PDCD2_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Programmed cell death protein 2, C-terminal putative domain containing protein, putative

Species:

Leishmania major

UniProt:

Q4QCA1_LEIMA

TriTrypDb:

LmjF.21.0950 , LMJLV39_210017200 , LMJSD75_210017400

Length:

430

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

Q4QCA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QCA1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	33	35	PF00675	0.503
CLV_NRD_NRD_1	363	365	PF00675	0.329
CLV_PCSK_KEX2_1	33	35	PF00082	0.503
CLV_PCSK_KEX2_1	363	365	PF00082	0.430
CLV_PCSK_KEX2_1	4	6	PF00082	0.560
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.560
CLV_PCSK_SKI1_1	224	228	PF00082	0.408
CLV_PCSK_SKI1_1	401	405	PF00082	0.682
DEG_SPOP_SBC_1	310	314	PF00917	0.210
DOC_MAPK_DCC_7	222	231	PF00069	0.355
DOC_MAPK_gen_1	235	242	PF00069	0.366
DOC_MAPK_gen_1	363	369	PF00069	0.337
DOC_PP4_FxxP_1	230	233	PF00568	0.297
DOC_USP7_MATH_1	138	142	PF00917	0.576
DOC_USP7_MATH_1	215	219	PF00917	0.440
DOC_USP7_MATH_1	290	294	PF00917	0.394
DOC_USP7_MATH_1	306	310	PF00917	0.469
DOC_USP7_MATH_1	82	86	PF00917	0.341
DOC_WW_Pin1_4	14	19	PF00397	0.439
DOC_WW_Pin1_4	300	305	PF00397	0.282
DOC_WW_Pin1_4	50	55	PF00397	0.422
LIG_14-3-3_CanoR_1	163	171	PF00244	0.590
LIG_14-3-3_CanoR_1	33	40	PF00244	0.399
LIG_14-3-3_CanoR_1	80	89	PF00244	0.431
LIG_Actin_WH2_2	167	183	PF00022	0.634
LIG_BIR_II_1	1	5	PF00653	0.670
LIG_BIR_III_2	137	141	PF00653	0.502
LIG_FHA_1	114	120	PF00498	0.696
LIG_FHA_1	175	181	PF00498	0.551
LIG_FHA_1	251	257	PF00498	0.392
LIG_FHA_1	341	347	PF00498	0.267
LIG_FHA_1	364	370	PF00498	0.435
LIG_FHA_1	393	399	PF00498	0.599
LIG_FHA_2	146	152	PF00498	0.512
LIG_FHA_2	163	169	PF00498	0.579
LIG_FHA_2	181	187	PF00498	0.480
LIG_FHA_2	323	329	PF00498	0.385
LIG_FHA_2	372	378	PF00498	0.651
LIG_FHA_2	397	403	PF00498	0.749
LIG_LIR_Apic_2	17	23	PF02991	0.541
LIG_LIR_Gen_1	186	197	PF02991	0.285
LIG_LIR_Gen_1	262	273	PF02991	0.315
LIG_LIR_Nem_3	186	192	PF02991	0.285
LIG_LIR_Nem_3	19	24	PF02991	0.467
LIG_LIR_Nem_3	262	268	PF02991	0.315
LIG_LIR_Nem_3	269	274	PF02991	0.333
LIG_LIR_Nem_3	340	344	PF02991	0.297
LIG_LIR_Nem_3	49	55	PF02991	0.412
LIG_NRBOX	399	405	PF00104	0.674
LIG_PDZ_Class_1	425	430	PF00595	0.562
LIG_PTAP_UEV_1	55	60	PF05743	0.572
LIG_SH2_CRK	271	275	PF00017	0.410
LIG_SH2_CRK	52	56	PF00017	0.555
LIG_SH2_PTP2	133	136	PF00017	0.472
LIG_SH2_SRC	133	136	PF00017	0.469
LIG_SH2_SRC	265	268	PF00017	0.410
LIG_SH2_STAP1	207	211	PF00017	0.428
LIG_SH2_STAP1	271	275	PF00017	0.410
LIG_SH2_STAT5	133	136	PF00017	0.472
LIG_SH2_STAT5	20	23	PF00017	0.473
LIG_SH2_STAT5	265	268	PF00017	0.316
LIG_SH2_STAT5	271	274	PF00017	0.316
LIG_SH2_STAT5	347	350	PF00017	0.357
LIG_SH2_STAT5	69	72	PF00017	0.316
