SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QC99_LEIMA

TriTrypDb:

LmjF.21.0970 , LMJLV39_210017400 , LMJSD75_210017600

Length:

713

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QC99

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QC99

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	138	142	PF00656	0.721
CLV_C14_Caspase3-7	352	356	PF00656	0.574
CLV_C14_Caspase3-7	385	389	PF00656	0.680
CLV_C14_Caspase3-7	480	484	PF00656	0.588
CLV_C14_Caspase3-7	537	541	PF00656	0.743
CLV_C14_Caspase3-7	699	703	PF00656	0.771
CLV_NRD_NRD_1	172	174	PF00675	0.515
CLV_NRD_NRD_1	326	328	PF00675	0.624
CLV_NRD_NRD_1	36	38	PF00675	0.645
CLV_NRD_NRD_1	42	44	PF00675	0.617
CLV_NRD_NRD_1	515	517	PF00675	0.575
CLV_NRD_NRD_1	52	54	PF00675	0.535
CLV_NRD_NRD_1	520	522	PF00675	0.634
CLV_NRD_NRD_1	529	531	PF00675	0.650
CLV_NRD_NRD_1	578	580	PF00675	0.657
CLV_NRD_NRD_1	606	608	PF00675	0.433
CLV_NRD_NRD_1	646	648	PF00675	0.444
CLV_PCSK_FUR_1	518	522	PF00082	0.649
CLV_PCSK_KEX2_1	172	174	PF00082	0.509
CLV_PCSK_KEX2_1	328	330	PF00082	0.565
CLV_PCSK_KEX2_1	36	38	PF00082	0.645
CLV_PCSK_KEX2_1	42	44	PF00082	0.617
CLV_PCSK_KEX2_1	517	519	PF00082	0.614
CLV_PCSK_KEX2_1	52	54	PF00082	0.535
CLV_PCSK_KEX2_1	520	522	PF00082	0.639
CLV_PCSK_KEX2_1	593	595	PF00082	0.531
CLV_PCSK_KEX2_1	606	608	PF00082	0.390
CLV_PCSK_KEX2_1	646	648	PF00082	0.463
CLV_PCSK_PC1ET2_1	328	330	PF00082	0.559
CLV_PCSK_PC1ET2_1	517	519	PF00082	0.638
CLV_PCSK_PC1ET2_1	593	595	PF00082	0.632
CLV_PCSK_PC7_1	516	522	PF00082	0.703
CLV_PCSK_SKI1_1	106	110	PF00082	0.576
CLV_PCSK_SKI1_1	172	176	PF00082	0.471
CLV_PCSK_SKI1_1	178	182	PF00082	0.470
CLV_PCSK_SKI1_1	223	227	PF00082	0.685
CLV_PCSK_SKI1_1	280	284	PF00082	0.517
CLV_PCSK_SKI1_1	379	383	PF00082	0.645
CLV_PCSK_SKI1_1	395	399	PF00082	0.586
CLV_PCSK_SKI1_1	472	476	PF00082	0.675
CLV_PCSK_SKI1_1	531	535	PF00082	0.710
CLV_PCSK_SKI1_1	583	587	PF00082	0.497
CLV_PCSK_SKI1_1	593	597	PF00082	0.450
CLV_PCSK_SKI1_1	646	650	PF00082	0.517
DEG_APCC_DBOX_1	646	654	PF00400	0.458
DEG_SPOP_SBC_1	124	128	PF00917	0.734
DEG_SPOP_SBC_1	234	238	PF00917	0.744
DEG_SPOP_SBC_1	562	566	PF00917	0.798
DEG_SPOP_SBC_1	68	72	PF00917	0.724
DEG_SPOP_SBC_1	693	697	PF00917	0.580
DOC_CYCLIN_RxL_1	466	476	PF00134	0.672
DOC_CYCLIN_RxL_1	643	652	PF00134	0.453
DOC_CYCLIN_yCln2_LP_2	340	346	PF00134	0.534
DOC_CYCLIN_yCln2_LP_2	360	363	PF00134	0.461
