF02991	0.390
LIG_LIR_Nem_3	31	37	PF02991	0.579
LIG_LIR_Nem_3	333	337	PF02991	0.475
LIG_LIR_Nem_3	67	71	PF02991	0.661
LIG_LIR_Nem_3	99	103	PF02991	0.414
LIG_MLH1_MIPbox_1	58	62	PF16413	0.564
LIG_NRBOX	304	310	PF00104	0.402
LIG_Pex14_2	325	329	PF04695	0.397
LIG_Rb_LxCxE_1	108	121	PF01857	0.411
LIG_REV1ctd_RIR_1	166	174	PF16727	0.280
LIG_SH2_CRK	100	104	PF00017	0.409
LIG_SH2_CRK	68	72	PF00017	0.661
LIG_SH2_GRB2like	126	129	PF00017	0.392
LIG_SH2_NCK_1	129	133	PF00017	0.446
LIG_SH2_NCK_1	68	72	PF00017	0.653
LIG_SH2_PTP2	216	219	PF00017	0.440
LIG_SH2_STAP1	100	104	PF00017	0.385
LIG_SH2_STAP1	129	133	PF00017	0.425
LIG_SH2_STAP1	68	72	PF00017	0.650
LIG_SH2_STAT5	100	103	PF00017	0.375
LIG_SH2_STAT5	216	219	PF00017	0.397
LIG_SH2_STAT5	334	337	PF00017	0.359
LIG_SH2_STAT5	61	64	PF00017	0.631
LIG_SH2_STAT5	68	71	PF00017	0.685
LIG_SUMO_SIM_par_1	101	109	PF11976	0.366
LIG_TRAF2_1	51	54	PF00917	0.521
MOD_CDC14_SPxK_1	21	24	PF00782	0.676
MOD_CDK_SPK_2	290	295	PF00069	0.646
MOD_CDK_SPxK_1	18	24	PF00069	0.699
MOD_CDK_SPxxK_3	290	297	PF00069	0.630
MOD_CK1_1	208	214	PF00069	0.428
MOD_CK1_1	67	73	PF00069	0.682
MOD_CK2_1	327	333	PF00069	0.344
MOD_GlcNHglycan	234	237	PF01048	0.579
MOD_GSK3_1	18	25	PF00069	0.633
MOD_GSK3_1	208	215	PF00069	0.427
MOD_NEK2_1	118	123	PF00069	0.374
MOD_NEK2_1	199	204	PF00069	0.396
MOD_NEK2_1	205	210	PF00069	0.389
MOD_NEK2_1	212	217	PF00069	0.314
MOD_NEK2_1	96	101	PF00069	0.410
MOD_NEK2_2	13	18	PF00069	0.724
MOD_PKA_1	232	238	PF00069	0.426
MOD_PKA_2	49	55	PF00069	0.632
MOD_Plk_1	287	293	PF00069	0.648
MOD_Plk_2-3	287	293	PF00069	0.655
MOD_Plk_4	13	19	PF00069	0.663
MOD_Plk_4	187	193	PF00069	0.401
MOD_Plk_4	212	218	PF00069	0.499
MOD_Plk_4	249	255	PF00069	0.360
MOD_Plk_4	98	104	PF00069	0.381
MOD_ProDKin_1	18	24	PF00069	0.644
MOD_ProDKin_1	290	296	PF00069	0.637
MOD_ProDKin_1	56	62	PF00069	0.660
MOD_SUMO_rev_2	116	121	PF00179	0.413
TRG_DiLeu_BaEn_1	108	113	PF01217	0.412
TRG_ENDOCYTIC_2	100	103	PF00928	0.382
TRG_ENDOCYTIC_2	216	219	PF00928	0.396
TRG_ENDOCYTIC_2	334	337	PF00928	0.475
TRG_ENDOCYTIC_2	68	71	PF00928	0.638

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1II52	Leptomonas seymouri	58%	100%
A0A0S4JMI1	Bodo saltans	31%	100%
A0A1X0NXQ9	Trypanosomatidae	32%	100%
A0A3S5H798	Leishmania donovani	91%	100%
A0A422NWG5	Trypanosoma rangeli	34%	100%
A4HBV4	Leishmania braziliensis	75%	100%
D0A1C0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AGW2	Leishmania infantum	92%	100%
E9AV78	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
V5BFJ0	Trypanosoma cruzi	32%	100%