LIG_SH2_STAT5	77	80	PF00017	0.360
LIG_SH3_3	115	121	PF00018	0.552
LIG_SH3_3	125	131	PF00018	0.400
LIG_SH3_3	237	243	PF00018	0.362
LIG_SH3_3	302	308	PF00018	0.288
LIG_SH3_3	53	59	PF00018	0.457
LIG_SUMO_SIM_par_1	175	183	PF11976	0.442
LIG_TRAF2_1	105	108	PF00917	0.687
LIG_TRAF2_1	167	170	PF00917	0.593
LIG_TYR_ITIM	263	268	PF00017	0.279
LIG_WW_1	130	133	PF00397	0.430
MOD_CK1_1	164	170	PF00069	0.629
MOD_CK1_1	250	256	PF00069	0.432
MOD_CK1_1	269	275	PF00069	0.355
MOD_CK1_1	293	299	PF00069	0.345
MOD_CK1_1	309	315	PF00069	0.407
MOD_CK1_1	318	324	PF00069	0.250
MOD_CK1_1	46	52	PF00069	0.361
MOD_CK2_1	145	151	PF00069	0.499
MOD_CK2_1	164	170	PF00069	0.513
MOD_CK2_1	322	328	PF00069	0.355
MOD_CK2_1	396	402	PF00069	0.753
MOD_GlcNHglycan	217	220	PF01048	0.407
MOD_GlcNHglycan	308	311	PF01048	0.417
MOD_GlcNHglycan	317	320	PF01048	0.228
MOD_GlcNHglycan	74	77	PF01048	0.445
MOD_GSK3_1	300	307	PF00069	0.292
MOD_GSK3_1	311	318	PF00069	0.276
MOD_GSK3_1	388	395	PF00069	0.685
MOD_GSK3_1	46	53	PF00069	0.450
MOD_GSK3_1	54	61	PF00069	0.564
MOD_GSK3_1	72	79	PF00069	0.327
MOD_NEK2_1	180	185	PF00069	0.417
MOD_NEK2_2	342	347	PF00069	0.279
MOD_PIKK_1	248	254	PF00454	0.210
MOD_PIKK_1	298	304	PF00454	0.243
MOD_PIKK_1	46	52	PF00454	0.361
MOD_PKA_1	33	39	PF00069	0.486
MOD_PKA_1	363	369	PF00069	0.438
MOD_PKA_2	162	168	PF00069	0.628
MOD_PKA_2	33	39	PF00069	0.494
MOD_PKA_2	363	369	PF00069	0.485
MOD_Plk_1	174	180	PF00069	0.553
MOD_Plk_1	207	213	PF00069	0.354
MOD_Plk_1	269	275	PF00069	0.355
MOD_Plk_2-3	371	377	PF00069	0.639
MOD_Plk_4	16	22	PF00069	0.422
MOD_Plk_4	259	265	PF00069	0.299
MOD_Plk_4	43	49	PF00069	0.480
MOD_Plk_4	82	88	PF00069	0.491
MOD_ProDKin_1	14	20	PF00069	0.443
MOD_ProDKin_1	300	306	PF00069	0.282
MOD_ProDKin_1	50	56	PF00069	0.438
MOD_SUMO_rev_2	175	183	PF00179	0.550
MOD_SUMO_rev_2	220	229	PF00179	0.294
MOD_SUMO_rev_2	6	14	PF00179	0.469
TRG_DiLeu_BaEn_4	169	175	PF01217	0.647
TRG_DiLeu_LyEn_5	115	120	PF01217	0.555
TRG_ENDOCYTIC_2	133	136	PF00928	0.472
TRG_ENDOCYTIC_2	189	192	PF00928	0.353
TRG_ENDOCYTIC_2	265	268	PF00928	0.279
TRG_ENDOCYTIC_2	271	274	PF00928	0.279
TRG_ENDOCYTIC_2	52	55	PF00928	0.538
TRG_ER_diArg_1	192	195	PF00400	0.279
TRG_ER_diArg_1	32	34	PF00400	0.497
TRG_ER_diArg_1	362	364	PF00400	0.431
TRG_NES_CRM1_1	169	182	PF08389	0.516
TRG_NES_CRM1_1	257	270	PF08389	0.297

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HTP0	Leptomonas seymouri	68%	96%
A0A1X0NZ44	Trypanosomatidae	44%	100%
A0A3Q8IC20	Leishmania donovani	93%	99%
A0A3S5IS34	Trypanosoma rangeli	42%	100%
A4HBV5	Leishmania braziliensis	81%	100%
D0A195	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9AGW3	Leishmania infantum	94%	100%
E9AV79	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5AR10	Trypanosoma cruzi	43%	100%