DOC_MAPK_DCC_7	502	510	PF00069	0.632
DOC_MAPK_gen_1	106	116	PF00069	0.577
DOC_MAPK_gen_1	374	382	PF00069	0.562
DOC_MAPK_gen_1	430	439	PF00069	0.550
DOC_MAPK_MEF2A_6	430	439	PF00069	0.532
DOC_MAPK_MEF2A_6	472	481	PF00069	0.649
DOC_MAPK_MEF2A_6	502	511	PF00069	0.593
DOC_PP1_RVXF_1	470	476	PF00149	0.655
DOC_PP2B_LxvP_1	197	200	PF13499	0.550
DOC_PP2B_LxvP_1	340	343	PF13499	0.773
DOC_PP2B_LxvP_1	360	363	PF13499	0.498
DOC_USP7_MATH_1	133	137	PF00917	0.812
DOC_USP7_MATH_1	140	144	PF00917	0.543
DOC_USP7_MATH_1	149	153	PF00917	0.733
DOC_USP7_MATH_1	165	169	PF00917	0.458
DOC_USP7_MATH_1	234	238	PF00917	0.747
DOC_USP7_MATH_1	246	250	PF00917	0.732
DOC_USP7_MATH_1	562	566	PF00917	0.783
DOC_USP7_MATH_1	660	664	PF00917	0.677
DOC_USP7_MATH_1	69	73	PF00917	0.691
DOC_USP7_MATH_1	693	697	PF00917	0.699
DOC_USP7_UBL2_3	106	110	PF12436	0.662
DOC_WW_Pin1_4	142	147	PF00397	0.763
DOC_WW_Pin1_4	237	242	PF00397	0.725
DOC_WW_Pin1_4	283	288	PF00397	0.652
DOC_WW_Pin1_4	338	343	PF00397	0.747
DOC_WW_Pin1_4	63	68	PF00397	0.749
DOC_WW_Pin1_4	9	14	PF00397	0.719
LIG_14-3-3_CanoR_1	166	172	PF00244	0.509
LIG_14-3-3_CanoR_1	178	187	PF00244	0.451
LIG_14-3-3_CanoR_1	247	254	PF00244	0.676
LIG_14-3-3_CanoR_1	311	321	PF00244	0.619
LIG_14-3-3_CanoR_1	327	334	PF00244	0.607
LIG_14-3-3_CanoR_1	472	478	PF00244	0.531
LIG_14-3-3_CanoR_1	52	56	PF00244	0.700
LIG_14-3-3_CanoR_1	594	601	PF00244	0.508
LIG_14-3-3_CanoR_1	606	614	PF00244	0.413
LIG_Actin_WH2_2	638	656	PF00022	0.512
LIG_BIR_III_4	622	626	PF00653	0.550
LIG_BRCT_BRCA1_1	502	506	PF00533	0.535
LIG_BRCT_BRCA1_1	92	96	PF00533	0.483
LIG_deltaCOP1_diTrp_1	467	475	PF00928	0.669
LIG_FHA_1	103	109	PF00498	0.546
LIG_FHA_1	145	151	PF00498	0.696
LIG_FHA_1	434	440	PF00498	0.610
LIG_FHA_1	441	447	PF00498	0.584
LIG_FHA_1	468	474	PF00498	0.630
LIG_FHA_1	569	575	PF00498	0.703
LIG_FHA_2	697	703	PF00498	0.758
LIG_LIR_Apic_2	63	68	PF02991	0.548
LIG_LIR_Gen_1	183	190	PF02991	0.675
LIG_LIR_Gen_1	423	433	PF02991	0.594
LIG_LIR_Nem_3	183	189	PF02991	0.556
LIG_LIR_Nem_3	192	198	PF02991	0.555
LIG_LIR_Nem_3	423	429	PF02991	0.602
LIG_LIR_Nem_3	503	509	PF02991	0.596
LIG_LIR_Nem_3	93	99	PF02991	0.488
LIG_MYND_1	342	346	PF01753	0.529
LIG_NRBOX	473	479	PF00104	0.645
LIG_NRBOX	614	620	PF00104	0.512
LIG_PDZ_Class_2	708	713	PF00595	0.584
LIG_PTB_Apo_2	157	164	PF02174	0.669
LIG_PTB_Apo_2	366	373	PF02174	0.628
LIG_PTB_Phospho_1	366	372	PF10480	0.635
