PDCD2_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Programmed cell death protein 2, C-terminal putative domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QCA1_LEIMA

TriTrypDb:

LmjF.21.0950 , LMJLV39_210017200 , LMJSD75_210017400

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

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Expansion

Sequence features

Q4QCA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCA1

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.503
CLV_NRD_NRD_1	363	365	PF00675	0.329
CLV_PCSK_KEX2_1	33	35	PF00082	0.503
CLV_PCSK_KEX2_1	363	365	PF00082	0.430
CLV_PCSK_KEX2_1	4	6	PF00082	0.560
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.560
CLV_PCSK_SKI1_1	224	228	PF00082	0.408
CLV_PCSK_SKI1_1	401	405	PF00082	0.682
DEG_SPOP_SBC_1	310	314	PF00917	0.210
DOC_MAPK_DCC_7	222	231	PF00069	0.355

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTP0	Leptomonas seymouri	68%	96%
A0A1X0NZ44	Trypanosomatidae	44%	100%
A0A3Q8IC20	Leishmania donovani	93%	99%
A0A3S5IS34	Trypanosoma rangeli	42%	100%
A4HBV5	Leishmania braziliensis	81%	100%
D0A195	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AGW3	Leishmania infantum	94%	100%
E9AV79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5AR10	Trypanosoma cruzi	43%	100%

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