LIG_Rb_pABgroove_1	490	498	PF01858	0.639
LIG_SH2_CRK	587	591	PF00017	0.562
LIG_SH2_CRK	65	69	PF00017	0.544
LIG_SH2_NCK_1	419	423	PF00017	0.587
LIG_SH2_NCK_1	587	591	PF00017	0.509
LIG_SH2_NCK_1	65	69	PF00017	0.544
LIG_SH2_SRC	186	189	PF00017	0.600
LIG_SH2_STAT5	186	189	PF00017	0.529
LIG_SH2_STAT5	196	199	PF00017	0.523
LIG_SH2_STAT5	224	227	PF00017	0.601
LIG_SH2_STAT5	632	635	PF00017	0.454
LIG_SH3_3	202	208	PF00018	0.727
LIG_SH3_3	304	310	PF00018	0.771
LIG_SH3_3	340	346	PF00018	0.689
LIG_SH3_4	106	113	PF00018	0.639
LIG_SUMO_SIM_anti_2	12	18	PF11976	0.642
LIG_SUMO_SIM_par_1	476	483	PF11976	0.655
LIG_TRAF2_1	276	279	PF00917	0.619
LIG_TRAF2_1	414	417	PF00917	0.568
LIG_TRAF2_1	456	459	PF00917	0.685
LIG_TRFH_1	338	342	PF08558	0.778
LIG_TYR_ITIM	585	590	PF00017	0.546
LIG_UBA3_1	425	432	PF00899	0.554
MOD_CDK_SPxxK_3	237	244	PF00069	0.696
MOD_CK1_1	145	151	PF00069	0.722
MOD_CK1_1	237	243	PF00069	0.685
MOD_CK1_1	249	255	PF00069	0.583
MOD_CK1_1	29	35	PF00069	0.567
MOD_CK1_1	315	321	PF00069	0.755
MOD_CK1_1	54	60	PF00069	0.725
MOD_CK1_1	561	567	PF00069	0.798
MOD_CK1_1	63	69	PF00069	0.773
MOD_CK1_1	696	702	PF00069	0.711
MOD_CK1_1	70	76	PF00069	0.681
MOD_CK2_1	132	138	PF00069	0.687
MOD_CK2_1	411	417	PF00069	0.564
MOD_CK2_1	479	485	PF00069	0.634
MOD_CK2_1	605	611	PF00069	0.533
MOD_GlcNHglycan	121	124	PF01048	0.733
MOD_GlcNHglycan	134	138	PF01048	0.617
MOD_GlcNHglycan	147	150	PF01048	0.771
MOD_GlcNHglycan	183	186	PF01048	0.574
MOD_GlcNHglycan	201	204	PF01048	0.504
MOD_GlcNHglycan	27	31	PF01048	0.629
MOD_GlcNHglycan	329	332	PF01048	0.684
MOD_GlcNHglycan	335	338	PF01048	0.694
MOD_GlcNHglycan	523	526	PF01048	0.680
MOD_GlcNHglycan	536	540	PF01048	0.762
MOD_GlcNHglycan	560	563	PF01048	0.799
MOD_GlcNHglycan	658	661	PF01048	0.718
MOD_GlcNHglycan	668	672	PF01048	0.740
MOD_GlcNHglycan	676	679	PF01048	0.727
MOD_GSK3_1	119	126	PF00069	0.691
MOD_GSK3_1	129	136	PF00069	0.733
MOD_GSK3_1	140	147	PF00069	0.731
MOD_GSK3_1	230	237	PF00069	0.668
MOD_GSK3_1	315	322	PF00069	0.666
MOD_GSK3_1	440	447	PF00069	0.606
MOD_GSK3_1	473	480	PF00069	0.555
MOD_GSK3_1	546	553	PF00069	0.749
MOD_GSK3_1	558	565	PF00069	0.711
MOD_GSK3_1	63	70	PF00069	0.732
MOD_GSK3_1	649	656	PF00069	0.521
MOD_GSK3_1	692	699	PF00069	0.799
MOD_GSK3_1	71	78	PF00069	0.678
MOD_N-GLC_1	433	438	PF02516	0.669
MOD_N-GLC_1	534	539	PF02516	0.567
MOD_NEK2_1	180	185	PF00069	0.624
MOD_NEK2_1	382	387	PF00069	0.670
MOD_NEK2_1	398	403	PF00069	0.475
MOD_NEK2_1	473	478	PF00069	0.531
MOD_NEK2_1	586	591	PF00069	0.592
MOD_NEK2_1	60	65	PF00069	0.771
MOD_NEK2_1	649	654	PF00069	0.550
MOD_NEK2_1	76	81	PF00069	0.610
MOD_PIKK_1	149	155	PF00454	0.748
MOD_PIKK_1	312	318	PF00454	0.619
MOD_PIKK_1	546	552	PF00454	0.714
MOD_PIKK_1	574	580	PF00454	0.704
MOD_PKA_1	327	333	PF00069	0.689
MOD_PKA_1	593	599	PF00069	0.515
MOD_PKA_2	165	171	PF00069	0.583
MOD_PKA_2	246	252	PF00069	0.716
MOD_PKA_2	51	57	PF00069	0.641
MOD_PKA_2	593	599	PF00069	0.568
MOD_PKA_2	605	611	PF00069	0.383
MOD_PKA_2	653	659	PF00069	0.645
MOD_Plk_1	433	439	PF00069	0.596
MOD_Plk_2-3	265	271	PF00069	0.614
MOD_Plk_2-3	295	301	PF00069	0.730
MOD_Plk_4	12	18	PF00069	0.614
MOD_Plk_4	29	35	PF00069	0.525
MOD_Plk_4	4	10	PF00069	0.621
MOD_Plk_4	444	450	PF00069	0.572
MOD_Plk_4	669	675	PF00069	0.539
MOD_Plk_4	72	78	PF00069	0.778
MOD_ProDKin_1	142	148	PF00069	0.760
MOD_ProDKin_1	237	243	PF00069	0.728
MOD_ProDKin_1	283	289	PF00069	0.653
MOD_ProDKin_1	338	344	PF00069	0.747
MOD_ProDKin_1	63	69	PF00069	0.749
MOD_ProDKin_1	9	15	PF00069	0.712
MOD_SUMO_for_1	255	258	PF00179	0.480
MOD_SUMO_for_1	533	536	PF00179	0.715
TRG_DiLeu_BaLyEn_6	340	345	PF01217	0.748
TRG_DiLeu_BaLyEn_6	469	474	PF01217	0.524
TRG_DiLeu_BaLyEn_6	614	619	PF01217	0.561
TRG_DiLeu_LyEn_5	504	509	PF01217	0.635
TRG_ENDOCYTIC_2	186	189	PF00928	0.551
TRG_ENDOCYTIC_2	587	590	PF00928	0.560
TRG_ER_diArg_1	171	173	PF00400	0.517
TRG_ER_diArg_1	326	329	PF00400	0.572
TRG_ER_diArg_1	36	38	PF00400	0.577
TRG_ER_diArg_1	377	380	PF00400	0.581
TRG_ER_diArg_1	516	519	PF00400	0.665
TRG_ER_diArg_1	605	607	PF00400	0.458
TRG_ER_diArg_1	645	647	PF00400	0.463
TRG_NLS_MonoCore_2	516	521	PF00514	0.697
TRG_NLS_MonoExtC_3	515	520	PF00514	0.608
TRG_NLS_MonoExtN_4	516	521	PF00514	0.617
TRG_Pf-PMV_PEXEL_1	36	41	PF00026	0.692
TRG_Pf-PMV_PEXEL_1	490	494	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	617	622	PF00026	0.603

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0P8	Leptomonas seymouri	48%	100%
A0A1X0NXZ3	Trypanosomatidae	36%	100%
A0A3S5IS33	Trypanosoma rangeli	37%	100%
A0A3S7WWN7	Leishmania donovani	90%	99%
A4HBV7	Leishmania braziliensis	70%	100%
D0A197	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	100%
E9AGW5	Leishmania infantum	90%	94%
E9AV81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
V5BFI7	Trypanosoma cruzi	39%	100%